LOCUS       NM_001357804            1261 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus general transcription factor IIH, polypeptide 5
            (Gtf2h5), transcript variant 2, mRNA.
ACCESSION   NM_001357804 XM_006523239
VERSION     NM_001357804.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1261)
  AUTHORS   Jiang,X., Cheng,Y., Zhu,Y., Xu,C., Li,Q., Xing,X., Li,W., Zou,J.,
            Meng,L., Azhar,M., Cao,Y., Tong,X., Qin,W., Zhu,X. and Bao,J.
  TITLE     Maternal NAT10 orchestrates oocyte meiotic cell-cycle progression
            and maturation in mice
  JOURNAL   Nat Commun 14 (1), 3729 (2023)
   PUBMED   37349316
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1261)
  AUTHORS   Pan,W., Song,D., He,W., Lu,H., Lan,Y., Tong,J., Gao,F. and Zhao,K.
  TITLE     The matrix protein of vesicular stomatitis virus inhibits
            host-directed transcription of target genes via interaction with
            the TFIIH subunit p8
  JOURNAL   Vet Microbiol 208, 82-88 (2017)
   PUBMED   28888655
REFERENCE   3  (bases 1 to 1261)
  AUTHORS   Nonnekens,J., Perez-Fernandez,J., Theil,A.F., Gadal,O., Bonnart,C.
            and Giglia-Mari,G.
  TITLE     Mutations in TFIIH causing trichothiodystrophy are responsible for
            defects in ribosomal RNA production and processing
  JOURNAL   Hum Mol Genet 22 (14), 2881-2893 (2013)
   PUBMED   23562818
REFERENCE   4  (bases 1 to 1261)
  AUTHORS   Theil,A.F., Nonnekens,J., Steurer,B., Mari,P.O., de Wit,J.,
            Lemaitre,C., Marteijn,J.A., Raams,A., Maas,A., Vermeij,M.,
            Essers,J., Hoeijmakers,J.H., Giglia-Mari,G. and Vermeulen,W.
  TITLE     Disruption of TTDA results in complete nucleotide excision repair
            deficiency and embryonic lethality
  JOURNAL   PLoS Genet 9 (4), e1003431 (2013)
   PUBMED   23637614
REFERENCE   5  (bases 1 to 1261)
  AUTHORS   Kamileri,I., Karakasilioti,I., Sideri,A., Kosteas,T., Tatarakis,A.,
            Talianidis,I. and Garinis,G.A.
  TITLE     Defective transcription initiation causes postnatal growth failure
            in a mouse model of nucleotide excision repair (NER) progeria
  JOURNAL   Proc Natl Acad Sci U S A 109 (8), 2995-3000 (2012)
   PUBMED   22323595
REFERENCE   6  (bases 1 to 1261)
  AUTHORS   Tang,F., Barbacioru,C., Nordman,E., Bao,S., Lee,C., Wang,X.,
            Tuch,B.B., Heard,E., Lao,K. and Surani,M.A.
  TITLE     Deterministic and stochastic allele specific gene expression in
            single mouse blastomeres
  JOURNAL   PLoS One 6 (6), e21208 (2011)
   PUBMED   21731673
REFERENCE   7  (bases 1 to 1261)
  AUTHORS   Schimenti,J.C., Reynolds,J.L. and Planchart,A.
  TITLE     Mutations in Serac1 or Synj2 cause proximal t haplotype-mediated
            male mouse sterility but not transmission ratio distortion
  JOURNAL   Proc Natl Acad Sci U S A 102 (9), 3342-3347 (2005)
   PUBMED   15722415
REFERENCE   8  (bases 1 to 1261)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154650.2, AK012257.1 and BM940130.1.
