LOCUS       NM_172977               7021 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus general transcription factor IIIC, polypeptide 4
            (Gtf3c4), transcript variant 1, mRNA.
ACCESSION   NM_172977
VERSION     NM_172977.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7021)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   2  (bases 1 to 7021)
  AUTHORS   Allis,C.D., Berger,S.L., Cote,J., Dent,S., Jenuwien,T.,
            Kouzarides,T., Pillus,L., Reinberg,D., Shi,Y., Shiekhattar,R.,
            Shilatifard,A., Workman,J. and Zhang,Y.
  TITLE     New nomenclature for chromatin-modifying enzymes
  JOURNAL   Cell 131 (4), 633-636 (2007)
   PUBMED   18022353
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN530016.1, BC117919.1 and AL732526.8.
            
            On Oct 3, 2009 this sequence version replaced NM_172977.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141269.1, BC117919.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                CN530016.1         1-88
            89-3617             BC117919.1         1-3529
            3618-7021           AL732526.8         50563-53966         c
FEATURES             Location/Qualifiers
     source          1..7021
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 19.38 cM"
     gene            1..7021
                     /gene="Gtf3c4"
                     /gene_synonym="5330400C03; KAT12; TFIIIC90"
                     /note="general transcription factor IIIC, polypeptide 4"
                     /db_xref="GeneID:269252"
                     /db_xref="MGI:MGI:2138937"
     exon            1..478
                     /gene="Gtf3c4"
                     /gene_synonym="5330400C03; KAT12; TFIIIC90"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..2587
                     /gene="Gtf3c4"
                     /gene_synonym="5330400C03; KAT12; TFIIIC90"
                     /EC_number="2.3.1.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     general transcription factor IIIC 4; general transcription
                     factor 3C polypeptide 4; TF3C-delta; TFIIIC 90 kDa
                     subunit; transcription factor IIIC subunit delta;
                     transcription factor IIIC 90 kDa subunit"
                     /codon_start=1
                     /product="general transcription factor 3C polypeptide 4
                     isoform 1"
                     /protein_id="NP_766565.2"
                     /db_xref="CCDS:CCDS15847.1"
                     /db_xref="GeneID:269252"
                     /db_xref="MGI:MGI:2138937"
                     /translation="MSEADQALVGPKADEPSPPAEEKDEGGGKEAAADAAPGPSASFR
                     LMVTRREPAVKLQYAVSGLEPLSWSEDHRVSVSTARSVAVLELICDVHNPGQDLVIHR
                     TSVPAPLNSCLLKVGSKTEVAECKEKFASSKDPTISQTFMLDRMFNPEGKALPPMRGF
                     KYTSWSPMGCDANGRCLLAALTMDNRLTVQVNLNRLQWVQLVDLTEIYGDRLYETSYR
                     LSKNEAPEGNLGDFAEFQRRHSMQTPVRMEWSSICTTQQVKHNNECRDVSSVLLAVLF
                     ENGNIAVWQFQLPFVGKESISSCNTIESGISSPSVLFWWEYEHNNRKMSGLIVGSAFG
                     PVKILPVNLKAVKGYFTLRQPVVLWKEMDKLPVHSIKCVPLYHPYQKCSCSLVVAARG
                     SYVFWCLLLISKAGLNVHNSHVTGLHSLPIVSITADKQNGTVYTCSSDGKVRQLIPIF
                     TDVALKFEHQLIKLSDVFGSVRTHGIAVSPCGAYLAIITTEGMMNGLHPVNKNYQVQF
                     VTLKTFEEAAAQLLESSVQNLFKQVDLIDLVRWKILKDKHIPQFLHEALEKKIESSGV
