LOCUS       NM_178747               2265 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus gulonolactone (L-) oxidase (Gulo), mRNA.
ACCESSION   NM_178747 XM_913206
VERSION     NM_178747.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2265)
  AUTHORS   Buchanan,R.A., Wang,Y., May,J.M. and Harrison,F.E.
  TITLE     Ascorbate insufficiency disrupts glutamatergic signaling and alters
            electroencephalogram phenotypes in a mouse model of Alzheimer's
            disease
  JOURNAL   Neurobiol Dis 199, 106602 (2024)
   PUBMED   39004234
REFERENCE   2  (bases 1 to 2265)
  AUTHORS   Chen,Y., Holland,K.D., Shertzer,H.G., Nebert,D.W. and Dalton,T.P.
  TITLE     Fatal Epileptic Seizures in Mice Having Compromised Glutathione and
            Ascorbic Acid Biosynthesis
  JOURNAL   Antioxidants (Basel) 12 (2), 448 (2023)
   PUBMED   36830006
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2265)
  AUTHORS   Aumailley,L., Bourassa,S., Gotti,C., Droit,A. and Lebel,M.
  TITLE     Vitamin C modulates the levels of several proteins of the
            mitochondrial complex III and its activity in the mouse liver
  JOURNAL   Redox Biol 57, 102491 (2022)
   PUBMED   36179436
REFERENCE   4  (bases 1 to 2265)
  AUTHORS   Thaler,R., Khani,F., Sturmlechner,I., Dehghani,S.S., Denbeigh,J.M.,
            Zhou,X., Pichurin,O., Dudakovic,A., Jerez,S.S., Zhong,J., Lee,J.H.,
            Natarajan,R., Kalajzic,I., Jiang,Y.H., Deyle,D.R., Paschalis,E.P.,
            Misof,B.M., Ordog,T. and van Wijnen,A.J.
  TITLE     Vitamin C epigenetically controls osteogenesis and bone
            mineralization
  JOURNAL   Nat Commun 13 (1), 5883 (2022)
   PUBMED   36202795
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2265)
  AUTHORS   Armstrong,N., Storey,C.M., Noll,S.E., Margulis,K., Soe,M.H., Xu,H.,
            Yeh,B., Fishbein,L., Kebebew,E., Howitt,B.E., Zare,R.N., Sage,J.
            and Annes,J.P.
  TITLE     SDHB knockout and succinate accumulation are insufficient for
            tumorigenesis but dual SDHB/NF1 loss yields SDHx-like
            pheochromocytomas
  JOURNAL   Cell Rep 38 (9), 110453 (2022)
   PUBMED   35235785
REFERENCE   6  (bases 1 to 2265)
  AUTHORS   Ha,M.N., Graham,F.L., D'Souza,C.K., Muller,W.J., Igdoura,S.A. and
            Schellhorn,H.E.
  TITLE     Functional rescue of vitamin C synthesis deficiency in human cells
            using adenoviral-based expression of murine l-gulono-gamma-lactone
            oxidase
  JOURNAL   Genomics 83 (3), 482-492 (2004)
   PUBMED   14962674
REFERENCE   7  (bases 1 to 2265)
  AUTHORS   Nakata,Y. and Maeda,N.
  TITLE     Vulnerable atherosclerotic plaque morphology in apolipoprotein
            E-deficient mice unable to make ascorbic Acid
  JOURNAL   Circulation 105 (12), 1485-1490 (2002)
   PUBMED   11914259
REFERENCE   8  (bases 1 to 2265)
  AUTHORS   Beamer,W.G., Rosen,C.J., Bronson,R.T., Gu,W., Donahue,L.R.,
            Baylink,D.J., Richardson,C.C., Crawford,G.C. and Barker,J.E.
  TITLE     Spontaneous fracture (sfx): a mouse genetic model of defective
            peripubertal bone formation
  JOURNAL   Bone 27 (5), 619-626 (2000)
   PUBMED   11062347
REFERENCE   9  (bases 1 to 2265)
  AUTHORS   Maeda,N., Hagihara,H., Nakata,Y., Hiller,S., Wilder,J. and
            Reddick,R.
  TITLE     Aortic wall damage in mice unable to synthesize ascorbic acid
  JOURNAL   Proc Natl Acad Sci U S A 97 (2), 841-846 (2000)
   PUBMED   10639167
REFERENCE   10 (bases 1 to 2265)
  AUTHORS   Braun,L., Kardon,T., El Koulali,K., Csala,M., Mandl,J. and
            Banhegyi,G.
