LOCUS       NM_001007576            9998 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus guanylate cyclase 2f (Gucy2f), mRNA.
ACCESSION   NM_001007576 XM_142224
VERSION     NM_001007576.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9998)
  AUTHORS   Dizhoor,A.M., Olshevskaya,E.V. and Peshenko,I.V.
  TITLE     Retinal guanylyl cyclase activation by calcium sensor proteins
            mediates photoreceptor degeneration in an rd3 mouse model of
            congenital human blindness
  JOURNAL   J Biol Chem 294 (37), 13729-13739 (2019)
   PUBMED   31346032
REFERENCE   2  (bases 1 to 9998)
  AUTHORS   Vinberg,F., Peshenko,I.V., Chen,J., Dizhoor,A.M. and Kefalov,V.J.
  TITLE     Guanylate cyclase-activating protein 2 contributes to
            phototransduction and light adaptation in mouse cone photoreceptors
  JOURNAL   J Biol Chem 293 (19), 7457-7465 (2018)
   PUBMED   29549122
REFERENCE   3  (bases 1 to 9998)
  AUTHORS   Peshenko,I.V., Olshevskaya,E.V. and Dizhoor,A.M.
  TITLE     Functional Study and Mapping Sites for Interaction with the Target
            Enzyme in Retinal Degeneration 3 (RD3) Protein
  JOURNAL   J Biol Chem 291 (37), 19713-19723 (2016)
   PUBMED   27471269
REFERENCE   4  (bases 1 to 9998)
  AUTHORS   Olshevskaya,E.V., Peshenko,I.V., Savchenko,A.B. and Dizhoor,A.M.
  TITLE     Retinal guanylyl cyclase isozyme 1 is the preferential in vivo
            target for constitutively active GCAP1 mutants causing congenital
            degeneration of photoreceptors
  JOURNAL   J Neurosci 32 (21), 7208-7217 (2012)
   PUBMED   22623665
REFERENCE   5  (bases 1 to 9998)
  AUTHORS   Makino,C.L., Wen,X.H., Olshevskaya,E.V., Peshenko,I.V.,
            Savchenko,A.B. and Dizhoor,A.M.
  TITLE     Enzymatic relay mechanism stimulates cyclic GMP synthesis in rod
            photoresponse: biochemical and physiological study in guanylyl
            cyclase activating protein 1 knockout mice
  JOURNAL   PLoS One 7 (10), e47637 (2012)
   PUBMED   23082185
REFERENCE   6  (bases 1 to 9998)
  AUTHORS   Baehr,W., Karan,S., Maeda,T., Luo,D.G., Li,S., Bronson,J.D.,
            Watt,C.B., Yau,K.W., Frederick,J.M. and Palczewski,K.
  TITLE     The function of guanylate cyclase 1 and guanylate cyclase 2 in rod
            and cone photoreceptors
  JOURNAL   J Biol Chem 282 (12), 8837-8847 (2007)
   PUBMED   17255100
  REMARK    GeneRIF: guanylate cyclase 1 and guanylate cyclase 2 have roles in
            function of rod and cone photoreceptors
REFERENCE   7  (bases 1 to 9998)
  AUTHORS   Corbo,J.C. and Cepko,C.L.
  TITLE     A hybrid photoreceptor expressing both rod and cone genes in a
            mouse model of enhanced S-cone syndrome
  JOURNAL   PLoS Genet 1 (2), e11 (2005)
   PUBMED   16110338
  REMARK    Erratum:[PLoS Genet. 2008 Jan;4(1):e18]
REFERENCE   8  (bases 1 to 9998)
  AUTHORS   Yamazaki,K., Okada,T., Mori,Y. and Tanaka,I.
  TITLE     Genetic mapping of mouse transient receptor potential (Trrp) genes
            responsible for capacitative calcium entry channels to chromosomes
            3, 7, 9, and X
  JOURNAL   Genomics 51 (2), 303-305 (1998)
   PUBMED   9722956
REFERENCE   9  (bases 1 to 9998)
  AUTHORS   Li,Y., Lemaire,P. and Behringer,R.R.
