LOCUS       NM_030678               3681 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus glycogen synthase 1, muscle (Gys1), mRNA.
ACCESSION   NM_030678 NM_008195
VERSION     NM_030678.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3681)
  AUTHORS   Grammer,C., Komorowska,J.A. and Swann,J.B.
  TITLE     Vhl safeguards thymic epithelial cell identity and thymopoietic
            capacity by constraining Hif1a activity during development
  JOURNAL   iScience 27 (7), 110258 (2024)
   PUBMED   39040069
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3681)
  AUTHORS   Brewer,M.K., Torres,P., Ayala,V., Portero-Otin,M., Pamplona,R.,
            Andres-Benito,P., Ferrer,I., Gentry,M.S., Guinovart,J.J. and
            Duran,J.
  TITLE     Glycogen accumulation modulates life span in a mouse model of
            amyotrophic lateral sclerosis
  JOURNAL   J Neurochem 168 (5), 744-759 (2024)
   PUBMED   37401737
REFERENCE   3  (bases 1 to 3681)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3681)
  AUTHORS   Pathmanapan,S., Poon,R., De Renshaw,T.B., Nadesan,P., Nakagawa,M.,
            Seesankar,G.A., Ho Loe,A.K., Zhang,H.H., Guinovart,J.J., Duran,J.,
            Newgard,C.B., Wunder,J.S. and Alman,B.A.
  TITLE     Mutant IDH regulates glycogen metabolism from early cartilage
            development to malignant chondrosarcoma formation
  JOURNAL   Cell Rep 42 (6), 112578 (2023)
   PUBMED   37267108
REFERENCE   5  (bases 1 to 3681)
  AUTHORS   Mitra,S., Chen,B., Wang,P., Chown,E.E., Dear,M., Guisso,D.R.,
            Mariam,U., Wu,J., Gumusgoz,E. and Minassian,B.A.
  TITLE     Laforin targets malin to glycogen in Lafora progressive myoclonus
            epilepsy
  JOURNAL   Dis Model Mech 16 (1) (2023)
   PUBMED   36511140
REFERENCE   6  (bases 1 to 3681)
  AUTHORS   Wodarz,A. and Nusse,R.
  TITLE     Mechanisms of Wnt signaling in development
  JOURNAL   Annu Rev Cell Dev Biol 14, 59-88 (1998)
   PUBMED   9891778
  REMARK    Review article
REFERENCE   7  (bases 1 to 3681)
  AUTHORS   Bajaj,N.P. and Miller,C.C.
  TITLE     Phosphorylation of neurofilament heavy-chain side-arm fragments by
            cyclin-dependent kinase-5 and glycogen synthase kinase-3alpha in
            transfected cells
  JOURNAL   J Neurochem 69 (2), 737-743 (1997)
   PUBMED   9231734
REFERENCE   8  (bases 1 to 3681)
  AUTHORS   Printen,J.A., Brady,M.J. and Saltiel,A.R.
  TITLE     PTG, a protein phosphatase 1-binding protein with a role in
            glycogen metabolism
  JOURNAL   Science 275 (5305), 1475-1478 (1997)
   PUBMED   9045612
REFERENCE   9  (bases 1 to 3681)
  AUTHORS   Pellegri,G., Rossier,C., Magistretti,P.J. and Martin,J.L.
  TITLE     Cloning, localization and induction of mouse brain glycogen
            synthase
  JOURNAL   Brain Res Mol Brain Res 38 (2), 191-199 (1996)
   PUBMED   8793107
REFERENCE   10 (bases 1 to 3681)
  AUTHORS   Seldin,M.F., Mott,D., Bhat,D., Petro,A., Kuhn,C.M., Kingsmore,S.F.,
            Bogardus,C., Opara,E., Feinglos,M.N. and Surwit,R.S.
  TITLE     Glycogen synthase: a putative locus for diet-induced hyperglycemia
  JOURNAL   J Clin Invest 94 (1), 269-276 (1994)
   PUBMED   8040269
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB853436.1, AK169344.1 and AK171426.1.
