LOCUS       NM_172810               2717 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus guanylate cyclase 1, soluble, beta 2 (Gucy1b2),
            transcript variant 1, mRNA.
ACCESSION   NM_172810 XM_912313
VERSION     NM_172810.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2717)
  AUTHORS   Koike K, Yoo SJ, Bleymehl K, Omura M, Zapiec B, Pyrski M, Blum T,
            Khan M, Bai Z, Leinders-Zufall T, Mombaerts P and Zufall F.
  TITLE     Danger perception and stress response through an olfactory sensor
            for the bacterial metabolite hydrogen sulfide
  JOURNAL   Neuron 109 (15), 2469-2484 (2021)
   PUBMED   34186026
REFERENCE   2  (bases 1 to 2717)
  AUTHORS   Zapiec B and Mombaerts P.
  TITLE     The Zonal Organization of Odorant Receptor Gene Choice in the Main
            Olfactory Epithelium of the Mouse
  JOURNAL   Cell Rep 30 (12), 4220-4234 (2020)
   PUBMED   32209480
REFERENCE   3  (bases 1 to 2717)
  AUTHORS   Pyrski M, Tusty M, Eckstein E, Oboti L, Rodriguez-Gil DJ, Greer CA
            and Zufall F.
  TITLE     P/Q Type Calcium Channel Cav2.1 Defines a Unique Subset of
            Glomeruli in the Mouse Olfactory Bulb
  JOURNAL   Front Cell Neurosci 12, 295 (2018)
   PUBMED   30233329
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2717)
  AUTHORS   Bleymehl K, Perez-Gomez A, Omura M, Moreno-Perez A, Macias D, Bai
            Z, Johnson RS, Leinders-Zufall T, Zufall F and Mombaerts P.
  TITLE     A Sensor for Low Environmental Oxygen in the Mouse Main Olfactory
            Epithelium
  JOURNAL   Neuron 92 (6), 1196-1203 (2016)
   PUBMED   27916458
  REMARK    GeneRIF: Low oxygen induces calcium influx in a subpopulation of
            olfactory epithelium neurons, and Gucy1b2 and Trpc2 are required
            for these responses.
REFERENCE   5  (bases 1 to 2717)
  AUTHORS   Omura M and Mombaerts P.
  TITLE     Trpc2-expressing sensory neurons in the mouse main olfactory
            epithelium of type B express the soluble guanylate cyclase Gucy1b2
  JOURNAL   Mol Cell Neurosci 65, 114-124 (2015)
   PUBMED   25701815
  REMARK    GeneRIF: Gucy1b2 is a marker for type B cells in olfactory
            epithelium.
REFERENCE   6  (bases 1 to 2717)
  AUTHORS   Wang H, Kohr MJ, Traynham CJ and Ziolo MT.
  TITLE     Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase
            signaling to L-type Ca2+ current in cardiac myocytes
  JOURNAL   J Mol Cell Cardiol 47 (2), 304-314 (2009)
   PUBMED   19345227
  REMARK    GeneRIF: These data suggests a novel physiological role for PDE5 in
            restricting the effects of NOS3/sGC/PKG signaling pathway to
            modulating beta-AR stimulated I(Ca), while limiting effects on
            cardiac contraction.[sGC]
REFERENCE   7  (bases 1 to 2717)
  AUTHORS   Schmidt H, Stonkute A, Juttner R, Schaffer S, Buttgereit J, Feil R,
            Hofmann F and Rathjen FG.
  TITLE     The receptor guanylyl cyclase Npr2 is essential for sensory axon
            bifurcation within the spinal cord
  JOURNAL   J Cell Biol 179 (2), 331-340 (2007)
   PUBMED   17954614
REFERENCE   8  (bases 1 to 2717)
  AUTHORS   Duranski MR, Elrod JW, Calvert JW, Bryan NS, Feelisch M and Lefer
            DJ.
  TITLE     Genetic overexpression of eNOS attenuates hepatic
            ischemia-reperfusion injury
  JOURNAL   Am J Physiol Heart Circ Physiol 291 (6), H2980-H2986 (2006)
   PUBMED   16877550
  REMARK    GeneRIF: These results suggest that hepatic protection in eNOS-TG
            mice may be mediated in part by NO signaling via the sGC-cGMP
            pathway and is independent of HO-1 signal transduction pathways.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK047129.1 and BY391897.1.