  TITLE     Esx1, a novel X chromosome-linked homeobox gene expressed in mouse
            extraembryonic tissues and male germ cells
  JOURNAL   Dev Biol 188 (1), 85-95 (1997)
   PUBMED   9245514
REFERENCE   10 (bases 1 to 9998)
  AUTHORS   Yang,R.B., Fulle,H.J. and Garbers,D.L.
  TITLE     Chromosomal localization and genomic organization of genes encoding
            guanylyl cyclase receptors expressed in olfactory sensory neurons
            and retina
  JOURNAL   Genomics 31 (3), 367-372 (1996)
   PUBMED   8838319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044234.1, AY651761.1 and AL671916.5.
            
            On Feb 26, 2011 this sequence version replaced NM_001007576.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY651761.1, SRR17784643.47345.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849381,
                                           SAMN00849383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AK044234.1         2-6
            6-8127              AY651761.1         1-8122
            8128-9998           AL671916.5         157132-159002       c
FEATURES             Location/Qualifiers
     source          1..9998
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 62.85 cM"
     gene            1..9998
                     /gene="Gucy2f"
                     /gene_synonym="A930002I06; GC-F; GC2"
                     /note="guanylate cyclase 2f"
                     /db_xref="GeneID:245650"
                     /db_xref="MGI:MGI:105119"
     exon            1..159
                     /gene="Gucy2f"
                     /gene_synonym="A930002I06; GC-F; GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            160..975
                     /gene="Gucy2f"
                     /gene_synonym="A930002I06; GC-F; GC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..3572
                     /gene="Gucy2f"
                     /gene_synonym="A930002I06; GC-F; GC2"
                     /EC_number="4.6.1.2"
                     /note="retinal guanylyl cyclase 2"
                     /codon_start=1
                     /product="retinal guanylyl cyclase 2 precursor"
                     /protein_id="NP_001007577.1"
                     /db_xref="CCDS:CCDS30446.1"
                     /db_xref="GeneID:245650"
                     /db_xref="MGI:MGI:105119"
                     /translation="MFLGPWPFSRLLSWFAISSRLSGQHGLPSSKFLRCLCLLALLPL
                     LRWGQALPYKIGVIGPWTCDPFFSKALPEVAAALAIERISRDKTFDRSYSFEYVILNE
                     DCQTSKALASFISHQQMASGFVGPANPGFCEAASLLGTSWDKGIFSWACVNHELDNKH
                     SFPTFSRTLPSPIRVLVTVMKYFQWAHAGVISSDEDIWMHTANRVSSALRSQGLPVGV
                     VLTSGRDSQSIQKALQQIRQADRIRIIIMCMHSALIGGETQTHFLELAHDLKMTDGTY
                     VFVPYDVLLYSLPYKHSPYQVLRNNPKLREAYDAVLTITVESHEKTFYEAYAEAAARG
                     EIPEKPDSNQVSPLFGTIYNSIYFIAQAMNNAMKKNGRASAASLVQHSRNMQFYGFNQ
                     LIKTDSNGNGISEYVILDTNGKEWELRGTYTVDMETELLRFRGTPIHFPGGRPTSADA
                     KCWFAERKICQGGIDPALAMMVCFALLIALLSINGFAYFIRRRINKIQLIKGPNRILL
                     TLEDVTFINPHFGSKRGSRASVSFQIISEVQSGRSPRLSFSSGSLTPATYENSNIAIY
                     EGDWVWLKKFPPGDFGDIKSIKSSASDVFEMMKDLRHENVNPLLGFFYDSGMFAIVSE
                     FCSRRSLEDILTNDDVKLDWMFKSSLLLDLIKGMKYLHHREFIHGRLKSRNCVVDGRF
