LOCUS       NM_021896               4740 bp    mRNA    linear   ROD 11-OCT-2024
DEFINITION  Mus musculus guanylate cyclase 1, soluble, alpha 1 (Gucy1a1),
            transcript variant 1, mRNA.
ACCESSION   NM_021896
VERSION     NM_021896.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4740)
  AUTHORS   Luo,M., Mo,D., Liu,L., Li,J., Lin,J., Liang,J., Ye,F., Wu,X.,
            Li,X., Li,J. and Sheng,W.
  TITLE     Loss of Gucy1a3 causes poor post-stroke recovery by reducing
            angiogenesis via the HIF-1alpha/VEGFA signaling pathway in mice
  JOURNAL   J Stroke Cerebrovasc Dis 33 (2), 107484 (2024)
   PUBMED   38064974
  REMARK    GeneRIF: Loss of Gucy1a3 causes poor post-stroke recovery by
            reducing angiogenesis via the HIF-1alpha/VEGFA signaling pathway in
            mice.
REFERENCE   2  (bases 1 to 4740)
  AUTHORS   Olivencia,M.A., Esposito,E., Brancaleone,V., Castaldo,S.,
            Cirino,G., Perez-Vizcaino,F., Sorrentino,R., d'Emmanuele di Villa
            Bianca,R. and Mitidieri,E.
  TITLE     Hydrogen sulfide regulates the redox state of soluble guanylate
            cyclase in CSE-/- mice corpus cavernosum microcirculation
  JOURNAL   Pharmacol Res 194, 106834 (2023)
   PUBMED   37343646
  REMARK    GeneRIF: Hydrogen sulfide regulates the redox state of soluble
            guanylate cyclase in CSE[-/-] mice corpus cavernosum
            microcirculation.
REFERENCE   3  (bases 1 to 4740)
  AUTHORS   Menges,L., Giesen,J., Yilmaz,K., Mergia,E., Fuchtbauer,A.,
            Fuchtbauer,E.M., Koesling,D. and Russwurm,M.
  TITLE     It takes two to tango: cardiac fibroblast-derived NO-induced cGMP
            enters cardiac myocytes and increases cAMP by inhibiting PDE3
  JOURNAL   Commun Biol 6 (1), 504 (2023)
   PUBMED   37165086
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4740)
  AUTHORS   Zhao,L., Song,W. and Chen,Y.G.
  TITLE     Mesenchymal-epithelial interaction regulates gastrointestinal tract
            development in mouse embryos
  JOURNAL   Cell Rep 40 (2), 111053 (2022)
   PUBMED   35830795
REFERENCE   5  (bases 1 to 4740)
  AUTHORS   Lee,D.R., Rhodes,C., Mitra,A., Zhang,Y., Maric,D., Dale,R.K. and
            Petros,T.J.
  TITLE     Transcriptional heterogeneity of ventricular zone cells in the
            ganglionic eminences of the mouse forebrain
  JOURNAL   Elife 11, e71864 (2022)
   PUBMED   35175194
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4740)
  AUTHORS   Cauwels,A., Janssen,B., Buys,E., Sips,P. and Brouckaert,P.
  TITLE     Anaphylactic shock depends on PI3K and eNOS-derived NO
  JOURNAL   J Clin Invest 116 (8), 2244-2251 (2006)
   PUBMED   16886062
REFERENCE   7  (bases 1 to 4740)
  AUTHORS   Mergia,E., Friebe,A., Dangel,O., Russwurm,M. and Koesling,D.
  TITLE     Spare guanylyl cyclase NO receptors ensure high NO sensitivity in
            the vascular system
  JOURNAL   J Clin Invest 116 (6), 1731-1737 (2006)
   PUBMED   16614755
REFERENCE   8  (bases 1 to 4740)
  AUTHORS   Fenske,T.S., McMahon,C., Edwin,D., Jarvis,J.C., Cheverud,J.M.,
            Minn,M., Mathews,V., Bogue,M.A., Province,M.A., McLeod,H.L. and
            Graubert,T.A.
