LOCUS       NM_146079               1681 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus guanylate cyclase activator 1B (Guca1b), mRNA.
ACCESSION   NM_146079
VERSION     NM_146079.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1681)
  AUTHORS   Turunen,T. and Koskelainen,A.
  TITLE     Functional modulation of phosphodiesterase-6 by calcium in mouse
            rod photoreceptors
  JOURNAL   Sci Rep 11 (1), 8938 (2021)
   PUBMED   33903621
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1681)
  AUTHORS   Maddala,R., Gao,J., Mathias,R.T., Lewis,T.R., Arshavsky,V.Y.,
            Levine,A., Backer,J.M., Bresnick,A.R. and Rao,P.V.
  TITLE     Absence of S100A4 in the mouse lens induces an aberrant
            retina-specific differentiation program and cataract
  JOURNAL   Sci Rep 11 (1), 2203 (2021)
   PUBMED   33500475
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1681)
  AUTHORS   Dizhoor,A.M., Olshevskaya,E.V. and Peshenko,I.V.
  TITLE     Retinal degeneration-3 protein promotes photoreceptor survival by
            suppressing activation of guanylyl cyclase rather than accelerating
            GMP recycling
  JOURNAL   J Biol Chem 296, 100362 (2021)
   PUBMED   33539922
REFERENCE   4  (bases 1 to 1681)
  AUTHORS   Plana-Bonamaiso,A., Lopez-Begines,S., Andilla,J., Fidalgo,M.J.,
            Loza-Alvarez,P., Estanyol,J.M., Villa,P. and Mendez,A.
  TITLE     GCAP neuronal calcium sensor proteins mediate photoreceptor cell
            death in the rd3 mouse model of LCA12 congenital blindness by
            involving endoplasmic reticulum stress
  JOURNAL   Cell Death Dis 11 (1), 62 (2020)
   PUBMED   31980596
  REMARK    GeneRIF: GCAP neuronal calcium sensor proteins mediate
            photoreceptor cell death in the rd3 mouse model of LCA12 congenital
            blindness by involving endoplasmic reticulum stress.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1681)
  AUTHORS   Dizhoor,A.M., Olshevskaya,E.V. and Peshenko,I.V.
  TITLE     Retinal guanylyl cyclase activation by calcium sensor proteins
            mediates photoreceptor degeneration in an rd3 mouse model of
            congenital human blindness
  JOURNAL   J Biol Chem 294 (37), 13729-13739 (2019)
   PUBMED   31346032
REFERENCE   6  (bases 1 to 1681)
  AUTHORS   Burns,M.E., Mendez,A., Chen,J. and Baylor,D.A.
  TITLE     Dynamics of cyclic GMP synthesis in retinal rods
  JOURNAL   Neuron 36 (1), 81-91 (2002)
   PUBMED   12367508
REFERENCE   7  (bases 1 to 1681)
  AUTHORS   Howes,K.A., Pennesi,M.E., Sokal,I., Church-Kopish,J., Schmidt,B.,
            Margolis,D., Frederick,J.M., Rieke,F., Palczewski,K., Wu,S.M.,
            Detwiler,P.B. and Baehr,W.
  TITLE     GCAP1 rescues rod photoreceptor response in GCAP1/GCAP2 knockout
            mice
  JOURNAL   EMBO J 21 (7), 1545-1554 (2002)
   PUBMED   11927539
REFERENCE   8  (bases 1 to 1681)
  AUTHORS   Mendez,A., Burns,M.E., Sokal,I., Dizhoor,A.M., Baehr,W.,
            Palczewski,K., Baylor,D.A. and Chen,J.
  TITLE     Role of guanylate cyclase-activating proteins (GCAPs) in setting
            the flash sensitivity of rod photoreceptors
  JOURNAL   Proc Natl Acad Sci U S A 98 (17), 9948-9953 (2001)
   PUBMED   11493703
REFERENCE   9  (bases 1 to 1681)
  AUTHORS   Duda,T., Venkataraman,V., Goraczniak,R., Lange,C., Koch,K.W. and
            Sharma,R.K.
  TITLE     Functional consequences of a rod outer segment membrane guanylate
            cyclase (ROS-GC1) gene mutation linked with Leber's congenital
            amaurosis
  JOURNAL   Biochemistry 38 (2), 509-515 (1999)
   PUBMED   9888789
REFERENCE   10 (bases 1 to 1681)
  AUTHORS   Howes,K., Bronson,J.D., Dang,Y.L., Li,N., Zhang,K., Ruiz,C.,
            Helekar,B., Lee,M., Subbaraya,I., Kolb,H., Chen,J. and Baehr,W.
