LOCUS       NM_001244936            4321 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus general transcription factor II I repeat
            domain-containing 1 (Gtf2ird1), transcript variant 11, mRNA.
ACCESSION   NM_001244936
VERSION     NM_001244936.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4321)
  AUTHORS   Schmithals,C., Kakoschky,B., Denk,D., von Harten,M., Klug,J.H.,
            Hintermann,E., Dropmann,A., Hamza,E., Jacomin,A.C., Marquardt,J.U.,
            Zeuzem,S., Schirmacher,P., Herrmann,E., Christen,U., Vogl,T.J.,
            Waidmann,O., Dooley,S., Finkelmeier,F. and Piiper,A.
  TITLE     Tumour-specific activation of a tumour-blood transport improves the
            diagnostic accuracy of blood tumour markers in mice
  JOURNAL   EBioMedicine 105, 105178 (2024)
   PUBMED   38889481
REFERENCE   2  (bases 1 to 4321)
  AUTHORS   Davenport,C.M., Teubner,B.J.W., Han,S.B., Patton,M.H., Eom,T.Y.,
            Garic,D., Lansdell,B.J., Shirinifard,A., Chang,T.C., Klein,J.,
            Pruett-Miller,S.M., Blundon,J.A. and Zakharenko,S.S.
  TITLE     Innate frequency-discrimination hyperacuity in Williams-Beuren
            syndrome mice
  JOURNAL   Cell 185 (21), 3877-3895 (2022)
   PUBMED   36152627
REFERENCE   3  (bases 1 to 4321)
  AUTHORS   Kopp,N.D., Nygaard,K.R., Liu,Y., McCullough,K.B., Maloney,S.E.,
            Gabel,H.W. and Dougherty,J.D.
  TITLE     Functions of Gtf2i and Gtf2ird1 in the developing brain:
            transcription, DNA binding and long-term behavioral consequences
  JOURNAL   Hum Mol Genet 29 (9), 1498-1519 (2020)
   PUBMED   32313931
  REMARK    GeneRIF: Functions of Gtf2i and Gtf2ird1 in the developing brain:
            transcription, DNA binding and long-term behavioral consequences.
REFERENCE   4  (bases 1 to 4321)
  AUTHORS   Kopp,N., McCullough,K., Maloney,S.E. and Dougherty,J.D.
  TITLE     Gtf2i and Gtf2ird1 mutation do not account for the full phenotypic
            effect of the Williams syndrome critical region in mouse models
  JOURNAL   Hum Mol Genet 28 (20), 3443-3465 (2019)
   PUBMED   31418010
  REMARK    GeneRIF: Gtf2i and Gtf2ird1 mutation do not account for the full
            phenotypic effect of the Williams syndrome critical region in mouse
            models
REFERENCE   5  (bases 1 to 4321)
  AUTHORS   Sonntag,R., Giebeler,N., Nevzorova,Y.A., Bangen,J.M.,
            Fahrenkamp,D., Lambertz,D., Haas,U., Hu,W., Gassler,N.,
            Cubero,F.J., Muller-Newen,G., Abdallah,A.T., Weiskirchen,R.,
            Ticconi,F., Costa,I.G., Barbacid,M., Trautwein,C. and Liedtke,C.
  TITLE     Cyclin E1 and cyclin-dependent kinase 2 are critical for
            initiation, but not for progression of hepatocellular carcinoma
  JOURNAL   Proc Natl Acad Sci U S A 115 (37), 9282-9287 (2018)
   PUBMED   30150405
REFERENCE   6  (bases 1 to 4321)
  AUTHORS   Kingsmore,S.F., Barbosa,M.D., Tchernev,V.T., Detter,J.C.,
            Lossie,A.C., Seldin,M.F. and Holcombe,R.F.
  TITLE     Positional cloning of the Chediak-Higashi syndrome gene: genetic
            mapping of the beige locus on mouse chromosome 13
  JOURNAL   J Investig Med 44 (8), 454-461 (1996)
   PUBMED   8952226
REFERENCE   7  (bases 1 to 4321)
  AUTHORS   Kingsmore,S.F., Barbosa,M.D., Nguyen,Q.A., Ashley,J.A.,
            Blaydes,S.M., Tchernev,V.T., Detter,J.C. and Lovett,M.
  TITLE     Physical mapping of the beige critical region on mouse chromosome
            13
  JOURNAL   Mamm Genome 7 (10), 773-775 (1996)
   PUBMED   8854868
REFERENCE   8  (bases 1 to 4321)
  AUTHORS   Santoni-Rugiu,E., Preisegger,K.H., Kiss,A., Audolfsson,T.,
            Shiota,G., Schmidt,E.V. and Thorgeirsson,S.S.
