LOCUS       NM_001411624            2522 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Mus musculus glycogen synthase 2 (Gys2), transcript variant 2,
            mRNA.
ACCESSION   NM_001411624 XM_006506957
VERSION     NM_001411624.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2522)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2522)
  AUTHORS   Zhao,H., Han,G., Jiang,Z., Gao,D., Zhang,H., Yang,L., Ma,T.,
            Gao,L., Wang,A., Chao,H.W., Li,Q., Jin,Y. and Chen,H.
  TITLE     Identification of BMAL1-Regulated circadian genes in mouse liver
            and their potential association with hepatocellular carcinoma: Gys2
            and Upp2 as promising candidates
  JOURNAL   Biochem Biophys Res Commun 696, 149422 (2024)
   PUBMED   38183795
  REMARK    GeneRIF: Identification of BMAL1-Regulated circadian genes in mouse
            liver and their potential association with hepatocellular
            carcinoma: Gys2 and Upp2 as promising candidates.
REFERENCE   3  (bases 1 to 2522)
  AUTHORS   Zhang,X., Yin,H., Zhang,X., Jiang,X., Liu,Y., Zhang,H., Peng,Y.,
            Li,D., Yu,Y., Zhang,J., Cheng,S., Yang,A. and Zhang,R.
  TITLE     N6-methyladenosine modification governs liver glycogenesis by
            stabilizing the glycogen synthase 2 mRNA
  JOURNAL   Nat Commun 13 (1), 7038 (2022)
   PUBMED   36396934
  REMARK    GeneRIF: N6-methyladenosine modification governs liver glycogenesis
            by stabilizing the glycogen synthase 2 mRNA.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2522)
  AUTHORS   Roberts,G.A.G. and Tunster,S.J.
  TITLE     Characterising the dynamics of placental glycogen stores in the
            mouse
  JOURNAL   Placenta 99, 131-140 (2020)
   PUBMED   32798765
REFERENCE   5  (bases 1 to 2522)
  AUTHORS   Li,Q., Zhao,Q., Zhang,J., Zhou,L., Zhang,W., Chua,B., Chen,Y.,
            Xu,L. and Li,P.
  TITLE     The Protein Phosphatase 1 Complex Is a Direct Target of AKT that
            Links Insulin Signaling to Hepatic Glycogen Deposition
  JOURNAL   Cell Rep 28 (13), 3406-3422 (2019)
   PUBMED   31553910
REFERENCE   6  (bases 1 to 2522)
  AUTHORS   Liu,S.P., Li,Y.S., Chen,Y.J., Chiang,E.P., Li,A.F., Lee,Y.H.,
            Tsai,T.F., Hsiao,M., Huang,S.F. and Chen,Y.M.
  TITLE     Glycine N-methyltransferase-/- mice develop chronic hepatitis and
            glycogen storage disease in the liver
  JOURNAL   Hepatology 46 (5), 1413-1425 (2007)
   PUBMED   17937387
  REMARK    Erratum:[Hepatology. 2008 Feb;47(2):769. Hwang, Shiu-Feng
            [corrected to Huang, Shiu-Feng]]
REFERENCE   7  (bases 1 to 2522)
  AUTHORS   Mandard,S., Stienstra,R., Escher,P., Tan,N.S., Kim,I.,
            Gonzalez,F.J., Wahli,W., Desvergne,B., Muller,M. and Kersten,S.
  TITLE     Glycogen synthase 2 is a novel target gene of peroxisome
            proliferator-activated receptors
  JOURNAL   Cell Mol Life Sci 64 (9), 1145-1157 (2007)
   PUBMED   17437057
  REMARK    GeneRIF: Mouse enzyme is a novel target of peroxisome
            proliferator-activated receptor, which is in turn mediated by two
            response elements.
REFERENCE   8  (bases 1 to 2522)
  AUTHORS   Briancon,N. and Weiss,M.C.
  TITLE     In vivo role of the HNF4alpha AF-1 activation domain revealed by
            exon swapping
  JOURNAL   EMBO J 25 (6), 1253-1262 (2006)
   PUBMED   16498401
REFERENCE   9  (bases 1 to 2522)
  AUTHORS   Clotman,F., Jacquemin,P., Plumb-Rudewiez,N., Pierreux,C.E., Van der
            Smissen,P., Dietz,H.C., Courtoy,P.J., Rousseau,G.G. and
            Lemaigre,F.P.
  TITLE     Control of liver cell fate decision by a gradient of TGF beta
            signaling modulated by Onecut transcription factors
  JOURNAL   Genes Dev 19 (16), 1849-1854 (2005)
   PUBMED   16103213
REFERENCE   10 (bases 1 to 2522)
  AUTHORS   Kuma,Y., Campbell,D.G. and Cuenda,A.
