LOCUS       NM_001413326            1694 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus general transcription factor II H, polypeptide 4
            (Gtf2h4), transcript variant 2, mRNA.
ACCESSION   NM_001413326 XM_006523668
VERSION     NM_001413326.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1694)
  AUTHORS   Bedez,F., Linard,B., Brochet,X., Ripp,R., Thompson,J.D., Moras,D.,
            Lecompte,O. and Poch,O.
  TITLE     Functional insights into the core-TFIIH from a comparative survey
  JOURNAL   Genomics 101 (3), 178-186 (2013)
   PUBMED   23147676
REFERENCE   2  (bases 1 to 1694)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1694)
  AUTHORS   Kamileri,I., Karakasilioti,I., Sideri,A., Kosteas,T., Tatarakis,A.,
            Talianidis,I. and Garinis,G.A.
  TITLE     Defective transcription initiation causes postnatal growth failure
            in a mouse model of nucleotide excision repair (NER) progeria
  JOURNAL   Proc Natl Acad Sci U S A 109 (8), 2995-3000 (2012)
   PUBMED   22323595
REFERENCE   4  (bases 1 to 1694)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   5  (bases 1 to 1694)
  AUTHORS   Le May,N., Dubaele,S., Proietti De Santis,L., Billecocq,A.,
            Bouloy,M. and Egly,J.M.
  TITLE     TFIIH transcription factor, a target for the Rift Valley
            hemorrhagic fever virus
  JOURNAL   Cell 116 (4), 541-550 (2004)
   PUBMED   14980221
REFERENCE   6  (bases 1 to 1694)
  AUTHORS   Lanning,D. and Lafuse,W.P.
  TITLE     The mouse p52 subunit of the transcription/DNA repair factor TFIIH
            is located in the class III region of the H2 complex: cloning and
            sequence polymorphism
  JOURNAL   Immunogenetics 49 (6), 498-504 (1999)
   PUBMED   10380693
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974483.16.
            
            On Oct 31, 2022 this sequence version replaced XM_006523668.4.
            
            Summary: This gene encodes a subunit of the general transcription
            factor multiprotein complex that plays roles in basal
            transcription, DNA repair and cell cycle control. [provided by
            RefSeq, Dec 2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422603.495081.1,
                                           SRR13422601.210244.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               CR974483.16        21255-21455         c
            202-344             CR974483.16        20426-20568         c
            345-449             CR974483.16        19733-19837         c
            450-581             CR974483.16        18966-19097         c
            582-678             CR974483.16        18606-18702         c
            679-767             CR974483.16        18397-18485         c
            768-879             CR974483.16        18105-18216         c
            880-948             CR974483.16        17930-17998         c
            949-1032            CR974483.16        17688-17771         c
            1033-1165           CR974483.16        17369-17501         c
            1166-1296           CR974483.16        17049-17179         c
            1297-1344           CR974483.16        16350-16397         c
            1345-1423           CR974483.16        16168-16246         c
            1424-1694           CR974483.16        15472-15742         c
FEATURES             Location/Qualifiers
     source          1..1694
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.7 cM"
     gene            1..1694
                     /gene="Gtf2h4"
                     /gene_synonym="BTF2 p52; p52"
                     /note="general transcription factor II H, polypeptide 4"
                     /db_xref="GeneID:14885"
                     /db_xref="MGI:MGI:1338799"
     exon            1..201
                     /gene="Gtf2h4"
                     /gene_synonym="BTF2 p52; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            202..344
                     /gene="Gtf2h4"
                     /gene_synonym="BTF2 p52; p52"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..1596
                     /gene="Gtf2h4"
                     /gene_synonym="BTF2 p52; p52"
                     /note="isoform 1 is encoded by transcript variant 2;
                     general transcription factor IIH subunit 4; basic
                     transcription factor 2 52 kDa subunit; TFIIH basal
                     transcription factor complex p52 subunit"
                     /codon_start=1
                     /product="general transcription factor IIH subunit 4
                     isoform 1"
                     /protein_id="NP_001400255.1"
                     /db_xref="GeneID:14885"
                     /db_xref="MGI:MGI:1338799"
                     /translation="MEITPARGGLNRAHLQCRNLQEFLGGLSPGVLDRLYGHPATCLA
                     VFRELPSLAKNWVMRMLFLEQPLPQAAVALWVKKEFSKAQEESTGLLSGLRIWHTQLL