                     VLKVTDYGFNDILEMLRLSEEEPSEEELLWTAPELLRAPGGIRLGSFAGDVYSFAIIM
                     QEVMVRGAPFCMMDLPAKEIIDRLKMPPPVYRPVVSPEYAPAECLQLMKQCWAEASEQ
                     RPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKL
                     LTQMLPLSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYT
                     LFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHM
                     PEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVT
                     ILQTLSEGYEVELRGRTELKGKGTEETFWLVGKKGFTKPLPVPPPVGKDGQVGHGLQP
                     AEIAAFQRRKAERQLVRNKP"
     exon            976..1277
                     /gene="Gucy2f"
                     /gene_synonym="A930002I06; GC-F; GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1632
                     /gene="Gucy2f"
                     /gene_synonym="A930002I06; GC-F; GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1717
                     /gene="Gucy2f"
                     /gene_synonym="A930002I06; GC-F; GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1814
                     /gene="Gucy2f"
                     /gene_synonym="A930002I06; GC-F; GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1946
                     /gene="Gucy2f"
                     /gene_synonym="A930002I06; GC-F; GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2036
                     /gene="Gucy2f"
                     /gene_synonym="A930002I06; GC-F; GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2213
                     /gene="Gucy2f"
                     /gene_synonym="A930002I06; GC-F; GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2370
                     /gene="Gucy2f"
                     /gene_synonym="A930002I06; GC-F; GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2520
                     /gene="Gucy2f"
                     /gene_synonym="A930002I06; GC-F; GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..2669
                     /gene="Gucy2f"
                     /gene_synonym="A930002I06; GC-F; GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..2833
                     /gene="Gucy2f"
                     /gene_synonym="A930002I06; GC-F; GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..3026
                     /gene="Gucy2f"
                     /gene_synonym="A930002I06; GC-F; GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3027..3201
                     /gene="Gucy2f"
                     /gene_synonym="A930002I06; GC-F; GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3202..3300
                     /gene="Gucy2f"
                     /gene_synonym="A930002I06; GC-F; GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3301..3395
                     /gene="Gucy2f"
                     /gene_synonym="A930002I06; GC-F; GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3396..3484
                     /gene="Gucy2f"
                     /gene_synonym="A930002I06; GC-F; GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3485..3573
                     /gene="Gucy2f"
                     /gene_synonym="A930002I06; GC-F; GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3574..9998
                     /gene="Gucy2f"