  TITLE     Identification of candidate alkylator-induced cancer susceptibility
            genes by whole genome scanning in mice
  JOURNAL   Cancer Res 66 (10), 5029-5038 (2006)
   PUBMED   16707424
REFERENCE   9  (bases 1 to 4740)
  AUTHORS   Vazquez-Padron,R.I., Pham,S.M., Pang,M., Li,S. and Aitouche,A.
  TITLE     Molecular dissection of mouse soluble guanylyl cyclase alpha1
            promoter
  JOURNAL   Biochem Biophys Res Commun 314 (1), 208-214 (2004)
   PUBMED   14715267
REFERENCE   10 (bases 1 to 4740)
  AUTHORS   Sharina,I.G., Krumenacker,J.S., Martin,E. and Murad,F.
  TITLE     Genomic organization of alpha1 and beta1 subunits of the mammalian
            soluble guanylyl cyclase genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (20), 10878-10883 (2000)
   PUBMED   10984516
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121563.3, BY150724.1, AK004815.1, BC057327.1 and CO042590.1.
            
            On Oct 14, 2017 this sequence version replaced NM_021896.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057327.1, SRR1660819.63091.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AC121563.3         173386-173454       c
            70-136              BY150724.1         2-68
            137-2538            AK004815.1         2-2403
            2539-4713           BC057327.1         2380-4554
            4714-4740           CO042590.1         1-27                c
FEATURES             Location/Qualifiers
     source          1..4740
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 35.97 cM"
     gene            1..4740
                     /gene="Gucy1a1"
                     /gene_synonym="1200016O07Rik; GCS-alpha-1; GCS-alpha-3;
                     Gucy1a3; sGC-alpha1"
                     /note="guanylate cyclase 1, soluble, alpha 1"
                     /db_xref="GeneID:60596"
                     /db_xref="MGI:MGI:1926562"
     exon            1..275
                     /gene="Gucy1a1"
                     /gene_synonym="1200016O07Rik; GCS-alpha-1; GCS-alpha-3;
                     Gucy1a3; sGC-alpha1"
                     /inference="alignment:Splign:2.1.0"
     exon            276..634
                     /gene="Gucy1a1"
                     /gene_synonym="1200016O07Rik; GCS-alpha-1; GCS-alpha-3;
                     Gucy1a3; sGC-alpha1"
                     /inference="alignment:Splign:2.1.0"
     CDS             380..2455
                     /gene="Gucy1a1"
                     /gene_synonym="1200016O07Rik; GCS-alpha-1; GCS-alpha-3;
                     Gucy1a3; sGC-alpha1"
                     /EC_number="4.6.1.2"
                     /note="guanylate cyclase soluble subunit alpha-3; soluble
                     guanylate cyclase large subunit; guanylate cyclase 1,
                     soluble, alpha 3"
                     /codon_start=1
                     /product="guanylate cyclase soluble subunit alpha-1"
                     /protein_id="NP_068696.2"
                     /db_xref="CCDS:CCDS17429.1"
                     /db_xref="GeneID:60596"