                     PGGLQGLILNPVFRQNLRIALLGGGKAWSDDTSQLGPDKHARDVPSLDKYAEERWEVV
                     LHFMVGSPSAAVSQDLAQLLSQAGLMKSTEPGEPPCITSAGFQFLLLDTPAQLWYFML
                     QYLQTAQSRGMDLVEILSFLFQLSFSTLGKDYSVEGMSDSLLNFLQHLREFGLVFQRK
                     RKSRRYYPTRLAINLSSGVSGAGGTVHQPGFIVVETNYRLYAYTESELQIALIALFSE
                     MLYRFPNMVVAQVTRESVQQAIASGITAQQIIHFLRTRAHPVMLKQNPVLPPTITDQI
                     RLWELERDRLRFTEGVLYNQFLSQVDFELLLAHARELGVLVFENSAKRLMVVTPAGHS
                     DVKRFWKRQKHSS"
     exon            345..449
                     /gene="Gtf2h4"
                     /gene_synonym="BTF2 p52; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            450..581
                     /gene="Gtf2h4"
                     /gene_synonym="BTF2 p52; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            582..678
                     /gene="Gtf2h4"
                     /gene_synonym="BTF2 p52; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            679..767
                     /gene="Gtf2h4"
                     /gene_synonym="BTF2 p52; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            768..879
                     /gene="Gtf2h4"
                     /gene_synonym="BTF2 p52; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            880..948
                     /gene="Gtf2h4"
                     /gene_synonym="BTF2 p52; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1032
                     /gene="Gtf2h4"
                     /gene_synonym="BTF2 p52; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1165
                     /gene="Gtf2h4"
                     /gene_synonym="BTF2 p52; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1296
                     /gene="Gtf2h4"
                     /gene_synonym="BTF2 p52; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1344
                     /gene="Gtf2h4"
                     /gene_synonym="BTF2 p52; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1423
                     /gene="Gtf2h4"
                     /gene_synonym="BTF2 p52; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1694
                     /gene="Gtf2h4"
                     /gene_synonym="BTF2 p52; p52"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1675..1680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtf2h4"
                     /gene_synonym="BTF2 p52; p52"
                     /note="hexamer: AATAAA"
     polyA_site      1686
                     /gene="Gtf2h4"
                     /gene_synonym="BTF2 p52; p52"
     polyA_site      1694
                     /gene="Gtf2h4"
                     /gene_synonym="BTF2 p52; p52"
                     /note="major polyA site"
ORIGIN      
        1 gacacatttc tctgctctcc cttctctttg gactgcttat tgactgggtc ctgtctgtga
       61 agttcttcgt ggttctccca ccttttagaa ttctcatcct ttatttccag gagccaatgc
      121 gagacattag cactgattag gcgacggctg gtgacccggg gtgcgcgagg gggagccgag
      181 tggtgagggg gtttgagaag ggtgatggag atcaccccgg cgaggggtgg actgaaccga
      241 gcacacctac aatgcaggaa tctccaggag ttcttaggag gcctgagccc tggggtgctg
      301 gaccgattgt atgggcaccc tgccacttgt ctggctgtct tcagggagct cccctctttg
      361 gctaagaact gggtcatgag gatgctcttt ctggagcagc cgctaccaca ggctgcggtg
      421 gccctgtggg tgaagaagga gttcagcaag gctcaggagg aaagtacggg gctgctgagt
      481 ggcctccgta tctggcatac ccagctgctc cctggtggac tccaaggcct catcttgaac
      541 cccgtcttcc gccagaacct ccgaattgcc cttctgggtg ggggcaaggc ctggtctgat
      601 gacacaagtc agctgggacc agacaagcat gcccgggacg tcccctcact ggacaagtat
      661 gctgaggagc gctgggaggt ggtcttgcac ttcatggtgg gctcccccag tgcagctgtc
      721 agccaagacc tggctcagct cctcagccag gccgggctta tgaaaagcac tgaacctgga
      781 gagccaccct gcatcacttc cgctggcttc cagttcctgc tactggacac gcctgcccag
      841 ctctggtact tcatgctgca gtatctgcag acagcccaga gccggggcat ggatctggtg
      901 gagattctct ccttcctttt ccagctcagc ttctccactc ttggcaagga ctactctgtg
      961 gaggggatga gtgactcttt gttgaacttc ctgcaacacc tgcgtgagtt cgggcttgtt
     1021 ttccagagga agaggaagtc ccggcgttac taccccacac gcctggccat caacctctca
     1081 tctggtgtct ctggggctgg gggcactgtg caccagccag gcttcattgt cgtggaaact
     1141 aattaccgac tgtacgccta taccgagtcg gaactgcaga tcgctctcat tgcccttttc
     1201 tccgaaatgc tctatcgatt ccccaacatg gtggtggcac aagtgacccg ggagagtgtg
     1261 cagcaggcca ttgctagtgg catcacagct cagcagataa tccatttcct aaggacaagg
     1321 gcacatccag tgatgctcaa acagaatcct gtgctgcccc ccaccataac agaccagatt
     1381 cggctgtggg agctggaaag ggacagactc cggttcactg aaggcgtcct gtataaccag
     1441 ttcctgtcgc aagtggactt tgaactgctg ctggcccacg cgcgggagct gggcgtgctt
     1501 gtgttcgaga actcggccaa gcggctgatg gtggtgacgc cggcagggca cagcgacgtc
     1561 aagcgcttct ggaagcggca gaagcacagc tcctgagccg gccaggtcca gccccgggcg
     1621 ggcagctttc caactcagat gtattttgtt tacacaccgg gatatttctt gtttaataaa
     1681 attatggaaa aaaa
//
