LOCUS       NM_001081465            3480 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus general transcription factor II I repeat
            domain-containing 1 (Gtf2ird1), transcript variant 5, mRNA.
ACCESSION   NM_001081465
VERSION     NM_001081465.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3480)
  AUTHORS   Schmithals,C., Kakoschky,B., Denk,D., von Harten,M., Klug,J.H.,
            Hintermann,E., Dropmann,A., Hamza,E., Jacomin,A.C., Marquardt,J.U.,
            Zeuzem,S., Schirmacher,P., Herrmann,E., Christen,U., Vogl,T.J.,
            Waidmann,O., Dooley,S., Finkelmeier,F. and Piiper,A.
  TITLE     Tumour-specific activation of a tumour-blood transport improves the
            diagnostic accuracy of blood tumour markers in mice
  JOURNAL   EBioMedicine 105, 105178 (2024)
   PUBMED   38889481
REFERENCE   2  (bases 1 to 3480)
  AUTHORS   Davenport,C.M., Teubner,B.J.W., Han,S.B., Patton,M.H., Eom,T.Y.,
            Garic,D., Lansdell,B.J., Shirinifard,A., Chang,T.C., Klein,J.,
            Pruett-Miller,S.M., Blundon,J.A. and Zakharenko,S.S.
  TITLE     Innate frequency-discrimination hyperacuity in Williams-Beuren
            syndrome mice
  JOURNAL   Cell 185 (21), 3877-3895 (2022)
   PUBMED   36152627
REFERENCE   3  (bases 1 to 3480)
  AUTHORS   Kopp,N.D., Nygaard,K.R., Liu,Y., McCullough,K.B., Maloney,S.E.,
            Gabel,H.W. and Dougherty,J.D.
  TITLE     Functions of Gtf2i and Gtf2ird1 in the developing brain:
            transcription, DNA binding and long-term behavioral consequences
  JOURNAL   Hum Mol Genet 29 (9), 1498-1519 (2020)
   PUBMED   32313931
  REMARK    GeneRIF: Functions of Gtf2i and Gtf2ird1 in the developing brain:
            transcription, DNA binding and long-term behavioral consequences.
REFERENCE   4  (bases 1 to 3480)
  AUTHORS   Kopp,N., McCullough,K., Maloney,S.E. and Dougherty,J.D.
  TITLE     Gtf2i and Gtf2ird1 mutation do not account for the full phenotypic
            effect of the Williams syndrome critical region in mouse models
  JOURNAL   Hum Mol Genet 28 (20), 3443-3465 (2019)
   PUBMED   31418010
  REMARK    GeneRIF: Gtf2i and Gtf2ird1 mutation do not account for the full
            phenotypic effect of the Williams syndrome critical region in mouse
            models
REFERENCE   5  (bases 1 to 3480)
  AUTHORS   Sonntag,R., Giebeler,N., Nevzorova,Y.A., Bangen,J.M.,
            Fahrenkamp,D., Lambertz,D., Haas,U., Hu,W., Gassler,N.,
            Cubero,F.J., Muller-Newen,G., Abdallah,A.T., Weiskirchen,R.,
            Ticconi,F., Costa,I.G., Barbacid,M., Trautwein,C. and Liedtke,C.
  TITLE     Cyclin E1 and cyclin-dependent kinase 2 are critical for
            initiation, but not for progression of hepatocellular carcinoma
  JOURNAL   Proc Natl Acad Sci U S A 115 (37), 9282-9287 (2018)
   PUBMED   30150405
REFERENCE   6  (bases 1 to 3480)
  AUTHORS   Kingsmore,S.F., Barbosa,M.D., Tchernev,V.T., Detter,J.C.,
            Lossie,A.C., Seldin,M.F. and Holcombe,R.F.
  TITLE     Positional cloning of the Chediak-Higashi syndrome gene: genetic
            mapping of the beige locus on mouse chromosome 13
  JOURNAL   J Investig Med 44 (8), 454-461 (1996)
   PUBMED   8952226
REFERENCE   7  (bases 1 to 3480)
  AUTHORS   Kingsmore,S.F., Barbosa,M.D., Nguyen,Q.A., Ashley,J.A.,
            Blaydes,S.M., Tchernev,V.T., Detter,J.C. and Lovett,M.
