LOCUS       NM_001081076            3904 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus guanylate cyclase 2g (Gucy2g), transcript variant 1,
            mRNA.
ACCESSION   NM_001081076 XM_129326
VERSION     NM_001081076.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3904)
  AUTHORS   Chao,Y.C., Fleischer,J. and Yang,R.B.
  TITLE     Guanylyl cyclase-G is an alarm pheromone receptor in mice
  JOURNAL   EMBO J 37 (1), 39-49 (2018)
   PUBMED   28963397
REFERENCE   2  (bases 1 to 3904)
  AUTHORS   Chao,Y.C., Chen,C.C., Lin,Y.C., Breer,H., Fleischer,J. and
            Yang,R.B.
  TITLE     Receptor guanylyl cyclase-G is a novel thermosensory protein
            activated by cool temperatures
  JOURNAL   EMBO J 34 (3), 294-306 (2015)
   PUBMED   25452496
  REMARK    GeneRIF: it was observed that dimerization/oligomerization of GC-G,
            a process generally considered as critical for enzymatic activity
            of GCs, is strongly enhanced by coolness.
REFERENCE   3  (bases 1 to 3904)
  AUTHORS   Lo,H.C., Yang,R.B. and Lee,C.H.
  TITLE     Guanylyl cyclase-G modulates jejunal apoptosis and inflammation in
            mice with intestinal ischemia and reperfusion
  JOURNAL   PLoS One 9 (7), e101314 (2014)
   PUBMED   24992336
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3904)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   5  (bases 1 to 3904)
  AUTHORS   Hanke,W., Mamasuew,K., Biel,M., Yang,R.B. and Fleischer,J.
  TITLE     Odorant-evoked electrical responses in Grueneberg ganglion neurons
            rely on cGMP-associated signaling proteins
  JOURNAL   Neurosci Lett 539, 38-42 (2013)
   PUBMED   23384572
REFERENCE   6  (bases 1 to 3904)
  AUTHORS   Huang,Y.H., Wei,C.C., Su,Y.H., Wu,B.T., Ciou,Y.Y., Tu,C.F.,
            Cooper,T.G., Yeung,C.H., Chu,S.T., Tsai,M.T. and Yang,R.B.
  TITLE     Localization and characterization of an orphan receptor, guanylyl
            cyclase-G, in mouse testis and sperm
  JOURNAL   Endocrinology 147 (10), 4792-4800 (2006)
   PUBMED   16857755
  REMARK    GeneRIF: mGC-G is a sperm cell surface protein that possibly
            functions in early signaling event regulating calcium influx/efflux
            and sperm motility.
REFERENCE   7  (bases 1 to 3904)
  AUTHORS   Kuhn,M., Ng,C.K., Su,Y.H., Kilic,A., Mitko,D., Bien-Ly,N.,
            Komuves,L.G. and Yang,R.B.
  TITLE     Identification of an orphan guanylate cyclase receptor selectively
            expressed in mouse testis
  JOURNAL   Biochem J 379 (Pt 2), 385-393 (2004)
   PUBMED   14713286
  REMARK    GeneRIF: Cloning of a guanylate cyclase receptor, GC-G, that is
            selective expressed in the testis [GC-G]
REFERENCE   8  (bases 1 to 3904)
  AUTHORS   Chambers,D.M., Kipling,D. and Abbott,C.M.
  TITLE     Isolation of a microsatellite that reveals paralogy between the
            subtelomeric regions of mouse chromosomes 17 and 19: further
            evidence for telomere-telomere exchange in the mouse
  JOURNAL   Genomics 53 (1), 113-114 (1998)
   PUBMED   9787084
REFERENCE   9  (bases 1 to 3904)
  AUTHORS   Schulz,S., Wedel,B.J., Matthews,A. and Garbers,D.L.
