LOCUS       NM_148928               2805 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus general transcription factor IIIC, polypeptide 5
            (Gtf3c5), transcript variant 2, mRNA.
ACCESSION   NM_148928
VERSION     NM_148928.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2805)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2805)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2805)
  AUTHORS   Rajan,S., Chu Pham Dang,H., Djambazian,H., Zuzan,H., Fedyshyn,Y.,
            Ketela,T., Moffat,J., Hudson,T.J. and Sladek,R.
  TITLE     Analysis of early C2C12 myogenesis identifies stably and
            differentially expressed transcriptional regulators whose
            knock-down inhibits myoblast differentiation
  JOURNAL   Physiol Genomics 44 (2), 183-197 (2012)
   PUBMED   22147266
REFERENCE   4  (bases 1 to 2805)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ179286.1, AK147014.1 and AU016996.1.
            
            On Mar 13, 2014 this sequence version replaced NM_148928.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1,
            resulting in an isoform (b) that is shorter than isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147014.1, BC027055.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BQ179286.1         1-23
            24-2732             AK147014.1         2-2710
            2733-2805           AU016996.1         1-73                c
FEATURES             Location/Qualifiers
     source          1..2805
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 19.38 cM"
     gene            1..2805
                     /gene="Gtf3c5"
                     /gene_synonym="2700084A09Rik; TFiiiC2-63; TFIIIC63"
                     /note="general transcription factor IIIC, polypeptide 5"
                     /db_xref="GeneID:70239"
                     /db_xref="MGI:MGI:1917489"
     exon            1..455
                     /gene="Gtf3c5"
                     /gene_synonym="2700084A09Rik; TFiiiC2-63; TFIIIC63"
                     /inference="alignment:Splign:2.1.0"
     CDS             303..1847
                     /gene="Gtf3c5"
                     /gene_synonym="2700084A09Rik; TFiiiC2-63; TFIIIC63"
                     /note="isoform b is encoded by transcript variant 2;
                     general transcription factor III polypeptide 5; general
                     transcription factor 3C polypeptide 5; TF3C-epsilon;
                     TFIIIC 63 kDa subunit; transcription factor IIIC subunit
                     epsilon; transcription factor IIIC 63 kDa subunit;
                     TFIIICepsilon"
                     /codon_start=1
                     /product="general transcription factor 3C polypeptide 5
                     isoform b"
                     /protein_id="NP_683730.1"
                     /db_xref="CCDS:CCDS15842.1"
                     /db_xref="GeneID:70239"
                     /db_xref="MGI:MGI:1917489"
                     /translation="MAAAEPDADPKAAIPVDLRRERRLVCVEYPGVVRNEAKMLQTLG
                     GEESVSRIYTDPTKRLELYFRPKDPYCHPVCANRFSTSSLLLRIRKRTRRRRGVLGDE
                     AHPQVTFNLEIIGIISTIYKFQGMSDFQYLAVHTEAGGKHVSMYDRVLMRKPEKEEFF
                     HQELPLYIPPPIFSRLDTPVDYFYRPETQHREGYHNPTISGENLIGLSRARRPHNAIF
                     VNFEDTEVPEQPLEAAVQTWKKACTNPIDQKVEEELRKLFDIRPVWSRNAVKSNVSVH
                     PDKLKILLPYMAYYMITGPWRSLWIRFGYDPRKHPDAKIYQVLDFRIRCGMKYGYGSR
                     DMPVKAKRSTYNYSLPITVKKTSNQPGTMHDLKQGLGPSGTDGPRKLTYNKYKLKDSV
                     YIFREGALPPYRQMFYQLCDLNVEELQKIVHRNDGTETVCTERDGWCLPKTTDHLRDT
                     MSLMILQTIRSERPGKADRGKEQLMFESGEEEEEEEEEEEEEEEDFKPSDGSENEMET
                     EILDYV"
     exon            456..675
                     /gene="Gtf3c5"
                     /gene_synonym="2700084A09Rik; TFiiiC2-63; TFIIIC63"
                     /inference="alignment:Splign:2.1.0"
     exon            676..874
                     /gene="Gtf3c5"
                     /gene_synonym="2700084A09Rik; TFiiiC2-63; TFIIIC63"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1070
                     /gene="Gtf3c5"
                     /gene_synonym="2700084A09Rik; TFiiiC2-63; TFIIIC63"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1175
                     /gene="Gtf3c5"
                     /gene_synonym="2700084A09Rik; TFiiiC2-63; TFIIIC63"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1290
                     /gene="Gtf3c5"
                     /gene_synonym="2700084A09Rik; TFiiiC2-63; TFIIIC63"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1371
                     /gene="Gtf3c5"
                     /gene_synonym="2700084A09Rik; TFiiiC2-63; TFIIIC63"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1469
                     /gene="Gtf3c5"