  TITLE     Physical mapping of the beige critical region on mouse chromosome
            13
  JOURNAL   Mamm Genome 7 (10), 773-775 (1996)
   PUBMED   8854868
REFERENCE   8  (bases 1 to 3480)
  AUTHORS   Santoni-Rugiu,E., Preisegger,K.H., Kiss,A., Audolfsson,T.,
            Shiota,G., Schmidt,E.V. and Thorgeirsson,S.S.
  TITLE     Inhibition of neoplastic development in the liver by hepatocyte
            growth factor in a transgenic mouse model
  JOURNAL   Proc Natl Acad Sci U S A 93 (18), 9577-9582 (1996)
   PUBMED   8790372
REFERENCE   9  (bases 1 to 3480)
  AUTHORS   Santoni-Rugiu,E., Nagy,P., Jensen,M.R., Factor,V.M. and
            Thorgeirsson,S.S.
  TITLE     Evolution of neoplastic development in the liver of transgenic mice
            co-expressing c-myc and transforming growth factor-alpha
  JOURNAL   Am J Pathol 149 (2), 407-428 (1996)
   PUBMED   8701981
REFERENCE   10 (bases 1 to 3480)
  AUTHORS   Murakami,H., Sanderson,N.D., Nagy,P., Marino,P.A., Merlino,G. and
            Thorgeirsson,S.S.
  TITLE     Transgenic mouse model for synergistic effects of nuclear oncogenes
            and growth factors in tumorigenesis: interaction of c-myc and
            transforming growth factor alpha in hepatic oncogenesis
  JOURNAL   Cancer Res 53 (8), 1719-1723 (1993)
   PUBMED   8467484
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ048288.1, BC083150.1, AK078488.1 and BC050822.1.
            
            [WARNING] On Mar 12, 2025 this sequence was replaced by
            NM_001081465.2.
            
            Transcript Variant: This variant (5) differs in the 5' UTR and
            lacks an in-frame coding exon, as compared to variant 1. The
            encoded isoform (d) lacks an internal segment, as compared to
            isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083150.1, SRR7345562.1319312.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                CJ048288.1         1-54
            55-1951             BC083150.1         14-1910
            1952-3226           AK078488.1         1877-3151
            3227-3269           BC083150.1         3186-3228
            3270-3480           BC050822.1         3322-3532
FEATURES             Location/Qualifiers
     source          1..3480
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 74.55 cM"
     gene            1..3480
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /note="general transcription factor II I repeat
                     domain-containing 1"
                     /db_xref="GeneID:57080"
                     /db_xref="MGI:MGI:1861942"
     exon            1..151
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            152..280
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..3295
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /note="isoform d is encoded by transcript variant 5; GTF2I
                     repeat domain-containing 1; general transcription factor
                     II-I repeat domain-containing protein 1; transcription
                     factor GTF3 gamma 2; transcription factor GTF3 alpha 2;
                     GTF2I repeat domain-containing protein 1; c-myc line
                     166.8; Alb/c-myc line 166.8; general transcription factor
                     3; binding factor for early enhancer; Williams-Beuren
                     syndrome chromosome region 11; muscle TFII-I repeat
                     domain-containing protein 1"
                     /codon_start=1
                     /product="general transcription factor II-I repeat
                     domain-containing protein 1 isoform d"
                     /protein_id="NP_001074934.1"
                     /db_xref="CCDS:CCDS39304.1"
                     /db_xref="GeneID:57080"
                     /db_xref="MGI:MGI:1861942"
                     /translation="MALLGKHCDIPTNGCGSERWNSTFARKDELINSLVSALDSMCSA
                     LSKLNTEVACVAVHNESVFVMGTEKGRVFLNTRKELQSDFLRFCRGPLWNDPEAGHPK
                     KVQRCEGGGRSLPRSSLEQCSDVYLLQKMVEEVFDVLYSEAMGRATVVPLPYERLLRE