  TITLE     Identification of glycogen synthase as a new substrate for
            stress-activated protein kinase 2b/p38beta
  JOURNAL   Biochem J 379 (Pt 1), 133-139 (2004)
   PUBMED   14680475
  REMARK    GeneRIF: The endogenous glycogen synthase in extracts from mouse
            liver bound specifically to SAPK2b/p38b & was phosphorylated at
            residues Ser644, Ser652, Thr718 and Ser724.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC142413.4.
            
            On Aug 29, 2022 this sequence version replaced XM_006506957.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189673.98261.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-421               AC142413.4         102159-102579       c
            422-603             AC142413.4         92703-92884         c
            604-795             AC142413.4         90612-90803         c
            796-978             AC142413.4         88860-89042         c
            979-1123            AC142413.4         85767-85911         c
            1124-1241           AC142413.4         84610-84727         c
            1242-1362           AC142413.4         83900-84020         c
            1363-1469           AC142413.4         81012-81118         c
            1470-1529           AC142413.4         79947-80006         c
            1530-1608           AC142413.4         78908-78986         c
            1609-1722           AC142413.4         77867-77980         c
            1723-1849           AC142413.4         75464-75590         c
            1850-1945           AC142413.4         59768-59863         c
            1946-2109           AC142413.4         57987-58150         c
            2110-2190           AC142413.4         56832-56912         c
            2191-2303           AC142413.4         52999-53111         c
            2304-2522           AC142413.4         52091-52309         c
FEATURES             Location/Qualifiers
     source          1..2522
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 74.04 cM"
     gene            1..2522
                     /gene="Gys2"
                     /gene_synonym="LGS"
                     /note="glycogen synthase 2"
                     /db_xref="GeneID:232493"
                     /db_xref="MGI:MGI:2385254"
     exon            1..421
                     /gene="Gys2"
                     /gene_synonym="LGS"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..2307
                     /gene="Gys2"
                     /gene_synonym="LGS"
                     /EC_number="2.4.1.11"
                     /note="isoform 2 is encoded by transcript variant 2;
                     glycogen [starch] synthase, liver; glycogen synthase,
                     liver"
                     /codon_start=1
                     /product="glycogen [starch] synthase, liver isoform 2"
                     /protein_id="NP_001398553.1"
                     /db_xref="GeneID:232493"
                     /db_xref="MGI:MGI:2385254"
                     /translation="MLRGRSLSVTSLGGLPVWEAERLPVEDLLLFEVSWEVTNKVGGI
                     CTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPTNDAVRKAVDAMNKHGCQV
                     HFGRWLIEGSPYVVLFDISSSAWNLDRWKGDFWEACGVGIPHHDREANDMLIFGSLTA
                     WFLKEVTDHADGKHVIAQFHEWQAGTGLILSRARKLPIATVFTTHATLLGRYLCAANI
                     DFYNQLDKFDIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDV
                     VTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEF
                     SNKGADIFLESLSRLNFLLRMHKSNVTVVVFFIMPAKTNNFNVETLKGQAVRKQLWDT
                     VHCLKEKFGKKLYDGLLRGEIPDMNSILDRDDLTIMKRAIFSTQRQSLPPVTTHNMID
                     DSTDPILSTIRRIGLFNNRADRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSY
                     YEPWGYTPAECTVMGIPSVTTNLSGFGCFVQEHVADPTAYGIYIVDRRFRSPDDSCNQ
                     LTQFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHLE
                     PTSPPTTDGFKYPRPSSVPPSPSGSQASSPQCSDAEDEEDEDER"
     exon            422..603
                     /gene="Gys2"
                     /gene_synonym="LGS"
                     /inference="alignment:Splign:2.1.0"
     exon            604..795
                     /gene="Gys2"
                     /gene_synonym="LGS"
                     /inference="alignment:Splign:2.1.0"
     exon            796..978
                     /gene="Gys2"
                     /gene_synonym="LGS"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1123
                     /gene="Gys2"
                     /gene_synonym="LGS"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1241
                     /gene="Gys2"
                     /gene_synonym="LGS"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1362
                     /gene="Gys2"
                     /gene_synonym="LGS"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1469
