LOCUS       NM_010365               4400 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus general transcription factor II I (Gtf2i), transcript
            variant 2, mRNA.
ACCESSION   NM_010365 XM_290039
VERSION     NM_010365.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4400)
  AUTHORS   Bar,E., Fischer,I., Rokach,M., Elad-Sfadia,G., Shirenova,S.,
            Ophir,O., Trangle,S.S., Okun,E. and Barak,B.
  TITLE     Neuronal deletion of Gtf2i results in developmental microglial
            alterations in a mouse model related to Williams syndrome
  JOURNAL   Glia 72 (6), 1117-1135 (2024)
   PUBMED   38450767
  REMARK    GeneRIF: Neuronal deletion of Gtf2i results in developmental
            microglial alterations in a mouse model related to Williams
            syndrome.
REFERENCE   2  (bases 1 to 4400)
  AUTHORS   Nir Sade,A., Levy,G., Schokoroy Trangle,S., Elad Sfadia,G., Bar,E.,
            Ophir,O., Fischer,I., Rokach,M., Atzmon,A., Parnas,H.,
            Rosenberg,T., Marco,A., Elroy Stein,O. and Barak,B.
  TITLE     Neuronal Gtf2i deletion alters mitochondrial and autophagic
            properties
  JOURNAL   Commun Biol 6 (1), 1269 (2023)
   PUBMED   38097729
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4400)
  AUTHORS   Singh,A., Kaileh,M., De,S., Mazan-Mamczarz,K., Bayarsaihan,D.,
            Sen,R. and Roy,A.L.
  TITLE     Transcription factor TFII-I fine tunes innate properties of B
            lymphocytes
  JOURNAL   Front Immunol 14, 1067459 (2023)
   PUBMED   36756127
  REMARK    GeneRIF: Transcription factor TFII-I fine tunes innate properties
            of B lymphocytes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4400)
  AUTHORS   Davenport,C.M., Teubner,B.J.W., Han,S.B., Patton,M.H., Eom,T.Y.,
            Garic,D., Lansdell,B.J., Shirinifard,A., Chang,T.C., Klein,J.,
            Pruett-Miller,S.M., Blundon,J.A. and Zakharenko,S.S.
  TITLE     Innate frequency-discrimination hyperacuity in Williams-Beuren
            syndrome mice
  JOURNAL   Cell 185 (21), 3877-3895 (2022)
   PUBMED   36152627
REFERENCE   5  (bases 1 to 4400)
  AUTHORS   Giorgetti,O.B., Nusser,A. and Boehm,T.
  TITLE     Human thymoma-associated mutation of the GTF2I transcription factor
            impairs thymic epithelial progenitor differentiation in mice
  JOURNAL   Commun Biol 5 (1), 1037 (2022)
   PUBMED   36175547
  REMARK    GeneRIF: Human thymoma-associated mutation of the GTF2I
            transcription factor impairs thymic epithelial progenitor
            differentiation in mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4400)
  AUTHORS   Bayarsaihan,D., Dunai,J., Greally,J.M., Kawasaki,K., Sumiyama,K.,
            Enkhmandakh,B., Shimizu,N. and Ruddle,F.H.
  TITLE     Genomic organization of the genes Gtf2ird1, Gtf2i, and Ncf1 at the
            mouse chromosome 5 region syntenic to the human chromosome 7q11.23
            Williams syndrome critical region
  JOURNAL   Genomics 79 (1), 137-143 (2002)
   PUBMED   11827466
REFERENCE   7  (bases 1 to 4400)
  AUTHORS   Wang,Y.K., Sporle,R., Paperna,T., Schughart,K. and Francke,U.
  TITLE     Characterization and expression pattern of the frizzled gene Fzd9,
            the mouse homolog of FZD9 which is deleted in Williams-Beuren
            syndrome
  JOURNAL   Genomics 57 (2), 235-248 (1999)
   PUBMED   10198163
REFERENCE   8  (bases 1 to 4400)
  AUTHORS   Paperna,T., Peoples,R., Wang,Y.K., Kaplan,P. and Francke,U.
