LOCUS       NM_001355261            1720 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus glycogenin 1 (Gyg1), transcript variant 1, mRNA.
ACCESSION   NM_001355261 XM_006535481
VERSION     NM_001355261.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1720)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1720)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1720)
  AUTHORS   Testoni,G., Olmeda,B., Duran,J., Lopez-Rodriguez,E., Aguilera,M.,
            Hernandez-Alvarez,M.I., Prats,N., Perez-Gil,J. and Guinovart,J.J.
  TITLE     Pulmonary glycogen deficiency as a new potential cause of
            respiratory distress syndrome
  JOURNAL   Hum Mol Genet 29 (21), 3554-3565 (2021)
   PUBMED   33219378
  REMARK    GeneRIF: Pulmonary glycogen deficiency as a new potential cause of
            respiratory distress syndrome.
REFERENCE   4  (bases 1 to 1720)
  AUTHORS   Zeqiraj,E. and Sicheri,F.
  TITLE     Getting a handle on glycogen synthase - Its interaction with
            glycogenin
  JOURNAL   Mol Aspects Med 46, 63-69 (2015)
   PUBMED   26278983
  REMARK    Review article
REFERENCE   5  (bases 1 to 1720)
  AUTHORS   Boj,S.F., van Es,J.H., Huch,M., Li,V.S., Jose,A., Hatzis,P.,
            Mokry,M., Haegebarth,A., van den Born,M., Chambon,P., Voshol,P.,
            Dor,Y., Cuppen,E., Fillat,C. and Clevers,H.
  TITLE     Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic
            response to perinatal and adult metabolic demand
  JOURNAL   Cell 151 (7), 1595-1607 (2012)
   PUBMED   23260145
REFERENCE   6  (bases 1 to 1720)
  AUTHORS   Douillard-Guilloux,G., Raben,N., Takikita,S., Batista,L.,
            Caillaud,C. and Richard,E.
  TITLE     Modulation of glycogen synthesis by RNA interference: towards a new
            therapeutic approach for glycogenosis type II
  JOURNAL   Hum Mol Genet 17 (24), 3876-3886 (2008)
   PUBMED   18782850
  REMARK    GeneRIF: Injection of recombinant adeno-associated virus-1 vector
            expressing glycogen synthase short hairpin ribonucleic acids into
            mice with type II glycogen storage disease leads to significant
            reduction in impaired glycogen accumulation.
REFERENCE   7  (bases 1 to 1720)
  AUTHORS   Katz,A.
  TITLE     Glycogenin, proglycogen, and glycogen biogenesis: what's the story?
  JOURNAL   Am J Physiol Endocrinol Metab 290 (4), E757-8;authorreplyE758-9
            (2006)
   PUBMED   16533952
REFERENCE   8  (bases 1 to 1720)
  AUTHORS   Suzuki,T., Li,W., Zhang,Q., Novak,E.K., Sviderskaya,E.V.,
            Wilson,A., Bennett,D.C., Roe,B.A., Swank,R.T. and Spritz,R.A.
  TITLE     The gene mutated in cocoa mice, carrying a defect of organelle
            biogenesis, is a homologue of the human Hermansky-Pudlak syndrome-3
            gene
  JOURNAL   Genomics 78 (1-2), 30-37 (2001)
   PUBMED   11707070
REFERENCE   9  (bases 1 to 1720)
  AUTHORS   van Maanen,M., Fournier,P.A., Palmer,T.N. and Abraham,L.J.
  TITLE     Characterization of mouse glycogenin-1 cDNA and promoter region
  JOURNAL   Biochim Biophys Acta 1447 (2-3), 284-290 (1999)
   PUBMED   10542328
REFERENCE   10 (bases 1 to 1720)
  AUTHORS   Burns,R.P. Jr., Natarajan,K., LoCascio,N.J., O'Brien,D.P.,
            Kobori,J.A., Shastri,N. and Barth,R.K.
  TITLE     Molecular analysis of skewed Tcra-V gene use in T-cell receptor
            beta-chain transgenic mice
  JOURNAL   Immunogenetics 47 (2), 107-114 (1998)
   PUBMED   9396856
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158937.5.