                     /gene="Gys2"
                     /gene_synonym="LGS"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1529
                     /gene="Gys2"
                     /gene_synonym="LGS"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1608
                     /gene="Gys2"
                     /gene_synonym="LGS"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1722
                     /gene="Gys2"
                     /gene_synonym="LGS"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1849
                     /gene="Gys2"
                     /gene_synonym="LGS"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1945
                     /gene="Gys2"
                     /gene_synonym="LGS"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2109
                     /gene="Gys2"
                     /gene_synonym="LGS"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2190
                     /gene="Gys2"
                     /gene_synonym="LGS"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2303
                     /gene="Gys2"
                     /gene_synonym="LGS"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2522
                     /gene="Gys2"
                     /gene_synonym="LGS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2500..2505
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gys2"
                     /gene_synonym="LGS"
                     /note="hexamer: AATAAA"
     polyA_site      2522
                     /gene="Gys2"
                     /gene_synonym="LGS"
                     /note="major polyA site"
ORIGIN      
        1 agtctgtcct ctggctacct gccctgctgt gaatagtcag gtttcagctg cgattttttg
       61 ttttgttttg tcttgttttt tttgtttttg ggtgtctgtg tggattataa ctgtgaggca
      121 ctgccctctc ctgaaaggca gcaaggagct gggcacgctt catccagctg cgctgggttc
      181 atgtgacctc agattgctgg ctcaccctgt agaggctatc ccaaggctgc tgctttttct
      241 cagtgctgac tgcagtcagc tgaatcaggt cccaaacggc accacacagc tggaagaaga
      301 atgctcagag gccgctcctt gtcggtgaca tcccttggtg ggctccctgt gtgggaagct
      361 gaaagactcc ctgtggaaga cttactgctt tttgaagttt cttgggaggt gaccaacaaa
      421 gttgggggca tctgtactgt gatccagacc aaggccaaaa cgacagccga tgagtgggga
      481 gagaattact tcctgatagg tccgtacttt gagcataata tgaagactca agtagaacaa
      541 tgtgagccca ccaacgatgc tgtcagaaaa gctgtggatg cgatgaataa acatggctgc
      601 caggtgcatt ttggaagatg gctcatagaa gggagtccct acgtggtgct ctttgacatc
      661 agctcctcag catggaacct ggacagatgg aagggtgact tctgggaagc ttgtggcgtt
      721 ggcatccctc atcatgaccg agaagctaac gacatgctca tatttgggtc tttaactgcc
      781 tggttcttaa aggaggtgac agaccacgca gacggtaaac acgtcattgc ccaattccat
      841 gaatggcagg ctgggactgg gctgatcctt tctcgtgcca ggaaactccc cattgccaca
      901 gtatttacaa cccatgccac actgcttggg cgttatctct gtgcagcaaa tattgacttc
      961 tacaaccagc ttgacaagtt cgacattgac aaagaggccg gggagaggca gatataccac
     1021 cgctactgca tggagcgggc atccgtgcac tgtgcgcacg tgttcaccac agtgtcagaa
     1081 atcacagcca tcgaggcaga gcacatgctg aagaggaagc ctgatgtagt gactccaaat
     1141 ggtttgaatg ttaagaagtt ttctgcagtg catgaatttc aaaatctcca cgccatgtac
     1201 aaggccagga tacaggattt cgttcgaggt catttctatg gtcatctgga ctttgatctt
     1261 gagaagactt tattcctctt cattgctggg agatatgaat tctcaaacaa aggagcagac
     1321 atcttcctgg agtccttatc caggcttaat ttcctcctga ggatgcataa gagtaacgtc
     1381 accgtggtag tgtttttcat catgcctgcc aagacaaaca atttcaacgt ggaaaccctg
     1441 aagggccagg cagtgcggaa acagctgtgg gacactgtgc attgtttgaa ggagaagttt
     1501 gggaagaaac tctatgacgg gttattaaga ggagaaattc ctgacatgaa tagtattttg
     1561 gatcgagatg acttaacaat tatgaaaagg gccatttttt caactcagag acagtctttg
     1621 cctcctgtga ccactcacaa tatgatcgat gattccacgg atcccatcct cagcaccatt
     1681 agacgaatcg gacttttcaa caatcgtgca gacagagtca aggtgatttt acacccagaa
     1741 ttcctgtcct ccaccagccc tctattgccc atggattatg aagagtttgt ccgaggttgt
     1801 caccttgggg tgtttccatc gtactatgaa ccctggggtt acacaccagc tgaatgcaca
     1861 gtgatgggca tccccagtgt gactacaaac ctctccggtt ttgggtgttt cgtgcaggag
     1921 catgtggctg accctactgc atacggtatt tacatcgtgg acagacgctt ccgctctcca
     1981 gacgattctt gcaaccagct gactcagttc ctctacgggt tttgtaaaca gtcacgccgg
     2041 caaaggatca ttcagaggaa ccgcacggag aggctctcag atctcctgga ctggagatac
     2101 ctgggcagat attaccagca tgccagacac ctgacactga gcagggcttt tccagacaaa
     2161 ttccacctag agcccacatc accaccaacg acggatggct ttaagtatcc caggccctcc
     2221 tcagtaccac cttctccgtc aggatcccag gcctccagtc ctcagtgcag tgatgcggaa
     2281 gacgaagaag atgaggatga gagatgattc agaatccaca agaaaatgag ctgccccaag
     2341 tccacaccct gatgcagacc aacagatatt tacatcctga catctgaaat ctagaatttg
     2401 tatccagatc attgatagga acttgtagcc accaatgtga gtcaccttac tgtaacggta
     2461 cttttgttgt ctaattggaa atttcaatct gttagagata ataaattgcc aaattcaaat
     2521 ga
//
