LOCUS       NM_008189                910 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus guanylate cyclase activator 1a (retina) (Guca1a),
            mRNA.
ACCESSION   NM_008189
VERSION     NM_008189.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 910)
  AUTHORS   Zhang,H., Jiang,J.C., Wu,Y.W., Yu,Y.S., Wang,H.N., Ding,N.Z. and
            Fan,H.Y.
  TITLE     The RNA ligase RNA terminal phosphate cyclase B regulates mRNA
            alternative splicing and is required for mouse oocyte development
            and maintenance
  JOURNAL   Development 149 (19) (2022)
   PUBMED   36178098
REFERENCE   2  (bases 1 to 910)
  AUTHORS   Turunen,T. and Koskelainen,A.
  TITLE     Functional modulation of phosphodiesterase-6 by calcium in mouse
            rod photoreceptors
  JOURNAL   Sci Rep 11 (1), 8938 (2021)
   PUBMED   33903621
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 910)
  AUTHORS   Dizhoor,A.M., Olshevskaya,E.V. and Peshenko,I.V.
  TITLE     Retinal degeneration-3 protein promotes photoreceptor survival by
            suppressing activation of guanylyl cyclase rather than accelerating
            GMP recycling
  JOURNAL   J Biol Chem 296, 100362 (2021)
   PUBMED   33539922
REFERENCE   4  (bases 1 to 910)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 910)
  AUTHORS   Buch,P.K., Mihelec,M., Cottrill,P., Wilkie,S.E., Pearson,R.A.,
            Duran,Y., West,E.L., Michaelides,M., Ali,R.R. and Hunt,D.M.
  TITLE     Dominant cone-rod dystrophy: a mouse model generated by gene
            targeting of the GCAP1/Guca1a gene
  JOURNAL   PLoS One 6 (3), e18089 (2011)
   PUBMED   21464903
  REMARK    GeneRIF: Mutant GCAP1, when under normal expression control, causes
            both rod and cone photoreceptors to lose function and degenerate,
            with cone cells being more severely affected, in keeping with the
            human disease phenotype.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 910)
  AUTHORS   Duda,T., Venkataraman,V., Goraczniak,R., Lange,C., Koch,K.W. and
            Sharma,R.K.
  TITLE     Functional consequences of a rod outer segment membrane guanylate
            cyclase (ROS-GC1) gene mutation linked with Leber's congenital
            amaurosis
  JOURNAL   Biochemistry 38 (2), 509-515 (1999)
   PUBMED   9888789
REFERENCE   7  (bases 1 to 910)
  AUTHORS   Cuenca,N., Lopez,S., Howes,K. and Kolb,H.
  TITLE     The localization of guanylyl cyclase-activating proteins in the
            mammalian retina
  JOURNAL   Invest Ophthalmol Vis Sci 39 (7), 1243-1250 (1998)
   PUBMED   9620085
REFERENCE   8  (bases 1 to 910)
  AUTHORS   Howes,K., Bronson,J.D., Dang,Y.L., Li,N., Zhang,K., Ruiz,C.,
            Helekar,B., Lee,M., Subbaraya,I., Kolb,H., Chen,J. and Baehr,W.
  TITLE     Gene array and expression of mouse retina guanylate cyclase
            activating proteins 1 and 2
  JOURNAL   Invest Ophthalmol Vis Sci 39 (6), 867-875 (1998)
   PUBMED   9579466
REFERENCE   9  (bases 1 to 910)
  AUTHORS   Subbaraya,I., Ruiz,C.C., Helekar,B.S., Zhao,X., Gorczyca,W.A.,
            Pettenati,M.J., Rao,P.N., Palczewski,K. and Baehr,W.
  TITLE     Molecular characterization of human and mouse photoreceptor
            guanylate cyclase-activating protein (GCAP) and chromosomal
            localization of the human gene
  JOURNAL   J Biol Chem 269 (49), 31080-31089 (1994)
   PUBMED   7983048
REFERENCE   10 (bases 1 to 910)
  AUTHORS   Palczewski,K., Subbaraya,I., Gorczyca,W.A., Helekar,B.S.,
            Ruiz,C.C., Ohguro,H., Huang,J., Zhao,X., Crabb,J.W., Johnson,R.S.
            et al.
  TITLE     Molecular cloning and characterization of retinal photoreceptor
            guanylyl cyclase-activating protein
  JOURNAL   Neuron 13 (2), 395-404 (1994)
   PUBMED   7520254
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC112683.10, BC026834.1 and
            BE954739.1.