  TITLE     Genes for the CPE receptor (CPETR1) and the human homolog of RVP1
            (CPETR2) are localized within the Williams-Beuren syndrome deletion
  JOURNAL   Genomics 54 (3), 453-459 (1998)
   PUBMED   9878248
REFERENCE   9  (bases 1 to 4400)
  AUTHORS   Wang,Y.K., Perez-Jurado,L.A. and Francke,U.
  TITLE     A mouse single-copy gene, Gtf2i, the homolog of human GTF2I, that
            is duplicated in the Williams-Beuren syndrome deletion region
  JOURNAL   Genomics 48 (2), 163-170 (1998)
   PUBMED   9521869
REFERENCE   10 (bases 1 to 4400)
  AUTHORS   Yang,W. and Desiderio,S.
  TITLE     BAP-135, a target for Bruton's tyrosine kinase in response to B
            cell receptor engagement
  JOURNAL   Proc Natl Acad Sci U S A 94 (2), 604-609 (1997)
   PUBMED   9012831
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB250008.1, BC053044.1 and AC093346.7.
            
            On Dec 27, 2013 this sequence version replaced NM_010365.3.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region compared to variant 1. The encoded
            isoform (2, also known as Beta or Long) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.1159.1,
                                           SRR7652917.687125.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                CB250008.1         1-30
            31-180              BC053044.1         1-150
            181-181             AC093346.7         206027-206027       c
            182-378             BC053044.1         151-347
            379-482             AC093346.7         186957-187060       c
            483-621             AC093346.7         185194-185332       c
            622-756             AC093346.7         180734-180868       c
            757-940             AC093346.7         178307-178490       c
            941-969             AC093346.7         178142-178170       c
            970-1024            AC093346.7         174641-174695       c
            1025-1068           AC093346.7         174234-174277       c
            1069-1146           AC093346.7         170884-170961       c
            1147-1203           AC093346.7         165986-166042       c
            1204-1266           AC093346.7         163971-164033       c
            1267-1380           AC093346.7         157990-158103       c
            1381-1446           AC093346.7         157184-157249       c
            1447-1630           AC093346.7         155032-155215       c
            1631-1689           AC093346.7         153290-153348       c
            1690-1761           AC093346.7         152014-152085       c
            1762-1945           AC093346.7         147272-147455       c
            1946-2004           AC093346.7         146460-146518       c
            2005-2076           AC093346.7         143313-143384       c
            2077-2260           AC093346.7         141289-141472       c
            2261-2319           AC093346.7         138666-138724       c
            2320-2394           AC093346.7         138268-138342       c
            2395-2496           AC093346.7         137957-138058       c
            2497-2562           AC093346.7         136564-136629       c
            2563-2746           AC093346.7         136141-136324       c
            2747-2802           AC093346.7         135348-135403       c
            2803-2883           AC093346.7         134954-135034       c
            2884-2967           AC093346.7         134355-134438       c
            2968-3151           AC093346.7         134051-134234       c
            3152-3180           AC093346.7         133578-133606       c
