LOCUS       NM_001403835             932 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus guanylate kinase 1 (Guk1), transcript variant 5, mRNA.
ACCESSION   NM_001403835 XM_006532245
VERSION     NM_001403835.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 932)
  AUTHORS   Zocher,S., McCloskey,A., Karasinsky,A., Schulte,R., Friedrich,U.,
            Lesche,M., Rund,N., Gage,F.H., Hetzer,M.W. and Toda,T.
  TITLE     Lifelong persistence of nuclear RNAs in the mouse brain
  JOURNAL   Science 384 (6691), 53-59 (2024)
   PUBMED   38574132
REFERENCE   2  (bases 1 to 932)
  AUTHORS   Wimberg,H., Janssen-Bienhold,U. and Koch,K.W.
  TITLE     Control of the Nucleotide Cycle in Photoreceptor Cell Extracts by
            Retinal Degeneration Protein 3
  JOURNAL   Front Mol Neurosci 11, 52 (2018)
   PUBMED   29515371
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 932)
  AUTHORS   Nechiporuk,T., McGann,J., Mullendorff,K., Hsieh,J., Wurst,W.,
            Floss,T. and Mandel,G.
  TITLE     The REST remodeling complex protects genomic integrity during
            embryonic neurogenesis
  JOURNAL   Elife 5, e09584 (2016)
   PUBMED   26745185
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 932)
  AUTHORS   Sekulic,N., Shuvalova,L., Spangenberg,O., Konrad,M. and Lavie,A.
  TITLE     Structural characterization of the closed conformation of mouse
            guanylate kinase
  JOURNAL   J Biol Chem 277 (33), 30236-30243 (2002)
   PUBMED   12036965
REFERENCE   5  (bases 1 to 932)
  AUTHORS   Brady,W.A., Kokoris,M.S., Fitzgibbon,M. and Black,M.E.
  TITLE     Cloning, characterization, and modeling of mouse and human
            guanylate kinases
  JOURNAL   J Biol Chem 271 (28), 16734-16740 (1996)
   PUBMED   8663313
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645854.10.
            
            On Apr 5, 2022 this sequence version replaced XM_006532245.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784648.184926.1,
                                           SRR17784651.995908.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AL645854.10        171050-171105       c
            57-170              AL645854.10        170117-170230       c
            171-212             AL645854.10        169743-169784       c
            213-309             AL645854.10        169285-169381       c
            310-448             AL645854.10        168537-168675       c
            449-533             AL645854.10        168372-168456       c
            534-619             AL645854.10        167779-167864       c
            620-932             AL645854.10        167218-167530       c
FEATURES             Location/Qualifiers
     source          1..932
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.05 cM"
     gene            1..932
                     /gene="Guk1"
                     /gene_synonym="Gmk; Guk-1"
                     /note="guanylate kinase 1"
                     /db_xref="GeneID:14923"
                     /db_xref="MGI:MGI:95871"
     exon            1..56
                     /gene="Guk1"
                     /gene_synonym="Gmk; Guk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            57..170
                     /gene="Guk1"
                     /gene_synonym="Gmk; Guk-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..655
                     /gene="Guk1"
                     /gene_synonym="Gmk; Guk-1"
                     /EC_number="2.7.4.8"
                     /note="isoform 3 is encoded by transcript variant 5; GMP
                     kinase"
                     /codon_start=1
                     /product="guanylate kinase isoform 3"
                     /protein_id="NP_001390764.1"
                     /db_xref="GeneID:14923"
                     /db_xref="MGI:MGI:95871"
                     /translation="MAGPRPVVLSGPSGAGKSTLLKKLFQEHSSIFGFSVSHTTRNPR
                     PGEEDGKDYYFVTREMMQRDIAAGDFIEHAEFSGNLYGTSKEAVRAVQAMNRICVLDV
                     DLQGVRSIKKTDLCPIYIFVQPPSLDVLEQRLRLRNTETEESLAKRLAAARTDMESSK
                     EPGLFDLVIINDDLDKAYATLKQALSEEIKKAQGTGHA"
     exon            171..212
                     /gene="Guk1"
                     /gene_synonym="Gmk; Guk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            213..309
                     /gene="Guk1"
                     /gene_synonym="Gmk; Guk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            310..448
                     /gene="Guk1"
                     /gene_synonym="Gmk; Guk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            449..533
                     /gene="Guk1"
                     /gene_synonym="Gmk; Guk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            534..619
                     /gene="Guk1"
                     /gene_synonym="Gmk; Guk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            620..932
                     /gene="Guk1"
                     /gene_synonym="Gmk; Guk-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      915..920
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Guk1"
                     /gene_synonym="Gmk; Guk-1"
                     /note="hexamer: AATAAA"
     polyA_site      929
                     /gene="Guk1"
                     /gene_synonym="Gmk; Guk-1"
     polyA_site      932
                     /gene="Guk1"
                     /gene_synonym="Gmk; Guk-1"
                     /note="major polyA site"
ORIGIN      
        1 agtgcagagc agccattgac tcttcccagg ctaccatgga ggctgcaaca catcaagcat
       61 ggcaggacct aggccagtag tgctgagcgg gccgtcaggg gcagggaaga gcactctgct
      121 caagaagctg ttccaggagc acagcagcat cttcggcttc agcgtgtctc atactacaag
      181 gaacccacga cctggtgaag aagatggcaa agattactac tttgtgacca gggagatgat
      241 gcagcgtgat attgcagcag gggacttcat tgagcatgct gagttctcag ggaacctgta
      301 cgggacaagc aaggaagctg ttcgggctgt gcaggccatg aaccgcatct gcgtgctaga
      361 tgtcgaccta caaggtgtgc gcagcatcaa gaagactgat ctgtgtccca tctacatctt
      421 tgtgcagcct ccctcgctgg acgtgctgga gcaacgactg cgactgcgca acactgagac
      481 tgaggagagt ctggcaaagc ggctggcagc tgcacggaca gacatggaga gcagcaagga
      541 gcctggcttg tttgacctgg tgatcatcaa tgacgacctg gataaagcct atgcaaccct
      601 gaagcaggcg ctctctgagg aaatcaagaa agcacaggga actggccacg cctgaaggcc
      661 tgcttcattc cacagagtga tgtctgtggt ctaaatttgc ctggaggtgg gggaaacttt
      721 gccagggcac caaggacttg tagtagactt ccactgtgga gtagaaggag ctaccctttg
      781 tctgaccaca aggtggctct gcaccgtggg ctgactcact ggctgaatga ctccaaagag
      841 tacccatatc taatctccct ggactatttg tgttcctttc cttgttcctt ctgctggagc
      901 gggactgacc tcttaataaa gtaattactg aa
//
