LOCUS       NM_181392               1191 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus general transcription factor IIH, polypeptide 5
            (Gtf2h5), transcript variant 1, mRNA.
ACCESSION   NM_181392
VERSION     NM_181392.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1191)
  AUTHORS   Jiang,X., Cheng,Y., Zhu,Y., Xu,C., Li,Q., Xing,X., Li,W., Zou,J.,
            Meng,L., Azhar,M., Cao,Y., Tong,X., Qin,W., Zhu,X. and Bao,J.
  TITLE     Maternal NAT10 orchestrates oocyte meiotic cell-cycle progression
            and maturation in mice
  JOURNAL   Nat Commun 14 (1), 3729 (2023)
   PUBMED   37349316
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1191)
  AUTHORS   Pan,W., Song,D., He,W., Lu,H., Lan,Y., Tong,J., Gao,F. and Zhao,K.
  TITLE     The matrix protein of vesicular stomatitis virus inhibits
            host-directed transcription of target genes via interaction with
            the TFIIH subunit p8
  JOURNAL   Vet Microbiol 208, 82-88 (2017)
   PUBMED   28888655
REFERENCE   3  (bases 1 to 1191)
  AUTHORS   Nonnekens,J., Perez-Fernandez,J., Theil,A.F., Gadal,O., Bonnart,C.
            and Giglia-Mari,G.
  TITLE     Mutations in TFIIH causing trichothiodystrophy are responsible for
            defects in ribosomal RNA production and processing
  JOURNAL   Hum Mol Genet 22 (14), 2881-2893 (2013)
   PUBMED   23562818
REFERENCE   4  (bases 1 to 1191)
  AUTHORS   Theil,A.F., Nonnekens,J., Steurer,B., Mari,P.O., de Wit,J.,
            Lemaitre,C., Marteijn,J.A., Raams,A., Maas,A., Vermeij,M.,
            Essers,J., Hoeijmakers,J.H., Giglia-Mari,G. and Vermeulen,W.
  TITLE     Disruption of TTDA results in complete nucleotide excision repair
            deficiency and embryonic lethality
  JOURNAL   PLoS Genet 9 (4), e1003431 (2013)
   PUBMED   23637614
REFERENCE   5  (bases 1 to 1191)
  AUTHORS   Kamileri,I., Karakasilioti,I., Sideri,A., Kosteas,T., Tatarakis,A.,
            Talianidis,I. and Garinis,G.A.
  TITLE     Defective transcription initiation causes postnatal growth failure
            in a mouse model of nucleotide excision repair (NER) progeria
  JOURNAL   Proc Natl Acad Sci U S A 109 (8), 2995-3000 (2012)
   PUBMED   22323595
REFERENCE   6  (bases 1 to 1191)
  AUTHORS   Tang,F., Barbacioru,C., Nordman,E., Bao,S., Lee,C., Wang,X.,
            Tuch,B.B., Heard,E., Lao,K. and Surani,M.A.
  TITLE     Deterministic and stochastic allele specific gene expression in
            single mouse blastomeres
  JOURNAL   PLoS One 6 (6), e21208 (2011)
   PUBMED   21731673
REFERENCE   7  (bases 1 to 1191)
  AUTHORS   Schimenti,J.C., Reynolds,J.L. and Planchart,A.
  TITLE     Mutations in Serac1 or Synj2 cause proximal t haplotype-mediated
            male mouse sterility but not transmission ratio distortion
  JOURNAL   Proc Natl Acad Sci U S A 102 (9), 3342-3347 (2005)
   PUBMED   15722415
REFERENCE   8  (bases 1 to 1191)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            W50582.1, AK003547.1, AK013225.1 and BM940130.1.