            3181-3222           AC093346.7         132320-132361       c
            3223-3264           AC093346.7         131690-131731       c
            3265-3339           AC093346.7         130944-131018       c
            3340-4400           AC093346.7         129279-130339       c
FEATURES             Location/Qualifiers
     source          1..4400
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 74.48 cM"
     gene            1..4400
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /note="general transcription factor II I"
                     /db_xref="GeneID:14886"
                     /db_xref="MGI:MGI:1202722"
     exon            1..378
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            379..482
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     CDS             384..3323
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /note="isoform 2 is encoded by transcript variant 2;
                     Bruton tyrosine kinase-associated protein 135;
                     BTK-associated protein 135; SRF-Phox1-interacting protein;
                     Williams-Beuren syndrome chromosomal region 6 protein"
                     /codon_start=1
                     /product="general transcription factor II-I isoform 2"
                     /protein_id="NP_034495.2"
                     /db_xref="CCDS:CCDS39299.1"
                     /db_xref="GeneID:14886"
                     /db_xref="MGI:MGI:1202722"
                     /translation="MAQVVMSALPAEDEESSESRMVVTFLMSALESMCKELAKSKAEV
                     ACIAVYETDVFVVGTERGRAFVNTRKDFQKDFVKYCVEEEEKAAEMHKMKSTTQANRM
                     SVDAVEIETLRKTVEDYFCFCYGKALGKSTVVPVPYEKMLRDQSAVVVQGLPEGVAFK
                     HPEHYDLATLKWILENKAGISFIIKRPFLEPKKHLGGRVLAAEAERSMLSPSGSCGPI
                     KVKTEPTEDSGISLEMAAVTVKEESEDPDYYQYNIQGSHHSSEGNEGTEVEVPAEDST
                     QHVPSETSEDPEVEVTIEDDDYSPPTKRLKSTEPPPPPPVPEPANAGKRKVREFNFEK
                     WNARITDLRKQVEELFERKYAQAIKAKGPVTIPYPLFQSHVEDLYVEGLPEGIPFRRP
                     STYGIPRLERILLAKERIRFVIKKHELLNSTREDLQLDKPASGVKEEWYARITKLRKM
                     VDQLFCKKFAEALGSTEAKAVPYQKFEAHPNDLYVEGLPENIPFRSPSWYGIPRLEKI
                     IQVGNRIKFVIKRPELLTHSTTEVTQPRTNTPVKEDWNVRITKLRKQVEEIFNLKFAQ
                     ALGLTEAVKVPYPVFESNPEFLYVEGLPEGIPFRSPTWFGIPRLERIVRGSNKIKFVV
                     KKPELVVSYLPPGMASKINTKALQSPKRPRSPGSNSKVPEIEVTVEGPNNSSPQTSAV
                     RTPTQTNGSNVPFKPRGREFSFEAWNAKITDLKQKVENLFNEKCGEALGLKQAVKVPF
                     ALFESFPEDFYVEGLPEGVPFRRPSTFGIPRLEKILRNKAKIKFIIKKPEMFETAIKE
                     STSSKSPPRKINSSPNVNTTASGVEDLNIIQVTIPDDDNERLSKVEKARQLREQVNDL
                     FSRKFGEAIGMGFPVKVPYRKITINPGCVVVDGMPPGVSFKAPSYLEISSMRRILDSA
                     EFIKFTVIRPFPGLVINNQLVDQNESEGPVIQESAEASQLEVPVTEEIKETDGSSQIK
                     QEPDPTW"
     exon            483..621
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            622..756
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            757..940
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            941..969
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1024
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1068
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1146
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1203
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1266
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1380
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1446
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1630
