LOCUS       NM_026816               1524 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus general transcription factor IIF, polypeptide 2
            (Gtf2f2), transcript variant 1, mRNA.
ACCESSION   NM_026816
VERSION     NM_026816.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1524)
  AUTHORS   Kamileri,I., Karakasilioti,I., Sideri,A., Kosteas,T., Tatarakis,A.,
            Talianidis,I. and Garinis,G.A.
  TITLE     Defective transcription initiation causes postnatal growth failure
            in a mouse model of nucleotide excision repair (NER) progeria
  JOURNAL   Proc Natl Acad Sci U S A 109 (8), 2995-3000 (2012)
   PUBMED   22323595
REFERENCE   2  (bases 1 to 1524)
  AUTHORS   Wagner,S.D., Kugel,J.F. and Goodrich,J.A.
  TITLE     TFIIF facilitates dissociation of RNA polymerase II from noncoding
            RNAs that lack a repression domain
  JOURNAL   Mol Cell Biol 30 (1), 91-97 (2010)
   PUBMED   19841064
REFERENCE   3  (bases 1 to 1524)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (bases 1 to 1524)
  AUTHORS   Georgas,K., Rumballe,B., Valerius,M.T., Chiu,H.S.,
            Thiagarajan,R.D., Lesieur,E., Aronow,B.J., Brunskill,E.W.,
            Combes,A.N., Tang,D., Taylor,D., Grimmond,S.M., Potter,S.S.,
            McMahon,A.P. and Little,M.H.
  TITLE     Analysis of early nephron patterning reveals a role for distal RV
            proliferation in fusion to the ureteric tip via a cap
            mesenchyme-derived connecting segment
  JOURNAL   Dev Biol 332 (2), 273-286 (2009)
   PUBMED   19501082
REFERENCE   5  (bases 1 to 1524)
  AUTHORS   Hsu,L.C., Liu,S., Abedinpour,F., Beech,R.D., Lahti,J.M., Kidd,V.J.,
            Greenspan,J.A. and Yeung,C.Y.
  TITLE     The murine G+C-rich promoter binding protein mGPBP is required for
            promoter-specific transcription
  JOURNAL   Mol Cell Biol 23 (23), 8773-8785 (2003)
   PUBMED   14612417
REFERENCE   6  (bases 1 to 1524)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122192.4 and AC140244.3.
            
            On Mar 21, 2023 this sequence version replaced NM_026816.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144858.1, SRR13948564.4559832.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-237               AC122192.4         121872-122108       c
            238-311             AC122192.4         118897-118970       c
            312-330             AC122192.4         108101-108119       c
            331-475             AC122192.4         106613-106757       c
            476-557             AC122192.4         60630-60711         c
            558-657             AC140244.3         4848-4947
            658-801             AC140244.3         15655-15798
            802-1524            AC140244.3         24928-25650
FEATURES             Location/Qualifiers
     source          1..1524
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 40.29 cM"
     gene            1..1524
                     /gene="Gtf2f2"
                     /gene_synonym="1110031C13Rik; TFIIF-beta"
                     /note="general transcription factor IIF, polypeptide 2"
                     /db_xref="GeneID:68705"
                     /db_xref="MGI:MGI:1915955"
     exon            1..237
                     /gene="Gtf2f2"
                     /gene_synonym="1110031C13Rik; TFIIF-beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..921
                     /gene="Gtf2f2"
                     /gene_synonym="1110031C13Rik; TFIIF-beta"
                     /EC_number="3.6.4.12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     general transcription factor IIF subunit 2; ATP-dependent
                     helicase GTF2F2; transcription initiation factor IIF
                     subunit beta"
                     /codon_start=1
                     /product="general transcription factor IIF subunit 2
                     isoform 1"
                     /protein_id="NP_081092.1"
                     /db_xref="CCDS:CCDS36981.1"
                     /db_xref="GeneID:68705"
                     /db_xref="MGI:MGI:1915955"
                     /translation="MAERGELDLTGAKQNTGVWLVKVPKYLSQQWAKASGRGEVGKLR
