LOCUS       NM_028797                740 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus gametocyte specific factor 1 (Gtsf1), mRNA.
ACCESSION   NM_028797 XM_895110 XM_917380
VERSION     NM_028797.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 740)
  AUTHORS   Arif,A., Bailey,S., Izumi,N., Anzelon,T.A., Ozata,D.M.,
            Andersson,C., Gainetdinov,I., MacRae,I.J., Tomari,Y. and
            Zamore,P.D.
  TITLE     GTSF1 accelerates target RNA cleavage by PIWI-clade Argonaute
            proteins
  JOURNAL   Nature 608 (7923), 618-625 (2022)
   PUBMED   35772669
  REMARK    GeneRIF: GTSF1 accelerates target RNA cleavage by PIWI-clade
            Argonaute proteins.
REFERENCE   2  (bases 1 to 740)
  AUTHORS   He,Y., Chen,Q., Dai,J., Cui,Y., Zhang,C., Wen,X., Li,J., Xiao,Y.,
            Peng,X., Liu,M., Shen,B., Sha,J., Hu,Z., Li,J. and Shu,W.
  TITLE     Single-cell RNA-Seq reveals a highly coordinated transcriptional
            program in mouse germ cells during primordial follicle formation
  JOURNAL   Aging Cell 20 (7), e13424 (2021)
   PUBMED   34174788
REFERENCE   3  (bases 1 to 740)
  AUTHORS   Ipsaro,J.J., O'Brien,P.A., Bhattacharya,S., Palmer,A.G. 3rd and
            Joshua-Tor,L.
  TITLE     Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposons
  JOURNAL   Cell Rep 34 (13), 108914 (2021)
   PUBMED   33789107
  REMARK    GeneRIF: Asterix/Gtsf1 links tRNAs and piRNA silencing of
            retrotransposons.
REFERENCE   4  (bases 1 to 740)
  AUTHORS   Yoshimura,T., Watanabe,T., Kuramochi-Miyagawa,S., Takemoto,N.,
            Shiromoto,Y., Kudo,A., Kanai-Azuma,M., Tashiro,F., Miyazaki,S.,
            Katanaya,A., Chuma,S. and Miyazaki,J.I.
  TITLE     Mouse GTSF1 is an essential factor for secondary piRNA biogenesis
  JOURNAL   EMBO Rep 19 (4) (2018)
   PUBMED   29437694
  REMARK    GeneRIF: Our findings indicate that GTSF1 is a crucial factor for
            the slicing of target RNAs by PIWI-piRNAs and thus affects
            secondary piRNA biogenesis in prospermatogonia.
REFERENCE   5  (bases 1 to 740)
  AUTHORS   Yoshimura,T., Toyoda,S., Kuramochi-Miyagawa,S., Miyazaki,T.,
            Miyazaki,S., Tashiro,F., Yamato,E., Nakano,T. and Miyazaki,J.
  TITLE     Gtsf1/Cue110, a gene encoding a protein with two copies of a CHHC
            Zn-finger motif, is involved in spermatogenesis and retrotransposon
            suppression in murine testes
  JOURNAL   Dev Biol 335 (1), 216-227 (2009)
   PUBMED   19735653
  REMARK    GeneRIF: Results indicate that Gtsf1/Cue110 is required for
            spermatogenesis and involved in retrotransposon suppression in male
            germ cells.
REFERENCE   6  (bases 1 to 740)
  AUTHORS   Krotz,S.P., Ballow,D.J., Choi,Y. and Rajkovic,A.
  TITLE     Expression and localization of the novel and highly conserved
            gametocyte-specific factor 1 during oogenesis and spermatogenesis
  JOURNAL   Fertil Steril 91 (5 Suppl), 2020-2024 (2009)
   PUBMED   18706558
  REMARK    GeneRIF: Expression pattern of Gtsf1 and its high conservation
            suggests that it may play an important role in germ cell
            development.
REFERENCE   7  (bases 1 to 740)
  AUTHORS   Yoshimura,T., Miyazaki,T., Toyoda,S., Miyazaki,S., Tashiro,F.,
            Yamato,E. and Miyazaki,J.
  TITLE     Gene expression pattern of Cue110: a member of the uncharacterized
            UPF0224 gene family preferentially expressed in germ cells
  JOURNAL   Gene Expr Patterns 8 (1), 27-35 (2007)
   PUBMED   17919994
  REMARK    GeneRIF: the Cue110 gene is expressed predominantly in male germ
            cells at stages from the pachytene spermatocytes to round
            spermatids
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU945975.1, AK005675.1 and CO812705.1.
