LOCUS       NM_001130693            3633 bp    mRNA    linear   ROD 02-JAN-2025
DEFINITION  Mus musculus guanylate cyclase 2d (Gucy2d), mRNA.
ACCESSION   NM_001130693 XM_001474410
VERSION     NM_001130693.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3633)
  AUTHORS   Serafin,E.K., Yoo,J.J., Li,J., Dong,X. and Baccei,M.L.
  TITLE     Development and characterization of a Gucy2d-cre mouse to
            selectively manipulate a subset of inhibitory spinal dorsal horn
            interneurons
  JOURNAL   PLoS One 19 (3), e0300282 (2024)
   PUBMED   38483883
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3633)
  AUTHORS   Zimmerman,A.D., Nagy,C.R. and Munger,S.D.
  TITLE     Sensory neurons expressing the atypical olfactory receptor guanylyl
            cyclase D are required for the acquisition of odor preferences by
            mice in diverse social contexts
  JOURNAL   Physiol Behav 227, 113150 (2020)
   PUBMED   32841674
  REMARK    GeneRIF: Sensory neurons expressing the atypical olfactory receptor
            guanylyl cyclase D are required for the acquisition of odor
            preferences by mice in diverse social contexts.
REFERENCE   3  (bases 1 to 3633)
  AUTHORS   Bloom,M.L., Johnston,L.B. and Datta,S.R.
  TITLE     Renewal and Differentiation of GCD Necklace Olfactory Sensory
            Neurons
  JOURNAL   Chem Senses 45 (5), 333-346 (2020)
   PUBMED   32333759
REFERENCE   4  (bases 1 to 3633)
  AUTHORS   Pyrski,M., Tusty,M., Eckstein,E., Oboti,L., Rodriguez-Gil,D.J.,
            Greer,C.A. and Zufall,F.
  TITLE     P/Q Type Calcium Channel Cav2.1 Defines a Unique Subset of
            Glomeruli in the Mouse Olfactory Bulb
  JOURNAL   Front Cell Neurosci 12, 295 (2018)
   PUBMED   30233329
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3633)
  AUTHORS   Boye,S.L., Olshevskaya,E.V., Peshenko,I.V., McCullough,K.T.,
            Boye,S.E. and Dizhoor,A.M.
  TITLE     Functional study of two biochemically unusual mutations in GUCY2D
            Leber congenital amaurosis expressed via adenoassociated virus
            vector in mouse retinas
  JOURNAL   Mol Vis 22, 1342-1351 (2016)
   PUBMED   27881908
  REMARK    GeneRIF: the S248W mutation contributes to Leber congenital
            amaurosis 1 by hampering the expression, processing, and/or
            cellular transport of GUCY2D, rather than its enzymatic properties.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3633)
  AUTHORS   Peshenko,I.V. and Dizhoor,A.M.
  TITLE     Guanylyl cyclase-activating proteins (GCAPs) are Ca2+/Mg2+ sensors:
            implications for photoreceptor guanylyl cyclase (RetGC) regulation
            in mammalian photoreceptors
  JOURNAL   J Biol Chem 279 (17), 16903-16906 (2004)
   PUBMED   14993224
  REMARK    GeneRIF: Mg(2+) binding to GCAPs is critical for setting the actual
            dynamic range of RetGC regulation by GCAPs at physiological levels
            of free Ca(2+)
REFERENCE   7  (bases 1 to 3633)
  AUTHORS   Glowacki,G., Braren,R., Cetkovic-Cvrlje,M., Leiter,E.H., Haag,F.
            and Koch-Nolte,F.
  TITLE     Structure, chromosomal localization, and expression of the gene for
            mouse ecto-mono(ADP-ribosyl)transferase ART5
  JOURNAL   Gene 275 (2), 267-277 (2001)
   PUBMED   11587854
REFERENCE   8  (bases 1 to 3633)
  AUTHORS   Xu,S., Ladak,R., Swanson,D.A., Soltyk,A., Sun,H., Ploder,L.,
            Vidgen,D., Duncan,A.M., Garami,E., Valle,D. and McInnes,R.R.
  TITLE     PHR1 encodes an abundant, pleckstrin homology domain-containing
            integral membrane protein in the photoreceptor outer segments
  JOURNAL   J Biol Chem 274 (50), 35676-35685 (1999)
   PUBMED   10585447
REFERENCE   9  (bases 1 to 3633)
  AUTHORS   Yoshitomi,H., Yamazaki,K. and Tanaka,I.