                     /gene_synonym="A930002I06; GC-F; GC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9838..9843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gucy2f"
                     /gene_synonym="A930002I06; GC-F; GC2"
                     /note="hexamer: AATAAA"
     polyA_site      9865
                     /gene="Gucy2f"
                     /gene_synonym="A930002I06; GC-F; GC2"
                     /note="major polyA site"
ORIGIN      
        1 gttatttact ctttcagtgg attttgtcaa cagactggag tccttggcag gattatgaca
       61 gcccagaaga tatgcagaaa tgagtgcatt ggagtagctg tgcctgagat ctgcttgtgc
      121 aggctgtcca ctggagatgc ttgaatggtg atttacatgg aactcggaaa caccactgtc
      181 cgtcttcaga gtgcagagta attctccagt atttcatcac tagtttgctg gaaggcagcg
      241 aggctatgtt cctcggaccc tggccttttt ctcgccttct gtcctggttt gccatttcca
      301 gcagactgtc aggacagcat ggcctccctt cctccaagtt cctgagatgt ttgtgcctct
      361 tggccctttt gcctctcctt cggtgggggc aagcactccc ctacaagatc ggggtcatag
      421 gtccctggac atgtgatccg ttcttttcca aggccctgcc tgaggttgct gctgctttag
      481 caattgagcg aatcagccgg gacaagacat ttgacaggag ttactccttc gaatacgtga
      541 ttcttaacga agactgtcag acttcaaagg ccctcgccag tttcatttcc caccagcaga
      601 tggcctcagg atttgttggg cctgccaacc ctggcttctg cgaggcagcc tcactcctgg
      661 gaaccagctg ggacaaaggg attttctctt gggcttgtgt gaatcatgaa ttagataaca
      721 aacatagctt cccaaccttc tctcggacac tcccttctcc gatacgggtg cttgtaaccg
      781 tcatgaagta tttccagtgg gcacatgctg gggtcatttc ctcagatgaa gacatttgga
      841 tgcatacagc caatcgagtc tcaagtgctc ttcggagcca gggcctacct gtaggggtcg
      901 tcctgacctc gggacgagac agccagagca ttcagaaagc tctccagcag attcgccagg
      961 cagacagaat tcgcataatc ataatgtgta tgcattcagc cttgattggg ggagagacac
     1021 aaacacactt cttggaattg gctcatgatc tgaaaatgac agatgggact tacgtctttg
     1081 tcccctatga tgtactgctc tacagtttac cttataagca cagcccctac caggtcctga
     1141 ggaacaatcc aaagctccgg gaagcctatg atgctgtgtt gactattaca gtggagtccc
     1201 atgaaaagac cttctacgaa gcctatgcag aagcagcagc ccgcggagaa attcctgaga
     1261 agcctgactc aaaccaagtt tcaccgttgt ttggaaccat ctacaattca atttatttta
     1321 tcgcacaagc catgaataat gctatgaaaa aaaatggacg ggctagtgct gccagcctgg
     1381 ttcagcattc cagaaacatg cagttctatg gattcaacca gttgataaag acagactcaa
     1441 atggaaatgg gatttctgaa tatgtaatcc tggacaccaa tgggaaagaa tgggaacttc
     1501 gtggcaccta cactgtggac atggaaactg aactgctaag gttcagaggg accccaattc
     1561 atttccctgg cggcagacct actagtgcag atgcaaaatg ctggtttgca gaaaggaaga
     1621 tctgccaagg aggtattgac cctgccttgg ccatgatggt ctgctttgct ttacttatag
     1681 ccttgctgtc tatcaatgga tttgcttact ttataaggcg acgtataaat aaaatccagt
     1741 tgattaaagg acccaacaga atcctactga ctttggaaga tgtgacattt attaatcccc
     1801 actttggcag taagagagga agccgtgcca gtgtaagctt ccagatcatc tcagaagttc
     1861 aaagtgggag gtccccaagg ctgtcctttt cttcaggtag tctaactcca gctacatatg
     1921 agaactccaa catagcaatc tatgagggtg actgggtatg gctgaaaaag ttccctcctg
     1981 gagattttgg agacattaag tctatcaaat cgagtgcaag tgatgtgttt gaaatgatga
     2041 aggacctgcg gcatgaaaat gtcaaccctc tattgggttt cttctatgat tcggggatgt
     2101 ttgccatcgt gtcagaattt tgttctcgaa ggagcctaga agacatactt acaaatgatg
     2161 atgtgaaact tgattggatg ttcaaatcat cactactgct tgacctcatc aaggggatga