  TITLE     The cloning and expression of a new guanylyl cyclase orphan
            receptor
  JOURNAL   J Biol Chem 273 (2), 1032-1037 (1998)
   PUBMED   9422765
REFERENCE   10 (bases 1 to 3904)
  AUTHORS   Yang,R.B., Fulle,H.J. and Garbers,D.L.
  TITLE     Chromosomal localization and genomic organization of genes encoding
            guanylyl cyclase receptors expressed in olfactory sensory neurons
            and retina
  JOURNAL   Genomics 31 (3), 367-372 (1996)
   PUBMED   8838319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133100.5 and AC110206.21.
            
            On Jun 21, 2019 this sequence version replaced NM_001081076.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY395631.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation, longest
                                                protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-400               AC133100.5         87574-87973
            401-749             AC133100.5         90728-91076
            750-859             AC133100.5         93169-93278
            860-1045            AC133100.5         95602-95787
            1046-1187           AC133100.5         97667-97808
            1188-1323           AC133100.5         98983-99118
            1324-1436           AC133100.5         100591-100703
            1437-1612           AC133100.5         101308-101483
            1613-1750           AC133100.5         102728-102865
            1751-1834           AC133100.5         105056-105139
            1835-1939           AC133100.5         105848-105952
            1940-2011           AC133100.5         106428-106499
            2012-2180           AC133100.5         111395-111563
            2181-2336           AC133100.5         113626-113781
            2337-2514           AC133100.5         118437-118614
            2515-2655           AC133100.5         120823-120963
            2656-2848           AC133100.5         122482-122674
            2849-3023           AC133100.5         125641-125815
            3024-3122           AC133100.5         126633-126731
            3123-3214           AC110206.21        198889-198980       c
            3215-3904           AC110206.21        197524-198213       c
FEATURES             Location/Qualifiers
     source          1..3904
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 51.18 cM"
     gene            1..3904
                     /gene="Gucy2g"
                     /gene_synonym="2410077I05Rik; GC-G"
                     /note="guanylate cyclase 2g"
                     /db_xref="GeneID:73707"
                     /db_xref="MGI:MGI:106025"
     exon            1..400
                     /gene="Gucy2g"
                     /gene_synonym="2410077I05Rik; GC-G"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..3319
                     /gene="Gucy2g"
                     /gene_synonym="2410077I05Rik; GC-G"
                     /EC_number="4.6.1.2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; guanylyl cyclase receptor G"
                     /codon_start=1
                     /product="guanylate cyclase 2G isoform 1 precursor"
                     /protein_id="NP_001074545.1"
                     /db_xref="CCDS:CCDS38026.1"
                     /db_xref="GeneID:73707"
                     /db_xref="MGI:MGI:106025"