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1689
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1761
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1945
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2004
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2076
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2260
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2319
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2394
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2496
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2562
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2563..2746
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2747..2802
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2803..2883
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2884..2967
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2968..3151
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            3152..3180
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            3181..3222
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            3223..3264
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            3265..3339
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            3340..4400
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4367..4372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /note="hexamer: AATAAA"
     polyA_site      4398
                     /gene="Gtf2i"
                     /gene_synonym="6030441I21Rik; BAP-135; Diws1t; GtfII-I;
                     Spin; TFII-I; WBSCR6"
                     /note="major polyA site"
ORIGIN      
        1 aaaaaaaaaa aggcaaaaaa aaaaaaaggg ggaaaaaaaa ggaggaggag gagggtgaga
       61 gagaagctgg gagagcagag aaaagggggc accggcggcc cccccgcttc cctgcacgcg
      121 cttgccgccc gcctgccgcg gttatccctg ggcttcgtcc ctgttccccc cccccccccc
      181 cggcgtctgg cgacccagcg tggagcgagg ccccgccggg ggcggccatg cggcggtgac
      241 aggagcacgg ccgagacgca cgggcccccc tcgccctctc acctccaccc cgttcgccag
      301 ctcgccgagg cccctccggc ctacactcgc ttgctgtccg catccccccc tccccgaccc
      361 tccccggctg ctcttcggga atcatggccc aagtagtgat gtctgccttg cctgccgaag
      421 atgaagagtc ttcagagagc aggatggtgg tgaccttcct catgtctgcc ctggagtcca
      481 tgtgtaaaga gctggccaag tccaaggctg aggtggcctg cattgctgtg tatgagaccg
      541 acgtgtttgt tgttggaacc gaaagagggc gtgcttttgt caataccaga aaagatttcc
      601 aaaaagactt tgtgaagtat tgtgttgaag aagaagaaaa ggccgccgag atgcataaga
      661 tgaaatctac cacccaggcc aatcggatga gtgtggatgc tgtagaaatt gaaacactca
      721 gaaaaacggt ggaggactat ttctgttttt gctatgggaa agctttaggc aaatccacag
      781 tggtccctgt gccatatgag aagatgctgc gcgaccagtc ggctgtggtg gtgcaggggc
      841 ttcccgaggg ggttgccttc aagcaccccg aacattacga cctcgcaacc ttgaagtgga
      901 ttttggagaa caaggcaggg atttccttca tcattaagag acctttcctc gagccgaaga
      961 aacacctcgg tggtcgagtg ctggcggccg aggctgagag gtccatgctg tctcctagtg
     1021 gaagttgtgg ccccatcaaa gtgaaaactg aacccacaga agattctggc atttctctgg
     1081 aaatggccgc tgtgacagtg aaggaggagt cagaagaccc tgattactat cagtataaca
     1141 ttcaaggaag ccatcactcc tcagaaggca acgagggaac ggaagtggaa gtgccagcag
     1201 aagattctac tcaacatgtc ccttcagaaa ccagtgagga ccccgaagtt gaggtgacca
     1261 ttgaagatga tgactattct ccacccacca agaggctaaa gagcacggag ccgcccccgc
     1321 ccccgcccgt cccggagccc gccaacgctg gcaagcgcaa agtgagggag ttcaactttg
     1381 agaaatggaa cgcacgcatc actgacctac ggaaacaagt tgaagagttg ttcgaaagaa
     1441 aatatgctca agccatcaaa gccaaaggcc cggtgacgat cccgtaccct cttttccagt
     1501 cccatgttga agatctttac gtagaagggc ttcctgaagg gattcctttt agaaggccgt