                     /db_xref="MGI:MGI:1926562"
                     /translation="MFCRKFKDLKITGECPFSLLAPGQVPKEPTEEVAGGSEGCQATL
                     PICQYFPEKNAEGSLPQRKTSRNRVYLHTLAESICKLIFPECERLNLALQRTLAKHKI
                     EENRKSSEKEDLEKIIAEEAIAAGAPVEALKDSLGEELFKICYEEDEHILGVVGGTLK
                     DFLNSFSTLLKQSSHCQEAERRGRLEDASILCLDKDQDFLNVYYFFPKRTTALLLPGI
                     IKAAARILYESHVEVSLMPPCFRSDCTEFVNQPYLLYSVHVKSTKPSLSPGKPQSSLV
                     IPASLFCKTFPFHFMLDRDLAILQLGNGIRRLVNKRDFQGKPNFEEFFEILTPKINQT
                     FSGIMTMLNMQFVIRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLED
                     FTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEHAHQALEEEKKRT
                     VDLLCSIFPSEVAQQLWQGQIVQAKKFSEVTMLFSDIVGFTAICSQCSPLQVITMLNA
                     LYTRFDQQCGELDVYKVETIGDAYCVAGGLHRESDTHAVQIALMALKMMELSNEVMSP
                     HGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYR
                     LLKDCPGFVFTPRSREELPPNFPSDIPGICHFLDAYHHQGPNSKPWFQDKDVEDGNAN
                     FLGKASGID"
     exon            635..696
                     /gene="Gucy1a1"
                     /gene_synonym="1200016O07Rik; GCS-alpha-1; GCS-alpha-3;
                     Gucy1a3; sGC-alpha1"
                     /inference="alignment:Splign:2.1.0"
     exon            697..755
                     /gene="Gucy1a1"
                     /gene_synonym="1200016O07Rik; GCS-alpha-1; GCS-alpha-3;
                     Gucy1a3; sGC-alpha1"
                     /inference="alignment:Splign:2.1.0"
     exon            756..1465
                     /gene="Gucy1a1"
                     /gene_synonym="1200016O07Rik; GCS-alpha-1; GCS-alpha-3;
                     Gucy1a3; sGC-alpha1"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1951
                     /gene="Gucy1a1"
                     /gene_synonym="1200016O07Rik; GCS-alpha-1; GCS-alpha-3;
                     Gucy1a3; sGC-alpha1"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2095
                     /gene="Gucy1a1"
                     /gene_synonym="1200016O07Rik; GCS-alpha-1; GCS-alpha-3;
                     Gucy1a3; sGC-alpha1"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2250
                     /gene="Gucy1a1"
                     /gene_synonym="1200016O07Rik; GCS-alpha-1; GCS-alpha-3;
                     Gucy1a3; sGC-alpha1"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..4723
                     /gene="Gucy1a1"
                     /gene_synonym="1200016O07Rik; GCS-alpha-1; GCS-alpha-3;
                     Gucy1a3; sGC-alpha1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4691..4696
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gucy1a1"
                     /gene_synonym="1200016O07Rik; GCS-alpha-1; GCS-alpha-3;
                     Gucy1a3; sGC-alpha1"
                     /note="hexamer: AATAAA"
     polyA_site      4713
                     /gene="Gucy1a1"
                     /gene_synonym="1200016O07Rik; GCS-alpha-1; GCS-alpha-3;
