LOCUS       NM_022011               1707 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus general transcription factor II H, polypeptide 2
            (Gtf2h2), transcript variant 1, mRNA.
ACCESSION   NM_022011 XR_105581 XR_106824
VERSION     NM_022011.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1707)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1707)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1707)
  AUTHORS   Kamileri,I., Karakasilioti,I., Sideri,A., Kosteas,T., Tatarakis,A.,
            Talianidis,I. and Garinis,G.A.
  TITLE     Defective transcription initiation causes postnatal growth failure
            in a mouse model of nucleotide excision repair (NER) progeria
  JOURNAL   Proc Natl Acad Sci U S A 109 (8), 2995-3000 (2012)
   PUBMED   22323595
REFERENCE   4  (bases 1 to 1707)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   5  (bases 1 to 1707)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (bases 1 to 1707)
  AUTHORS   Fribourg,S., Kellenberger,E., Rogniaux,H., Poterszman,A., Van
            Dorsselaer,A., Thierry,J.C., Egly,J.M., Moras,D. and Kieffer,B.
  TITLE     Structural characterization of the cysteine-rich domain of TFIIH
            p44 subunit
  JOURNAL   J Biol Chem 275 (41), 31963-31971 (2000)
   PUBMED   10882739
REFERENCE   7  (bases 1 to 1707)
  AUTHORS   Growney,J.D. and Dietrich,W.F.
  TITLE     High-resolution genetic and physical map of the Lgn1 interval in
            C57BL/6J implicates Naip2 or Naip5 in Legionella pneumophila
            pathogenesis
  JOURNAL   Genome Res 10 (8), 1158-1171 (2000)
   PUBMED   10958634
REFERENCE   8  (bases 1 to 1707)
  AUTHORS   Endrizzi,M.G., Hadinoto,V., Growney,J.D., Miller,W. and
            Dietrich,W.F.
  TITLE     Genomic sequence analysis of the mouse Naip gene array
  JOURNAL   Genome Res 10 (8), 1095-1102 (2000)
   PUBMED   10958627
REFERENCE   9  (bases 1 to 1707)
  AUTHORS   Growney,J.D., Scharf,J.M., Kunkel,L.M. and Dietrich,W.F.
  TITLE     Evolutionary divergence of the mouse and human Lgn1/SMA repeat
            structures
  JOURNAL   Genomics 64 (1), 62-81 (2000)
   PUBMED   10708519
REFERENCE   10 (bases 1 to 1707)
  AUTHORS   von Deimling,F., Scharf,J.M., Liehr,T., Rothe,M., Kelter,A.R.,
            Albers,P., Dietrich,W.F., Kunkel,L.M., Wernert,N. and Wirth,B.
  TITLE     Human and mouse RAD17 genes: identification, localization, genomic
            structure and histological expression pattern in normal testis and
            seminoma
  JOURNAL   Hum Genet 105 (1-2), 17-27 (1999)
   PUBMED   10480350
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY277671.1, BC053382.1, DV662169.1 and BY480509.1.
