LOCUS       NM_010368               2694 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus glucuronidase, beta (Gusb), transcript variant 1,
            mRNA.
ACCESSION   NM_010368
VERSION     NM_010368.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2694)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2694)
  AUTHORS   Wei,Y., Tan,H., Yang,R., Yang,F., Liu,D., Huang,B., OuYang,L.,
            Lei,S., Wang,Z., Jiang,S., Cai,H., Xie,X., Yao,S. and Liang,Y.
  TITLE     Gut dysbiosis-derived beta-glucuronidase promotes the development
            of endometriosis
  JOURNAL   Fertil Steril 120 (3 Pt 2), 682-694 (2023)
   PUBMED   37178109
  REMARK    GeneRIF: Gut dysbiosis-derived beta-glucuronidase promotes the
            development of endometriosis.
REFERENCE   3  (bases 1 to 2694)
  AUTHORS   Kashiwagi,M., Nakao,K., Yamanaka,S., Yamauchi,I., Yamashita,T.,
            Fujii,T., Ueda,Y., Kawai,M.Y., Watanabe,T., Fukuhara,S. and
            Bessho,K.
  TITLE     Circulatory C-type natriuretic peptide reduces
            mucopolysaccharidosis-associated craniofacial hypoplasia in vivo
  JOURNAL   PLoS One 17 (11), e0277140 (2022)
   PUBMED   36355797
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2694)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2694)
  AUTHORS   Nguyen,Q.H., Witt,R.G., Wang,B., Eikani,C., Shea,J., Smith,L.K.,
            Boyle,G., Cadaoas,J., Sper,R., MacKenzie,J.D., Villeda,S. and
            MacKenzie,T.C.
  TITLE     Tolerance induction and microglial engraftment after fetal therapy
            without conditioning in mice with Mucopolysaccharidosis type VII
  JOURNAL   Sci Transl Med 12 (532) (2020)
   PUBMED   32102934
REFERENCE   6  (bases 1 to 2694)
  AUTHORS   Kozak,C.A. and Rowe,W.P.
  TITLE     Genetic mapping of the ecotropic murine leukemia virus-inducing
            locus of BALB/c mouse to chromosome 5
  JOURNAL   Science 204 (4388), 69-71 (1979)
   PUBMED   219475
REFERENCE   7  (bases 1 to 2694)
  AUTHORS   Paigen,K.
  TITLE     Acid hydrolases as models of genetic control
  JOURNAL   Annu Rev Genet 13, 417-466 (1979)
   PUBMED   231933
  REMARK    Review article
REFERENCE   8  (bases 1 to 2694)
  AUTHORS   Meredith,S.A. and Ganschow,R.E.
  TITLE     Apparent trans control of murine beta-glucuronidase synthesis by a
            temporal genetic element
  JOURNAL   Genetics 90 (4), 725-734 (1978)
   PUBMED   744474
REFERENCE   9  (bases 1 to 2694)
  AUTHORS   Lusis,A.J. and Paigen,K.
  TITLE     The large scale isolation of mouse beta-glucuronidase and
            comparison of allozymes
  JOURNAL   J Biol Chem 253 (20), 7336-7345 (1978)
   PUBMED   701256
REFERENCE   10 (bases 1 to 2694)
  AUTHORS   Watson,G. and Paigen,K.
  TITLE     Segregation of genetic determinants for murine glucuronidase
            synthesis and loss in CXB recombinant-inbred strains
  JOURNAL   Biochem Genet 16 (9-10), 897-903 (1978)
   PUBMED   743194
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161345.4, AK150048.1 and AI325302.1.