                     Gucy1a3; sGC-alpha1"
                     /note="major polyA site"
ORIGIN      
        1 gtgtgtgtgt gtgtgtgtgt gtgtgtgtct gcctttggtg gtttggagga tggcgactgg
       61 gcgggagcag actcagttct ctagctgagc ctgggagaag tgggagggac tcagagccgc
      121 gggtttctca cacaccgcct tctaggcagc cctcctccag tgcctgccag ccggaccgga
      181 ccccaaggcg aagagcagca gtgcacagcc tggggagcca gcggagcaaa gacacctttg
      241 gcccgatgcc cctggcctcc tgtgatcgca tcatggtgct gggtcactcc tgtccttgag
      301 tcagtagaag cagatcttca tcagtccaca tcaacaccag ctagtcagaa ggaagccact
      361 gccaagctcc aggaacacca tgttctgcag gaagttcaag gatctcaaga tcacagggga
      421 gtgtcctttc tccttactgg cccctggtca ggttcctaag gagccaacag aggaggtggc
      481 tggaggctct gagggctgcc aggctactct gcccatctgc cagtactttc ctgagaagaa
      541 tgcagaaggg agtctccccc aaagaaagac aagccgcaac agagtctacc tgcacaccct
      601 ggcagagagt atttgcaagc tcatcttccc agagtgtgag cgactgaacc ttgcacttca
      661 gagaaccttg gcaaagcata aaatagaaga aaacaggaaa tcttcagaaa aagaagacct
      721 tgaaaaaata atcgcagaag aagcaattgc agcaggtgcc ccagtggagg cgctcaaaga
      781 ctctctgggc gaggagctgt tcaagatctg ctatgaggaa gatgagcaca ttttgggcgt
      841 ggttggcggc accctgaagg actttctaaa tagcttcagc acgctcctca agcagagcag
      901 ccactgccaa gaggcggaga ggcggggacg actggaagat gcctccatct tatgcctgga
      961 caaggaccag gactttctaa atgtttacta cttcttcccg aagagaacca cagccctgct
     1021 tctccctggt atcattaaag cggctgctcg catactgtac gaaagccacg tggaggtgtc
     1081 cctgatgcct ccctgcttcc gaagtgactg taccgagttt gtgaaccagc cctatttgct
     1141 ctactccgtt catgtgaaga gcaccaagcc gtccctgtcc ccaggcaagc cccagtcctc
     1201 gctagtgatc cccgcttcgc tcttctgcaa gactttcccg ttccatttca tgctggaccg
     1261 agacctggcc atcctgcagc tgggtaacgg catcagaagg ctggtgaaca agagggactt
     1321 ccaagggaag cccaactttg aagagttctt tgaaattcta actcccaaaa tcaaccagac
     1381 atttagtggc atcatgacaa tgttgaacat gcagtttgtc atccgggtga ggagatggga
     1441 taactcggtg aagaaatcgt caagggttat ggatctcaaa ggtcaaatga tctacatcgt
     1501 tgaatccagt gccatcttgt tcttagggtc accatgtgtg gacaggctgg aagatttcac
     1561 aggacggggg ctctatctgt ccgacatccc aattcataac gccctgaggg atgttgtctt
     1621 gataggggag caggcacggg ctcaagatgg cctcaagaag aggttgggga agctgaaggc
     1681 aaccctggag catgcccacc aagccctgga ggaggagaag aagaggacag tggatctgct
     1741 gtgctctatc ttcccctctg aggttgctca gcagctgtgg caaggacaaa ttgtgcaagc
     1801 caagaaattc agcgaggtca ccatgctttt ctcagatatc gtagggttca ctgctatctg
     1861 ctctcagtgt tcacctctgc aggtcatcac gatgctcaac gctctctaca ctcgctttga
     1921 ccagcagtgt ggagagctgg atgtctacaa ggtggagacc atcggggatg catattgtgt
     1981 ggcaggtgga ttgcacagag agagtgacac ccatgctgtc cagatagcac tgatggccct
     2041 gaagatgatg gagctctcca atgaggtcat gtctccccac ggagaaccta tcaagatgcg
     2101 aattggacta cattctggat cagtgtttgc tggagttgtc ggagtgaaga tgccccggta
     2161 ttgcctgttt ggaaacaatg tcactctggc taacaaattt gaatcctgca gtgtgcctcg
     2221 gaaaatcaat gtcagcccca ccacatacag gttactcaaa gactgtcctg gctttgtgtt
     2281 caccccgaga tcaagggagg agcttccacc aaacttccct agtgacattc ctgggatctg