            
            On or before Nov 1, 2008 this sequence version replaced
            XM_917380.3, XM_895110.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU939747.1, DV661953.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BU945975.1         4-26
            24-718              AK005675.1         2-696
            719-740             CO812705.1         737-758
FEATURES             Location/Qualifiers
     source          1..740
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 58.93 cM"
     gene            1..740
                     /gene="Gtsf1"
                     /gene_synonym="1700006H03Rik; Cue110"
                     /note="gametocyte specific factor 1"
                     /db_xref="GeneID:74174"
                     /db_xref="MGI:MGI:1921424"
     exon            1..72
                     /gene="Gtsf1"
                     /gene_synonym="1700006H03Rik; Cue110"
                     /inference="alignment:Splign:2.1.0"
     exon            73..117
                     /gene="Gtsf1"
                     /gene_synonym="1700006H03Rik; Cue110"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..605
                     /gene="Gtsf1"
                     /gene_synonym="1700006H03Rik; Cue110"
                     /codon_start=1
                     /product="gametocyte-specific factor 1"
                     /protein_id="NP_083073.1"
                     /db_xref="CCDS:CCDS49744.1"
                     /db_xref="GeneID:74174"
                     /db_xref="MGI:MGI:1921424"
                     /translation="MEDTYIDSLDPEKLLQCPYDKNHQIRACRFPYHLIKCRKNHPDV
                     ANKLATCPFNARHQVPRAEISHHISSCDDKSCIEQDVVNQTRNLGQETLAESTWQCPP
                     CDEDWDKDLWEQTSTPFVWGTASFCGNNSPANNIVMEHKSNLASGMRVPKSLPYVLPW
                     KNNGNAQ"
     exon            118..218
                     /gene="Gtsf1"
                     /gene_synonym="1700006H03Rik; Cue110"
                     /inference="alignment:Splign:2.1.0"
     exon            219..345
                     /gene="Gtsf1"
                     /gene_synonym="1700006H03Rik; Cue110"
                     /inference="alignment:Splign:2.1.0"
     exon            346..429
                     /gene="Gtsf1"
                     /gene_synonym="1700006H03Rik; Cue110"
                     /inference="alignment:Splign:2.1.0"
     exon            430..493
                     /gene="Gtsf1"
                     /gene_synonym="1700006H03Rik; Cue110"
                     /inference="alignment:Splign:2.1.0"
     exon            494..588
                     /gene="Gtsf1"
                     /gene_synonym="1700006H03Rik; Cue110"
                     /inference="alignment:Splign:2.1.0"
     exon            589..622
                     /gene="Gtsf1"
                     /gene_synonym="1700006H03Rik; Cue110"
                     /inference="alignment:Splign:2.1.0"
     exon            623..723
                     /gene="Gtsf1"
                     /gene_synonym="1700006H03Rik; Cue110"
                     /inference="alignment:Splign:2.1.0"
     regulatory      700..705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtsf1"
                     /gene_synonym="1700006H03Rik; Cue110"
                     /note="hexamer: AGTAAA"
     polyA_site      723
                     /gene="Gtsf1"
                     /gene_synonym="1700006H03Rik; Cue110"
                     /note="major polyA site"
ORIGIN      
        1 aggccggaag tgggcgttgc cggggcctgg ctgtgaggcg aagtcggcgg tggggagagc
       61 ttctggactg agcacttgaa caggactcct ttgccatcag catggaagac acttacatcg
      121 actccctgga ccctgaaaag ttattacagt gcccctatga taaaaatcac cagatcaggg
      181 cctgcaggtt tccttatcat cttatcaagt gcagaaagaa tcatcctgat gtcgcaaaca
      241 aattggctac ttgtcccttc aatgctcggc atcaggttcc ccgggctgag atcagtcatc
      301 acatctcgag ctgtgatgac aagagctgta ttgagcagga tgtggtcaac caaaccagga
      361 accttggaca agagactctg gctgagagca catggcagtg ccctccttgt gatgaagact
      421 gggataaaga tttgtgggaa cagactagca ccccatttgt ctggggcaca gccagtttct
      481 gtggcaacaa cagtcctgca aataacatag ttatggaaca taagagtaac cttgcttcag
      541 gcatgcgagt tcccaagtct ctgccctatg ttttgccatg gaaaaacaat ggaaatgcac
      601 agtaactgaa catctttttc aaatgccaga ctgtggaaga ctcttgctta ttcctgctac
      661 caagggttct tcttttttct ctttatctaa ttatagaaca gtaaactgtc tgtgactttc
      721 aaaaaaaaaa aaaaaaaaaa
//