                     /gene_synonym="2700084A09Rik; TFiiiC2-63; TFIIIC63"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1552
                     /gene="Gtf3c5"
                     /gene_synonym="2700084A09Rik; TFiiiC2-63; TFIIIC63"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1695
                     /gene="Gtf3c5"
                     /gene_synonym="2700084A09Rik; TFiiiC2-63; TFIIIC63"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1872
                     /gene="Gtf3c5"
                     /gene_synonym="2700084A09Rik; TFiiiC2-63; TFIIIC63"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..2805
                     /gene="Gtf3c5"
                     /gene_synonym="2700084A09Rik; TFiiiC2-63; TFIIIC63"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2719..2724
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtf3c5"
                     /gene_synonym="2700084A09Rik; TFiiiC2-63; TFIIIC63"
                     /note="hexamer: TATAAA"
     polyA_site      2735
                     /gene="Gtf3c5"
                     /gene_synonym="2700084A09Rik; TFiiiC2-63; TFIIIC63"
                     /note="major polyA site"
     polyA_site      2782
                     /gene="Gtf3c5"
                     /gene_synonym="2700084A09Rik; TFiiiC2-63; TFIIIC63"
ORIGIN      
        1 ccggaaaaac ccggtcgaat cctggcttgt cttggttggg tcggctggtg ggatacgccc
       61 tcgtctcgcc cctttgtcca accctcttca ttttaaatta aaaagccccc agttctgtgt
      121 ggtgtagcaa aataaacagt tgcggcgacg cacttcttcc tggaggcctt cgagtctcca
      181 tgatttaagg agacgagaaa ggtaaggagg accggaacaa ttccttcgcg gaacctttga
      241 ggtgaggcct cgcggagcca tttgagaacg gaccgcggcg ggctggaacc agactagtag
      301 gcatggcggc ggcggagccg gatgcggacc cgaaggccgc catccctgtg gacctgcggc
      361 gggaacggcg cttggtgtgc gtggagtacc cgggcgtagt acgtaacgag gccaagatgc
      421 tacagaccct gggcggcgag gaaagcgtct ctcgaatcta cactgaccct accaagaggc
      481 tcgaactcta cttccggccc aaggacccat actgccaccc tgtgtgtgct aaccgtttca
      541 gtaccagcag cctgctgctc cggatccgga aaagaacaag gcgtcggaga ggtgtcctgg
      601 gagacgaggc ccacccccag gtcacgttca acttggagat cattggcatc atctccacaa
      661 tttacaaatt ccagggaatg tctgacttcc agtacttggc agtgcacaca gaagctggtg
      721 gcaagcatgt ttccatgtat gacagagtgc tcatgcgcaa gcctgagaag gaggagttct
      781 tccatcagga gctaccactc tacatccccc cacccatctt ctccaggctg gacacccctg
      841 tggactattt ctatcgccct gagacacagc accgagaagg ctatcataat cccaccatct
      901 caggggagaa cctgattgga ctgagtagag cccggcgccc ccacaacgcc atctttgtca
      961 actttgagga cactgaggtt cctgaacagc ctttggaggc tgcagtccag acatggaaga
     1021 aggcctgcac caatcccata gatcagaagg tggaagagga gctgaggaag ctctttgaca
     1081 tccgtcctgt ttggtcacga aatgctgtca agtctaacgt cagtgtccat cctgacaagc
     1141 ttaagatctt gcttccctat atggcttatt acatgataac aggcccgtgg agaagcttgt
     1201 ggattcgatt tggctatgac cctcgaaaac acccagatgc caagatttat caagtccttg
     1261 attttcgaat ccgctgtgga atgaaatacg gttatggctc cagggacatg cctgttaaag
     1321 cgaagcgtag cacgtacaac tacagcctgc ccatcaccgt caagaagaca tccaaccagc
     1381 ctggcaccat gcatgacctg aagcagggcc tgggcccatc aggaactgat ggcccacgga
     1441 aattgaccta caataaatac aaactcaagg attcggtcta catcttccgg gaaggggctc
     1501 tgccacccta tcgacagatg ttctaccagc tgtgtgattt gaatgtggag gagttgcaga
     1561 aaattgttca ccgaaacgat gggacagaga ctgtgtgcac agagagagat gggtggtgcc
     1621 tccccaagac cacagatcac ctgagagaca ccatgtcact catgattcta cagaccatcc
     1681 gctctgagag gcctggtaag gctgatcgtg ggaaagagca gctgatgttt gaatctggag
     1741 aggaagagga ggaggaggag gaagaggagg aagaggagga ggaggatttc aagccctcag
     1801 atgggagcga gaatgagatg gagacagaga ttctggatta cgtgtgagga agcgctgttc
     1861 ccaggcaacc aggacatgct ggcgagtcat gatgggacag ttgggacagg cttgtgcccc
     1921 catccaggca gtgagatgag gatactgggc aaccccaggc tgtgctcagc ctgacttcac
     1981 caaatggacc tgaaaacacc ccgtctcaca tcttcctttt gtctctgtca agcggacatc
     2041 catggaaggt ccctgggtgt aagccccaga gcagcagcgc cacttcctga agggtgctgc
     2101 gccagagatg ggccattgcc ttgtgtctct gtgtggcctc tgtgccttga acagcctggt
     2161 gcacacagtc aagtcacagc aaatccaaag ccaaatgcct cgagccagcc gagattgaag
     2221 atccattgtt tgatttgggt caagtgagca ctcctgggaa cttcccagtc ttgcatggaa
     2281 tcagacagac cgaccctgtg tccccgctga ccctgcttcc tgctgcttca aagaatgctc
     2341 agccctgagg caggaagtag ctcttccaaa aggctagcca gccttgcctg tccccatagg
     2401 acttctttcc tggtgactgc caggaagctt cagctgggcg ttttctcact tctagttgct
     2461 gcccatcctg gttcttgggg aggagaccag ggttctgatc ccatgtaccc aggaatgctt
     2521 tgactctgga tgtgaggagg ttctgagtga gggccccgtg ccctctggag gcctcactta
     2581 cacagagccc agggcgatgg ccattcctgc cataggttgg acagactaga aggacttcct
     2641 gaagtctagc cacacttggc aaagtattgt aactgtcctg aattcccatg taaatcaaag
     2701 tgcttttggt acaataaata taaaactccc ccaaagccag cactggtgtt tgatgccctg
     2761 gtcacctggc atatgagtca cagcactgag tcttgttgca tagtg
//