                     TYFWRFKLFLLRILYQSMQKSPSEALWKPTHEDSKILLVDSPGMGDGEDEQQEEGTSK
                     QGTKAGLQEKSKEGDTEETPEDSLTAGGDTGGREPVEEKLLEIQGKIEAVEMHLTREH
                     MKRVLGEVYLHTWITENTSIPTRGLCNFLMSDEDYDDRTAQVLIGHISKKMNKQTFPE
                     RCSLCKEILPFTDRKQAVCSNGHIWLRCFLTYQSCQSLIYRRCLLHDSIARHPVPEDP
                     DWIKRLLQSPCPFCDSPVF"
     exon            479..2302
                     /gene="Gtf3c4"
                     /gene_synonym="5330400C03; KAT12; TFIIIC90"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2433
                     /gene="Gtf3c4"
                     /gene_synonym="5330400C03; KAT12; TFIIIC90"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2522
                     /gene="Gtf3c4"
                     /gene_synonym="5330400C03; KAT12; TFIIIC90"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..7021
                     /gene="Gtf3c4"
                     /gene_synonym="5330400C03; KAT12; TFIIIC90"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6992..6997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtf3c4"
                     /gene_synonym="5330400C03; KAT12; TFIIIC90"
                     /note="hexamer: AATAAA"
     polyA_site      7021
                     /gene="Gtf3c4"
                     /gene_synonym="5330400C03; KAT12; TFIIIC90"
                     /note="major polyA site"
ORIGIN      
        1 acggggtcct ttctggctcg gtggcgctcg gggcctgcgg ggagtgaacg ggcgcggagg
       61 gcgctgggag aggccggggc aaggtggcga gcgttcagtg tgccggtaac ccgacctcct
      121 cgctcctagt aagatgagcg aggcggacca ggccctggtg gggcccaagg ccgacgagcc
      181 ctcgccgccc gcagaggaga aggacgaagg gggcgggaag gaggcggctg ccgacgcggc
      241 ccccgggccc agcgcctcgt ttcgcctcat ggtgactcgg cgggagcctg ccgtgaagct
      301 gcaatacgcg gtgagcgggt tagagccgct ctcctggtct gaggaccacc gcgtgtctgt
      361 gtccacggct cgcagcgtcg ccgtgctgga gcttatctgc gatgtgcaca acccaggcca
      421 ggatctggtg atccaccgca cctcggtacc cgcacctctc aacagctgcc tcctcaaggt
      481 tggctcaaaa acagaagttg ctgagtgcaa ggaaaagttc gcttcctcta aagaccccac
      541 catcagccag actttcatgc tagacaggat gttcaacccc gaggggaagg ccttgccccc
      601 aatgcggggt ttcaaataca ctagctggtc tccaatgggt tgtgatgcaa atggcaggtg
      661 cctcttggca gcactgacca tggacaatcg cctgactgtg caggtgaacc tcaacagact
      721 ccagtgggtt cagctggttg atctgacgga gatttatgga gaccgtcttt atgagactag
      781 ttatagactg tctaaaaatg aggctcctga gggaaatctc ggggattttg ctgagtttca
      841 gaggagacac agtatgcaga ccccagtcag aatggaatgg tcgagtatct gtaccactca
      901 gcaggtcaag cacaacaacg agtgccggga tgtgagcagc gtgctgctgg ctgtcctctt
      961 tgagaacggg aatatagctg tgtggcagtt ccagctgcca ttcgtgggga aggagtccat
     1021 ctcttcatgc aacactattg agtcaggaat cagctccccc agtgttttgt tttggtggga
     1081 atatgagcac aataatagga aaatgagtgg ccttattgtg ggcagtgctt ttggacctgt
     1141 aaaaattctc cctgtcaatc tcaaagcagt gaaaggctac tttactttaa ggcagcctgt
     1201 tgtcttgtgg aaagaaatgg acaagttacc tgtgcacagc atcaaatgtg tgccacttta
     1261 ccacccctac cagaagtgta gctgtagctt agtggtagct gcaagaggct cctatgtgtt
     1321 ttggtgtctt cttctgatct ccaaggcagg tctgaatgtt cacaattccc acgtcacagg
     1381 cctccactca ctgcccatcg tctccattac tgcagacaag cagaatggaa cagtgtacac
     1441 ctgctctagt gatgggaagg tgaggcagtt gattcccatt ttcacagatg ttgcattaaa
     1501 gtttgaacac cagctgatta agctctcaga tgtctttggc tcagtgagga ctcacggcat
     1561 tgcagtgagt ccctgtggtg cttatctggc catcatcacc actgagggca tgatgaatgg