  TITLE     Inhibition of neoplastic development in the liver by hepatocyte
            growth factor in a transgenic mouse model
  JOURNAL   Proc Natl Acad Sci U S A 93 (18), 9577-9582 (1996)
   PUBMED   8790372
REFERENCE   9  (bases 1 to 4321)
  AUTHORS   Santoni-Rugiu,E., Nagy,P., Jensen,M.R., Factor,V.M. and
            Thorgeirsson,S.S.
  TITLE     Evolution of neoplastic development in the liver of transgenic mice
            co-expressing c-myc and transforming growth factor-alpha
  JOURNAL   Am J Pathol 149 (2), 407-428 (1996)
   PUBMED   8701981
REFERENCE   10 (bases 1 to 4321)
  AUTHORS   Murakami,H., Sanderson,N.D., Nagy,P., Marino,P.A., Merlino,G. and
            Thorgeirsson,S.S.
  TITLE     Transgenic mouse model for synergistic effects of nuclear oncogenes
            and growth factors in tumorigenesis: interaction of c-myc and
            transforming growth factor alpha in hepatic oncogenesis
  JOURNAL   Cancer Res 53 (8), 1719-1723 (1993)
   PUBMED   8467484
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ178886.1, BC050822.1, AF257475.1, AC167419.4 and AI413504.1.
            
            [WARNING] On Mar 12, 2025 this sequence was replaced by
            NM_001244936.2.
            
            Transcript Variant: This variant (11) differs in the 3' coding
            region and the 3' UTR, as compared to variant 1. The encoded
            isoform (j) lacks two internal segments and has a longer and
            distinct C-terminus, as compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF247161.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 CJ178886.1         1-5
            6-2805              BC050822.1         1-2800
            2806-3327           AF257475.1         3172-3693
            3328-4249           AC167419.4         42209-43130         c
            4250-4321           AI413504.1         1-72                c
FEATURES             Location/Qualifiers
     source          1..4321
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 74.55 cM"
     gene            1..4321
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /note="general transcription factor II I repeat
                     domain-containing 1"
                     /db_xref="GeneID:57080"
                     /db_xref="MGI:MGI:1861942"
     exon            1..208
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            209..337
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..3139
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /note="isoform j is encoded by transcript variant 11;
                     GTF2I repeat domain-containing 1; general transcription
                     factor II-I repeat domain-containing protein 1;
                     transcription factor GTF3 gamma 2; transcription factor
                     GTF3 alpha 2; GTF2I repeat domain-containing protein 1;
                     c-myc line 166.8; Alb/c-myc line 166.8; general
                     transcription factor 3; binding factor for early enhancer;
                     Williams-Beuren syndrome chromosome region 11; muscle
                     TFII-I repeat domain-containing protein 1"
                     /codon_start=1
                     /product="general transcription factor II-I repeat
                     domain-containing protein 1 isoform j"
                     /protein_id="NP_001231865.1"
                     /db_xref="GeneID:57080"
                     /db_xref="MGI:MGI:1861942"
                     /translation="MALLGKHCDIPTNGCGSERWNSTFARKDELINSLVSALDSMCSA
                     LSKLNTEVACVAVHNESVFVMGTEKGRVFLNTRKELQSDFLRFCRGPLWNDPEAGHPK
                     KVQRCEGGGRSLPRSSLEQCSDVYLLQKMVEEVFDVLYSEAMGRATVVPLPYERLLRE
                     PGLLAVQGLPEGLAFRRPAEYDPKALMAILEHSHRIRFKLRRPPDDGGQDTKALVEMN
                     GISLLPKGSRDCGLHGQASKVAPQDLTPTATPSSMANFLYSTSMPNHTIRELKQEVPT
                     CPLTPSDLGMGWPVPEPHVPSTQDFSDCCGQTPAGPAGPLIQNVHASKRILFSIVHDK
                     SEKWDPFIKEMEDINTLRECVQILFNSRYAEALGLDHMVPVPYRKIACDPEAVEIVGI
                     PDKIPFKRPCTYGVPKLKRILEERHSIHFIIKRMFDERIFTGNKFTKDPMKLEPASPP