     2221 aatacttaca ccacagagaa tttattcacg ggaggctaaa gtctcggaac tgtgtggtag
     2281 atgggcgttt tgtcctaaaa gtgacagatt atggctttaa tgacatttta gaaatgctga
     2341 gactctctga agaggaacct tctgaagaag agctgctgtg gacggcccct gaactgttaa
     2401 gagcccctgg gggcatcagg ttaggttcat ttgcaggaga cgtctatagc tttgccatca
     2461 tcatgcaaga agtgatggtt cggggtgctc ctttctgcat gatggatctg cctgccaaag
     2521 aaatcataga cagacttaaa atgcctcccc ctgtgtacag acccgtggtt tctcctgagt
     2581 atgcccctgc agaatgtctc cagctgatga agcagtgctg ggctgaggcg tcagaacagc
     2641 gaccaacttt tgatgaaata tttaaccagt ttaaaacttt caacaaaggg aaaaagacta
     2701 atattattga ttctatgctt cggatgttgg agcagtattc tagcaacttg gaagatttga
     2761 tccgggaacg gactgaagaa ttggaaattg aaaaacagaa aacggaaaag cttctaacac
     2821 agatgctacc actatcagtt gctgaatccc tcaagaaggg ctgtacagtt gaacctgagg
     2881 gatttgactt ggtcaccttg tacttcagtg acattgtggg cttcaccacc atctcagcca
     2941 tgagtgagcc cattgaagtt gtggaccttc tgaatgacct gtacacactc tttgatgcca
     3001 tcattggcag tcatgatgtc tataaagtag agaccattgg agatgcctac atggtggcct
     3061 caggccttcc caagaggaat ggcagtaggc atgcagctga gattgcaaac atgtccctgg
     3121 atatcctgag ttctgtgggt acctttaaga tgcgacacat gccagaggtg ccagtccgaa
     3181 ttcgaatagg cctgcactcg gggcctgttg ttgctggagt ggtgggcctc accatgccca
     3241 gatattgctt gtttggggac actgtgaaca cagcttctcg aatggaatca acagggctac
     3301 cataccgaat tcatgtcagt ctcagcacag taacaattct tcaaactctg agtgaaggct
     3361 atgaagtaga gcttcgtgga agaacagagc tcaagggcaa aggcacagag gagacctttt
     3421 ggcttgttgg aaaaaagggt ttcaccaaac ctcttcctgt acccccacca gtgggcaaag
     3481 atgggcaagt gggccatggc ttgcaaccag cagagattgc agcattccaa aggagaaaag
     3541 cagagaggca gttggtgcga aacaagccat aagatggaaa gaagtccagc atttgaatct
     3601 cctcttggca aagcaacatt gaagctcatt acagaagctc attaaagatc atgatattct
     3661 cctgcctgag caagatacta gtgaatgatt attcctctga ggtggcctaa tctccaggga
     3721 aaagtcaagc ccaatcccag tgtatggagt ctcctgggaa ggaactttgc ccataggttt
     3781 tgttcattac taggctatca ccaaaaccaa accaaacaaa agcataggga aaaaaacccc
     3841 aaactattgg aatgcaaact gaaatgaatg taaacaccca ggagagggat ataaccaact
     3901 ctgagtttag tcattccaaa gtagcgtggt caacttggat gaagaaaaga ggtctctctt
     3961 ttcataaaaa gtaggcagta ctttgttttc cttgtaattt tatttgaatt tttagaaaga
     4021 ttttagtaca cataactgat aactcagatg ccatgagatt aactgcaggg aaagggacag
     4081 ctgacttcta gtctatgtct ataaagctat gacattaggt gactggagaa cagagacaat
     4141 gaatgggagg taaagagcct aggtagctgt gttatctgaa taactgaagg ctatgaagaa
     4201 atttcttttc ttaccactta ttgttcaaaa tctttcaaaa ttgttatctt tttttcttat
     4261 ccaagtacag acaatctgga caatataatt gaattgtcct tgctaggtga ggctcttcct
     4321 gggcctcagg gacatacact gaacatacca gaataaatgt aagagacact gtcagggtaa
     4381 aagacataga agtcacagaa gcaagggagc gatttctttg aagtcttata tttccccttc
     4441 cttctgactg ctctgcctcc aacctcatat tcattttcca agagagattc ctttcaatat
     4501 gtgttatgat tttacaattt tagttttcaa ggttgtattt tcaagaggct attggcagtg
     4561 gcttgccata gtcacacgga ctaaagcagt aagacttaag gcataggcat tttcaaaatg
     4621 gttaagcaag cttttcttcc cttttattat aaaaataatc tctttattaa aacctaaccc
     4681 aaacatgtaa gccaataaag aagttaattc ttttagaaca acccctttaa aaggaagaaa
     4741 tgcctaaggt ataatttgat acctttgtca actgtttaat ttttccataa ccaacttacc