     1561 cgacgtacgg cattcctcgc cttgagagga tattgctggc gaaggaaagg atccgcttcg
     1621 tgattaagaa acatgagctt ctgaactcaa cacgagaaga tttacagctt gataaaccag
     1681 cctcaggagt gaaagaagag tggtacgctc gcatcaccaa actgaggaag atggttgacc
     1741 agctcttctg caagaaattt gccgaggcct tgggaagcac ggaagccaag gctgtaccgt
     1801 accaaaaatt tgaggcccat cccaatgatc tctatgtgga aggacttcca gaaaacattc
     1861 ctttccgaag cccctcgtgg tatggaatcc caagactgga aaaaatcatc caagtgggca
     1921 atcgaattaa atttgttatc aagagaccag agctgctcac tcacagcaca actgaagtga
     1981 ctcagccacg gacaaacaca ccagtcaaag aagattggaa tgtcagaatc accaagctcc
     2041 gaaagcaagt ggaagagatc tttaatttga agtttgctca ggctctgggc ctcacagagg
     2101 ctgtgaaggt gccatatcct gtgttcgaat ccaacccgga gtttctgtat gtggaagggc
     2161 tccccgaagg gatccccttc cgaagcccta cctggtttgg gattccacgc ctcgagagga
     2221 ttgtccgtgg cagcaataag atcaagtttg ttgttaaaaa gcctgagcta gttgtgtcct
     2281 atttgcctcc tgggatggct agcaaaatca acactaaagc attgcagtcc ccaaaacgac
     2341 cacgaagccc tgggagcaac tccaaggttc ctgaaattga ggtcactgtg gaaggcccca
     2401 acaacagcag tcctcagacc tctgcggttc gaactcctac ccagaccaat ggttcaaatg
     2461 ttcccttcaa gcctcgaggg agagagtttt cctttgaggc ctggaatgct aagatcacag
     2521 acctgaagca gaaagtggag aacctcttca atgaaaagtg cggggaagcg cttggcctta
     2581 agcaggctgt gaaagtcccg tttgcgttgt tcgagtcctt cccagaagac ttctatgtgg
     2641 aaggcttgcc cgagggggtg cccttccgaa ggccgtccac atttggcatt cccaggctgg
     2701 agaagatact ccggaacaag gccaagataa agttcatcat taaaaaacct gagatgttcg
     2761 agacggccat caaagagagc acctcttcca aaagccctcc aagaaagata aactcatcac
     2821 ccaacgttaa tactactgca tcaggtgtgg aagacctgaa catcatccag gtgacaattc
     2881 cagatgacga taatgaacga ctgtccaaag ttgaaaaggc caggcagctg cgggagcagg
     2941 tcaacgacct cttcagtcgg aagtttggtg aagctattgg gatgggcttc ccggtgaagg
     3001 tcccctacag gaagatcacc atcaaccctg gctgcgtggt ggtcgatggc atgccccccg
     3061 gggtgtcctt caaagccccc agttacctgg agatcagctc catgaggagg atcttagact
     3121 ctgcggagtt tatcaagttc actgtcatta gaccatttcc aggacttgtg attaataacc
     3181 agctggttga tcagaacgag tctgaaggcc ctgtgataca agaatcagcc gaggcaagcc
     3241 agttggaagt cccagtaaca gaagaaatta aagagacaga tgggagttca cagatcaagc
     3301 aggagccaga ccccacgtgg tagaccgtgg ctctccaggt tcgtccagtg tccagcgtgc
     3361 gtggtggaga agagctttgg gacccgttcc tgccagctct gtaatatact tgtataacag
     3421 aaataccttc tatacaaacc ttcttttcta cttttagata gaaatgtcta ctttctcagc
     3481 agttctgtga attgagctac acagcgtgat gagatgcgcg tgcctggtgg cttgggaacg
     3541 cactagaagg gtcttgcagc agtgctgaaa gaggcgggaa tggcagggac gactcgtagg
     3601 gtttcttatg catcgggcag agccttgggc tgtggtgcgt gttcccgtca gtgagatatt
     3661 cctacagggc atcttggctt ccgcagcaaa ggaagtccct gtgctagtca gtgctttagt
     3721 ttttctattg aagaccagtt ccgtggtctt gcactcggct gcccctcctg ccaggggagg
     3781 gctgctgtct gtgtgtgtga ctaagcctct tcccaagctc catcacgatt cctttgtcct
     3841 cactgccatt cagagcaaag ccggccagct cgcctgaccg ccagtgagca gccagtgcat
     3901 ccgtgcagtg cagctggaga ggctagcctc agagcctcgc tccggttact ttacagcaag
     3961 tagatttctg ggtgtgtcct aaaggtcaga ggtcaggtct gcatgcttga gcaggtggag
     4021 gatttgcccc tccccaactg ggacccacag tggcctcagg ggctctgggc cgcagctctg
     4081 ggtctgggtc gagtcaggct gggctgtgtg tctgcctggt tggttagtct ctaaccacct
     4141 gtctggcctc tgcgccaggg tggggagtga ggacattggt gtcccgccct atgtgggggc
     4201 tcacagacga tgataaggta acagctctca gcagttaggc acgtgagggc acggttctcg
     4261 gtagtcacca caatgttcac aatgggaaat tatatcacac ggtagcagag ataggcattt
     4321 tatgtgttcc ttatatttta cctcaaattg tagatatagg gtaataaata aaatccatcc
     4381 atgcctttca catgcaaact
//