                     /translation="MASRTRSESPLEPRLYAGAGSRADHPSLVLMLSVVMLVTCLEAA
                     KLTVGFHAPWNISHPFSVQRLGAGLQTVVDKLNSEPVGLGNVSWEFTYTNSTCSAKES
                     LAVFIDQVQKEHISALFGPACPEAAEVIGLLASEWNIPLFDFVGQMAALKDHFWCDTC
                     VTLVPPKQEISAVLRESLRYLGWEHIGVFGGSSADSSWEQVDEMWGAVEDGLQFHFNI
                     TASMRYNSSSSDLLQEGLRNMSYVARVIILICSSEDARRILQAAVDLGLDTGEFVFIL
                     LQQLEDSFWKEVLTKDKVIRFPKVYESVFLIAPSAYGGGIGDDGFRKQVSQELRRPPF
                     QSSITSEDQVSPYSAYLHDALLLYAQTVEEMRKAEKDFRDGRQLISTLRAGQVTLQGI
                     TGPVLLDSQGKRHVDYSVYALQESGNRSLFLPFLHYDSFQKVIRPWRNDSNTSWPHGS
                     LPEYKPGCGFHNDLCKTKPPTVAGMTVTVTAVIPTVTFLVLASAAAITGLMLWRLRGK
                     VQSHPGDTWWQIRYDSITLLPQHKLSHRGTPVSRRNVSDTSTVKASADCGSLVKRHQD
                     EELFFAPVGLYQGNQVALCYIGDEAEAWVKKPTVRREVCLMCELKHENIVPFFGVCTE
                     PPNICIVTQYCKKGSLQDVMRNSDHEIDWIFKLSFAYDIVNGLLFLHGSPLRSHGNLK
                     PSNCLVDSHMQLKLSGFGLWEFKHGSTWRSYNQEATDHSELYWTAPELLRLRESPCSG
                     TPQGDVYSFAILLRDLIHQQAHGPFEDLEAAPEEIISRIKDPRAPVPLRPSLLEDKGD
                     GRIVALVRECWDESPELRPIFPSIKKTLREASPRGHVSILDSMMGKLETYANHLEEVV
                     EERTRELVAEKRKVEKLLSTMLPSFVGEQLIAGKSVEPEHFESVTIFFSDIVGFTKLC
                     SLSSPLQVVKLLNDLYSLFDHTIQSHDVYKVETIGDAYMVASGLPIRNGAQHADEIAT
                     MALHLLSVTTHFQIGHMPEERLKLRIGLHTGPVVAGVVGITMPRYCLFGDTVNMASRM
                     ESSSLPLRIHVSQSTAGALLAAGGYHLQKRGTISVKGKGEQTTFWLKGKDGFPVPLPE
                     FTEEEAKVSEIL"
     exon            401..749
                     /gene="Gucy2g"
                     /gene_synonym="2410077I05Rik; GC-G"
                     /inference="alignment:Splign:2.1.0"
     exon            750..859
                     /gene="Gucy2g"
                     /gene_synonym="2410077I05Rik; GC-G"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1045
                     /gene="Gucy2g"
                     /gene_synonym="2410077I05Rik; GC-G"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1187
                     /gene="Gucy2g"
                     /gene_synonym="2410077I05Rik; GC-G"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1323
                     /gene="Gucy2g"
                     /gene_synonym="2410077I05Rik; GC-G"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1436
                     /gene="Gucy2g"
                     /gene_synonym="2410077I05Rik; GC-G"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1612
                     /gene="Gucy2g"
                     /gene_synonym="2410077I05Rik; GC-G"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1750
                     /gene="Gucy2g"
                     /gene_synonym="2410077I05Rik; GC-G"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1834
                     /gene="Gucy2g"
                     /gene_synonym="2410077I05Rik; GC-G"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1939
                     /gene="Gucy2g"
                     /gene_synonym="2410077I05Rik; GC-G"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2011
                     /gene="Gucy2g"
                     /gene_synonym="2410077I05Rik; GC-G"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2180
                     /gene="Gucy2g"