     4801 ccaaatctga gtttggagtc gagagccaac cccagcagtt ctttttctct ccagtgctga
     4861 atcaaagtgc cctacattgc taggtatcac agcctcaggt ggttcactta ctatgcagga
     4921 ggatgtagca agactgatgt tgacttcact tccttctgat gagttttttt gttctttgtc
     4981 tggatgttct agagaagaag gagacagaca tgtcatcacc tctttgtgtc agtcaagagc
     5041 tgagctttaa aaactttcct tctagaataa gagatgatgt gaagcagtgt ttctctttca
     5101 ggagaggtaa cacagttctt tactaggaaa atggatggag cattggaggc aaagcatggg
     5161 cactagtgct aagtcatcca tagaatgttg ggtacagcat tctattgata tgaatcatcc
     5221 cagacatatc ccattctgtg cttccccacg tgtaggcctt caagttaatt gctgtctaac
     5281 ccagtggttc tcaacatgtg gatcacaaac tctttggcag agccagtgaa cctttcacaa
     5341 agattgccta agatgattgg aaaacagata tttacattat gactgataac ggtagcaaca
     5401 ttacagttat gaagtagcaa caaaactagt tttatggttg gagtcaccac aacatacgaa
     5461 actatattaa agggttggag gattaagaag gttgagcatc actggtctgg ccaaaatctt
     5521 tcatcagata acaaacccta atgaggatgc tcctttgctg tcttcctgac cctactccct
     5581 acttcctttc tttcccttta gctgttcagt atgtccacaa aatttatctt tctagcctgt
     5641 tttctttctc acatcttgct tcccttgatt taatcacaag tgagttccaa ggtaaagctg
     5701 ttatattcat cttagtttct tttgcataaa tgcctttacc attaacccaa actcagcttt
     5761 cttctatttg ccttggtatt tattaattat ataagaagaa ggcacacatt tccgattctc
     5821 atttgattga cttagtgagc tagagtctga ttcctataca caattgattg attgctagca
     5881 cagtgggtgg agctggtagg gacctgaatg atttctttca aagcactgtt cttatttgtt
     5941 tgtttggttg gtttggtttg gttttttgtt ggtggtgggt ttttcctttt agatattttt
     6001 ctttttattt attcctctct catatattac accctgactg cagttttccc ttcttcctct
     6061 ccacccactc tctccctccc ccacctctta tttcccctgc cctatcattc caactttgtc
     6121 tcccctcaga aaagtacagt tcttccagag acatcaacca aatacagcat aacatgctac
     6181 aataagacca ggcatatatt ctcacactaa agctagatga gtcaacccag taatatgaaa
     6241 agagttccaa aagccagcaa aagaatcaaa gacagccccc aactccacta ctacgaatcc
     6301 cacaaactac tgtcctacac aaccataaca tatatacaga ggacctaggt cagactcata
     6361 caggctccct gatctctgtg agcccacttg agtcccagtc agttacaatg ttttgttttg
     6421 tttttgtttt taaatggctt acatttcctg tatgagaaaa aatattcaga aaactaagga
     6481 tttttcaatt gacgttttaa gttagtttta ttctaaccat tttatctcct tgttttctgg
     6541 tgattcgcct cttttcaaaa tggattactg aaaaaggaga gcaaaatgct aaggaagaac
     6601 aagttaactt ttgtttattt gaagttttac cctatattgt agaccatggc atattgcaat
     6661 ggtcatccat tgagtattat atagattttt tttctctttt tcctctgtag atcacaataa
     6721 cagtatatgg tccttgtata gaatgtagaa aacatagaaa gccacaagtg aagttagaat
     6781 cgctcaacat aactttagtt agttattcta ttttgtgatt cccatttggg ttggcataat
     6841 agattatgac atgttataat atctattcag cctaaatcag ctgattctca aactaaactg
     6901 ttttgcattt attttcttgt ccgtaatgtt tctaatattt tgatggtaca agccgattct
     6961 tgtatattgt cggccaattt cagtgatcta tttgttcttt atctcacttg gcatagcaga
     7021 gtagacggag ataactgatg actacctctt ctaagcacta taacttgact acacgaagtt
     7081 actccatcaa gatgtattag tctaaggact cccataactg ccttgtctta cacttagaat
     7141 tattatacaa acaacttgat tagcgtgaat cttgtctcat cacatcaatt ggattgtcct
     7201 caatccaaat ggaatcagct tgcaaagagt aggaagtggc acacagccaa gcagctaggt
     7261 gctcacatct atctgataat ccagcaatgg gatataactt aaacatgcag ttgaatcaag
     7321 ccagtattat taagctgaaa gagcacagtg gttgaaccat ttacattcac ttcttcaggc
     7381 aaccatgggt ggtctaatca ataatatgtc ccacctggtt gattgttaga ccattaaaat