                     IAKNQGRTEVSFTLNEDLANIHDIGGKPASVSAPREHPFVLQSVGGQTLTVFTESSSD
                     KLSLEGIVVQRAECRPAASENYMKLKRLQIEESSKPVRLSQQLDKVVTTNYKPVANHQ
                     YNIEYERKKKEDGKRARADKQHVLDMLFSAFEKHQYYNLKDLVDITKQPVGYLKEILK
                     EIGIQNVKGIHKNTWELKPEYRHYQTEEKSD"
     exon            238..311
                     /gene="Gtf2f2"
                     /gene_synonym="1110031C13Rik; TFIIF-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            312..330
                     /gene="Gtf2f2"
                     /gene_synonym="1110031C13Rik; TFIIF-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            331..475
                     /gene="Gtf2f2"
                     /gene_synonym="1110031C13Rik; TFIIF-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            476..557
                     /gene="Gtf2f2"
                     /gene_synonym="1110031C13Rik; TFIIF-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            558..657
                     /gene="Gtf2f2"
                     /gene_synonym="1110031C13Rik; TFIIF-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            658..801
                     /gene="Gtf2f2"
                     /gene_synonym="1110031C13Rik; TFIIF-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            802..1524
                     /gene="Gtf2f2"
                     /gene_synonym="1110031C13Rik; TFIIF-beta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1058..1063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtf2f2"
                     /gene_synonym="1110031C13Rik; TFIIF-beta"
                     /note="hexamer: CATAAA"
     polyA_site      1085
                     /gene="Gtf2f2"
                     /gene_synonym="1110031C13Rik; TFIIF-beta"
     regulatory      1495..1500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtf2f2"
                     /gene_synonym="1110031C13Rik; TFIIF-beta"
                     /note="hexamer: AATAAA"
     polyA_site      1524
                     /gene="Gtf2f2"
                     /gene_synonym="1110031C13Rik; TFIIF-beta"
                     /note="major polyA site"
ORIGIN      
        1 attcggcggc gtgttcttct catctaagtt cctggttccc gggctgtgtg cgacgccggc
       61 ttttcgcggt ctacttactc ccttggccgg ctctggactg tcgctctctg cctttcagcg
      121 ccgggaccac tgcttgtgcg cgcactgcac gcctcctcac gcgacaagct catggcggag
      181 cgcggggaac tcgatctgac gggcgccaaa cagaacaccg gcgtgtggct ggtcaaggtt
      241 cctaaatatt tgtcccagca atgggcaaaa gcctctggaa gaggtgaagt tgggaaactg
      301 aggattgcca aaaatcaagg aaggactgag gtatcattta ctttgaacga ggatcttgca
      361 aatattcatg acatcggtgg gaaaccagct tcagtcagtg ctcctagaga acacccattt
      421 gtcttgcaaa gtgttggcgg acagacatta acagtgttta cggagagctc ctcagataaa
      481 ctgtcattgg aaggaatagt ggtgcagaga gcggaatgcc ggcctgctgc cagtgaaaac
      541 tacatgaaat taaagagatt gcaaatagaa gaatcttcga aacctgtaag gctctcacaa
      601 cagctggaca aagttgtgac aaccaattac aagcctgttg ctaaccatca gtacaatatt
      661 gaatatgaaa ggaagaagaa agaggatgga aagcgagctc gggcagacaa acaacacgtc
      721 ctagacatgc tgttctctgc ctttgagaag catcagtact ataatctcaa ggacttggtg
      781 gacatcacaa agcagcctgt gggatacctg aaagaaatct tgaaagaaat tggcattcag
      841 aatgtaaaag gaattcacaa gaacacatgg gagctgaagc cggagtacag gcattaccaa
      901 acagaagaga agagcgactg agagactcgt gtgctaaaga gtcagtcaca ggcaggcctg
      961 gccagcccac accacaagtt gcctgcctgc ctgccttgac aggacaaaga cacctgggtc
     1021 taccactcct ctcagtaaac tgttaaagct gagattccat aaaagtttct taagtgtttt
     1081 ctgaagagaa agatgttatt tatagactaa actcatgtta caccattcag cgggcatgct
     1141 ggcacatgaa tgtgtccaaa actcaggaga ctgaggcagg caggtgtgag tttgagacca
     1201 gcctggaata cacagcaaga cctcctccat agaagaaaaa aattatggta tgggtggagc
     1261 tctgggaatt aaaactactt ttgtttttat tggttaactt tgcaagcgta aatgggatat
     1321 ctcctaaatg aaaattttgt ctctgaggaa ctaaggtaag aaaggagaaa ggtgggaggc
     1381 aggggcatca gctaagaaat gattacagga acacagagtc caaattcctt ctgcaactga
     1441 agagggaact tgtccctgtc tgcagaggta atgtttcacc tccacactta agttaataaa
     1501 gagatctgtt ccctttgtac taga
//