  TITLE     Cloning of mouse uncoupling protein 3 cDNA and 5'-flanking region,
            and its genetic map
  JOURNAL   Gene 215 (1), 77-84 (1998)
   PUBMED   9666083
REFERENCE   10 (bases 1 to 3633)
  AUTHORS   Yang,R.B., Fulle,H.J. and Garbers,D.L.
  TITLE     Chromosomal localization and genomic organization of genes encoding
            guanylyl cyclase receptors expressed in olfactory sensory neurons
            and retina
  JOURNAL   Genomics 31 (3), 367-372 (1996)
   PUBMED   8838319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC111084.12 and AC115069.6.
            
            On Dec 17, 2013 this sequence version replaced NM_001130693.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN00849383, SAMN01164131
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               AC111084.12        205381-205480
            101-859             AC115069.6         104190-104948       c
            860-1155            AC115069.6         98336-98631         c
            1156-1510           AC115069.6         96485-96839         c
            1511-1595           AC115069.6         94887-94971         c
            1596-1692           AC115069.6         94224-94320         c
            1693-1821           AC115069.6         94014-94142         c
            1822-1902           AC115069.6         92243-92323         c
            1903-2079           AC115069.6         89927-90103         c
            2080-2236           AC115069.6         89593-89749         c
            2237-2377           AC115069.6         89228-89368         c
            2378-2526           AC115069.6         86189-86337         c
            2527-2690           AC115069.6         84276-84439         c
            2691-2883           AC115069.6         80602-80794         c
            2884-3058           AC115069.6         77185-77359         c
            3059-3157           AC115069.6         75986-76084         c
            3158-3252           AC115069.6         75086-75180         c
            3253-3338           AC115069.6         73631-73716         c
            3339-3633           AC115069.6         70895-71189         c
FEATURES             Location/Qualifiers
     source          1..3633
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 53.86 cM"
     gene            1..3633
                     /gene="Gucy2d"
                     /note="guanylate cyclase 2d"
                     /db_xref="GeneID:14918"
                     /db_xref="MGI:MGI:106030"
     exon            1..100
                     /gene="Gucy2d"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..3447
                     /gene="Gucy2d"
                     /EC_number="4.6.1.2"
                     /note="guanylate cyclase D; guanylyl cyclase 2d; guanylyl
                     cyclase D; olfactory guanylyl cyclase GC-D"
                     /codon_start=1
                     /product="guanylate cyclase D precursor"
                     /protein_id="NP_001124165.1"
                     /db_xref="CCDS:CCDS85343.1"
                     /db_xref="GeneID:14918"
                     /db_xref="MGI:MGI:106030"
                     /translation="MAGLQQGCHFEGQNWTAPHWKTCLPCQGPWRLTVSHLKTVSSIS
                     VLSVVFWSVLLWADSLSLLAWARETFTLGVLGPWDCDPIFAQALPSIATQLAVDQVNQ
                     DASLLPGSQLDFKVLPTGCDTPHALATFVAHKNIVAAFVGPVNPGFCSAAALLAQGWG
                     KSLFSWACEAPEGGGDLVPTLPSAADVLLSVMRHFGWARWAIVSSHQDIWVTTAQQLA
                     TAFRTHGLPIGLVTSLGPGEKGATEVCKQLHSVHGLKIVVLCMHSALLGGLEQTTLLH
                     CAWEEGLTDGRLVFLPYDTLLFALPYGNRSYLVLDDHGPLQEAYDAVLTVSLESSPES
                     HAFTATEMSGGATANLEPEQVSPLFGTIYDAVILLAHALNRSETHGAGLSGAHLGDHV
                     RALDVAGFSQRIRTDGKGRRLAQYVILDTDGEGSQLVPTHILDTSTWQVQPLGKPIHF