     1621 cctccatcct gtgaataaga actaccaggt ccagtttgtt actctgaaga cctttgaaga
     1681 ggcagctgct cagctcttgg agtcttcagt tcagaatctc tttaagcagg tagacttgat
     1741 cgacctggtc cgctggaaaa ttttaaaaga taaacatatt cctcagtttt tacatgaagc
     1801 attggaaaaa aagattgaaa gcagcggggt tacctatttt tggcgtttta agcttttcct
     1861 tctaaggatt ttgtatcagt caatgcagaa atccccttcc gaggccttat ggaaacccac
     1921 ccatgaggac tcaaaaatct tactggttga ctcacctggg atgggcgacg gtgaggatga
     1981 gcagcaagaa gaaggtactt ccaagcaggg gactaaggct ggcctgcagg agaagagcaa
     2041 agaaggtgac acagaggaga cccctgagga ctcactcact gcagggggag acaccggagg
     2101 ccgtgaacct gtagaggaaa agctccttga gatccaaggg aagattgagg ctgtggagat
     2161 gcacctgacc agggagcaca tgaagcgggt cctgggagaa gtgtacctgc acacctggat
     2221 cacagagaac accagcatac ccaccagagg gctctgtaac ttcctgatgt ctgatgagga
     2281 ttatgatgac aggacagcac aggtcttgat tggacatatc tccaagaaga tgaacaaaca
     2341 gaccttccct gagcgctgca gtctgtgtaa ggagatctta ccattcacag atcgcaagca
     2401 agctgtttgt tccaatgggc acatctggct ccggtgcttt ctaacctacc agtcctgcca
     2461 gagcttgata tacagacggt gtttgctcca tgacagcatc gccaggcatc ctgttccaga
     2521 agatcctgac tggattaaga ggttgctgca gagtccttgt cctttctgtg attctcctgt
     2581 cttctgagtt cagtgaggag gatggaggat atgaagttgg ctatagagag tgccctgaag
     2641 cctgaagagc aggtgtgctg gagggagccg ggcactgctc ggtggagaca ctcttctagc
     2701 tggaaggagg agctcattgc accagcacac tccgacttca aggactgaag gctatctttt
     2761 aaatgactcc attcagagag tctgagtcat ttaaagggga acagaagcca tcccaagctc
     2821 ctcaccaatg aggaccactt gtttcccaag tgtcttgcct aaagcagttt gagcagaagc
     2881 cttctgcttc tagaaacata atggtctctt ctagagaatc taaggacctt cttgtgagtt
     2941 tggttttcgt ccttgctttg gtcggggact gtctctggct ccagagggct gaagtggttg
     3001 gtacatgaca ctgcatgtgc cagtacacct taaagtgtgt aatgctggct ggctgcggct
     3061 ggggcttgct cagcagactc agctgcccat tgactcattc atatggagac attttcctaa
     3121 aactatattt ttgaagccaa gaataaaatc atcttaatgt atcaaatgat caggtgacta
     3181 ttagaagtaa ataattgtca tttattttta tctcctgtca tcagattttc tggcccagct
     3241 ctttaatatg taagaagaga ttaagtatcc ctactcttca cagccccact tgatgaccat
     3301 gtggtaacct agatatttgt acatccaggg gaagtattgt cttcctttag tattaaagtg
     3361 aagcctcagt atttctaaca ttggcttatc cggacatctc cctgagcatt tggagggaaa
     3421 gctggtctag agacttgtgg agaaagatgg agttggacgt ccttgagctc tgtgctccaa
     3481 gcatgtgcag ctcaagtgga aaacctaaga gtttcctctc ctgccaaagg tccttaatct
     3541 ttggaacaca ggtattcttc tgtgggctta aagaggagat gtgcactgtc aattgactgc
     3601 tcgctcttaa cccagccctg aagcattctg gagtcacagt cggggtatta gagtaagttt
     3661 cctgggattg gtgctaatga actggacaca ttttgaaact gtgcaattgg aaatgagata
     3721 ggaaatacag aacatgaaat gctttactcc ttgatgattc tgttttatca tgagtattat
     3781 tttaacacac tttcccactt tgattttata tctttagcaa aagaaataat gtcttagtac
     3841 ttgggtacca cggcgagaga caggtcacct gccaccctgc cacacttctg cactctgggc
     3901 acagaccctg agaggcactt ccagaagctg ctctgaattg tcctgttaag actgttgccc
     3961 tgtgctgtgt gtttaatgga ttgtttgttg gggttgttaa tgtcctgacg tagggttgtt
     4021 tcaagaacag catctctcca gacttgaggg gcagcaagga aagagccccg agtgacccag
     4081 ttcagagtct gcatggctgc agcagagcct gccgctgtta ctcctcagag ggagatgaca
     4141 ggagtggaga tggtaccgat agtcgttgct agtctgtcta ccgtgcgtgc caagcttcct
     4201 ttctcttgct ctttggaatc aatctcccta ggtgttctca cagggaattc gggggaactt
     4261 aaaacttggt tgtttaaagc agtttgcatt tctgtgaaat tttatcattt agaagtaaca