                     EDTSTEVCRDSMLDLAGTAWSDMSSVSEDCGPGTSGEIAMLRPIKIEPEELDIIQVTV
                     SDPSPTSEEMTDSLPGHLPSEDSGYGMEMPADKGPSEEPWSEERPAEESPGDVIRPLR
                     KQVEMLFNTKYAKAIGTSEPVKVPYSKFLMHPEELFVLGLPEGISLRRPNCFGIAKLR
                     KILEASNSIQFVIKRPELLTDGVKEPVLDTQERDSWDRLVDETPKRQGLQENYNTRLS
                     RIDIANTLREQVQDLFNKKYGEALGIKYPVQVPYKRIKSNPGSVIIEGLPPGIPFRKP
                     CTFGSQNLERILSVADKIKFTVTRPFQGLIPKPDEDDANRLGEKVILREQVKELFNEK
                     YGEALGLNRPVLVPYKLIRDSPDAVEVKGLPDDIPFRNPNTYDIHRLEKILKAREHVR
                     MVIINQLQPFGDVCNNAKVPAKDNIPKRKRKRVSEGNSVSSSSSSSSSSSNPESVAST
                     NQISLVVKSRGSELHPNSVWPLPLPRAGPSTAPGTGRHWALRGTQPTTEGQAHPLVLP
                     TR"
     exon            338..479
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            480..635
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            636..819
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            820..1130
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1220
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1304
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1488
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1514
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1623
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1661
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1742
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1832
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1880
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..1946
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2130
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2180
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2237
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2321
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2505
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..2534
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..2612
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            2613..2805
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..2843
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            2844..4301
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4281..4286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /note="hexamer: AGTAAA"
     regulatory      4285..4290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /note="hexamer: AAGAAA"
     polyA_site      4298
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /note="major polyA site"
     polyA_site      4301
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /note="major polyA site"
ORIGIN      
        1 tccgccgcag cccgcgccgg gggtgggggc cccgcgcagc ccccggccgg ccgcccgcac
       61 cgcgtccgcc ctccttccct ccctccctct actgatcctg tcccccattc ccggattatt
      121 aactcagcaa ccagaggcga ctggatctac cgagtcctgg ccaccgggcc cgggccgggg
      181 cgcccggagc gcttggggat cctgcaaggt gaccatggcc ttgctgggga agcactgtga
      241 catccccacc aacggctgtg ggtctgagcg ctggaactcc accttcgccc gcaaggacga
      301 actcatcaac agtctggtgt ccgccttaga ctccatgtgc tcggcgctct ccaagctgaa
      361 cacggaggtg gcctgcgtgg cggtacacaa tgagagcgtc ttcgtgatgg gcaccgagaa
      421 gggaagggtg tttctgaaca ctcggaagga gctacagtca gacttcctca ggttctgccg
      481 gggacccctg tggaacgatc cagaagcagg acaccctaaa aaggtgcagc gctgtgaagg
      541 cggtggccgg agcctcccgc ggtcctctct ggagcagtgc tcggatgtgt acctgctgca
      601 gaagatggta gaggaagtgt ttgatgttct ttatagtgag gctatgggca gggccaccgt
      661 ggtacctttg ccctatgaga ggctgctcag ggagccgggg ctactggcgg tgcaggggct
      721 gcccgagggc ctggccttcc ggaggccagc agagtatgac cccaaggcac tcatggccat
      781 attggagcac agtcaccgaa ttcggtttaa gctcaggagg cctcctgatg acggtgggca
      841 ggacacgaag gcgctggtgg agatgaacgg tatctctctg ctacccaagg ggtcccgaga
      901 ctgtggtctg catggccagg cctccaaggt cgctccccaa gacctgaccc ccaccgccac
      961 cccatcctct atggccaact tcctgtacag cacttcgatg cccaaccaca cgatccggga
     1021 actcaagcag gaggtgccaa cctgcccgtt gacccccagc gacctgggca tgggctggcc