                     PGLLAVQGLPEGLAFRRPAEYDPKALMAILEHSHRIRFKLRRPPDDGGQDTKALVEMN
                     GISLLPKGSRDCGLHGQASKVAPQDLTPTATPSSMANFLYSTSMPNHTIRELKQEVPT
                     CPLTPSDLGMGWPVPEPHVPSTQDFSDCCGQTPAGPAGPLIQNVHASKRILFSIVHDK
                     SEKWDPFIKEMEDINTLRECVQILFNSRYAEALGLDHMVPVPYRKIACDPEAVEIVGI
                     PDKIPFKRPCTYGVPKLKRILEERHSIHFIIKRMFDERIFTGNKFTKDPMKLEPASPP
                     EDTSTEVCRDSMLDLAGTAWSDMSSVSEDCGPGTSGEIAMLRPIKIEPEELDIIQVTV
                     SDPSPTSEEMTDSLPGHLPSEDSGYGMEMPADKGPSEEPWSEERPAEESPGDVIRPLR
                     KQVEMLFNTKYAKAIGTSEPVKVPYSKFLMHPEELFVLGLPEGISLRRPNCFGIAKLR
                     KILEASNSIQFVIKRPELLTDGVKEPVLDTQERDSWDRLVDETPKRQGLQENYNTRLS
                     RIDIANTLREQVQDLFNKKYGEALGIKYPVQVPYKRIKSNPGSVIIEGLPPGIPFRKP
                     CTFGSQNLERILSVADKIKFTVTRPFQGLIPKPDEDDANRLGEKVILREQVKELFNEK
                     YGEALGLNRPVLVPYKLIRDSPDAVEVKGLPDDIPFRNPNTYDIHRLEKILKAREHVR
                     MVIINQLQPFAEVCNDPKVPEEDDSNKLGKKVILREQVKELFNEKYGEALGLNRPVLV
                     PYKLIRDSPDAVEVKGLPDDIPFRNPNTYDIHRLEKILKAREHVRMVIINQLQPFGDV
                     CNNAKVPAKDNIPKRKRKRVSEGNSVSSSSSSSSSSSNPESVASTNQISLVQWPVYMV
                     DYSGLNVQLPGPLDY"
     exon            281..422
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            423..578
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            579..762
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            763..1073
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1163
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1247
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1431
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1457
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1566
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1604
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1685
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1775
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1823
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1889
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2073
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2123
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2180
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2264
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2448
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2477
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..2555
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2748
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..2786
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            2787..2864
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..3057
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            3058..3095
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            3096..3226
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     exon            3227..3462
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3442..3447
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /note="hexamer: AGTAAA"
     regulatory      3446..3451
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /note="hexamer: AAGAAA"
     polyA_site      3459
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /note="major polyA site"
     polyA_site      3462
                     /gene="Gtf2ird1"
                     /gene_synonym="1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il;
                     GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11"
                     /note="major polyA site"
ORIGIN      
        1 tgggttggga tggtcagctt cttccctccg gatacctgct ggaatcgggg aaagcagaca
       61 cccctctcac cctcgaattc cctggaggtg gagagagaag cgccccactg gcctggagcc
      121 cagcaggcct ggatacagtt gggcgaatga ggtgaccatg gccttgctgg ggaagcactg
      181 tgacatcccc accaacggct gtgggtctga gcgctggaac tccaccttcg cccgcaagga
      241 cgaactcatc aacagtctgg tgtccgcctt agactccatg tgctcggcgc tctccaagct
