LOCUS       NM_008193                959 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus guanylate kinase 1 (Guk1), transcript variant 1, mRNA.
ACCESSION   NM_008193
VERSION     NM_008193.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 959)
  AUTHORS   Zocher,S., McCloskey,A., Karasinsky,A., Schulte,R., Friedrich,U.,
            Lesche,M., Rund,N., Gage,F.H., Hetzer,M.W. and Toda,T.
  TITLE     Lifelong persistence of nuclear RNAs in the mouse brain
  JOURNAL   Science 384 (6691), 53-59 (2024)
   PUBMED   38574132
REFERENCE   2  (bases 1 to 959)
  AUTHORS   Wimberg,H., Janssen-Bienhold,U. and Koch,K.W.
  TITLE     Control of the Nucleotide Cycle in Photoreceptor Cell Extracts by
            Retinal Degeneration Protein 3
  JOURNAL   Front Mol Neurosci 11, 52 (2018)
   PUBMED   29515371
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 959)
  AUTHORS   Nechiporuk,T., McGann,J., Mullendorff,K., Hsieh,J., Wurst,W.,
            Floss,T. and Mandel,G.
  TITLE     The REST remodeling complex protects genomic integrity during
            embryonic neurogenesis
  JOURNAL   Elife 5, e09584 (2016)
   PUBMED   26745185
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 959)
  AUTHORS   Sekulic,N., Shuvalova,L., Spangenberg,O., Konrad,M. and Lavie,A.
  TITLE     Structural characterization of the closed conformation of mouse
            guanylate kinase
  JOURNAL   J Biol Chem 277 (33), 30236-30243 (2002)
   PUBMED   12036965
REFERENCE   5  (bases 1 to 959)
  AUTHORS   Brady,W.A., Kokoris,M.S., Fitzgibbon,M. and Black,M.E.
  TITLE     Cloning, characterization, and modeling of mouse and human
            guanylate kinases
  JOURNAL   J Biol Chem 271 (28), 16734-16740 (1996)
   PUBMED   8663313
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645854.10.
            
            On Apr 5, 2022 this sequence version replaced NM_008193.3.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is more supported by available transcript
            and conservation data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024625.1, AK004205.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AL645854.10        175094-175176       c
            84-197              AL645854.10        170117-170230       c
            198-239             AL645854.10        169743-169784       c
            240-336             AL645854.10        169285-169381       c
            337-475             AL645854.10        168537-168675       c
            476-560             AL645854.10        168372-168456       c
            561-646             AL645854.10        167779-167864       c
            647-959             AL645854.10        167218-167530       c
FEATURES             Location/Qualifiers
     source          1..959
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.05 cM"
     gene            1..959
                     /gene="Guk1"
                     /gene_synonym="Gmk; Guk-1"
                     /note="guanylate kinase 1"
                     /db_xref="GeneID:14923"
                     /db_xref="MGI:MGI:95871"
     exon            1..83
                     /gene="Guk1"
                     /gene_synonym="Gmk; Guk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            84..197
                     /gene="Guk1"
                     /gene_synonym="Gmk; Guk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            198..239
                     /gene="Guk1"
                     /gene_synonym="Gmk; Guk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            240..336
                     /gene="Guk1"
                     /gene_synonym="Gmk; Guk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            337..475
                     /gene="Guk1"
                     /gene_synonym="Gmk; Guk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            476..560
                     /gene="Guk1"
                     /gene_synonym="Gmk; Guk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            561..646
                     /gene="Guk1"
                     /gene_synonym="Gmk; Guk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            647..959
                     /gene="Guk1"
                     /gene_synonym="Gmk; Guk-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      942..947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Guk1"
                     /gene_synonym="Gmk; Guk-1"
                     /note="hexamer: AATAAA"
     polyA_site      956
                     /gene="Guk1"
                     /gene_synonym="Gmk; Guk-1"
     polyA_site      959
                     /gene="Guk1"
                     /gene_synonym="Gmk; Guk-1"
                     /note="major polyA site"
ORIGIN      
        1 gtagtcctgc gggcggtccc tgatgctgcg gcgcccgctg gtcgggctgg cggtggccgc
       61 cctgggtcgg gtccccgcgg acggcatggc aggacctagg ccagtagtgc tgagcgggcc
      121 gtcaggggca gggaagagca ctctgctcaa gaagctgttc caggagcaca gcagcatctt
      181 cggcttcagc gtgtctcata ctacaaggaa cccacgacct ggtgaagaag atggcaaaga
      241 ttactacttt gtgaccaggg agatgatgca gcgtgatatt gcagcagggg acttcattga
      301 gcatgctgag ttctcaggga acctgtacgg gacaagcaag gaagctgttc gggctgtgca
      361 ggccatgaac cgcatctgcg tgctagatgt cgacctacaa ggtgtgcgca gcatcaagaa
      421 gactgatctg tgtcccatct acatctttgt gcagcctccc tcgctggacg tgctggagca
      481 acgactgcga ctgcgcaaca ctgagactga ggagagtctg gcaaagcggc tggcagctgc
      541 acggacagac atggagagca gcaaggagcc tggcttgttt gacctggtga tcatcaatga
      601 cgacctggat aaagcctatg caaccctgaa gcaggcgctc tctgaggaaa tcaagaaagc
      661 acagggaact ggccacgcct gaaggcctgc ttcattccac agagtgatgt ctgtggtcta
      721 aatttgcctg gaggtggggg aaactttgcc agggcaccaa ggacttgtag tagacttcca
      781 ctgtggagta gaaggagcta ccctttgtct gaccacaagg tggctctgca ccgtgggctg
      841 actcactggc tgaatgactc caaagagtac ccatatctaa tctccctgga ctatttgtgt
      901 tcctttcctt gttccttctg ctggagcggg actgacctct taataaagta attactgaa
//