                     PGGSPPAHDASCWFDPNTLCIRGVQPLGSLLTLTIACVLALVGGFLAYFIRLGLQQLR
                     LLRGPHRILLTSQELTFLQRTPSRRRPHVDSGSESRSVVDGGSPRSVTQGSARSLPAF
                     LEHTNVALYQGEWVWLKKFEAGVAPDLRPSSLSFLRKLREMRHENVTAFLGLFVGPGV
                     SAMVLEHCARGSLEDLLQNENLRLDWTFKASLLLDLIRGLRYLHHRRFPHGRLKSRNC
                     VVDTRFVLKITDHGYAEFLESHCSSRPQPAPEELLWTAPELLRGPGKATFKGDVFSLA
                     IILQEVLTRDPPYCSWGLSAEEIIRKVASPPPLCRPLVSPDQGPLECIQLMQLCWEEA
                     PDDRPSLDQIYTQFKSINQGKKTSVVDSMLRMLEKYSESLEDLVQERTEELELERRKT
                     ERLLSQMLPPSVAHALKMGTTVEPEYFDQVTIYFSDIVGFTTISALSEPIEVVGFLND
                     LYTLFDAVLDSHDVYKVETIGDAYMVASGLPRRNGNRHAAEIANLALDILSYAGNFRM
                     RHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSQS
                     TVQALLSLDEGYKIDVRGQTELKGKGLEETYWLTGKVGFCRPLPTPLSIKPGDPWQDR
                     INQEIRTGFAKARQGLAEPRKSGEAGPGP"
     exon            101..859
                     /gene="Gucy2d"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1155
                     /gene="Gucy2d"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1510
                     /gene="Gucy2d"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1595
                     /gene="Gucy2d"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1692
                     /gene="Gucy2d"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1821
                     /gene="Gucy2d"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..1902
                     /gene="Gucy2d"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2079
                     /gene="Gucy2d"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2236
                     /gene="Gucy2d"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2377
                     /gene="Gucy2d"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2526
                     /gene="Gucy2d"
                     /inference="alignment:Splign:2.1.0"
     exon            2527..2690
                     /gene="Gucy2d"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2883
                     /gene="Gucy2d"
                     /inference="alignment:Splign:2.1.0"
     exon            2884..3058
                     /gene="Gucy2d"
                     /inference="alignment:Splign:2.1.0"
     exon            3059..3157
                     /gene="Gucy2d"
                     /inference="alignment:Splign:2.1.0"
     exon            3158..3252
                     /gene="Gucy2d"
                     /inference="alignment:Splign:2.1.0"
     exon            3253..3338
                     /gene="Gucy2d"
                     /inference="alignment:Splign:2.1.0"
     exon            3339..3633
                     /gene="Gucy2d"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcagagagt gctcagaaag cctcgcctct gaggaccctg gtgtgcgacc ctccggtctg
       61 acaaagatcc agtgtcaact ctgacagccc atcatggcag gtctgcagca gggctgtcac
      121 tttgaaggcc agaactggac agcaccacac tggaagacct gcctgccctg ccagggcccg
      181 tggagactca ctgtcagtca tctgaagact gtctcttcca tatcagtcct ctctgtggta
      241 ttttggagtg tcctactttg ggctgactcc ctttccctgt tagcatgggc aagagagacc
      301 ttcacccttg gggtgctggg tccctgggac tgtgacccca tctttgccca ggccctcccc
      361 agcatagcta cccagctggc tgtagatcaa gttaatcagg atgcctcact gctgccaggc
      421 tcacagttgg atttcaaggt cctccccaca ggctgtgaca ctcctcatgc cctggccaca
      481 ttcgtggccc acaagaacat agtggctgct tttgtaggcc ctgttaatcc tgggttctgc
      541 tcagcagcag ccctgctggc ccaaggctgg ggcaagtccc tcttctcctg ggcctgtgaa
      601 gctccagagg gaggaggtga cttagtgccc actttacctt ctgcggccga tgtgctactg
      661 tctgtcatga gacactttgg ctgggctcgc tgggccattg tgtcctctca ccaggacatc