  TITLE     Different induction of gulonolactone oxidase in aromatic
            hydrocarbon-responsive or -unresponsive mouse strains
  JOURNAL   FEBS Lett 463 (3), 345-349 (1999)
   PUBMED   10606751
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC126444.3.
            
            On Mar 21, 2007 this sequence version replaced NM_178747.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077740.1, BC028828.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               AC126444.3         108479-108644       c
            167-268             AC126444.3         107473-107574       c
            269-394             AC126444.3         105271-105396       c
            395-489             AC126444.3         103516-103610       c
            490-580             AC126444.3         102025-102115       c
            581-766             AC126444.3         99268-99453         c
            767-874             AC126444.3         96994-97101         c
            875-951             AC126444.3         96258-96334         c
            952-1101            AC126444.3         90464-90613         c
            1102-1266           AC126444.3         89813-89977         c
            1267-1357           AC126444.3         87616-87706         c
            1358-2265           AC126444.3         86221-87128         c
FEATURES             Location/Qualifiers
     source          1..2265
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 34.36 cM"
     gene            1..2265
                     /gene="Gulo"
                     /gene_synonym="5730581M22; GLO; LGO; sfx; unh; unhip"
                     /note="gulonolactone (L-) oxidase"
                     /db_xref="GeneID:268756"
                     /db_xref="MGI:MGI:1353434"
     exon            1..166
                     /gene="Gulo"
                     /gene_synonym="5730581M22; GLO; LGO; sfx; unh; unhip"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1486
                     /gene="Gulo"
                     /gene_synonym="5730581M22; GLO; LGO; sfx; unh; unhip"
                     /EC_number="1.1.3.8"
                     /note="L-gulono-gamma-lactone oxidase"
                     /codon_start=1
                     /product="L-gulonolactone oxidase"
                     /protein_id="NP_848862.1"
                     /db_xref="CCDS:CCDS36958.1"
                     /db_xref="GeneID:268756"
                     /db_xref="MGI:MGI:1353434"
                     /translation="MVHGYKGVQFQNWAKTYGCSPEMYYQPTSVGEVREVLALARQQN
                     KKVKVVGGGHSPSDIACTDGFMIHMGKMNRVLQVDKEKKQVTVEAGILLTDLHPQLDK
                     HGLALSNLGAVSDVTVGGVIGSGTHNTGIKHGILATQVVALTLMKADGTVLECSESSN
                     ADVFQAARVHLGCLGVILTVTLQCVPQFHLLETSFPSTLKEVLDNLDSHLKKSEYFRF
                     LWFPHSENVSIIYQDHTNKEPSSASNWFWDYAIGFYLLEFLLWTSTYLPRLVGWINRF
                     FFWLLFNCKKESSNLSHKIFSYECRFKQHVQDWAIPREKTKEALLELKAMLEAHPKVV
                     AHYPVEVRFTRGDDILLSPCFQRDSCYMNIIMYRPYGKDVPRLDYWLAYETIMKKFGG
                     RPHWAKAHNCTRKDFEKMYPAFHKFCDIREKLDPTGMFLNSYLEKVFY"
     exon            167..268
                     /gene="Gulo"
                     /gene_synonym="5730581M22; GLO; LGO; sfx; unh; unhip"
                     /inference="alignment:Splign:2.1.0"
     exon            269..394
                     /gene="Gulo"
                     /gene_synonym="5730581M22; GLO; LGO; sfx; unh; unhip"
                     /inference="alignment:Splign:2.1.0"
     exon            395..489
                     /gene="Gulo"
                     /gene_synonym="5730581M22; GLO; LGO; sfx; unh; unhip"
                     /inference="alignment:Splign:2.1.0"
     exon            490..580
                     /gene="Gulo"
                     /gene_synonym="5730581M22; GLO; LGO; sfx; unh; unhip"
                     /inference="alignment:Splign:2.1.0"
     exon            581..766
                     /gene="Gulo"
                     /gene_synonym="5730581M22; GLO; LGO; sfx; unh; unhip"