      301 gaacacggag gtggcctgcg tggcggtaca caatgagagc gtcttcgtga tgggcaccga
      361 gaagggaagg gtgtttctga acactcggaa ggagctacag tcagacttcc tcaggttctg
      421 ccggggaccc ctgtggaacg atccagaagc aggacaccct aaaaaggtgc agcgctgtga
      481 aggcggtggc cggagcctcc cgcggtcctc tctggagcag tgctcggatg tgtacctgct
      541 gcagaagatg gtagaggaag tgtttgatgt tctttatagt gaggctatgg gcagggccac
      601 cgtggtacct ttgccctatg agaggctgct cagggagccg gggctactgg cggtgcaggg
      661 gctgcccgag ggcctggcct tccggaggcc agcagagtat gaccccaagg cactcatggc
      721 catattggag cacagtcacc gaattcggtt taagctcagg aggcctcctg atgacggtgg
      781 gcaggacacg aaggcgctgg tggagatgaa cggtatctct ctgctaccca aggggtcccg
      841 agactgtggt ctgcatggcc aggcctccaa ggtcgctccc caagacctga cccccaccgc
      901 caccccatcc tctatggcca acttcctgta cagcacttcg atgcccaacc acacgatccg
      961 ggaactcaag caggaggtgc caacctgccc gttgaccccc agcgacctgg gcatgggctg
     1021 gcccgtgcct gagccccatg tccccagcac ccaagatttc tctgattgct gtggacagac
     1081 gcctgcaggg cctgctgggc ctctcatcca gaatgtccat gcttccaagc gcatcctctt
     1141 ctccatcgtc catgacaagt cagagaagtg ggatcccttc atcaaggaaa tggaggacat
     1201 caataccctg cgggagtgcg tgcagattct gtttaacagc agatacgcgg aagccctggg
     1261 cctggaccac atggtccctg tgccctatag gaagattgcc tgtgaccccg aggctgtgga
     1321 aattgtgggt attccagaca agatcccctt caagcgaccc tgtacttacg gagtgccgaa
     1381 gctgaagagg attctggagg agcgacacag cattcacttc attatcaaga gaatgttcga
     1441 tgagcgcatt ttcacaggga acaagtttac caaagacccc atgaagctgg agccagctag
     1501 cccaccagaa gacacttcca cagaagtctg tagggacagc atgctggacc tggctgggac
     1561 tgcttggtca gacatgagca gcgtctctga agactgtggg ccaggaacct caggagagat
     1621 agcaatgttg aggcctatca aaatcgagcc agaggagctg gacattattc aggttacggt
     1681 ctcagatcct tcacctacct ctgaggagat gactgactcg ttacctgggc atctgccctc
     1741 agaggattcc ggttatggga tggaaatgcc ggctgacaaa ggccccagtg aagaaccgtg
     1801 gtcagaagag aggccggccg aagagagccc tggtgacgtg atccggcccc tacggaagca
     1861 ggtggagatg ctgttcaaca cgaaatatgc caaagctatt ggtacctcag agccggtcaa
     1921 ggtgccctac tccaagttcc tgatgcaccc ggaggagctg ttcgtactgg gactgcctga
     1981 aggcatctct cttcggagac ccaactgctt tgggattgca aagctgcgga agattctgga
     2041 agcgagcaac agcatccagt ttgtcatcaa gagacccgaa ctgctcactg acggtgtcaa
     2101 agaacctgtt ctggacactc aagagaggga ctcctgggac cgtcttgtgg acgagacccc
     2161 gaagagacag ggccttcaag aaaattacaa caccagactc tcgcggatcg acatcgccaa
     2221 cacgcttagg gaacaagtcc aagacctgtt taacaagaaa tacggtgaag ctctgggcat
     2281 caaataccca gtgcaggtgc cctacaagag aatcaaaagc aacccaggct cggtaatcat
     2341 tgaaggccta ccccccggga tcccattccg caaaccctgc acctttggct cccagaacct
     2401 ggaaaggatt ctctctgtgg ctgacaagat caagttcacg gtcaccaggc cattccaagg
     2461 acttatccca aagcctgatg aggatgatgc caacagactg ggggagaagg tgatcctccg
     2521 agagcaggtg aaggagctct tcaatgagaa atacggtgag gccctgggac tgaatcggcc
     2581 tgtgctggtc ccttacaaac tgatccggga cagcccagat gccgtggagg tgaagggcct
     2641 cccagatgac atccccttcc ggaaccccaa cacctatgac atccatcggc tggagaagat
     2701 cctgaaggcc agggagcatg tgcggatggt catcatcaac cagctccaac cctttgcgga
     2761 agtctgcaat gaccccaagg tgccagagga ggatgactct aacaagctcg ggaagaaggt
     2821 gatcctccga gagcaggtga aggagctctt caatgagaaa tacggtgagg ccctgggact
     2881 gaatcggcct gtgctggtcc cttacaaact gatccgggac agcccagatg ccgtggaggt
     2941 gaagggcctc ccagatgaca tccccttccg gaaccccaac acctatgaca tccatcggct
     3001 ggagaagatc ctgaaggcca gggagcatgt gcggatggtc atcatcaacc agctccaacc
     3061 ttttggggac gtctgcaaca atgccaaggt gccagccaaa gacaacattc ccaagcgcaa
     3121 gagaaagagg gtctctgaag gcaactcagt ctcctcttct tcctcctctt catcttcgtc
     3181 ctctaaccca gagtctgtgg catccaccaa ccagatctcc ctcgtgcagt ggccagtgta
     3241 catggtggac tattccggac taaacgtgca gcttccgggc ccccttgatt attagacctc
     3301 agagccgaat caggacctca actcaaaaga ctaaaggaaa atgtaattta tgtacaaagt
     3361 atattcggat atgtatcaat gccttttagt ttttccaatg atttttacac tatattcctg
     3421 ccgccaaggc ctttttaaat aagtaaagaa aatgaaaaag aaaaaaaaaa aaaaaaaaaa
//