            
            On Nov 10, 2017 this sequence version replaced XM_006523239.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK012257.1, CD241002.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC154650.2         77356-77364         c
            10-888              AK012257.1         2-880
            889-1120            AC154650.2         71921-72152         c
            1121-1261           BM940130.1         130-270
FEATURES             Location/Qualifiers
     source          1..1261
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 3.7 cM"
     gene            1..1261
                     /gene="Gtf2h5"
                     /gene_synonym="2700017P07Rik; 2810432H05Rik; D17Wsu155e"
                     /note="general transcription factor IIH, polypeptide 5"
                     /db_xref="GeneID:66467"
                     /db_xref="MGI:MGI:107227"
     exon            1..154
                     /gene="Gtf2h5"
                     /gene_synonym="2700017P07Rik; 2810432H05Rik; D17Wsu155e"
                     /inference="alignment:Splign:2.1.0"
     exon            155..227
                     /gene="Gtf2h5"
                     /gene_synonym="2700017P07Rik; 2810432H05Rik; D17Wsu155e"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..408
                     /gene="Gtf2h5"
                     /gene_synonym="2700017P07Rik; 2810432H05Rik; D17Wsu155e"
                     /note="TFB5 ortholog; TFIIH basal transcription factor
                     complex TTD-A subunit; TFIIH subunit p8"
                     /codon_start=1
                     /product="general transcription factor IIH subunit 5"
                     /protein_id="NP_001344733.1"
                     /db_xref="CCDS:CCDS37423.1"
                     /db_xref="GeneID:66467"
                     /db_xref="MGI:MGI:107227"
                     /translation="MVNVLKGVLIECDPAMKQFLLYLDEANALGKKFIIQDIDDTHVF
                     VIAELVNVLQERVGELMDQNAFSLTQK"
     exon            228..1244
                     /gene="Gtf2h5"
                     /gene_synonym="2700017P07Rik; 2810432H05Rik; D17Wsu155e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      565..570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtf2h5"
                     /gene_synonym="2700017P07Rik; 2810432H05Rik; D17Wsu155e"
                     /note="hexamer: ATTAAA"
     polyA_site      590
                     /gene="Gtf2h5"
                     /gene_synonym="2700017P07Rik; 2810432H05Rik; D17Wsu155e"
                     /note="major polyA site"
     regulatory      855..860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtf2h5"
                     /gene_synonym="2700017P07Rik; 2810432H05Rik; D17Wsu155e"
                     /note="hexamer: AATACA"
     polyA_site      872
                     /gene="Gtf2h5"
                     /gene_synonym="2700017P07Rik; 2810432H05Rik; D17Wsu155e"
                     /note="major polyA site"
     regulatory      1225..1230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtf2h5"
                     /gene_synonym="2700017P07Rik; 2810432H05Rik; D17Wsu155e"
                     /note="hexamer: TATAAA"
     polyA_site      1244
                     /gene="Gtf2h5"
                     /gene_synonym="2700017P07Rik; 2810432H05Rik; D17Wsu155e"
ORIGIN      
        1 gtggggctcg gctgcctcgg agataaggcg gggaagagga aagacacaga gccttcggtc
       61 ctgtgggcgg gccgaagtcc cgcacccttt ctaaggcctg tgttgtgggt ccgcgcggcc
      121 atcacgcatt gcatcgcggt tttctgtggg gaagaattct tgaagtcatc tgcaccgtct
      181 gcctgggaaa agatggtcaa cgtgctgaaa ggggtgctta tagaatgtga ccctgccatg
      241 aagcagttct tgctgtactt ggatgaggcc aacgccttgg ggaagaagtt catcattcag
      301 gacattgatg acacgcacgt cttcgtcatt gccgagctgg tcaacgtcct ccaggagcga
      361 gtaggggaac tgatggacca gaatgccttt tctcttaccc agaagtgaga gcgctggtgt
      421 tgagcacttg ggaatcccag ccacagacac ttgagagagg ccagctcagt gtctcgtggg
      481 gtttatactt gttatgagca tgtcgtggga aaggctgcag ggtcattcat tcagatgaaa
      541 gcccctaact gatttggttg gaccattaaa aaaaaaatat gtgtacagaa gaactttagc
      601 tgcaatttgg ctttttaagt gttatttgtt attaaaatgt aatcataatt gtgctggtga
      661 gatggctcag ttggtaaagg tccttgccac taagcctgac agcctgaata taatcccagg
      721 ggcctacaca ctggaagggg agaactctac aggctgttgt ctgacctgtg tgtgtgtagc
      781 tccctcccac acaaatacgg aaatataaga aaatgaaatc ataaatgttt ttcctacctt
      841 cttagaacca attaaataca ccagaaaaat aatggagttt ggttaaatta tccttttacc
      901 ctgggtatta ttaatttttg cttgttcctg ttaacgaatg tgcatttttt ttgtactgtg
      961 gagttagaaa ccagtgggaa agagagagaa acattgcttt gcatctttag ttttcccttt
     1021 ttcacactat tggtcacgtt ttcctatcaa ggcaggtact ccttgatagt gcaaggtaca
     1081 gcaaaagtgt atgtgtgtaa ctaacaggtg ggaagatacc tgcaattatg cttaatattt
     1141 atagagatta cggttggaag atttgcatgt gtgtgaactc ttacattgtc tgaaactatt
     1201 aatgtatatc aacaaaatac ataatataaa ggttcaaaca aaaaaaaaaa aaaaaaaaaa
     1261 a
//