            
            On or before Aug 27, 2011 this sequence version replaced
            XR_105581.1, XR_106824.1, NM_022011.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053382.1, SRR7345562.3129118.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                BY277671.1         1-49
            50-701              BC053382.1         14-665
            702-1007            DV662169.1         442-747
            1008-1663           BC053382.1         972-1627
            1664-1707           BY480509.1         374-417
FEATURES             Location/Qualifiers
     source          1..1707
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 53.21 cM"
     gene            1..1707
                     /gene="Gtf2h2"
                     /gene_synonym="44kDa; BTF2 p44; BTF2-p44; Btf2p44; p44"
                     /note="general transcription factor II H, polypeptide 2"
                     /db_xref="GeneID:23894"
                     /db_xref="MGI:MGI:1345669"
     exon            1..153
                     /gene="Gtf2h2"
                     /gene_synonym="44kDa; BTF2 p44; BTF2-p44; Btf2p44; p44"
                     /inference="alignment:Splign:2.1.0"
     exon            154..242
                     /gene="Gtf2h2"
                     /gene_synonym="44kDa; BTF2 p44; BTF2-p44; Btf2p44; p44"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..1377
                     /gene="Gtf2h2"
                     /gene_synonym="44kDa; BTF2 p44; BTF2-p44; Btf2p44; p44"
                     /note="isoform 1 is encoded by transcript variant 1;
                     general transcription factor IIH, polypeptide 2 (44 kDa
                     subunit); general transcription factor II H, polypeptide 2
                     (44 kDa subunit); general transcription factor IIH subunit
                     2; basic transcription factor 2 44 kDa subunit; TFIIH
                     basal transcription factor complex p44 subunit; basal
                     transcription factor 2, p44 subunit"
                     /codon_start=1
                     /product="general transcription factor IIH subunit 2
                     isoform 1"
                     /protein_id="NP_071294.3"
                     /db_xref="CCDS:CCDS26730.1"
                     /db_xref="GeneID:23894"
                     /db_xref="MGI:MGI:1345669"
                     /translation="MDEEPERTKRWEGGYERTWEILKEDETGSLKATIEDILFKAKRK
                     RVFEHHGQVRLGMMRHLYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPIS
                     QIGIIVTKSKRAEKLTELSGNPRKHITSLKKAVDMTCHGEPSLYNSLSMAMQTLKHMP
                     GHTSREVLIIFSSLTTCDPSNIYDLIKTLKTAKIRVSVIGLSAEVRVCTVLARETGGT
                     YHVILDETHYKELLAHHVSPPPASSSSECSLIRMGFPQHTIASLSDQDAKPSFSMAHL
                     DNNSTEPGLTLGGYFCPQCRAKYCELPVECKICGLTLVSAPHLARSYHHLFPLDAFQE
                     ISLEEYKGERFCYGCQGELKDQHVYVCTVCQNVFCVDCDVFVHDSLHCCPGCIHKIPT
                     PSGI"
     exon            243..320
                     /gene="Gtf2h2"
                     /gene_synonym="44kDa; BTF2 p44; BTF2-p44; Btf2p44; p44"
                     /inference="alignment:Splign:2.1.0"
     exon            321..357
                     /gene="Gtf2h2"
                     /gene_synonym="44kDa; BTF2 p44; BTF2-p44; Btf2p44; p44"
                     /inference="alignment:Splign:2.1.0"
     exon            358..444
                     /gene="Gtf2h2"
                     /gene_synonym="44kDa; BTF2 p44; BTF2-p44; Btf2p44; p44"
                     /inference="alignment:Splign:2.1.0"
     exon            445..495
                     /gene="Gtf2h2"
                     /gene_synonym="44kDa; BTF2 p44; BTF2-p44; Btf2p44; p44"
                     /inference="alignment:Splign:2.1.0"
     exon            496..550
                     /gene="Gtf2h2"
                     /gene_synonym="44kDa; BTF2 p44; BTF2-p44; Btf2p44; p44"
                     /inference="alignment:Splign:2.1.0"
     exon            551..656
                     /gene="Gtf2h2"
                     /gene_synonym="44kDa; BTF2 p44; BTF2-p44; Btf2p44; p44"
                     /inference="alignment:Splign:2.1.0"
     exon            657..747
                     /gene="Gtf2h2"
                     /gene_synonym="44kDa; BTF2 p44; BTF2-p44; Btf2p44; p44"
