LOCUS       NM_001419475            1757 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus general transcription factor IIF, polypeptide 1
            (Gtf2f1), transcript variant 16, mRNA.
ACCESSION   NM_001419475
VERSION     NM_001419475.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1757)
  AUTHORS   Kamileri,I., Karakasilioti,I., Sideri,A., Kosteas,T., Tatarakis,A.,
            Talianidis,I. and Garinis,G.A.
  TITLE     Defective transcription initiation causes postnatal growth failure
            in a mouse model of nucleotide excision repair (NER) progeria
  JOURNAL   Proc Natl Acad Sci U S A 109 (8), 2995-3000 (2012)
   PUBMED   22323595
REFERENCE   2  (bases 1 to 1757)
  AUTHORS   Wagner,S.D., Kugel,J.F. and Goodrich,J.A.
  TITLE     TFIIF facilitates dissociation of RNA polymerase II from noncoding
            RNAs that lack a repression domain
  JOURNAL   Mol Cell Biol 30 (1), 91-97 (2010)
   PUBMED   19841064
REFERENCE   3  (bases 1 to 1757)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (bases 1 to 1757)
  AUTHORS   Combes,A.N., Lesieur,E., Harley,V.R., Sinclair,A.H., Little,M.H.,
            Wilhelm,D. and Koopman,P.
  TITLE     Three-dimensional visualization of testis cord morphogenesis, a
            novel tubulogenic mechanism in development
  JOURNAL   Dev Dyn 238 (5), 1033-1041 (2009)
   PUBMED   19334288
REFERENCE   5  (bases 1 to 1757)
  AUTHORS   Newberry,E.P., Latifi,T., Battaile,J.T. and Towler,D.A.
  TITLE     Structure-function analysis of Msx2-mediated transcriptional
            suppression
  JOURNAL   Biochemistry 36 (34), 10451-10462 (1997)
   PUBMED   9265625
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT571247.13 and AC073683.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422603.598116.1,
                                           SRR12282455.32483118.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-290               CT571247.13        29475-29764         c
            291-337             CT571247.13        29342-29388         c
            338-412             CT571247.13        26198-26272         c
            413-531             AC073683.3         1-119
            532-702             AC073683.3         676-846
            703-887             AC073683.3         2288-2472
            888-1041            AC073683.3         3013-3166
            1042-1103           AC073683.3         3260-3321
            1104-1223           AC073683.3         3404-3523
            1224-1297           AC073683.3         3637-3710
            1298-1436           AC073683.3         3779-3917
            1437-1527           AC073683.3         4021-4111
            1528-1757           AC073683.3         4201-4430
FEATURES             Location/Qualifiers
     source          1..1757
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.62 cM"
     gene            1..1757
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /note="general transcription factor IIF, polypeptide 1"
                     /db_xref="GeneID:98053"
                     /db_xref="MGI:MGI:1923848"
     exon            1..290
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            291..337
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            338..531
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     CDS             389..1732
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /note="isoform 16 is encoded by transcript variant 16;
                     general transcription factor IIF subunit 1; general
                     transcription factor IIF polypeptide 1 (74kD subunit);
                     TFIIF-alpha; transcription initiation factor IIF subunit
                     alpha"
                     /codon_start=1
                     /product="general transcription factor IIF subunit 1
                     isoform 16"