     4321 aaagaatttc taggatctgt acttgtgtaa aggaagaaac gtgacaactg gaacacaagt
     4381 tttcagcaag aagcctagcc ctgcaaaatt tttggactct gagatccagc cacagccaag
     4441 tgtttccaca gccagtagag atgtccccct cccctcacaa acaccacact gatgttaatc
     4501 ttcagagctg ggtgaatgag agaatttggg gttgatggca gcctcctgtg tgcaacctgt
     4561 gcacttctga atcgctctcc aagggtcagc atataggccc acagagggtt gatggagaga
     4621 ccttggaaaa gtgggagtgg cgccagagtc ttgcgctatg cctcttgcag cttgaactca
     4681 cctgtgctgc ttgagggagg agttcagtag cttccagttg cagctatagt agctgtttct
     4741 gcagggggaa gaagagtagc catcaaattg ctgccctgca tttagaagac tggagcagac
     4801 tctacagaga acttacacgc tgcagcactg ctgtgtacca ggttccatgc ctagatggtt
     4861 tctgttactc taggtaggaa tgggtagctt gttgtggttg gcattcaaac caatgtcctg
     4921 atatgttcac ccccagactt gaagctgtct ctgctcctac cagatctgcc agaagctgtc
     4981 aatgagtacc agcaaagttt atgatgggat gtaacaattg ttctgcttgt ccctctgggg
     5041 tctagcaagt ttttaagaac atctgtgtgg gcacaggtag gctgaaccta gcaataagtt
     5101 taacaaatga attgcattgg gaaagttttg ttttctgttt gttttgttct gttttttgga
     5161 atggggtctc actatgctat agctctggct gccctgaaac tcttgtagac cagactgcca
     5221 ttgaactcaa atatctgcct gcctctgcct ccaatattgg gaaagtttta agggttaatt
     5281 attaagtcac ttgattggtt atattggtat caaataaggt gcagatggtg gaacacagcc
     5341 ctagcctggg agccctgcat ccctggcagc agctaaatgg cctgggtaaa tgacctgtta
     5401 agcagctgca gtttctgaag tagaacagac tcagcttctg gccatcccct tcttacttta
     5461 ccttccccaa gaagtggctc ccagcattag gatgcattca aggccaggaa aatatataat
     5521 gataagcatt tctaaaggct aagtcatgtg ggtcttccta aaaaaaacca gtgtctcatg
     5581 gtaagagggc caaggtactc aaggctgact gccggctcct tgccaccaca gtgttggctg
     5641 ttgatgctga gctgaatggg gtacattcca agtcggtctg gaccctcaac agtcagacac
     5701 acacagggct ctttgaccac agcacacctt ggacttgagt aaccacagct aggctttgcg
     5761 gtcactcatg gtatggtaga ctgcaaaatc tcaacagcct tccctctccc ccccccccaa
     5821 gtatcggctt ggaaggacac cctgctgggt acaagaaagt ggataatctg gagattatgg
     5881 aaaagcacca gtgtccccta aagtgtcaca ctttagaatg tgcctcagat tggtgtggcc
     5941 atttcttgtc tgctctttct tgaagctaag acgttattga aggtaaatct gctttgagtc
     6001 tgctgctcaa ctaagtgctc agtaggtaag atgtccttaa gtggaactaa gctgtgctca
     6061 tggtagcctc gtttctagct tccacagaca tggcagctct gtccacagaa caggcaggag
     6121 gcagtgttct tggattgttt tcttcaaggt catgtttata tcgaggggag agaccctgat
     6181 gcagtcaaca ggttctagtc atgaatttat ttagagccag atggtgtggt tcactaacaa
     6241 ggcctaagtc ttccttcctt gtgattaagt gaagcagaaa aggaagcggt gtacatctga
     6301 attacactgt aggctcacaa gcaaaaacgt ggtcctatgg tgaacagatg acatctcaga
     6361 gttctaaatc tccactttat ttttaagatt agaagttctc aaagctgagg ctgtagcttg
     6421 gtggatagag agagcacttg cctagcattg acaagacctc aagttccatc ctcagcactt
     6481 ggggtggggt tattatttat atcactacca tgaaattata ttgttttcat aaagaaaaat
     6541 actctaaaat agactgggta aggcattgtg gcacactgtg ttctaagcac ccaggagtct
     6601 gtgaggcagg agactcaagt tgaaggccag cctgagctgt gtggagagag cacgtctcag
     6661 aaaaccagtg ctcaggttgg gcagcatcag aggcagtgat ggcgtagtga cattttcaga
     6721 ccaggtgtac atttggctga cgcgctaggg tgagtgctgg tgttctcgct gtctctgtaa
     6781 ggtactaata taaagtccca caccagtgtc ccatgaactg tcttttccaa ggcttcgttt
     6841 cacagttgta ttttgataca acatggatgt gagcatcaca cttgtttaaa cagatgtctg
     6901 ctgtgcttag tggttttacc tctgtttacc tgatgcctgt gtaaagtctg tgcttggctt
     6961 tgaattgtgt gtttacacct tactgtctct aaataaagag aaaattttat ggttatgcaa
     7021 a
//