            
            On Oct 6, 2007 this sequence version replaced NM_181392.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: W50582.1, SRR1660815.177424.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                W50582.1           1-27
            28-576              AK003547.1         17-565
            577-1165            AK013225.1         541-1129
            1166-1191           BM940130.1         245-270
FEATURES             Location/Qualifiers
     source          1..1191
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 3.7 cM"
     gene            1..1191
                     /gene="Gtf2h5"
                     /gene_synonym="2700017P07Rik; 2810432H05Rik; D17Wsu155e"
                     /note="general transcription factor IIH, polypeptide 5"
                     /db_xref="GeneID:66467"
                     /db_xref="MGI:MGI:107227"
     exon            1..84
                     /gene="Gtf2h5"
                     /gene_synonym="2700017P07Rik; 2810432H05Rik; D17Wsu155e"
                     /inference="alignment:Splign:2.1.0"
     exon            85..157
                     /gene="Gtf2h5"
                     /gene_synonym="2700017P07Rik; 2810432H05Rik; D17Wsu155e"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..338
                     /gene="Gtf2h5"
                     /gene_synonym="2700017P07Rik; 2810432H05Rik; D17Wsu155e"
                     /note="TFB5 ortholog; TFIIH basal transcription factor
                     complex TTD-A subunit; TFIIH subunit p8"
                     /codon_start=1
                     /product="general transcription factor IIH subunit 5"
                     /protein_id="NP_852057.2"
                     /db_xref="CCDS:CCDS37423.1"
                     /db_xref="GeneID:66467"
                     /db_xref="MGI:MGI:107227"
                     /translation="MVNVLKGVLIECDPAMKQFLLYLDEANALGKKFIIQDIDDTHVF
                     VIAELVNVLQERVGELMDQNAFSLTQK"
     exon            158..1174
                     /gene="Gtf2h5"
                     /gene_synonym="2700017P07Rik; 2810432H05Rik; D17Wsu155e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      495..500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtf2h5"
                     /gene_synonym="2700017P07Rik; 2810432H05Rik; D17Wsu155e"
                     /note="hexamer: ATTAAA"
     polyA_site      520
                     /gene="Gtf2h5"
                     /gene_synonym="2700017P07Rik; 2810432H05Rik; D17Wsu155e"
                     /note="major polyA site"
     regulatory      785..790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtf2h5"
                     /gene_synonym="2700017P07Rik; 2810432H05Rik; D17Wsu155e"
                     /note="hexamer: AATACA"
     polyA_site      802
                     /gene="Gtf2h5"
                     /gene_synonym="2700017P07Rik; 2810432H05Rik; D17Wsu155e"
                     /note="major polyA site"
     regulatory      1155..1160
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtf2h5"
                     /gene_synonym="2700017P07Rik; 2810432H05Rik; D17Wsu155e"
                     /note="hexamer: TATAAA"
     polyA_site      1174
                     /gene="Gtf2h5"
                     /gene_synonym="2700017P07Rik; 2810432H05Rik; D17Wsu155e"
ORIGIN      
        1 cgcaggcgca gtgagtcggc gacgccgggc cagctctggt ttgttggagt tggaacgctg
       61 ctgcctctgc gcgcctagaa aaagaattct tgaagtcatc tgcaccgtct gcctgggaaa
      121 agatggtcaa cgtgctgaaa ggggtgctta tagaatgtga ccctgccatg aagcagttct
      181 tgctgtactt ggatgaggcc aacgccttgg ggaagaagtt catcattcag gacattgatg
      241 acacgcacgt cttcgtcatt gccgagctgg tcaacgtcct ccaggagcga gtaggggaac
      301 tgatggacca gaatgccttt tctcttaccc agaagtgaga gcgctggtgt tgagcacttg
      361 ggaatcccag ccacagacac ttgagagagg ccagctcagt gtctcgtggg gtttatactt
      421 gttatgagca tgtcgtggga aaggctgcag ggtcattcat tcagatgaaa gcccctaact
      481 gatttggttg gaccattaaa aaaaaaatat gtgtacagaa gaactttagc tgcaatttgg
      541 ctttttaagt gttatttgtt attaaaatgt aatcataatt gtgctggtga gatggctcag
      601 ttggtaaagg tccttgccac taagcctgac agcctgaata taatcccagg ggcctacaca
      661 ctggaagggg agaactctac aggctgttgt ctgacctgtg tgtgtgtagc tccctcccac
      721 acaaatacgg aaatataaga aaatgaaatc ataaatgttt ttcctacctt cttagaacca
      781 attaaataca ccagaaaaat aatggagttt ggttaaatta tccttttacc ctgggtatta
      841 ttaatttttg cttgttcctg ttaacgaatg tgcatttttt ttgtactgtg gagttagaaa
      901 ccagtgggaa agagagagaa acattgcttt gcatctttag ttttcccttt ttcacactat
      961 tggtcacgtt ttcctatcaa ggcaggtact ccttgatagt gcaaggtaca gcaaaagtgt
     1021 atgtgtgtaa ctaacaggtg ggaagatacc tgcaattatg cttaatattt atagagatta
     1081 cggttggaag atttgcatgt gtgtgaactc ttacattgtc tgaaactatt aatgtatatc
     1141 aacaaaatac ataatataaa ggttcaaaca aaaaaaaaaa aaaaaaaaaa a
//