     1081 cgtgcctgag ccccatgtcc ccagcaccca agatttctct gattgctgtg gacagacgcc
     1141 tgcagggcct gctgggcctc tcatccagaa tgtccatgct tccaagcgca tcctcttctc
     1201 catcgtccat gacaagtcag agaagtggga tcccttcatc aaggaaatgg aggacatcaa
     1261 taccctgcgg gagtgcgtgc agattctgtt taacagcaga tacgcggaag ccctgggcct
     1321 ggaccacatg gtccctgtgc cctataggaa gattgcctgt gaccccgagg ctgtggaaat
     1381 tgtgggtatt ccagacaaga tccccttcaa gcgaccctgt acttacggag tgccgaagct
     1441 gaagaggatt ctggaggagc gacacagcat tcacttcatt atcaagagaa tgttcgatga
     1501 gcgcattttc acagggaaca agtttaccaa agaccccatg aagctggagc cagctagccc
     1561 accagaagac acttccacag aagtctgtag ggacagcatg ctggacctgg ctgggactgc
     1621 ttggtcagac atgagcagcg tctctgaaga ctgtgggcca ggaacctcag gagagatagc
     1681 aatgttgagg cctatcaaaa tcgagccaga ggagctggac attattcagg ttacggtctc
     1741 agatccttca cctacctctg aggagatgac tgactcgtta cctgggcatc tgccctcaga
     1801 ggattccggt tatgggatgg aaatgccggc tgacaaaggc cccagtgaag aaccgtggtc
     1861 agaagagagg ccggccgaag agagccctgg tgacgtgatc cggcccctac ggaagcaggt
     1921 ggagatgctg ttcaacacga aatatgccaa agctattggt acctcagagc cggtcaaggt
     1981 gccctactcc aagttcctga tgcacccgga ggagctgttc gtactgggac tgcctgaagg
     2041 catctctctt cggagaccca actgctttgg gattgcaaag ctgcggaaga ttctggaagc
     2101 gagcaacagc atccagtttg tcatcaagag acccgaactg ctcactgacg gtgtcaaaga
     2161 acctgttctg gacactcaag agagggactc ctgggaccgt cttgtggacg agaccccgaa
     2221 gagacagggc cttcaagaaa attacaacac cagactctcg cggatcgaca tcgccaacac
     2281 gcttagggaa caagtccaag acctgtttaa caagaaatac ggtgaagctc tgggcatcaa
     2341 atacccagtg caggtgccct acaagagaat caaaagcaac ccaggctcgg taatcattga
     2401 aggcctaccc cccgggatcc cattccgcaa accctgcacc tttggctccc agaacctgga
     2461 aaggattctc tctgtggctg acaagatcaa gttcacggtc accaggccat tccaaggact
     2521 tatcccaaag cctgatgagg atgatgccaa cagactgggg gagaaggtga tcctccgaga
     2581 gcaggtgaag gagctcttca atgagaaata cggtgaggcc ctgggactga atcggcctgt
     2641 gctggtccct tacaaactga tccgggacag cccagatgcc gtggaggtga agggcctccc
     2701 agatgacatc cccttccgga accccaacac ctatgacatc catcggctgg agaagatcct
     2761 gaaggccagg gagcatgtgc ggatggtcat catcaaccag ctccaacctt ttggggacgt
     2821 ctgcaacaat gccaaggtgc cagccaaaga caacattccc aagcgcaaga gaaagagggt
     2881 ctctgaaggc aactcagtct cctcttcttc ctcctcttca tcttcgtcct ctaacccaga
     2941 gtctgtggca tccaccaacc agatctccct cgtggtaaag tcacgcggat ccgaacttca
     3001 ccctaattct gtgtggcctt tgccccttcc tcgggcaggg ccatccacag ctccaggaac
     3061 tgggaggcac tgggctctga gagggactca gccaaccaca gaggggcagg cacatccact
     3121 cgttttgccc acaagataga cggagggtcc gcgcaatcag cgcagtgctt gaagtgtggc
     3181 tatcacctgc gatgtgtata aatgacgtca gcaggagcca gagggggaag gtcacgtgac
     3241 agaactcaac ctccatcttt tggctacatt gctttgttta gccctttcct gattcagaag
     3301 aactcatgta aaaaaaaaaa aaaacaaaac aaacacaaac acaaaaccca cccagggtat
     3361 ggtgtcttac gtccacagtc ccagtagtag aagggggaag atcggcgttc aaggccctct
     3421 gaggctatat ggagactgtc tcaaagaaaa ctggctaaac tgggggcaga gggtgtggct
     3481 tagtcagcag ggtacatgct ttgcatgcat gaagccctgg gttctatttg cagctccata
     3541 taaactggac ctggtggtac acgcctggga tcctaacact ggagaggtag agtcaggaga
     3601 atcaaaaagt tcaaggttag cctcagctac gtagaaagtt tgaggctagc ctgggctaca
     3661 tgagactgct tcgagaaaaa ggaatgaagg aaagaaaagc tgttttgttg ttggtttttg
     3721 gggtgttttt tttttatcat ttttttctat cattgactcc ctcccttcac cccaggaggt
     3781 gagatagtgt ctgtggggtg agactgtgtg aaccatggtt tccgctcatg ctgacgcagc
     3841 cctcaatggt gtctaatcca tgtattgaac acaggtgggg acaatcacta tgctccacct
     3901 gtgtgacctc gggcaggtct ctttccctct ctgggcctca gtggctgcat aataagtacc
     3961 atttgaattc atcctcaaag aaagcgtgct aattattctg ggagttcctc catgtcacct
     4021 ggagtcctaa cgtggtccct ctgtcccctc cccccctctc tctagcagtg gccagtgtac
     4081 atggtggact attccggact aaacgtgcag cttccgggcc cccttgatta ttagacctca
     4141 gagccgaatc aggacctcaa ctcaaaagac taaaggaaaa tgtaatttat gtacaaagta
     4201 tattcggata tgtatcaatg ccttttagtt tttccaatga tttttacact atattcctgc
     4261 cgccaaggcc tttttaaata agtaaagaaa atgaaaaaga aaaaaaaaaa aaaaaaaaaa
     4321 a
//
