LOCUS       NM_028450               2976 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Mus musculus GULP, engulfment adaptor PTB domain containing 1
            (Gulp1), mRNA.
ACCESSION   NM_028450
VERSION     NM_028450.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2976)
  AUTHORS   Harders,R.H., Morthorst,T.H., Landgrebe,L.E., Lande,A.D.,
            Fuglsang,M.S., Mortensen,S.B., Feteira-Montero,V., Jensen,H.H.,
            Wesseltoft,J.B. and Olsen,A.
  TITLE     CED-6/GULP and components of the clathrin-mediated endocytosis
            machinery act redundantly to correctly display CED-1 on the cell
            membrane in Caenorhabditis elegans
  JOURNAL   G3 (Bethesda) 14 (7) (2024)
   PUBMED   38696649
  REMARK    GeneRIF: CED-6/GULP and components of the clathrin-mediated
            endocytosis machinery act redundantly to correctly display CED-1 on
            the cell membrane in Caenorhabditis elegans.
REFERENCE   2  (bases 1 to 2976)
  AUTHORS   Kim,D., Kim,J.E., Lee,S.B., Lee,N.Y. and Park,S.Y.
  TITLE     Gulp1 regulates chondrocyte growth arrest and differentiation via
            the TGF-beta/SMAD2/3 pathway
  JOURNAL   FEBS Lett 598 (8), 935-944 (2024)
   PUBMED   38553249
  REMARK    GeneRIF: Gulp1 regulates chondrocyte growth arrest and
            differentiation via the TGF-beta/SMAD2/3 pathway.
REFERENCE   3  (bases 1 to 2976)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2976)
  AUTHORS   Kim,S.Y., Park,S.Y. and Kim,J.E.
  TITLE     GULP1 deficiency reduces adipogenesis and glucose uptake via
            downregulation of PPAR signaling and disturbing of insulin/ERK
            signaling in 3T3-L1 cells
  JOURNAL   J Cell Physiol 239 (2), e31173 (2024)
   PUBMED   38214103
  REMARK    GeneRIF: GULP1 deficiency reduces adipogenesis and glucose uptake
            via downregulation of PPAR signaling and disturbing of insulin/ERK
            signaling in 3T3-L1 cells.
REFERENCE   5  (bases 1 to 2976)
  AUTHORS   Kim,S.Y., Park,G.I., Park,S.Y., Lee,E.H., Choi,H., Koh,J.T.,
            Han,S., Choi,M.H., Park,E.K., Kim,I.S. and Kim,J.E.
  TITLE     Gulp1 deficiency augments bone mass in male mice by affecting
            osteoclasts due to elevated 17beta-estradiol levels
  JOURNAL   J Cell Physiol 238 (5), 1006-1019 (2023)
   PUBMED   36870066
  REMARK    GeneRIF: Gulp1 deficiency augments bone mass in male mice by
            affecting osteoclasts due to elevated 17beta-estradiol levels.
REFERENCE   6  (bases 1 to 2976)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2976)
  AUTHORS   Combes,A.N., Lesieur,E., Harley,V.R., Sinclair,A.H., Little,M.H.,
            Wilhelm,D. and Koopman,P.
  TITLE     Three-dimensional visualization of testis cord morphogenesis, a
            novel tubulogenic mechanism in development
  JOURNAL   Dev Dyn 238 (5), 1033-1041 (2009)
   PUBMED   19334288
REFERENCE   8  (bases 1 to 2976)
  AUTHORS   Osada,Y., Sunatani,T., Kim,I.S., Nakanishi,Y. and Shiratsuchi,A.
  TITLE     Signalling pathway involving GULP, MAPK and Rac1 for SR-BI-induced
            phagocytosis of apoptotic cells
  JOURNAL   J Biochem 145 (3), 387-394 (2009)
   PUBMED   19122200
  REMARK    GeneRIF: Phosphatidylserine-recognizing SR-BI activates associated
            GULP; activated GULP induces MAPK phosphorylation; activated MAPK
            increases GTP-bound Rac1; and activated Rac1 induces a
            rearrangement of the actin cytoskeleton.
REFERENCE   9  (bases 1 to 2976)
  AUTHORS   Banerjee,H., Hawkins,Z., Johnson,T., Eley,S., Alikhan,A.,
            Mcdaniel,M., Singh,I. and Raymond,J.
  TITLE     Identification of a mouse orthologue of the CED-6 gene of
            Caenorhabditis elegans
  JOURNAL   Plasmid 49 (1), 30-33 (2003)
   PUBMED   12583998
  REMARK    GeneRIF: in this study we report the identification of a novel C.
            elegans CED-6-like orthologue in mouse, which has probable
            apoptotic like function
REFERENCE   10 (bases 1 to 2976)
  AUTHORS   Su,H.P., Nakada-Tsukui,K., Tosello-Trampont,A.C., Li,Y., Bu,G.,
            Henson,P.M. and Ravichandran,K.S.