     2341 tcactttctg gatgcttatc accatcaagg acctaattcc aaaccatggt tccaggataa
     2401 agatgtggaa gatggaaacg ccaacttctt aggcaaagcg tcagggatag attagtgagc
     2461 cacatgctct tatgtttgat gcctttgaag gtgtgcagaa cctctgtgtt gaccttagga
     2521 ttacagaaga taaaaaaaat cagtgttaaa attacagagg ctaaacacag gtttcctctg
     2581 tctcccattt aagatggaaa agaaaagtgt tcacttcagc gcttcaacct tcttctattt
     2641 aagaaacaga cctcaaaagt gacctgtgac ttttgggggc atagttgtgt tctagaacag
     2701 tcactacctg cactcaaaat ccagcacatt gtacatattc caggcaactg tagtcaagtt
     2761 taagtgttga agtaatgggt tcacctatgg cctgtggcca gcacaagctg tggttattaa
     2821 agtgtatgtg tgtgtgatag tgtcgcctgt aaaatctctg aatagaaaca acagtgttta
     2881 gttctgcaag aactcccagc ctctcgactc tacattcaat tagatttcct tatttaatcg
     2941 tgtcatatgt agcacaatag accagcatca cctttccagc tacatctttg tgcctatgta
     3001 tgtgatttct tttccttttt tttaaaagaa aataagcaat tagacattag atgaaatgtg
     3061 atataagata gttctacaag tatcaaagaa tattctcatg ttttgtcatt taaaatatcc
     3121 tctatagcac actatataat acagcaaata cttttctttt tgatgttata tgtaataaaa
     3181 cattttaatt aatcgtaaca acaatgtact tcctactaat ccacgtaaaa tgtacgaata
     3241 gcaaaactat cagaatacaa agacttatag taaccctagt taaaatgcaa taatattcaa
     3301 atttaataaa gtcatagagt taacatttgc atccagagag cctgctgtag aggacagtgg
     3361 taaactattc acaaacatac atgtataaat gatcctctac tgccatgttg agccataaaa
     3421 tccaagggga aacgttttaa ctcagaagta gaagatgagg ctccattttg tcttttttga
     3481 tagcttctta agtattttta ctgaccattt tagtgtatgt gtatgtatta ggaatctaat
     3541 tttgttatta ttcagtgtac gcctgtgaag tgttattcta gttaaaatat tctaatattt
     3601 tctacaggaa ccactagtat caatgaagaa agctcccccc cccccatggt ttcattgtgg
     3661 agaactctaa actttttttt ttttctgctg gagtttgaac taatatcctt tccctcccat
     3721 gccctcctct caagttccct ttcttccctt cccattgtgc atgtatgtat gattctgtga
     3781 gtggaacaca gggactgtgc atgcctggta agggcttttt ccccatgaag cttggattgt
     3841 attgctaact gtgacagttt atactccctc ccaagtgagc tccagtgtga attctgtaaa
     3901 aggatgtggc tttaaaacaa gaccagcttc aaagccaaga gagattgaca cagttgagta
     3961 tttgaatcag tattagcaga actatagaca cgctgacttt ctatgtgtat atttgaaaag
     4021 aactttagtt taaaagtcct tttctacctc cattagtctc caagcagtca tcattaccta
     4081 gctctagttt ttccaaggga tacgactaaa ctattccagt ggatttcttt aaaggctgtt
     4141 taaaggctca ttaaacagtc gcactgatgt tggagagtat cacaggcctt gcgaaggtct
     4201 atttatgatg tcacaatgat gtgaagttca atgaaaatct atgaagacag taaagaggta
     4261 aataccctct ctttctggaa ctaaaattta atacagggga actaatagga atcacagaca
     4321 attagaaagc acaaaacagg atgtcatcct cttaagctgt gcagttaggt agttgctaca
     4381 ttagtaataa tctgattcag atgcttgcac agtaaataga attaattccc caccgtcttt
     4441 tagagatgga gatagagctt agtgacaaag cacttgtcta gcatttaggc agtccttagt
     4501 tctaacccaa gcggtgtgaa ggaactatat gcatctctca tgagcatatg atgtatgatc
     4561 gcactcactt gtgtcgcctg tgtacacacc tggggcaaat ggaggaactt tatctaattc
     4621 aagtcaaaag aagtatagaa gctccatgta cggttcctat aacttttcta ttattttgtc
     4681 attttatcta aataaaaaca ttatcaagca ttattttcct ggaaaaaaaa aaaaaaaaaa
//