                     /inference="alignment:Splign:2.1.0"
     exon            767..874
                     /gene="Gulo"
                     /gene_synonym="5730581M22; GLO; LGO; sfx; unh; unhip"
                     /inference="alignment:Splign:2.1.0"
     exon            875..951
                     /gene="Gulo"
                     /gene_synonym="5730581M22; GLO; LGO; sfx; unh; unhip"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1101
                     /gene="Gulo"
                     /gene_synonym="5730581M22; GLO; LGO; sfx; unh; unhip"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1266
                     /gene="Gulo"
                     /gene_synonym="5730581M22; GLO; LGO; sfx; unh; unhip"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1357
                     /gene="Gulo"
                     /gene_synonym="5730581M22; GLO; LGO; sfx; unh; unhip"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..2265
                     /gene="Gulo"
                     /gene_synonym="5730581M22; GLO; LGO; sfx; unh; unhip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctttcttg gtacctgtgg ctaaacttcc agtcccgttc tgcctgaggt aacccagagc
       61 cgaggttgcc tgaccactgc atctgctgct gcccagggct ttgttcaact tcctgtggga
      121 acgcttcaag tcaagtcgtc tgaccctgtt gatcgctgga atcatggtcc atgggtacaa
      181 aggggtccag ttccaaaact gggcgaagac ctatggctgc agtccagaga tgtactacca
      241 gcccacatca gtgggggagg tcagagaggt gctggccctg gcccggcagc agaacaagaa
      301 agtgaaggtg gtgggtggcg gccactcgcc ttcagacatc gcctgcaccg atggcttcat
      361 gattcacatg ggcaagatga accgggttct ccaggtggac aaggagaaga agcaggtcac
      421 agtggaagcc ggtatcctcc tgactgacct gcacccacag ctggacaagc atggcctggc
      481 cctgtctaat ctgggagccg tgtctgatgt gacggttggt ggcgtcattg ggtctggaac
      541 acataacacc gggatcaagc acggtatcct ggccacccag gtggtggccc tgaccctgat
      601 gaaggctgat ggaacagttc tggaatgttc tgagtcaagt aatgcagatg tgttccaggc
      661 tgcaagggtg cacctgggct gcctgggtgt tatcctcact gtcaccctgc agtgtgtgcc
      721 acagttccac cttctggaga catcctttcc ttcgaccctc aaggaggtcc ttgacaacct
      781 ggacagccac ctgaagaagt ctgagtactt ccgcttcctc tggtttcctc acagtgagaa
      841 cgtcagcatc atctaccaag atcacaccaa caaggagccc tcctctgcat ctaactggtt
      901 ttgggactat gccattgggt tctacctcct ggaattcttg ctctggacca gcacctacct
      961 gccacgcctc gtgggctgga tcaaccgctt cttcttctgg ctgctgttca actgcaagaa
     1021 ggagagcagc aacctcagcc acaagatctt ctcctacgag tgtcgcttca agcagcatgt
     1081 ccaagactgg gccatcccca gggagaagac caaggaggcc ctgctggagc taaaggccat
     1141 gctggaggcc caccccaagg tggtagccca ctaccccgtg gaggtgcgct tcacccgagg
     1201 tgatgacatc ctgctgagcc cgtgcttcca gagggacagc tgctacatga acatcattat
     1261 gtacaggccc tatgggaagg atgtgcctcg gttggattac tggctggcct atgagaccat
     1321 catgaagaag tttggaggca ggccccactg ggcaaaggcc cacaattgca ccaggaagga
     1381 ctttgagaaa atgtaccccg cctttcacaa gttctgtgac atccgcgaga agctggaccc
     1441 cactggaatg ttcttgaatt cgtacctgga aaaggttttc tactaaagta gaagcagaag
     1501 caagctgccc tgacccctca cttctgctgc cttggggggg ggggggcagg gcagtgtctc
     1561 acaggcacag tgggagacga cctctcctga acacaaggag gggctgggct ctggccgagg
     1621 cctctgcctt ctttatcatc ttcataacac cccaggcaag aagtggcctc tcactcaaat
     1681 tcctgtttgc atctccacga gccatacata aactacaatc atctcaggaa aaggggttcc
     1741 ccttgcatca tatctgtcca ggctaaggat ttggtccttc taggttctac tggtccacca
     1801 agtatagaga gatccctggg gcctgcagtt ttccctccct cttcagaagg gatctcttgg
     1861 caacagaggt agcatgaggc atgctctgct tacttttatc cttaaaggcc tttcagatgc
     1921 ccagagtctg tctgttggtc ctgagcaagc catcttccag atgggtccac gtggccttct
     1981 gactgccatg gcctggccct cacagtgtct ctttcgggtg gtgtttagag tggaatttgc
     2041 ctcgtcttct taaccagttc ctgttagatc cctgtgtttt ctcccttcac ctcagagaca
     2101 attctttggg ctgggatctc gccgtgtccc tgggtttccc tgggtcttgg tttcatcttt
     2161 ctcttcacag agatgatttc agtttatttg tggcctttct ggaatgttcc ttggagagcc
     2221 aatatgttcc aggtactttg tcagaattaa aagactctga aagat
//