            
            On Dec 20, 2006 this sequence version replaced NM_030678.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170404.1, AK171148.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 BB853436.1         1-5
            6-22                AK169344.1         2-18
            23-532              AK171426.1         2-511
            533-3089            AK169344.1         529-3085
            3090-3640           AK171426.1         3071-3621
            3641-3641           AK169344.1         3654-3654
            3642-3681           AK171426.1         3623-3662
FEATURES             Location/Qualifiers
     source          1..3681
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.31 cM"
     gene            1..3681
                     /gene="Gys1"
                     /gene_synonym="Gys3; MGS"
                     /note="glycogen synthase 1, muscle"
                     /db_xref="GeneID:14936"
                     /db_xref="MGI:MGI:101805"
     exon            1..332
                     /gene="Gys1"
                     /gene_synonym="Gys3; MGS"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..2431
                     /gene="Gys1"
                     /gene_synonym="Gys3; MGS"
                     /EC_number="2.4.1.11"
                     /note="glycogen synthase 3, brain"
                     /codon_start=1
                     /product="glycogen [starch] synthase, muscle"
                     /protein_id="NP_109603.2"
                     /db_xref="CCDS:CCDS21244.1"
                     /db_xref="GeneID:14936"
                     /db_xref="MGI:MGI:101805"
                     /translation="MPLSRSLSVSSLPGLEDWEDEFDPENAVLFEVAWEVANKVGGIY
                     TVLQTKAKVTGDEWGDNYYLVGPYTEQGVRTQVELLEPPTPELKRTLDSMNSKGCKVY
                     FGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTW
                     FLGEFLAQNEEKPYVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAV
                     DFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDI
                     VTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEF
                     SNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDT
                     ANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLD
                     DSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSY
                     YEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQ
                     LTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALAKAFPDHFTYE
                     PHEVDATQGYRYPRPASVPPSPSLSRHSSPHQSEDEEEPRDGPLGEDSERYDEEEEAA
                     KDRRNIRAPEWPRRASCSSSTGGSKRSNSVDTGPSSSLSTPTEPLSPTSSLGEERN"
     exon            333..514
                     /gene="Gys1"
                     /gene_synonym="Gys3; MGS"
                     /inference="alignment:Splign:2.1.0"
     exon            515..706
                     /gene="Gys1"
                     /gene_synonym="Gys3; MGS"
                     /inference="alignment:Splign:2.1.0"
     exon            707..892
                     /gene="Gys1"
                     /gene_synonym="Gys3; MGS"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1037
                     /gene="Gys1"
                     /gene_synonym="Gys3; MGS"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1155
                     /gene="Gys1"
                     /gene_synonym="Gys3; MGS"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1276
                     /gene="Gys1"
                     /gene_synonym="Gys3; MGS"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1383
                     /gene="Gys1"
                     /gene_synonym="Gys3; MGS"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1443
                     /gene="Gys1"
                     /gene_synonym="Gys3; MGS"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1522
                     /gene="Gys1"
                     /gene_synonym="Gys3; MGS"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1636
                     /gene="Gys1"
                     /gene_synonym="Gys3; MGS"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1763
                     /gene="Gys1"
                     /gene_synonym="Gys3; MGS"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1859
                     /gene="Gys1"
                     /gene_synonym="Gys3; MGS"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..2023
                     /gene="Gys1"
                     /gene_synonym="Gys3; MGS"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2104
                     /gene="Gys1"
                     /gene_synonym="Gys3; MGS"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..3681
                     /gene="Gys1"