                     /gene_synonym="2410077I05Rik; GC-G"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2336
                     /gene="Gucy2g"
                     /gene_synonym="2410077I05Rik; GC-G"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2514
                     /gene="Gucy2g"
                     /gene_synonym="2410077I05Rik; GC-G"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2655
                     /gene="Gucy2g"
                     /gene_synonym="2410077I05Rik; GC-G"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2848
                     /gene="Gucy2g"
                     /gene_synonym="2410077I05Rik; GC-G"
                     /inference="alignment:Splign:2.1.0"
     exon            2849..3023
                     /gene="Gucy2g"
                     /gene_synonym="2410077I05Rik; GC-G"
                     /inference="alignment:Splign:2.1.0"
     exon            3024..3122
                     /gene="Gucy2g"
                     /gene_synonym="2410077I05Rik; GC-G"
                     /inference="alignment:Splign:2.1.0"
     exon            3123..3214
                     /gene="Gucy2g"
                     /gene_synonym="2410077I05Rik; GC-G"
                     /inference="alignment:Splign:2.1.0"
     exon            3215..3904
                     /gene="Gucy2g"
                     /gene_synonym="2410077I05Rik; GC-G"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3447..3452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gucy2g"
                     /gene_synonym="2410077I05Rik; GC-G"
                     /note="hexamer: AATGAA"
     polyA_site      3469
                     /gene="Gucy2g"
                     /gene_synonym="2410077I05Rik; GC-G"
                     /note="major polyA site"
ORIGIN      
        1 ttagatgcta ctacccatgg cttctaggac acgctctgag tctccactag aacctaggct
       61 ctatgctggg gcaggaagcc gtgcagatca tccatctctg gttttgatgc tgtctgtcgt
      121 tatgctagtg acttgtctcg aagctgctaa gctcaccgtg gggttccatg ccccctggaa
      181 catctctcat ccatttagtg ttcaaaggtt gggggcagga ctccagactg ttgtggacaa
      241 gctcaactca gagccagtgg gtcttgggaa cgtgagctgg gagttcactt acaccaattc
      301 aacatgcagt gccaaggagt cccttgcggt tttcatcgac caggtccaga aagaacacat
      361 ttctgctctg tttggaccag catgcccaga agcagcagag gttattggtt tattggcctc
      421 tgagtggaac atccctttgt ttgacttcgt tggacaaatg gcagccctga aagaccactt
      481 ctggtgtgac acctgcgtga cacttgtgcc acccaagcag gaaatcagtg cggtgcttcg
      541 ggaaagcctg cggtacctgg gctgggaaca tatcggggtg tttggaggtt cctctgcaga
      601 ttcctcctgg gaacaagtgg atgagatgtg gggggctgtt gaggatggac tccagttcca
      661 tttcaacatc actgccagca tgaggtacaa cagcagcagc tcagaccttc tgcaggaagg
      721 cctcaggaac atgtcgtatg tcgccagggt catcatccta atctgcagct cggaggatgc
      781 aaggcgcatt ctgcaggctg cagtggacct gggactcgac actggagaat tcgttttcat
      841 cctcttgcag cagctggagg acagtttttg gaaggaagta ctgacaaagg acaaggtgat
      901 acgctttccc aaagtctatg agtcggtgtt tctcatcgca cccagcgcct atggaggagg
      961 cattggagat gacggtttcc ggaagcaagt ctcccaagaa ctgaggaggc caccctttca
     1021 aagctccatc acctcagagg accaggtgag cccgtactct gcctacctgc acgatgctct
     1081 cttactctac gctcagactg tggaggaaat gaggaaggct gagaaagact tccgggatgg
     1141 gcggcagctg attagcaccc tgagagctgg tcaggtcaca ctgcagggaa tcaccggtcc
     1201 tgtgcttttg gactcccagg ggaaaaggca cgtggattac tccgtctatg ctctgcagga