            
            On Oct 17, 2017 this sequence version replaced NM_010368.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146247.1, BC071226.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               AC161345.4         45004-45224
            222-2676            AK150048.1         2-2456
            2677-2694           AI325302.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..2694
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 68.32 cM"
     gene            1..2694
                     /gene="Gusb"
                     /gene_synonym="asd; g; Gur; Gus; Gus-r; Gus-s; Gus-t;
                     Gus-u; Gut"
                     /note="glucuronidase, beta"
                     /db_xref="GeneID:110006"
                     /db_xref="MGI:MGI:95872"
     exon            1..443
                     /gene="Gusb"
                     /gene_synonym="asd; g; Gur; Gus; Gus-r; Gus-s; Gus-t;
                     Gus-u; Gut"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..2180
                     /gene="Gusb"
                     /gene_synonym="asd; g; Gur; Gus; Gus-r; Gus-s; Gus-t;
                     Gus-u; Gut"
                     /EC_number="3.2.1.31"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; beta-glucuronidase; adipose storage deficiency"
                     /codon_start=1
                     /product="beta-glucuronidase isoform 1 precursor"
                     /protein_id="NP_034498.1"
                     /db_xref="CCDS:CCDS19705.1"
                     /db_xref="GeneID:110006"
                     /db_xref="MGI:MGI:95872"
                     /translation="MSLKWSACWVALGQLLCSCALALKGGMLFPKESPSRELKALDGL
                     WHFRADLSNNRLQGFEQQWYRQPLRESGPVLDMPVPSSFNDITQEAALRDFIGWVWYE
                     REAILPRRWTQDTDMRVVLRINSAHYYAVVWVNGIHVVEHEGGHLPFEADISKLVQSG
                     PLTTCRITIAINNTLTPHTLPPGTIVYKTDTSMYPKGYFVQDTSFDFFNYAGLHRSVV
                     LYTTPTTYIDDITVITNVEQDIGLVTYWISVQGSEHFQLEVQLLDEGGKVVAHGTGNQ
                     GQLQVPSANLWWPYLMHEHPAYMYSLEVKVTTTESVTDYYTLPIGIRTVAVTKSKFLI
                     NGKPFYFQGVNKHEDSDIRGKGFDWPLLVKDFNLLRWLGANSFRTSHYPYSEEVLQLC
                     DRYGIVVIDECPGVGIVLPQSFGNESLRHHLEVMEELVRRDKNHPAVVMWSVANEPSS
                     ALKPAAYYFKTLITHTKALDLTRPVTFVSNAKYDADLGAPYVDVICVNSYFSWYHDYG
                     HLEVIQPQLNSQFENWYKTHQKPIIQSEYGADAIPGIHEDPPRMFSEEYQKAVLENYH
                     SVLDQKRKEYVVGELIWNFADFMTNQSPLRVIGNKKGIFTRQRQPKTSAFILRERYWR
                     IANETGGHGSGPRTQCFGSRPFTF"
     exon            444..629
                     /gene="Gusb"
                     /gene_synonym="asd; g; Gur; Gus; Gus-r; Gus-s; Gus-t;
                     Gus-u; Gut"
                     /inference="alignment:Splign:2.1.0"
     exon            630..811
                     /gene="Gusb"
                     /gene_synonym="asd; g; Gur; Gus; Gus-r; Gus-s; Gus-t;
                     Gus-u; Gut"
                     /inference="alignment:Splign:2.1.0"
     exon            812..954
                     /gene="Gusb"
                     /gene_synonym="asd; g; Gur; Gus; Gus-r; Gus-s; Gus-t;
                     Gus-u; Gut"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1142
                     /gene="Gusb"
                     /gene_synonym="asd; g; Gur; Gus; Gus-r; Gus-s; Gus-t;
                     Gus-u; Gut"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1286
                     /gene="Gusb"
                     /gene_synonym="asd; g; Gur; Gus; Gus-r; Gus-s; Gus-t;
                     Gus-u; Gut"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1465
                     /gene="Gusb"
                     /gene_synonym="asd; g; Gur; Gus; Gus-r; Gus-s; Gus-t;
                     Gus-u; Gut"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1612
                     /gene="Gusb"
                     /gene_synonym="asd; g; Gur; Gus; Gus-r; Gus-s; Gus-t;
                     Gus-u; Gut"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1697
                     /gene="Gusb"
                     /gene_synonym="asd; g; Gur; Gus; Gus-r; Gus-s; Gus-t;