  TITLE     Interaction of CED-6/GULP, an adapter protein involved in
            engulfment of apoptotic cells with CED-1 and CD91/low density
            lipoprotein receptor-related protein (LRP)
  JOURNAL   J Biol Chem 277 (14), 11772-11779 (2002)
   PUBMED   11729193
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK036670.1, BY713087.1 and BE632215.1.
            
            On Jan 9, 2008 this sequence version replaced NM_028450.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032154.1, AK036670.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-515               AK036670.1         2-516
            516-1050            BY713087.1         263-797
            1051-2488           AK036670.1         1052-2489
            2489-2976           BE632215.1         1-488               c
FEATURES             Location/Qualifiers
     source          1..2976
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 23.63 cM"
     gene            1..2976
                     /gene="Gulp1"
                     /gene_synonym="3110030A04Rik; 5730529O06Rik; CED-6; Ced6;
                     GULP; Gulp-2"
                     /note="GULP, engulfment adaptor PTB domain containing 1"
                     /db_xref="GeneID:70676"
                     /db_xref="MGI:MGI:1920407"
     exon            1..202
                     /gene="Gulp1"
                     /gene_synonym="3110030A04Rik; 5730529O06Rik; CED-6; Ced6;
                     GULP; Gulp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            203..274
                     /gene="Gulp1"
                     /gene_synonym="3110030A04Rik; 5730529O06Rik; CED-6; Ced6;
                     GULP; Gulp-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..1161
                     /gene="Gulp1"
                     /gene_synonym="3110030A04Rik; 5730529O06Rik; CED-6; Ced6;
                     GULP; Gulp-2"
                     /note="CED 6; cell death protein 6 homolog; PTB domain
                     adapter protein CED-6"
                     /codon_start=1
                     /product="PTB domain-containing engulfment adapter protein
                     1"
                     /protein_id="NP_082726.2"
                     /db_xref="CCDS:CCDS48250.1"
                     /db_xref="GeneID:70676"
                     /db_xref="MGI:MGI:1920407"
                     /translation="MNRAFSRKKDKTWMHTPEALSKHYIPYNAKFLGSTEVEQPKGTE
                     VVRDAVRKLKFARHIKKSEGQKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCA
                     DDKTDKRIFTFICKDSESNKHLCFVFDSEKCAEEITLTIGQAFDLAYRKFLESGGKDV
                     ETRKQIAGMQKRIQDLETENMELKNKVQDLESRLRTTQVSTSPAHGVTVMSPSTDIFD
                     MIPFSPISHQSPTSARNGTQLPPIPSRSAETKRDLFGAEPFDPFNCGSGDFPPDIQSK
                     LDEMQEGFKMGLTLEGTVFCLDPLDSRC"
     exon            275..336
                     /gene="Gulp1"
                     /gene_synonym="3110030A04Rik; 5730529O06Rik; CED-6; Ced6;
                     GULP; Gulp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            337..408
                     /gene="Gulp1"
                     /gene_synonym="3110030A04Rik; 5730529O06Rik; CED-6; Ced6;
                     GULP; Gulp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            409..507
                     /gene="Gulp1"
                     /gene_synonym="3110030A04Rik; 5730529O06Rik; CED-6; Ced6;
                     GULP; Gulp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            508..645
                     /gene="Gulp1"
                     /gene_synonym="3110030A04Rik; 5730529O06Rik; CED-6; Ced6;
                     GULP; Gulp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            646..762
                     /gene="Gulp1"
                     /gene_synonym="3110030A04Rik; 5730529O06Rik; CED-6; Ced6;
                     GULP; Gulp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            763..855
                     /gene="Gulp1"
                     /gene_synonym="3110030A04Rik; 5730529O06Rik; CED-6; Ced6;
                     GULP; Gulp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            856..994
                     /gene="Gulp1"
                     /gene_synonym="3110030A04Rik; 5730529O06Rik; CED-6; Ced6;
                     GULP; Gulp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1089
                     /gene="Gulp1"
                     /gene_synonym="3110030A04Rik; 5730529O06Rik; CED-6; Ced6;