     1261 atctggaaac aggtccctct tccttccctt tcttcattat gacagttttc agaaagtaat
     1321 cagaccctgg aggaatgact cgaacacctc atggccccat ggctcccttc ctgagtataa
     1381 acctggctgt ggatttcata acgacctttg caaaacgaag ccacccactg tagcaggtat
     1441 gacagtgact gtgactgctg tgatccccac ggtgacgttc ctggttcttg cctcggcagc
     1501 tgccatcaca ggtctgatgt tatggaggtt gagagggaaa gtgcagagcc atcctggaga
     1561 cacctggtgg cagatccgtt atgacagcat cactcttctg cctcagcaca aactgtccca
     1621 ccgaggcaca cctgtgtcaa gacgtaatgt tagcgataca tctactgtga aggcttctgc
     1681 agattgtggc tccttggtca agaggcacca ggatgaagag ctgttctttg cccccgtggg
     1741 gctttaccag ggaaatcagg tggccctctg ctatattggt gacgaagcag aagcttgggt
     1801 taagaagcca actgtgcggc gggaagtctg cctgatgtgc gaactaaagc atgaaaacat
     1861 cgtccccttc tttggtgttt gcacagagcc acctaacatc tgcatcgtta cacagtactg
     1921 caaaaaagga agtctccagg atgttatgag gaactccgat catgagatag attggatatt
     1981 caagctctcc tttgcgtatg acatagtcaa tggcttgctg ttcctgcatg ggagcccact
     2041 gaggtctcac ggcaacctga aaccttccaa ctgcctggta gatagtcaca tgcagctgaa
     2101 gctgtcagga tttgggttgt gggagttcaa gcacggcagc acatggagga gctacaacca
     2161 ggaggccaca gaccattcag agctctactg gacagcccca gagctgctgc ggcttcggga
     2221 gagtccctgt tctggcaccc ctcagggaga cgtttacagc tttgccattc tcctgaggga
     2281 cttgatccac cagcaggccc acgggccctt tgaggacctc gaggcagctc cagaggaaat
     2341 catcagccgc atcaaagacc cccgggcacc cgttccgctt cggccgtccc tgttggagga
     2401 taaaggtgat ggaaggattg tggccctagt gagggagtgc tgggatgaat ctccagagct
     2461 aaggcccatc ttcccttcca tcaagaagac gttacgagaa gccagtccca gaggccacgt
     2521 gagcatcctg gatagcatga tggggaagct ggaaacgtac gccaatcacc tggaggaagt
     2581 ggtagaggag cggacccgcg agttggtggc agagaaaaga aaggtggaga aactcctgtc
     2641 taccatgttg ccaagcttcg tgggagaaca gctaatagcc ggaaagtctg tagaaccgga
     2701 acactttgag tctgtcacca tcttcttctc tgacatcgtg gggttcacaa agctgtgttc
     2761 cctcagctcc cccctgcaag tggtgaagct cctcaacgac ctgtacagct tgtttgacca
     2821 cacgatacag agccatgatg tatacaaggt tgaaaccatt ggagatgcct acatggtggc
     2881 aagtgggctc cccatccgca acggagctca gcatgccgac gagattgcca ccatggccct
     2941 gcacttactc agtgtcacca cccacttcca gatcgggcac atgcctgagg agaggctcaa
     3001 gctccgcata ggcctccaca caggtcctgt ggtggccggt gtggtgggaa tcaccatgcc
     3061 caggtactgt ctgtttggag acactgtgaa catggcatcc aggatggaaa gcagcagctt
     3121 gcctctccgg attcacgttt cccagagcac cgcaggagct cttctagcag caggggggta
     3181 ccatctgcaa aagagaggca ccatttcagt caagggcaag ggagaacaga cgaccttctg
     3241 gctgaaaggc aaagatggct tccctgtccc actccctgag tttacggagg aagaagctaa
     3301 agtttcagaa atattgtgag gttctctcaa gatgtttgta gagccccact aatgtctgtg
     3361 ggtgtccttc gggggcaggg ggtggggggg acaacaatga cgatgaatgc atccaacatt
     3421 cctttgaaca gttgtagctc tgtgtcaatg aatcaatgac ccgccactag atggtgctgt
     3481 ctgactggtg tctcattctg tcccaacctt tgctcccaga ccccccagct attgtgcagt
     3541 tggaagaggt ggctgtaggg aactcacttc caggcatggc cagtcataga ggcttttagc
     3601 ctcacaacta gtgtcattag tccatcatgc cttactcttt cttgcgacac ttatttcttt
     3661 gccccagcct atatggttgc tagcgaatga atgcagagaa tattcgtata ccatgcagct
     3721 ctcaagactt tttgttctgt tgcaacacca aagaatgaag aggcaagacc caatgagagc
     3781 agttagattt tctttgttgc tggcatgctc tgtggagata cttttgagta ctctattgag
     3841 aaacaaacta ccttttgttt tcttggggag ctttcatgcg aatatttata aaaaaatgct
     3901 tgat
//