      721 tgggtaacca cagcccagca gctggccact gctttcagga ctcatgggct gcccatcgga
      781 ctggtgacct ctttgggacc tggagagaag ggggccacag aggtttgcaa gcagctccac
      841 agtgttcatg gtctgaaaat tgtggttctg tgcatgcact cggcgctgct tggaggcctg
      901 gagcagacca ccctgctgca ctgtgcctgg gaggagggcc tcacagacgg aaggctggtc
      961 ttcctgccct acgacacgct gctctttgcc ctgccctatg gaaaccgctc ctacctggtc
     1021 ctggatgacc atgggcccct tcaggaagcc tatgacgcag tactcactgt cagtctggag
     1081 tccagtcctg agagccacgc cttcactgct accgagatga gtggaggggc aactgccaac
     1141 ttggagccag agcaggtgtc cccactcttt ggaactatct atgatgccgt catcctgttg
     1201 gcccatgccc tgaaccgatc tgagacccat ggagcggggc tctcaggggc tcacttaggg
     1261 gaccacgtaa gagctcttga tgtggctggt tttagccaga gaatccgaac agatgggaaa
     1321 ggcagaaggc tagcccaata tgtcatcctg gacacagatg gtgaaggaag ccagttggtt
     1381 cctacccaca ttctggacac aagcacatgg caggtgcagc ctctgggaaa gcctatacac
     1441 tttcctgggg ggagccctcc agcccatgac gccagctgct ggttcgaccc caacacacta
     1501 tgcatcagag gtgtgcagcc cctgggcagc ctcctgactc tgacgatagc ctgtgtcctg
     1561 gcactggttg gtggattcct tgcttacttc atcaggttag gcctccagca gctgcggctg
     1621 ttgcggggcc cccatcggat cctgctgaca tctcaggagc tcaccttcct ccagcggacc
     1681 cccagccgga ggaggccaca tgtggacagc ggcagtgagt caagaagtgt ggtggatggt
     1741 ggaagtccac ggtcggtgac ccaggggtca gcaaggagcc taccagcctt cctggagcac
     1801 accaacgtgg ccctgtacca gggagagtgg gtatggctga agaagtttga agcaggcgtg
     1861 gctcctgatc ttcggccaag tagccttagc ttcctgagaa agttgcggga gatgcggcat
     1921 gagaatgtta ctgccttcct gggcctcttt gtgggccctg gggtcagtgc aatggtgctg
     1981 gagcactgtg cccgtggcag cctggaggac ctgctgcaga atgagaacct gaggctagac
     2041 tggaccttca aggcctcctt actgttggat ctgatccgag gtttgcggta tctgcaccat
     2101 cggcgcttcc cccacgggcg cctcaagtcc aggaactgtg tggtggacac tcgctttgtg
     2161 ctcaagatca ctgatcatgg ctatgcagag ttcctggagt ctcactgttc ttccaggccc
     2221 cagccagccc cagaagagct tctgtggacg gctcctgagc tgctgcgggg gcctgggaag
     2281 gccaccttca aaggtgatgt tttcagcttg gccatcatcc tgcaggaggt actgacccga
     2341 gacccaccct actgctcctg gggactctca gcagaagaga tcatccggaa ggtggcatct
     2401 ccccctcctc tgtgccggcc actggtgtcc cctgaccagg gtcccctcga gtgtatccag
     2461 ttgatgcagc tatgctggga ggaagctcca gatgacaggc caagcttgga ccagatctac
     2521 acacagttca aaagcatcaa ccaaggcaag aagacaagtg ttgtagactc catgctgcgg
     2581 atgctggaga agtattccga aagcctggaa gatctggtcc aggagcggac tgaggagctg
     2641 gaactggaga ggcggaagac agagaggctg ctctcgcaga tgctccctcc gtctgtcgcc
     2701 catgctctaa agatggggac aacagtggag cccgagtact tcgaccaggt caccatctat
     2761 ttcagtgaca tcgtgggctt caccaccatc tcagccttga gtgagcccat tgaggtggtg
     2821 ggcttcctca atgatctcta cacgctgttt gatgctgttc tcgacagcca tgatgtgtat
     2881 aaggtggaga ccatagggga tgcctacatg gtggcttctg gtctccctcg gcgcaatgga
     2941 aatcggcacg ctgctgagat cgccaacctg gccctggaca tccttagcta tgcaggcaac
     3001 tttcggatga ggcatgcacc cgatgtaccc atccgtgtca gggcaggtct gcattcagga
     3061 ccctgtgtgg caggtgttgt gggtctcacc atgcctcggt actgcctctt tggggacacc
     3121 gtcaacactg cctctaggat ggagtccact gggctgcctt acaggatcca tgtcagtcaa
     3181 agcactgtcc aggccctgct cagccttgat gaaggctaca aaattgatgt cagaggtcag
     3241 actgaactga aggggaaggg cttggaggag acctactggc tgacagggaa ggtaggattc
     3301 tgcagacccc tgcctacacc tctgtctatc aagcctggag acccatggca ggaccgcata
     3361 aaccaagaaa tccggactgg ctttgccaaa gcacgccagg gactggctga gcccagaaaa
     3421 tcaggggagg ctgggccagg tccctgatag caagtcagtg ggcaagggcc aaggcagtca
     3481 agatgccccc accacccctg ctctgctagg aatgtcagct ccctggctgt ctgccaccca
     3541 tgagtggtat gagcagttgg tgtcttccct agtaactcca ggggtgtcct tgcctcctgt
     3601 caggaaaaca ataaaaatag aatacccgct tcc
//