            
            On Dec 4, 2015 this sequence version replaced NM_008189.2.
            
            Summary: This gene encodes a calcium-binding photoreceptor protein.
            The encoded protein may be involved in modulation of guanylyl
            cyclase activity, and in turn, the mammalian cone phototransduction
            cascade. Disruption of this gene results in the retinal
            degeneration associated with cone dystrophy. [provided by RefSeq,
            Dec 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB849217.2, BC026834.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC112683.10        183928-183949       c
            23-895              BC026834.1         1-873
            896-910             BE954739.1         1-15                c
FEATURES             Location/Qualifiers
     source          1..910
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 23.07 cM"
     gene            1..910
                     /gene="Guca1a"
                     /gene_synonym="GC-A; Gcap1; Guca1; mGCAP1"
                     /note="guanylate cyclase activator 1a (retina)"
                     /db_xref="GeneID:14913"
                     /db_xref="MGI:MGI:102770"
     exon            1..388
                     /gene="Guca1a"
                     /gene_synonym="GC-A; Gcap1; Guca1; mGCAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..796
                     /gene="Guca1a"
                     /gene_synonym="GC-A; Gcap1; Guca1; mGCAP1"
                     /note="GCAP 1"
                     /codon_start=1
                     /product="guanylyl cyclase-activating protein 1"
                     /protein_id="NP_032215.2"
                     /db_xref="CCDS:CCDS28848.1"
                     /db_xref="GeneID:14913"
                     /db_xref="MGI:MGI:102770"
                     /translation="MGNIMEGKSVEELSSTECHQWYKKFMTECPSGQLTLYEFRQFFG
                     LKNLSPSASQYVEQMFETFDFNKDGYIDFMEYVAALSLVLKGKVEQKLRWYFKLYDVD
                     GNGCIDRDELLTIIRAIRTINPWSDSSMSAEEFTDTVFAKIDINGDGELSLEEFMEGV
                     QKDQMLLDTLTRSLDLTGIVRRLQNGEHEEAGTGDLAAEAAG"
     exon            389..538
                     /gene="Guca1a"
                     /gene_synonym="GC-A; Gcap1; Guca1; mGCAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            539..632
                     /gene="Guca1a"
                     /gene_synonym="GC-A; Gcap1; Guca1; mGCAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            633..896
                     /gene="Guca1a"
                     /gene_synonym="GC-A; Gcap1; Guca1; mGCAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      876..881
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Guca1a"
                     /gene_synonym="GC-A; Gcap1; Guca1; mGCAP1"
                     /note="hexamer: ATTACA"
     polyA_site      895
                     /gene="Guca1a"
                     /gene_synonym="GC-A; Gcap1; Guca1; mGCAP1"
                     /note="major polyA site"
ORIGIN      
        1 ccggcatctc tagtttgggt gtgagttacg gccggctcat ctcccttttt agtccgactc
       61 acagggctgt ctttgtttag gctggtgata ggggaggtcc cgaagccaag ccacccttgt
      121 gcaggggaca ttagaaaata agatctacct gtccatctag ggcatccgtc tcttgtgagc
      181 ctggaccatg ggcaacatca tggagggcaa gtccgtggaa gagctgagca gcaccgagtg
      241 ccatcagtgg tataagaaat ttatgacgga gtgcccatct ggccagctca ccctctacga
      301 attccgccag ttctttggtc tcaagaacct gagcccctca gccagccagt atgtggaaca
      361 gatgttcgag acctttgact tcaacaagga tggctacatt gacttcatgg agtacgtggc
      421 agccctcagc ctggtcctca agggcaaagt ggaacagaag ttgcgctggt atttcaagct
      481 ctacgacgtc gacggcaacg ggtgcataga cagggacgag ctgctcacca tcatccgggc
      541 catccgaacc attaatccct ggagcgactc atccatgagt gccgaggaat tcacagatac
      601 cgtgtttgcc aagatcgaca tcaacgggga tggggaactg tccctggagg agttcatgga
      661 aggtgtgcag aaggaccaga tgctcctgga cacgctgacc cgaagcctgg acttgaccgg
      721 catcgtgcgc agactccaga acggcgaaca cgaggaggca ggcaccggcg acctggcagc
      781 ggaggctgcg ggttgagcat tcaccctgtg gcttctgcct gctgagggct ggccccgtgc
      841 ggtgcctggt gtggttgttc tgttcttgtc ttaacattac atagaacctc ctgaacaaaa
      901 aaaaaaaaaa
//