            
            On Feb 26, 2011 this sequence version replaced NM_172810.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK047129.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849379,
                                           SAMN00849383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2711              AK047129.1         2-2712
            2712-2717           BY391897.1         407-412
FEATURES             Location/Qualifiers
     source          1..2717
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 33.21 cM"
     gene            1..2717
                     /gene="Gucy1b2"
                     /gene_synonym="B930025B03; GC-SB2"
                     /note="guanylate cyclase 1, soluble, beta 2"
                     /db_xref="GeneID:239134"
                     /db_xref="MGI:MGI:2660873"
     exon            1..214
                     /gene="Gucy1b2"
                     /gene_synonym="B930025B03; GC-SB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..2566
                     /gene="Gucy1b2"
                     /gene_synonym="B930025B03; GC-SB2"
                     /EC_number="4.6.1.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     soluble guanylyl cyclase beta2 subunit"
                     /codon_start=1
                     /product="guanylate cyclase soluble subunit beta-2 isoform
                     1"
                     /protein_id="NP_766398.1"
                     /db_xref="CCDS:CCDS27190.1"
                     /db_xref="GeneID:239134"
                     /db_xref="MGI:MGI:2660873"
                     /translation="MVMSEVLCAEYTLKVKMSDTADGVLYEPLRAEFRSKRTHLQGSA
                     EGRGQFLASLQSTSTAFQRFGKTPGVQLRPGDTTLDTMYGFINTCLQSLVTEKFGEET
                     WEKLKASAEVQDVFMTYTVYDDTITVKLIQEACKALDVSMEAILKLFGEYFFKFCKMS
                     GYDRMLRTLGGNLTEFIENLDALHSYLALSYQEMNAPSFRVEGGADGAMRLHYYSDRR
                     GLCHIVPGIIEAVAKDFFDTDVAMSILDMNEEVERTGKKEHVVFLVVQKARRQIRGAK
                     VNRPRDSENIQAKQESLQGTLLRKKERYLSIPVCPGEKSHSAVVRASVLLGKGPLGDT
                     FQPVFPERLWIEEEVFCNAFPFHVVFDEALRVKQAGVNIQKYVPGILTQKFGLDEYFS
                     IVHPQVTFNISSICKFINSQFILKTRREMMPEAWKSQPTLKLRGQMIWMESLKCMVFM
                     CSPKLRSLQELEESKMHLSDIAPHDTTRDLILLNQQRLAEMELSCQLEKKKEELRVLS
                     NHLAIEKKKTETLLYAMLPEHVANQLKEGKKVAAGEFETCTILFSDVVTFTNICAACE
                     PIQIVNMLNSMYSKFDRLTNIHDVYKVETIGDAYMVVGGVPVPVESHAQRVANFALGM
                     RISAKEVMNPVTGEPIQIRVGIHTGPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLP
                     NKVHLSPTAHRALENKGFEIVTRGEIEVKGKGKMTTYFLIRNLNATEVEIMGRPSALA
                     DGKEASTPRNQVKKPRAVLSNMDHHQQQVYNSDPADASDEVTLAGSPVAGRDDTDAVN
                     SQSSPDETKTSAFASDPVLSAFCAVL"
     exon            215..337
                     /gene="Gucy1b2"
                     /gene_synonym="B930025B03; GC-SB2"
                     /inference="alignment:Splign:2.1.0"
     exon            338..411
                     /gene="Gucy1b2"
                     /gene_synonym="B930025B03; GC-SB2"
                     /inference="alignment:Splign:2.1.0"
     exon            412..506
                     /gene="Gucy1b2"
                     /gene_synonym="B930025B03; GC-SB2"
                     /inference="alignment:Splign:2.1.0"
     exon            507..667
                     /gene="Gucy1b2"
                     /gene_synonym="B930025B03; GC-SB2"
                     /inference="alignment:Splign:2.1.0"
     exon            668..767
                     /gene="Gucy1b2"
                     /gene_synonym="B930025B03; GC-SB2"
                     /inference="alignment:Splign:2.1.0"
     exon            768..964
                     /gene="Gucy1b2"
                     /gene_synonym="B930025B03; GC-SB2"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1076
                     /gene="Gucy1b2"
                     /gene_synonym="B930025B03; GC-SB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1180
                     /gene="Gucy1b2"
                     /gene_synonym="B930025B03; GC-SB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1397
                     /gene="Gucy1b2"
                     /gene_synonym="B930025B03; GC-SB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1718
                     /gene="Gucy1b2"
                     /gene_synonym="B930025B03; GC-SB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1867