                     /inference="alignment:Splign:2.1.0"
     exon            748..835
                     /gene="Gtf2h2"
                     /gene_synonym="44kDa; BTF2 p44; BTF2-p44; Btf2p44; p44"
                     /inference="alignment:Splign:2.1.0"
     exon            836..943
                     /gene="Gtf2h2"
                     /gene_synonym="44kDa; BTF2 p44; BTF2-p44; Btf2p44; p44"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1007
                     /gene="Gtf2h2"
                     /gene_synonym="44kDa; BTF2 p44; BTF2-p44; Btf2p44; p44"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1114
                     /gene="Gtf2h2"
                     /gene_synonym="44kDa; BTF2 p44; BTF2-p44; Btf2p44; p44"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1217
                     /gene="Gtf2h2"
                     /gene_synonym="44kDa; BTF2 p44; BTF2-p44; Btf2p44; p44"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1257
                     /gene="Gtf2h2"
                     /gene_synonym="44kDa; BTF2 p44; BTF2-p44; Btf2p44; p44"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1707
                     /gene="Gtf2h2"
                     /gene_synonym="44kDa; BTF2 p44; BTF2-p44; Btf2p44; p44"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1457..1462
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtf2h2"
                     /gene_synonym="44kDa; BTF2 p44; BTF2-p44; Btf2p44; p44"
                     /note="hexamer: AATAAA"
     polyA_site      1487
                     /gene="Gtf2h2"
                     /gene_synonym="44kDa; BTF2 p44; BTF2-p44; Btf2p44; p44"
                     /note="major polyA site"
     regulatory      1570..1575
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtf2h2"
                     /gene_synonym="44kDa; BTF2 p44; BTF2-p44; Btf2p44; p44"
                     /note="hexamer: ATTAAA"
     polyA_site      1590
                     /gene="Gtf2h2"
                     /gene_synonym="44kDa; BTF2 p44; BTF2-p44; Btf2p44; p44"
                     /note="major polyA site"
ORIGIN      
        1 gaattttggc ggcgcactca gactgccggt acttccggtg agggtcgtct cgtcgaggct
       61 ggtgggtcta cgcgaggaga cctgcggggt cctgaggctg tggagggctg gagtgaggcg
      121 gacaggagaa gaagcctgga gctgaggacc gagagttgaa taagcatata tatcattata
      181 agcaccatgg atgaagaacc tgagagaacc aagcggtggg aaggaggcta tgagagaacc
      241 tgggaaattc ttaaagaaga tgaaactgga tcacttaaag ctacaataga agatattctc
      301 ttcaaggcaa agaggaaaag agtgtttgag caccatggac aagtccgact tggaatgatg
      361 cgccacctgt atgtggtggt ggatggatcg agaacaatgg aagatcagga tttaaagccc
      421 aatagactga cttgcacttt aaagttgctg gaatactttg tagaagaata ttttgatcaa
      481 aaccctatca gtcagattgg aataattgta actaagagta aaagagctga aaaactgact
      541 gaactctcag gaaacccaag gaaacatata acatctttga agaaagctgt agatatgacc
      601 tgccatggag aaccatcgct ctataattcc ttaagcatgg ctatgcagac cctaaaacac
      661 atgcctggac atacaagtag agaagtgctc atcatcttca gcagcctcac cacctgtgat
      721 ccatctaata tttacgatct catcaagacc ctgaagacag ctaaaattag agtgtctgtt
      781 attggattat ctgcggaggt tcgagtttgt actgtacttg ctcgtgaaac tggtggcaca
      841 taccatgtta tcttagatga aacccattac aaggagttgt tggcacatca tgtgagcccc
      901 cctcctgcca gctcaagctc cgagtgctca ctcattcgca tgggattccc tcagcatacc
      961 attgcttctt tgtctgatca ggatgcaaaa ccatccttca gcatggcgca tttggataac
     1021 aacagcactg agccagggct tacactggga ggctacttct gcccacagtg ccgagcaaag
     1081 tactgcgagc ttcctgttga atgtaaaata tgtggtctta ctttggtgtc tgcacctcat
     1141 ttggcaagat cttaccatca tttatttcct ttggatgctt ttcaagaaat ttccctagaa
     1201 gaatataaag gagaaaggtt ttgttatgga tgtcaggggg aattgaaaga ccaacatgtc
     1261 tatgtttgca cagtgtgcca aaatgttttt tgtgtggact gtgatgtctt tgttcatgac
     1321 tctctccatt gttgtcctgg ctgtattcat aagatcccaa ctccttcagg tatttaatac
     1381 caatatgaag aacacacaca tcgagtgggt ttaaaaacaa aacaaaagtt gtaactgtaa
     1441 ataaaatgat tctttgaata aagtgattct ctaattaaaa catgaaagca ctttgaaaga
     1501 agatctgatt taagaaactt ttaactatga aaatagagta tttttatttg gattctatca
     1561 ccaatatgca ttaaaattta attaactttg ttttctgtta ttttgagcca tttttattct
     1621 aactcattag tgtgtgtgtg tatacacaca cacacacaca cacatatata gatattactt
     1681 gtaatgatta aattgatgtc ataatct
//
