LOCUS       NM_181410               2664 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus general transcription factor IIH, polypeptide 3
            (Gtf2h3), mRNA.
ACCESSION   NM_181410
VERSION     NM_181410.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2664)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2664)
  AUTHORS   Gervais,V., Muller,I., Mari,P.O., Mourcet,A., Movellan,K.T.,
            Ramos,P., Marcoux,J., Guillet,V., Javaid,S., Burlet-Schiltz,O.,
            Czaplicki,G., Milon,A. and Giglia-Mari,G.
  TITLE     Small molecule-based targeting of TTD-A dimerization to control
            TFIIH transcriptional activity represents a potential strategy for
            anticancer therapy
  JOURNAL   J Biol Chem 293 (39), 14974-14988 (2018)
   PUBMED   30068551
  REMARK    GeneRIF: Using quantitative imaging of TFIIH in living mouse cells,
            we found that these molecules reduce the intracellular
            concentration of TFIIH and its transcriptional activity to levels
            similar to that observed in individuals with trichothiodystrophy
            owing to mutated TTD-A
REFERENCE   3  (bases 1 to 2664)
  AUTHORS   Traboulsi,H., Davoli,S., Catez,P., Egly,J.M. and Compe,E.
  TITLE     Dynamic partnership between TFIIH, PGC-1alpha and SIRT1 is impaired
            in trichothiodystrophy
  JOURNAL   PLoS Genet 10 (10), e1004732 (2014)
   PUBMED   25340339
  REMARK    GeneRIF: extensive molecular analyses unveiled that wild-type TFIIH
            cooperated in an ATP-dependent manner with PGC1-alpha as well as
            with the deacetylase SIRT1, thereby contributing to the PGC1-a
            deacetylation by SIRT1
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2664)
  AUTHORS   Nonnekens,J., Perez-Fernandez,J., Theil,A.F., Gadal,O., Bonnart,C.
            and Giglia-Mari,G.
  TITLE     Mutations in TFIIH causing trichothiodystrophy are responsible for
            defects in ribosomal RNA production and processing
  JOURNAL   Hum Mol Genet 22 (14), 2881-2893 (2013)
   PUBMED   23562818
  REMARK    GeneRIF: Mutations in TFIIH causing trichothiodystrophy are
            responsible for defects in ribosomal RNA production and processing.
REFERENCE   5  (bases 1 to 2664)
  AUTHORS   Kamileri,I., Karakasilioti,I., Sideri,A., Kosteas,T., Tatarakis,A.,
            Talianidis,I. and Garinis,G.A.
  TITLE     Defective transcription initiation causes postnatal growth failure
            in a mouse model of nucleotide excision repair (NER) progeria
  JOURNAL   Proc Natl Acad Sci U S A 109 (8), 2995-3000 (2012)
   PUBMED   22323595
REFERENCE   6  (bases 1 to 2664)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 2664)
  AUTHORS   Compe,E., Malerba,M., Soler,L., Marescaux,J., Borrelli,E. and
            Egly,J.M.
  TITLE     Neurological defects in trichothiodystrophy reveal a coactivator
            function of TFIIH
  JOURNAL   Nat Neurosci 10 (11), 1414-1422 (2007)
   PUBMED   17952069
  REMARK    GeneRIF: Molecular analyses performed on the mice brain tissue
            demonstrate that TFIIH is required for the stabilization of thyroid
            hormone receptors (TR) to their DNA-responsive elements.
REFERENCE   8  (bases 1 to 2664)
  AUTHORS   Yoshikawa,T., Piao,Y., Zhong,J., Matoba,R., Carter,M.G., Wang,Y.,
            Goldberg,I. and Ko,M.S.
  TITLE     High-throughput screen for genes predominantly expressed in the ICM
            of mouse blastocysts by whole mount in situ hybridization
  JOURNAL   Gene Expr Patterns 6 (2), 213-224 (2006)
   PUBMED   16325481
REFERENCE   9  (bases 1 to 2664)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2664)
  AUTHORS   De Graeve,F., Bahr,A., Chatton,B. and Kedinger,C.
  TITLE     A murine ATFa-associated factor with transcriptional repressing
            activity
  JOURNAL   Oncogene 19 (14), 1807-1819 (2000)
   PUBMED   10777215
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB637936.1, AK133941.1 and AK050227.1.