                     /gene_synonym="Gys3; MGS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgcagctg cccgcccgat tcagtgtctc agctcaccct acctgagtcg gagcgctctg
       61 gggcgggggt gcggtcgtgc aataggaagc ggagcgcctt gcaagcttcc cctgggacac
      121 ccgctaactc taccggtcac caagtctgct gcgttcccag ccgatctctc tggtttccag
      181 ttttggtgct cgaagtcccc tgcccgcagt agccatgcct ctcagccgca gtctctctgt
      241 gtcctcgctt ccaggattgg aagactggga ggatgaattc gaccccgaga acgcagtgct
      301 tttcgaggtg gcctgggagg tggccaacaa ggtgggtggc atctacactg tgctgcagac
      361 gaaggcgaag gtgacagggg atgaatgggg tgacaactac tatctggtgg gaccatacac
      421 ggagcagggt gtgaggacgc aggtagagct cctggagccc ccaactccgg aactgaagag
      481 gactttggat tccatgaaca gcaagggttg taaggtgtat tttgggcgtt ggctgatcga
      541 ggggggaccc ctagtggtgc tcctggatgt aggagcctca gcttgggccc tggagcgctg
      601 gaagggtgag ctttgggaca cctgcaacat cggggtaccc tggtacgacc gcgaggccaa
      661 tgacgctgtc ctgttcggct tcctcaccac ctggttcctg ggtgagttcc tggcccagaa
      721 cgaagagaag ccgtatgtgg ttgcccactt ccacgaatgg ttggctggcg ttggtctgtg
      781 tctgtgccgt gcccggcgct tgccggtggc aaccatcttc accactcatg ccacgctgct
      841 ggggcgctac ctgtgtgctg gcgctgtgga cttctacaac aacctggaga atttcaatgt
      901 agacaaggaa gcaggagaga ggcagatcta tcaccggtac tgcatggagc gtgcagcagc
      961 tcactgtgcc catgtcttca ctaccgtatc ccagatcacc gcaatcgagg ctcaacacct
     1021 ccttaagaga aaaccagata ttgtgacccc caacgggctg aatgtgaaga agttctctgc
     1081 tatgcacgaa ttccagaacc ttcatgctca gagcaaagca cgaatccagg aatttgtgcg
     1141 tggccatttt tatgggcacc tggacttcaa cctagacaag actttgtatt tctttatcgc
     1201 tggccgctat gagttttcca acaagggagc tgatgtgttc ctggaggcat tggcccggct
     1261 caactatctg ctcagagtga atggcagtga gcaaacagtt gtcgcattct tcatcatgcc
     1321 ggcccggacc aataatttca acgtggaaac cctgaagggc caagccgtgc gcaaacaact
     1381 atgggacaca gccaatacag tcaaggagaa atttgggagg aagctctacg aatccctttt
     1441 agtggggagc ctcccggaca tgaacaagat gctggacaag gaggacttca ctatgatgaa
     1501 gagagccatc tttgccactc agcggcagtc tttcccacca gtgtgcaccc acaacatgct
     1561 ggacgactcc tcagacccca tcttgaccac catccgccga attggccttt tcaacagcag
     1621 tgccgaccgt gtgaaggtga tttttcaccc agaattcctt tcttccacaa gccctctcct
     1681 ccccgtggat tatgaggaat ttgtccgcgg ctgtcacctt ggggtcttcc cctcctacta
     1741 tgagccctgg ggctacacac cagcggagtg cactgtcatg ggcatcccca gcatctccac
     1801 caacctctcc ggctttggct gctttatgga ggaacacatc gcagatccct cagcttacgg
     1861 catttacatt ctggatcgga ggttccgcag cctggatgat tcatgctcac agctcacctc
     1921 cttcctgtac agcttctgcc agcagagccg gcgacagcgc atcatccagc ggaaccgcac
     1981 agaacggttg tcggacttgc tagattggaa gtacctgggc cggtactaca tgtctgcgcg
     2041 ccacatggct ctggccaagg cctttccaga ccacttcacc tatgaacccc atgaggtaga
     2101 tgcgacccag gggtaccggt acccacgacc agcctccgtc ccgccgtcgc cctcactgtc
     2161 tcgacactcc agcccacacc agagtgagga tgaggaagag ccacgggatg gacccctggg
     2221 ggaagacagt gagcgttatg atgaggaaga ggaggctgcc aaggaccgcc gcaacatccg
     2281 ggcacctgag tggccacgca gggcctcctg ttcctcctcc acaggtggca gcaagagaag
     2341 caactcggtg gacactgggc cctccagctc actcagcaca cccactgagc ccctgagtcc
     2401 taccagttcc ctgggtgagg agcgcaacta agctcccacc cccatcccat tccctgcctg
     2461 tccagtgctc ctctcgcaga gggcctatgc agatgggagg gtgcctgaac cccactccag
     2521 actcttgagt gggaccccta cccagtgtgg tccatagcct aacctctgtt tcagacactc
     2581 cagcccttga gctccaatct tggagttccc gcactccacg ccgccgtgcc tttcttggat
     2641 tgcaggatgc attctttgtg cactgatctg gagtctccag gcttagactg ggtcccagag
     2701 gccaggcatc tgccattgtt tttcaatgcc agaggtttta ggacacctgg tttattggct
     2761 tccaggctgt ggcttcttcg tttgatccta taatcataca gagtatgctt tgctcaggcc
     2821 tgcctctggg accacctcat gttggattct gtgtggcttc ccgaatcagc caagttcaga
     2881 gttaggacat ttcagggatt aacataattg aaaatcagcc tgcaaggtag ctcagtagct
     2941 ctgtcgacag attgcttgtc tagcatgccc gaagccctgg gatctaactc tagaacctca
     3001 taaacctggt gcggtgatac acatctgtaa tcccagcact cggtaggtag aggtagacgg
     3061 atcaagagtt aaaggccatc atcctctgct acatagggag ttcaaggcca aactgggcaa
     3121 catgagacac tgtctcaaaa gcaaagtaaa ggtggtggaa tgctcacggt cctccatttc
     3181 aacccacgac tgcgatgctg ggacatgctg caaggttggc ctccctgggt gtgttcttca
     3241 aaggagcatg cggagttgga ccagacacct ttctgccttt tttctggacc agaccttctt
     3301 ttccttggtc cagtgtcccc tctagggaat gcctccattg agggcagaat gtctgtcaac
     3361 cccacaagtg ctcagcccac tgtgaaacca ctgggttctg ggtcccagtg gctgaatcag
     3421 gagtcttttg tcactgtgct gcaccccggt cccctttcct gatacaaaac cgagcccacc
     3481 ggcttcttga agccccacat gtacctcgag gcctttctgc ctgcaagctt cagtgaatgg
     3541 gcgggcccct cctcacgtgt gctgtgtctg gcccagtgcc tttggtttgc atttgggagg
     3601 gggagggcag aaggtgtgtg attggagtgt gtctagagat gaaaaaaaaa aaaagaaaat
     3661 acacctgtat ttaagaatgc c
//