                     Gus-u; Gut"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1874
                     /gene="Gusb"
                     /gene_synonym="asd; g; Gur; Gus; Gus-r; Gus-s; Gus-t;
                     Gus-u; Gut"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2010
                     /gene="Gusb"
                     /gene_synonym="asd; g; Gur; Gus; Gus-r; Gus-s; Gus-t;
                     Gus-u; Gut"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2687
                     /gene="Gusb"
                     /gene_synonym="asd; g; Gur; Gus; Gus-r; Gus-s; Gus-t;
                     Gus-u; Gut"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcaggcata tggggaaacg atccaggact tcaagcgact tcctctttct gcagagtcca
       61 gccttggggc ctctagatag ccttgagcca gcagctgtac aagcgcttgc cctcaaccaa
      121 gttggcgcag gcggcttctc tcgagaacat gtgactcttc caggtcccgc ctctgccctc
      181 ccagagagga ggctaaaaag cccagccgct ggtcggtggg cagcctggcc agtatgtccc
      241 taaaatggag tgcgtgttgg gtcgcgctgg gccagctgct gtgcagctgc gcgctggctc
      301 tgaagggcgg gatgctgttc ccgaaggaga gcccgtcgcg ggagctcaag gcgctggacg
      361 gactgtggca cttccgcgcc gacctctcga acaaccggct gcagggtttc gagcagcaat
      421 ggtaccggca gccgctacgg gagtcgggcc cagtcttgga catgcctgtc ccttctagct
      481 tcaatgacat cacccaagaa gcagcccttc gggactttat tggctgggtg tggtatgaac
      541 gggaagcaat cctgccacgg cgatggaccc aagataccga catgagagtg gtgttgagga
      601 tcaacagtgc ccattattat gcagttgtgt gggtgaatgg gattcatgtg gtggaacatg
      661 agggaggtca cctccccttt gaggctgaca ttagcaagct ggtccagagt gggcccctga
      721 ccacctgccg gatcacgatt gccatcaaca acacactgac ccctcatacc cttccgccgg
      781 ggaccatcgt ctacaagact gacacctcca tgtatcccaa gggttacttt gtccaggaca
      841 caagctttga cttcttcaac tatgcgggac tgcatcgatc tgtggtcctc tataccaccc
      901 ctaccactta catcgatgat atcactgtga tcactaatgt ggagcaagac atcgggctgg
      961 tgacctactg gatttctgtg cagggcagtg aacatttcca gctagaagtg caacttttgg
     1021 atgagggtgg caaagtcgtg gcccatggga cagggaacca gggtcaactt caggttccca
     1081 gtgccaacct ctggtggcct tacctgatgc atgagcatcc agcctacatg tactccttgg
     1141 aggtgaaggt gacaacaact gagtctgtga ctgactacta cacccttcct atcgggattc
     1201 gaacagtggc tgtcacaaag agcaagttcc tcataaacgg gaagcccttc tatttccaag
     1261 gggtcaataa gcacgaggat tcagatatcc gagggaaagg cttcgactgg ccgctgctgg
     1321 taaaggattt caacctgctc cgttggctcg gggcaaattc ctttcgtacc agccactatc
     1381 cctactcaga ggaggtactt cagctctgtg accgatacgg gattgtggtc atcgatgagt
     1441 gtcccggtgt gggcattgtg ctacctcaga gttttggcaa cgagtcactt cggcaccacc
     1501 tagaggtgat ggaggagctg gttcgccggg acaaaaatca ccctgcggtt gtgatgtggt
     1561 ctgtggccaa tgagccttcc tctgctctga aacccgccgc atattacttt aagacgctga
     1621 tcacccacac caaagccctg gacctcaccc gtcccgtgac ctttgtgagc aacgccaaat
     1681 atgatgcaga cctgggggcc ccgtacgtgg atgttatctg tgtaaacagc tacttttctt
     1741 ggtatcatga ctatgggcat ttggaggtga ttcagccaca gctgaatagc cagtttgaga
     1801 actggtataa gacgcatcag aagccgatta tccagagcga gtatggagca gacgcaatcc
     1861 cagggatcca cgaggacccg cctcgcatgt tcagtgagga gtaccagaag gctgttctgg
     1921 agaattacca ttcagttctg gatcagaaac gtaaagaata cgtggtcgga gagctcatct
     1981 ggaatttcgc cgacttcatg acgaaccagt caccgctgag agtaatcgga aacaagaagg
     2041 ggatcttcac tcgccagaga cagcccaaaa cttcggcctt tattttgcga gagagatact
     2101 ggaggattgc caacgaaacc ggaggtcacg gttcagggcc gagaacccag tgtttcggaa
     2161 gcagaccgtt cacgttctaa agttacaact acctcactgc agactcaaag gtgtccccag
     2221 acacttcctg acactagtgt ttctatttgg gattttgtga actgatacaa ggggacttta
     2281 gaagtgacat caaagctttt cttccgtggg gataataact tacagtgcct taggctcagt
     2341 aatatgtcct gctgagaggt gtccaagata atttgttagt tttttggcct tggctttgtg
     2401 aactcttgaa agcctgctgt gtgaacattc tcactaaatt aagagctact ggtgagaggc
     2461 tggagtgaag gctggctcac aatttaagag cactgactgt tctactggag gttccagatt
     2521 caattcctag cacccacctg gtggctaact atgagctggt cctccatttc ccaggtgatc
     2581 caaatgccct tttggcccct gcgggtacca catgtatgtg gtatgtggat ctacatgtgg
     2641 ggaaaaaagt catacatgca aaataaaaat gaatctaaaa aaaaaaaaaa aaaa
//