                     /gene="Gucy1b2"
                     /gene_synonym="B930025B03; GC-SB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2014
                     /gene="Gucy1b2"
                     /gene_synonym="B930025B03; GC-SB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2169
                     /gene="Gucy1b2"
                     /gene_synonym="B930025B03; GC-SB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2321
                     /gene="Gucy1b2"
                     /gene_synonym="B930025B03; GC-SB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2420
                     /gene="Gucy1b2"
                     /gene_synonym="B930025B03; GC-SB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2717
                     /gene="Gucy1b2"
                     /gene_synonym="B930025B03; GC-SB2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagtctgtct tgctgggtca gcttacatgt aatcagaagt gtgtgtgtgt gtgatgaggt
       61 tgtatttaca aacacctgtc taattgaaag gatggtgatg tctgaagtgt tgtgtgctga
      121 gtatacgcta aaagttaaaa tgtcagacac agcagacggt gtgctgtatg agcctctgcg
      181 agcggagttt aggagcaagc gaacccatct acagggctca gcagaaggcc gaggtcagtt
      241 cctagcttca ctgcagagca cctcaactgc cttccagaga ttcggtaaga cgccgggtgt
      301 gcagctccgg cctggagaca cgacgctgga caccatgtac ggatttatca acacctgtct
      361 gcagtctctt gtgacagaga aatttggaga ggagacgtgg gaaaagctaa aggcttctgc
      421 agaagtgcaa gatgtcttca tgacctacac cgtgtatgat gataccatca ccgttaagct
      481 catccaagaa gcctgcaagg ctctggatgt ttccatggaa gccattctga agctctttgg
      541 cgaatacttc tttaagttct gtaagatgtc cggctatgac aggatgctac ggacacttgg
      601 aggaaatctc acagagttta ttgaaaatct agatgccctc cacagttacc tggcactgtc
      661 ctatcaggaa atgaacgcac cgtcctttcg agtggaggga ggagcagacg gggcaatgcg
      721 tctccattac tactcagaca gacgtggtct gtgtcacatc gtaccaggca tcattgaagc
      781 tgtggccaag gacttctttg acactgatgt ggccatgagt atccttgata tgaatgaaga
      841 ggtggaaagg acagggaaga aagaacatgt cgtgttcctt gttgtgcaga aggctcgaag
      901 acagataaga ggggcaaagg taaaccggcc acgagacagt gagaacatcc aggccaagca
      961 ggagtctctt cagggaacac tccttaggaa gaaggagagg tatttaagca tccctgtttg
     1021 ccctggggag aaatctcact cagctgttgt gagggcatca gtcctgcttg gaaaagggcc
     1081 ccttggggac accttccagc ctgtctttcc tgagagactg tggattgaag aggaggtgtt
     1141 ctgcaatgct tttcctttcc acgttgtctt tgacgaagca ctaagggtca agcaagctgg
     1201 agtgaatatt cagaagtatg tccctggaat cttgacccag aagtttggtc tagatgagta
     1261 tttctccatc gtccaccctc aagttacttt caacatctcc agcatctgca agttcattaa
     1321 cagtcagttt atcttgaaga cacgaagaga gatgatgccc gaagcatgga agagccagcc
     1381 gacactcaaa ctccggggtc agatgatctg gatggagtct ctgaagtgca tggtcttcat
     1441 gtgttctcca aagctccgca gcctgcaaga gctggaggag agcaagatgc atctttccga
     1501 catcgctccc cacgacacga ccagggatct catcctcctc aaccagcaga ggctggcaga
     1561 gatggaactg tcctgccaac tggagaagaa gaaggaggag ttgcgtgtcc tttccaatca
     1621 cctggccatt gaaaagaaga agacagagac cttgctgtat gccatgctgc ctgaacatgt
     1681 ggccaaccag ctcaaggagg gcaaaaaggt ggcggcagga gaattcgaga cgtgtaccat
     1741 ccttttcagc gatgttgtga cattcaccaa catctgtgcg gcctgtgaac ctatccaaat
     1801 agtgaacatg ctcaactcaa tgtactccaa gtttgacagg ttaaccaaca tccatgatgt
     1861 ctataaagta gaaacaatag gtgatgctta catggtggta ggtggagtac cagtacccgt
     1921 tgaaagccat gctcaaagag ttgctaattt tgctctgggg atgagaattt ctgcaaaaga
     1981 agtgatgaat cctgtcactg gggaacccat acagatcaga gtgggaatcc atactggacc
     2041 agtcttagca ggtgttgtgg gagacaagat gccccggtac tgcctgtttg gtgacaccgt
     2101 aaacacggcc tctaggatgg aaagtcacgg gcttcccaac aaagtgcatc tgagccccac
     2161 agcccacagg gctctggaaa acaaagggtt tgaaattgtc acgagagggg agatagaggt
     2221 gaaggggaaa ggaaaaatga ccacatactt cctgatccgg aacctgaatg ccaccgaggt
     2281 tgagatcatg gggcgacctt cagctctcgc tgatgggaag gaagcaagta ctcctagaaa
     2341 ccaagtcaag aagccccgtg ctgtcctgag caacatggac caccaccagc agcaagtcta
     2401 caacagtgat ccagcagacg cttctgatga agtcacactt gctgggagtc cagtggcagg
     2461 gcgagacgac acagatgcag tcaatagcca gtcatcacca gatgagacca agacaagtgc
     2521 ctttgccagt gaccctgtgt tgtctgcctt ctgtgctgtg ttgtgatcaa gggagaaaat
     2581 gaagccctgg gatccatttc ctatattcat ggcaggaaag aacattgact tgtaaaaaaa
     2641 tgcagaagtt caaaatgtgg tcctttccat atcttcctca ggaccccttt gagaataaat
     2701 aattaggaat gaaacac
//