            
            On Sep 19, 2009 this sequence version replaced NM_181410.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017515.1, AK133941.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BB637936.1         9-38
            31-1108             AK133941.1         2-1079
            1109-2664           AK050227.1         1094-2649
FEATURES             Location/Qualifiers
     source          1..2664
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 63.67 cM"
     gene            1..2664
                     /gene="Gtf2h3"
                     /gene_synonym="34kDa; 5033417D07Rik; BTF2; BTF2 p34;
                     C730029A10; D5Ertd679e; TFIIH"
                     /note="general transcription factor IIH, polypeptide 3"
                     /db_xref="GeneID:209357"
                     /db_xref="MGI:MGI:1277143"
     exon            1..54
                     /gene="Gtf2h3"
                     /gene_synonym="34kDa; 5033417D07Rik; BTF2; BTF2 p34;
                     C730029A10; D5Ertd679e; TFIIH"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..971
                     /gene="Gtf2h3"
                     /gene_synonym="34kDa; 5033417D07Rik; BTF2; BTF2 p34;
                     C730029A10; D5Ertd679e; TFIIH"
                     /note="general transcription factor IIH, polypeptide 3,
                     34kDa; BTF2-p34; basic transcription factor 2 34 kDa
                     subunit; TFIIH basal transcription factor complex p34
                     subunit"
                     /codon_start=1
                     /product="general transcription factor IIH subunit 3"
                     /protein_id="NP_852075.1"
                     /db_xref="CCDS:CCDS19680.1"
                     /db_xref="GeneID:209357"
                     /db_xref="MGI:MGI:1277143"
                     /translation="MAADEDELNLLVIIVDTNPIWWGKQALKESQFTLSKCMDAVMVL
                     ANSHLFMNRSNQLAVIASHIQESRLLYPGKNGGLGDFFGDPGNALPDCNPSGSKDGKY
                     ELLTVANEVIAEEIKDLMTKSDIKGQHTETLLAGSLAKALCYIHRVNKAVKDNQEMKS
                     RILVIKAAEDSALQYMNFMNVIFAAQKQNILIDACVLDSDSGLLQQACDITGGLYLKV
                     PQMPSLLQYLLWVFLPDQDQRSQLILPPPIHVDYRAACFCHRSLIEIGYVCSVCLSIF
                     CNFSPICTTCETAFKISLPPVLKAKKKKQKVSL"
     exon            55..134
                     /gene="Gtf2h3"
                     /gene_synonym="34kDa; 5033417D07Rik; BTF2; BTF2 p34;
                     C730029A10; D5Ertd679e; TFIIH"
                     /inference="alignment:Splign:2.1.0"
     exon            135..241
                     /gene="Gtf2h3"
                     /gene_synonym="34kDa; 5033417D07Rik; BTF2; BTF2 p34;
                     C730029A10; D5Ertd679e; TFIIH"
                     /inference="alignment:Splign:2.1.0"
     exon            242..408
                     /gene="Gtf2h3"
                     /gene_synonym="34kDa; 5033417D07Rik; BTF2; BTF2 p34;
                     C730029A10; D5Ertd679e; TFIIH"
                     /inference="alignment:Splign:2.1.0"
     exon            409..471
                     /gene="Gtf2h3"
                     /gene_synonym="34kDa; 5033417D07Rik; BTF2; BTF2 p34;
                     C730029A10; D5Ertd679e; TFIIH"
                     /inference="alignment:Splign:2.1.0"
     exon            472..501
                     /gene="Gtf2h3"
                     /gene_synonym="34kDa; 5033417D07Rik; BTF2; BTF2 p34;
                     C730029A10; D5Ertd679e; TFIIH"
                     /inference="alignment:Splign:2.1.0"
     exon            502..530
                     /gene="Gtf2h3"
                     /gene_synonym="34kDa; 5033417D07Rik; BTF2; BTF2 p34;
                     C730029A10; D5Ertd679e; TFIIH"
                     /inference="alignment:Splign:2.1.0"
     exon            531..605
                     /gene="Gtf2h3"
                     /gene_synonym="34kDa; 5033417D07Rik; BTF2; BTF2 p34;
                     C730029A10; D5Ertd679e; TFIIH"
                     /inference="alignment:Splign:2.1.0"
     exon            606..659
                     /gene="Gtf2h3"
                     /gene_synonym="34kDa; 5033417D07Rik; BTF2; BTF2 p34;
                     C730029A10; D5Ertd679e; TFIIH"
                     /inference="alignment:Splign:2.1.0"
     exon            660..728
                     /gene="Gtf2h3"
                     /gene_synonym="34kDa; 5033417D07Rik; BTF2; BTF2 p34;
                     C730029A10; D5Ertd679e; TFIIH"
                     /inference="alignment:Splign:2.1.0"
     exon            729..864
                     /gene="Gtf2h3"