                     /protein_id="NP_001406404.1"
                     /db_xref="GeneID:98053"
                     /db_xref="MGI:MGI:1923848"
                     /translation="MPESGAGSEFNRKLREEARRKKYGIVLKEFRPEDQPWLLRVNGK
                     SGRKFKGIKKGGVTENTAYYIFTQCADGAFEAFPVQNWYNFTPLARHRTLTAEEAEEE
                     WERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRSRKKPSELRIHDLEDDLEMSSDAS
                     DASGEEGSRTSKAKKKAPVTKAGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSS
                     SSPDETEGKPKVPQQEDGPKGVDEQSESSEESEEEKPPEEDKEEEEEKKAPTPQEKKR
                     RKDSSDDSDSSEESDIDSETSSALFMAKKKTPPKRERKPSGGSSKGTSRPGTPSAEAA
                     STSSTLRAAASKLEQGKRTSETPAAKRLRMDTGPQSLSGKSTPSSGDVQVTEDAVRRY
                     LTRKPMTTKDLLKKFQTKKTGLSSEQTVNVLAQILKRLNPERKMIGDKMHFSLKE"
     exon            532..702
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            703..887
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1041
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1103
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1223
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1297
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1436
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1527
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1757
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1737..1742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /note="hexamer: AATAAA"
     polyA_site      1757
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /note="major polyA site"
ORIGIN      
        1 ggctttctct ccgaagctgg tgatctagag tagttacagc ggctgcgctc ttctcggtgt
       61 ggcagctcaa cttccgggtc aggctctaac gcatgcgcag agagttaggt ctctttttct
      121 cgtcttccag cattctccga gacttaagga tttggaaatc caaagcacag catcacacta
      181 acgtgacaac caggaaaggt gccttccctt tcctggagcc gagggacaca acgaagttca
      241 tcccgtcagg ccgaccggga gcagcttgag caacggccat ggcggctcta ggctccagca
      301 gccagaatgt caccgagtac gtcgtccgag tccccaagca cggctggagc gagatctgag
      361 caacaagaag atttaccagg aagaagagat gccagagtcc ggtgcaggca gtgaattcaa
      421 ccgcaagctt agggaggagg cgcgccggaa gaagtatggc attgtcctaa aggagtttcg
      481 gcctgaggac cagccttggc tactccgtgt caatggcaaa tcaggacgga agttcaaagg
      541 cattaagaaa ggcggggtaa cagagaacac agcctactac atcttcacac agtgtgctga
      601 tggtgccttt gaggctttcc ctgtacagaa ctggtacaat ttcacaccac tggcccgaca
      661 ccgcacactc actgctgagg aagccgagga ggaatgggag aggaggaaca aggtcctaaa
      721 ccacttcagc atcatgcagc agcggcggct caaggaccag gaccaggatg aagatgagga
      781 ggagaaggag aagcgcagtc gcaagaagcc tagtgagctg cgcattcatg acctggagga
      841 tgacctggaa atgtcctccg atgccagcga tgccagtggt gaagagggca gcagaacctc
      901 caaggctaag aaaaaggccc ctgtgaccaa ggcaggcagg aagaagaaaa agaagaaggg
      961 ctcagatgat gaggcttttg aggacagcga tgatggggac ttcgagggcc aggaggtaga
     1021 ctacatgtct gatggctcca gcagctctcc agatgagaca gaaggcaagc ccaaagtgcc
     1081 ccagcaggag gatggcccaa agggggtgga tgagcagagc gagagcagtg aggagagtga
     1141 ggaggagaag ccccccgagg aggacaagga ggaggaagaa gagaagaagg cccctacccc
     1201 acaagagaag aagcgcagga aagacagcag tgatgactca gacagctcag aagagagcga
     1261 cattgacagt gagacctcct ctgcactctt catggcgaag aagaagacac ccccaaagag
     1321 ggagcggaag ccatcggggg ggagttcaaa gggcaccagt cggccaggga ctcccagtgc
     1381 agaagcagca agcacctctt ctaccctgcg ggctgcagcc agcaagctgg agcaggggaa
     1441 gcggacgagt gagactccag cagccaagcg tcttcggatg gacacgggtc cccagagcct
     1501 gtctgggaag tccacaccca gcagcggtga tgtccaggtg acagaggacg ctgtgcgccg
     1561 ctacctgacc cgcaagccca tgaccacaaa ggacctgctg aagaagttcc agaccaagaa
     1621 gacagggctg agcagcgagc agacagtaaa tgtgctggcg cagatcctca agcgcctcaa
     1681 ccctgagcgc aagatgattg gtgataagat gcacttctcc ctcaaagagt gatgccaata
     1741 aagagagcag gcccaga
//