     7441 aatggattct ggcatggggt gtagcttaga tggtagagtg cttacctagc accaacatga
     7501 ccctagcaag gtccaacccc cagtatgcca gtcagatgtg gtggtacata actgtaatcc
     7561 taaccctaag gaggtagagg taagaatcag aggttcaagg ccatcatcat ctactcagtg
     7621 agtttgagac cagcctgtgt gatacatgag agcttcataa aaaaaactta aatgaaataa
     7681 tagagtctgc acaataaaat gtgttgtttt tctgtctcat gtcttcttgc caggtcaaga
     7741 tagttgatag atatagcaca ggcatagaca taaacgagct tttataaaac agttatgtca
     7801 gttagttgta ttttgtttgg ttttctgctt gagtggtttg tagaaaccct gacatctttc
     7861 ttatttttcc ttttggattt gctataagct aaacaataac gaattgcatt ccaaagaaag
     7921 acccagagca gaagtaatta ctaatctgta tactcacatt ggcttcctat aaattagact
     7981 agttagaatt gttcctaagt attttcaaaa gtgtttaacc ccaattaaat tgcttatgta
     8041 accagacttg gtagggcctt tggaggtgtc aagtccatca tactacagag gaaatcaatg
     8101 gagtttagga aagagaagcc gtctccctga attcaccatt tagttagcag aaaatcagcc
     8161 atttttacca aagcaaagat attatctagg acaaccattg atattcaaga ctgcttgata
     8221 gacatcctaa ggacagtatt tctaacttta tatatagaca tgagtttgac atgtgttagc
     8281 ctgggatggt gtagctgttg acaccatcac aagtcagcaa gaaagaaaag atagagaaat
     8341 cctggaaaat aaattgcctt ttaccacaca catggaatcc catgcagggc catacaattg
     8401 gtaagttgat ttgacataaa tggacacaaa ataaatctcc agttctactt catcctattg
     8461 gttcactcac aggttatggt acatggttca tgtctgacca agttagagtc tcagaaattc
     8521 ctgagtaatg gctggacatc tgcacatgtc aagaacagtt tcaatgtgtc tattatccaa
     8581 agggaggcta cagttttgaa tgagggaaga tggaggaaat ctaagccttc atgctttaaa
     8641 gtaagattaa aaactgaata tgattactat ttgtaaacaa cccttttatc catcagagcc
     8701 atgaaagggg ccgagttgcg gctacaatcg tgtgttccca gtaaggtcat gttgccaata
     8761 gagaggcttt gctcctgtgc tcactgacac cagcagctgc agaggtgatt gggcccagaa
     8821 tgggaactag cctcagatga actcttcatg accacgtttc ccaggattat aaatcaaagg
     8881 aaaggcaatt gttctaagtc aaattggcaa taaaaagaaa caacttagag cattgcctgt
     8941 tggaacttgt ttctttatca gtgacagcat tttaatttag tctttggtgt ggtttagaat
     9001 caagagcggc ttgttctttt aggcatctct tgatctagga gccatctagg catggaggaa
     9061 gaatgctttc taatatgtag gacctcttcg atcagatttg gattggttta gtcacttgtg
     9121 tcgaggacaa acattcctgt gaatcatctc catttatgcc tataatttga aagtccagca
     9181 ctactttaat gatttttttt cagggatagt actccaaaag cctgttacaa gatggttgtg
     9241 atcctgtagg gaatttccct acatggtgta taactctttc tgtatttcag tgtatctggg
     9301 agaaggggct agagtactga tcttagaatt cttctacttt aaaaacttga gggtttgttt
     9361 tagttgattc cttggctttc acttagcttt ccttaccctg ccttccaagt tttgctctag
     9421 cccagaccta ttgcttcctc taacctggtc ctgtatttga gtttactcct ttggttgtgc
     9481 tgttcctaca agtcattctc tgtctccttg cctccacgcg tccaaattcc acccatcctt
     9541 caaaaaaagt ctacttaaat atcacttcct ctagcaagct ctttttattt cttctaaaca
     9601 tgtatcctta tttctgaact cttataataa ttttatccgt acatctttag tggttatgac
     9661 ctcttaactt cttgtataag tgtttggaca gttgtcatct tgaattatac tttgatttag
     9721 agaaacaaat aaaagttaca cacttcttga gggctaaaac tatgtttgat tcccctttgt
     9781 atttcataca atgcctgata tatttaagag gcactcagta tgtatttgac tgtatgaaat
     9841 aaatggatcc ttctatgtgt ctctatatat gtctattctc tgtgaagttt tcccttttga
     9901 cttaatattt tcttgtattt ccatccatgt gactgtattg ccttcctttt accatcatta
     9961 tatatgcata taaaacttca tgcttattat ttaaaagc
//