                     /gene_synonym="34kDa; 5033417D07Rik; BTF2; BTF2 p34;
                     C730029A10; D5Ertd679e; TFIIH"
                     /inference="alignment:Splign:2.1.0"
     exon            865..901
                     /gene="Gtf2h3"
                     /gene_synonym="34kDa; 5033417D07Rik; BTF2; BTF2 p34;
                     C730029A10; D5Ertd679e; TFIIH"
                     /inference="alignment:Splign:2.1.0"
     exon            902..2664
                     /gene="Gtf2h3"
                     /gene_synonym="34kDa; 5033417D07Rik; BTF2; BTF2 p34;
                     C730029A10; D5Ertd679e; TFIIH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1801..1806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtf2h3"
                     /gene_synonym="34kDa; 5033417D07Rik; BTF2; BTF2 p34;
                     C730029A10; D5Ertd679e; TFIIH"
                     /note="hexamer: AATAAA"
     polyA_site      1825
                     /gene="Gtf2h3"
                     /gene_synonym="34kDa; 5033417D07Rik; BTF2; BTF2 p34;
                     C730029A10; D5Ertd679e; TFIIH"
                     /note="major polyA site"
ORIGIN      
        1 cttggcccgt gggcggcgct tcacggaggc gtagggaagc aatggccgct gacgaagatg
       61 agttgaacct tctggtgatc atagttgaca ccaacccgat ttggtgggga aagcaagcat
      121 taaaggaatc tcagtttact ttatccaaat gcatggatgc agtgatggtg ctggcgaatt
      181 ctcacctgtt catgaaccgc tccaaccagc tggctgtcat cgccagtcac attcaggaaa
      241 gccggctctt atacccgggg aagaacggtg gacttggaga cttcttcgga gaccctggca
      301 atgcgctccc cgactgtaac ccctctggga gtaaagatgg gaaatacgag ctgttgacag
      361 ttgcaaacga ggtgatcgct gaggagatca aggatctgat gaccaagagt gacatcaagg
      421 gccagcatac ggagacacta ctggcaggat ccctggccaa agctctgtgc tacattcaca
      481 gagtgaacaa ggcagttaaa gataatcagg agatgaaatc aaggattttg gtgatcaagg
      541 ctgcagagga cagcgcactg cagtacatga acttcatgaa cgtcatcttt gctgctcaga
      601 agcagaatat cctcatcgac gcctgcgtgc tggactcgga ttcagggctc ctccagcagg
      661 cttgtgacat cactggggga ctgtacctga aggtgcctca gatgccttct ctcctgcagt
      721 acttactgtg ggtttttctt ccggaccaag atcagcggtc tcagctaatc ctcccacccc
      781 cgatccacgt ggactacagg gctgcctgct tctgtcatcg cagtctcatt gagattggct
      841 atgtctgctc tgtgtgtctg tctattttct gcaatttcag ccccatctgc accacgtgcg
      901 agacagcttt taagatctcc ctccctcctg tgctgaaggc caagaagaag aaacagaagg
      961 tgtccctgtg accagcgcca caggcttccc cagctcgtcc cacaggctga ctctgtaggg
     1021 agcatggagg aattctttga aacactgctc ttgccctgtg cttccagggt gtgaagctgc
     1081 agaggaccca cacctccgat ttctctggga agggggacag gtgtacttat ttgttgttgt
     1141 agggtagcag ttgcctggca gatgctaagc tgttgctgtt ttgttgtcgc tttgattttg
     1201 gtgctgggtt ttgaagccca gccttgcagg agccaggccg gcagccccgc actgagctgc
     1261 agtcagctcc ctgggactct ctgttcagat gatcctctgt cagcgcttat ggcggatgct
     1321 gggtcttctg cacttcagga ttggtagtgt gtgaagttgg atgccatttg ggaagatgac
     1381 cagcattggg tcacggcagc agtcataaca gagcatctta gttgctcatg gtacactgct
     1441 agaaccttga acctgggagg ctgagacagg aaagttttgg gttcagatcc tgcctgggat
     1501 gtgtagaaga tcctggcttt tttttttttt ttaaagaaca ttttacttaa aataaattgt
     1561 ttcctttaac tatactcaac tgtaacctga gctaaaggca caagccttca gtctcagcac
     1621 tcagggagca gagacaggtg tatctctgag tttgaggcca gcctggtcta cagagggagt
     1681 tcaaaccaac cagggttgca tcttgccacc ttttttacaa aaatataaaa actagtaaca
     1741 ttaacattgg agaacttttg aatactagac atgtaaatga gaaacatttg taatctcaac
     1801 aataaaaatc ctatttttat atttactaat tttccttaga gtgtttttct aactatttgc
     1861 attgagtagt ttttcttaaa attactaaga gctgtgggat ggtggtggtg cacaacttta
     1921 gtcccagcac tctgtgagat caaggccaga gctggtctac agtacaagtc ctaggacagc
     1981 acagagaaac cctgctcttc cagaagatcc aggttcaatt cccagcaccc acatatgagc
     2041 tcacaactat gtgtaactcc agttctaagg aatcggatgc cccctttttg gcctctacag
     2101 gcaccaagca caaacagggt gcccagacat tcatgcataa accacaatac acatagacta
     2161 aagatgaaaa gaaaatcagc agtctggcat gacggctcag caggtcttga cgattctcag
     2221 ggcccgagaa ttgtcttcat tcaattctat gtgggactgt ccctgccttt ttacatacaa
     2281 ggagctgagg catagactta ccagagctgg agcctagaag ggcagggcat gaaggtggca
     2341 gtggccatgc agggcttcct gctgttgctc tgggggccac tgctgatcac atgactgtgg
     2401 cctgagatgg cagtgggatg cccaaaccag tttgctgtgc ctagtggaag gtggcagtgg
     2461 caacagatcc acagccactt tactggattc tttggaaggg gaggaccagg tcactccaac
     2521 ctgattcggc ttgcatcccc ctaactggca cggacaccac caccctgtcc catctcctta
     2581 tttaaacatg gatccacact gtcttcttca ggatactgtt gggtttattt tcaactggaa
     2641 ctaataaaac tcaaggcaga tttg
//