                     GULP; Gulp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..2976
                     /gene="Gulp1"
                     /gene_synonym="3110030A04Rik; 5730529O06Rik; CED-6; Ced6;
                     GULP; Gulp-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2954..2959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gulp1"
                     /gene_synonym="3110030A04Rik; 5730529O06Rik; CED-6; Ced6;
                     GULP; Gulp-2"
                     /note="hexamer: AATAAA"
     polyA_site      2973
                     /gene="Gulp1"
                     /gene_synonym="3110030A04Rik; 5730529O06Rik; CED-6; Ced6;
                     GULP; Gulp-2"
                     /note="major polyA site"
ORIGIN      
        1 agcccctgcc gtcgccagca ccagtttggg cttcagcgga ttagaaggag ggagaggacc
       61 agagccctag ggtccggagc ccagtgcctt tcgaacctgc acaaagtttt cctgtgggat
      121 acgaacacgc gatcgtgggc cacggttccc ggagctcctg tgcctgcccc agccctgcga
      181 ccgcatccct ctacaagcca ggggtactgg gtattactga gctgagcagt tgggaggctc
      241 cacaccatga accgtgcttt cagcagaaag aaagacaaaa catggatgca tacgcctgaa
      301 gctttatcaa aacattacat tccctataat gcaaagtttc ttggcagtac cgaagtggag
      361 cagccaaagg gaacagaagt tgtgagagat gctgtcagga agctgaagtt tgcaagacac
      421 atcaaaaaat ctgaaggcca gaagattcct aaagttgaat tgcaaatatc aatttatgga
      481 gtaaaaattc tcgaacccaa aacaaaggag gttcaacaca actgccagct tcatagaata
      541 tcattttgcg cagatgataa aactgacaag aggatattca ctttcatatg caaagattct
      601 gagtcaaata aacatttgtg ttttgtattt gacagcgaaa agtgtgctga agaaattaca
      661 ttaacaattg gccaagcttt tgacttggca tacagaaaat ttctagaatc tggaggaaaa
      721 gatgtagaga caagaaaaca gattgctgga atgcagaaaa gaatccaaga cttagaaaca
      781 gaaaacatgg aacttaaaaa taaagtacaa gatttagaaa gccggttgag aacaactcaa
      841 gtatccacgt ctccagccca tggtgtgaca gtgatgtctc cttccactga tatctttgac
      901 atgattccat tttccccaat atcacatcag tctccaacat ctgctcgcaa tggcacacag
      961 ctaccaccca tccctagcag atctgctgag accaaacggg acctttttgg agctgaacct
     1021 tttgacccat ttaactgtgg atcaggggac tttcctcctg atattcagtc caaattggat
     1081 gagatgcagg aggggttcaa aatgggacta actcttgaag gaacagtgtt ttgtctcgac
     1141 ccattagaca gcaggtgctg acgtcatgaa tgagtgatcc tgacgtgctt aatttgttta
     1201 tttacatata tgtcattcat tattttaaga cagctattat acttgtgcca atatattttt
     1261 gaatatctaa atgtttttag atctgttgaa gtaacaatat ccttactttc agtgttgatt
     1321 tatcttttat tttaaacagg acttagtata atgtatattg gacttttatg ttccctttta
     1381 cattataggt gaatttataa ttgaaaaaca gattttcctg ctttgtctga attttaaact
     1441 atcattacct tgacatttat gctcattctc taggacatta gttcattatc cttttcccaa
     1501 aaagccatac cttgatatca tccaaatatc tggagacagg ccaatatata tgttctattt
     1561 tgacaacaat aaataggctg ccagtgatta gctctatgtc attttgtgaa taaaaggttt
     1621 acctcattat gaaaacctaa agcttagcta ttatgctaca atcttactaa attctatctg
     1681 gtaaaataag aatataagtt ttaatagtaa tcacagaaaa tatacttaaa ctattagtaa
     1741 atatgaaata ataatttcag tcatttaagt tatattctaa acatgtttaa tttgtctcaa
     1801 aagtaacagt tgaggaaaaa ttgcttcttt ggaaaactta aaatttcctt tctaatgtgc
     1861 tgtcgtatta gtgtatcact gggctaacat ctgctcaagt attttgagaa atgaagtttt
     1921 tactttctac agatgtgatg cctattgcct gtttttatgt taccagtatt ctgtagttat
     1981 catgtgatat agtatttctt tcactagtct tatgcctcaa tgccatatta atttttatcc
     2041 tctaaatttt tggtgggata ttttatttaa atttaagaca atttaacaat tttaattttc
     2101 atttgctctg ttaaagtcag aatttcattt ttcacacaca cacacaaaac tcatcagctt
     2161 tatcatgaat atgagcaata aaactctcca gcactcattc tggtgtacta atgaacctac
     2221 cctttcaaaa catatgcttc cacaacattt gcccatatta taaaatacta ccagtgcaga
     2281 aaacaattat tgttgaaagt tctgatgtgg tttatcacaa taaaagaaaa ataaagtaat
     2341 aaaaatctgg gtttggtttg tgggaattta atcaaaattg gatatgttac tcctggcgtt
     2401 ttatggaagt gttaaaggtt cctttccatt aggagcagag cagaaatcaa atgtgcttat
     2461 gtaattttat gtttgaatga tgatgcccta tggcatacat attgcattcc tgcttatgtt
     2521 ctgttatacc tgctaagtta gaccttaatt agcaggtact gtgtatttca tcaggaagtc
     2581 tttgtagttc tagatactca gctagtattt tggaatttgt ataatgagaa tgtttagaag
     2641 ccatctatat ggctttttta aaaacagaat ttgttatttt tattgtactt ttaaaagctt
     2701 tatgtaatag gtatatattt agcaaacatt tagtatcaat tgtaacacaa tagaatacta
     2761 agatgatatt tgcacattta tgatatgtta cttaccagtt tttaatggtg acctgttctg
     2821 ctactggcat gatcaaatag tagatagaat tggtcattaa tatgaacatt aacttcacca
     2881 gtgaattttt atgaagacat gattggcaat ttaatttcta tgtagactcg atgatatgta
     2941 tgattttgct aagaataaaa gattttaaat aaatta
//