            
            On Aug 23, 2022 this sequence version replaced NM_001355261.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189670.94041.1,
                                           SRR5189679.177308.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC158937.5         134652-134718
            68-203              AC158937.5         136851-136986
            204-378             AC158937.5         138589-138763
            379-541             AC158937.5         139015-139177
            542-668             AC158937.5         151573-151699
            669-888             AC158937.5         164239-164458
            889-939             AC158937.5         166544-166594
            940-1720            AC158937.5         166852-167632
FEATURES             Location/Qualifiers
     source          1..1720
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 6.19 cM"
     gene            1..1720
                     /gene="Gyg1"
                     /gene_synonym="GN1; Gyg"
                     /note="glycogenin 1"
                     /db_xref="GeneID:27357"
                     /db_xref="MGI:MGI:1351614"
     exon            1..67
                     /gene="Gyg1"
                     /gene_synonym="GN1; Gyg"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1113
                     /gene="Gyg1"
                     /gene_synonym="GN1; Gyg"
                     /EC_number="2.4.1.186"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glycogenin"
                     /codon_start=1
                     /product="glycogenin-1 isoform 1"
                     /protein_id="NP_001342190.1"
                     /db_xref="GeneID:27357"
                     /db_xref="MGI:MGI:1351614"
                     /translation="MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRMVVLTSPQVS
                     DSMRKVLETVFDDVIMVDVLDSGDSAHLTLMKRPELGITLTKLHCWSLTQYSKCVFMD
                     ADTLVLSNIDDLFEREELSAAPDPGWPDCFNSGVFVYQPSIETYNQLLHLASEQGSFD
                     GGDQGLLNTYFSGWATTDITKHLPFVYNLSSISIYSYLPAFKAFGKNAKVVHFLGRTK
                     PWNYTYNPQTKSVNCDSQDPTVSHPEFLNLWWDTFTTNVLPLLQHHGLVKDASSYLMM
                     LSDLVYTLAFSCGFCRKEHVSGALSDLSFGEAPAAPQPSMSSEERKERWEQGQADYMG
                     ADSFDNIKRKLDTYLQ"
     exon            68..203
                     /gene="Gyg1"
                     /gene_synonym="GN1; Gyg"
                     /inference="alignment:Splign:2.1.0"
     exon            204..378
                     /gene="Gyg1"
                     /gene_synonym="GN1; Gyg"
                     /inference="alignment:Splign:2.1.0"
     exon            379..541
                     /gene="Gyg1"
                     /gene_synonym="GN1; Gyg"
                     /inference="alignment:Splign:2.1.0"
     exon            542..668
                     /gene="Gyg1"
                     /gene_synonym="GN1; Gyg"
                     /inference="alignment:Splign:2.1.0"
     exon            669..888
                     /gene="Gyg1"
                     /gene_synonym="GN1; Gyg"
                     /inference="alignment:Splign:2.1.0"
     exon            889..939
                     /gene="Gyg1"
                     /gene_synonym="GN1; Gyg"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1720
                     /gene="Gyg1"
                     /gene_synonym="GN1; Gyg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1701..1706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gyg1"
                     /gene_synonym="GN1; Gyg"
                     /note="hexamer: AATAAA"
     polyA_site      1720
                     /gene="Gyg1"
                     /gene_synonym="GN1; Gyg"
                     /note="major polyA site"
ORIGIN      
        1 ctccctgctg gccgcggtca cctaccggcg cccggctcct ccgacccacc cggccacact
       61 atgacagatc aggcttttgt gacgctgacc acaaacgatg cctatgccaa aggtgcgctg
      121 gtcctgggct catctttgaa acagcacagg actactagga ggatggttgt actcaccagc
      181 ccacaggttt cagactccat gagaaaagtt ttagagactg tctttgatga cgtcatcatg
      241 gtagatgtct tggacagtgg tgattctgct catctaacct taatgaagag acctgagttg
      301 ggcatcacat tgactaaact ccactgctgg tcacttactc agtattccaa atgtgtgttc
      361 atggatgcag atactctggt cctctcaaat attgatgatc tgtttgaaag agaagaatta
      421 tcagcagcac cagacccagg gtggcctgac tgtttcaatt ctggagtctt tgtctatcaa
      481 ccctccattg aaacgtataa ccagctgttg catctggctt ctgagcaagg tagttttgat
      541 ggtggggacc agggcctact gaatacatat tttagtggct gggcaacgac agatatcaca
      601 aaacacctgc catttgtgta taacctaagc agcatttcaa tatactccta cctcccggca
      661 tttaaagcgt ttggtaaaaa tgccaaagtt gtgcacttcc tgggacgaac caagccatgg
      721 aattacactt ataaccccca aacaaaaagt gtcaactgtg actcccagga cccaaccgtg
      781 agtcacccag agtttctgaa cctgtggtgg gacaccttca ccaccaacgt cttacccctg
      841 ctccaacacc atggccttgt caaagatgcc agctcctatc taatgatgct ttcagacttg
      901 gtctatacac tggctttctc ttgtggcttc tgtagaaagg aacatgtctc aggagccttg
      961 tcagacctgt cctttgggga ggccccagct gcaccacaac cttctatgtc ctcagaagaa
     1021 aggaaggaac ggtgggaaca gggccaggcc gattacatgg gagcagattc ttttgataac
     1081 atcaagagaa aacttgacac ttacctgcaa tagaagcact gccattttcc tgtggacaca
     1141 cccatgtctt aggcacgttt ccatacatag tatgtgaagt ctgttacagt tgttagaggc
     1201 tttcactaaa cctcatcaga tgaggggttt gggcaggaca acaggtgaga actgggcaaa
     1261 tgttattagg tcgtaattcc atcatgtgga caagtgttct gtttaaccct agactttttt
     1321 tttttaattc tcaattctta aattgccaat gtgtgataaa agaaagccaa cattaagcta
     1381 ctaagatggc tctctcaagt ggtgcataac ttgactctcc atcttcaaaa caaggtgtga
     1441 cattttccaa tcttcacttg ttgcatcctt cacaagacct gcaatgtaga actgctcaaa
     1501 gcctgtcaga gaagtagcct tccagactaa agtggccttt attaacactg cggagtgatt
     1561 cctaagccta ccagctagtg ttagttcacc agttttctat gcaccgtgaa ggcagcatgc
     1621 agacttgttc tttctcagtt gtctacttga aaattgcagt gtgctctctg atggtagctg
     1681 tggtagcact gtgtataaca aataaacact tattgacata
//