  TITLE     Gene array and expression of mouse retina guanylate cyclase
            activating proteins 1 and 2
  JOURNAL   Invest Ophthalmol Vis Sci 39 (6), 867-875 (1998)
   PUBMED   9579466
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC031916.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031916.1, AK033052.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1681
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 23.04 cM"
     gene            1..1681
                     /gene="Guca1b"
                     /gene_synonym="GCAP2"
                     /note="guanylate cyclase activator 1B"
                     /db_xref="GeneID:107477"
                     /db_xref="MGI:MGI:1194489"
     exon            1..304
                     /gene="Guca1b"
                     /gene_synonym="GCAP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..703
                     /gene="Guca1b"
                     /gene_synonym="GCAP2"
                     /note="GCAP2 (retina)"
                     /codon_start=1
                     /product="guanylyl cyclase-activating protein 2"
                     /protein_id="NP_666191.1"
                     /db_xref="CCDS:CCDS28847.1"
                     /db_xref="GeneID:107477"
                     /db_xref="MGI:MGI:1194489"
                     /translation="MGQQLSWEEAEAAGEMDVAELQEWYKKFVVECPSGTLFMHEFKR
                     FFKVTGNEEASQYVESMFRAFDKNGDNTIDFLEYVAALNLVLRGSLEHKLKWTFKIYD
                     KDRNGCIDRLELLDIVEAIYKLKKACRAELDLEHQGQLLTPEEVVDRIFLLVDENGDG
                     QLSLTEFIEGARRDKWVMKMLQMDINPGCWITQQRRRSAMF"
     exon            305..454
                     /gene="Guca1b"
                     /gene_synonym="GCAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            455..575
                     /gene="Guca1b"
                     /gene_synonym="GCAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            576..1668
                     /gene="Guca1b"
                     /gene_synonym="GCAP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1649..1654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Guca1b"
                     /gene_synonym="GCAP2"
                     /note="hexamer: ATTAAA"
     polyA_site      1668
                     /gene="Guca1b"
                     /gene_synonym="GCAP2"
                     /note="major polyA site"
ORIGIN      
        1 tgaaagggct gctcagacca aggagagagg agcctaaggt cagcggagga cttggaggag
       61 gtagcgggcc tggctgagtc tctttctaaa agccgggatg gggcagcagc tgagctggga
      121 agaggcggag gcggccgggg agatggatgt ggcggagttg caggagtggt acaagaagtt
      181 tgtcgtggag tgtcccagtg ggacgctctt catgcacgag ttcaagcgct tcttcaaggt
      241 cacgggcaat gaggaggcca gccagtatgt agagagcatg ttccgagcct tcgacaagaa
      301 tggggacaac accattgact tcctggagta tgtggcagcc ctgaacctcg tgctgagggg
      361 cagcctggaa cacaagctca agtggacctt caagatctat gacaaggacc gaaatggctg
      421 catcgaccgc ctggaactcc tggacattgt ggaggcgatt tacaagctga agaaagcctg
      481 ccgagcggag ctggatctgg aacaccaggg ccagctgctc acgcccgagg aggtggtgga
      541 caggatcttc ctcctggtgg acgagaatgg agacggccag ctgtctctga ccgagttcat
      601 cgagggcgcc cgtcgcgata agtgggtaat gaagatgcta caaatggata tcaacccagg
      661 ctgctggatc acgcagcaga ggcggagaag cgccatgttc tgagagccca gggacccttc
      721 aggggcccac actcccctcc aagactcctc cagggtcccc ggagttacat agcaggaggt
      781 cttgttggct gaagcctgtt cccggttggt gtggacttcc gcaaggggcc aagcaatggc
      841 tgctggatct gaagtggggt tcagtcagtc tcttcttcag gattcactag cattgtaggg
      901 gtcccgacgt tactctgctc cactgctgct cctgggagaa ctgggcttta actgggagat
      961 gtggggatcc tactaatctt cagcggttct cagaggaaat ggggccggcg aggggcgggg
     1021 caaaggctgg tagaacgcag tctggaaaga aagcaaggat ggggaaggat cataacgacc
     1081 cagtccaacc aacctgagca ccggctgggg aggactctgc ccagctcctc cccaggatgt
     1141 gctcaccaag gatgacaaag gggagggcta cctccgtgat cttccgccct tagaggcctg
     1201 gcgggcttag gtggggatgt ttcaggtctg ctcggtgttg ctccccaggt ccttcttctc
     1261 atcccgtctc tagtgtgagc ctgctaccat ttccatgcct cctcaaggat ggagacgtct
     1321 tctctgcatc tctggggtaa cctggcattt gaattccagg ccagactttg cctccgacag
     1381 ctgttggact ccctaacctc ctgcaggtcg actagatggc ttccagttat cccgcaaatg
     1441 tccttcatgc acccaatata gaagctaggc taccagggaa cctctctgcc tttctctgcc
     1501 tccttccatc tgtgcagctg gggaagtcac ctcagaggac aggaagtagg accagtgtca
     1561 cactaagtag gaccagtgtc acacttggca aattctatct ggaacctggt ggattgttgg
     1621 tgttaccttg aatagatata gatttcacat taaaatacag tcaactaaaa aaaaaaaaaa
     1681 a
//
