LOCUS       NM_001419463            1827 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus general transcription factor IIF, polypeptide 1
            (Gtf2f1), transcript variant 4, mRNA.
ACCESSION   NM_001419463
VERSION     NM_001419463.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1827)
  AUTHORS   Kamileri,I., Karakasilioti,I., Sideri,A., Kosteas,T., Tatarakis,A.,
            Talianidis,I. and Garinis,G.A.
  TITLE     Defective transcription initiation causes postnatal growth failure
            in a mouse model of nucleotide excision repair (NER) progeria
  JOURNAL   Proc Natl Acad Sci U S A 109 (8), 2995-3000 (2012)
   PUBMED   22323595
REFERENCE   2  (bases 1 to 1827)
  AUTHORS   Wagner,S.D., Kugel,J.F. and Goodrich,J.A.
  TITLE     TFIIF facilitates dissociation of RNA polymerase II from noncoding
            RNAs that lack a repression domain
  JOURNAL   Mol Cell Biol 30 (1), 91-97 (2010)
   PUBMED   19841064
REFERENCE   3  (bases 1 to 1827)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (bases 1 to 1827)
  AUTHORS   Combes,A.N., Lesieur,E., Harley,V.R., Sinclair,A.H., Little,M.H.,
            Wilhelm,D. and Koopman,P.
  TITLE     Three-dimensional visualization of testis cord morphogenesis, a
            novel tubulogenic mechanism in development
  JOURNAL   Dev Dyn 238 (5), 1033-1041 (2009)
   PUBMED   19334288
REFERENCE   5  (bases 1 to 1827)
  AUTHORS   Newberry,E.P., Latifi,T., Battaile,J.T. and Towler,D.A.
  TITLE     Structure-function analysis of Msx2-mediated transcriptional
            suppression
  JOURNAL   Biochemistry 36 (34), 10451-10462 (1997)
   PUBMED   9265625
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT571247.13 and AC073683.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253013.2996580.1,
                                           SRR17784646.37025.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-290               CT571247.13        29475-29764         c
            291-337             CT571247.13        29342-29388         c
            338-410             CT571247.13        28054-28126         c
            411-485             CT571247.13        26198-26272         c
            486-604             AC073683.3         1-119
            605-775             AC073683.3         676-846
            776-960             AC073683.3         2288-2472
            961-1114            AC073683.3         3013-3166
            1115-1176           AC073683.3         3260-3321
            1177-1296           AC073683.3         3404-3523
            1297-1370           AC073683.3         3637-3710
            1371-1506           AC073683.3         3782-3917
            1507-1597           AC073683.3         4021-4111
            1598-1827           AC073683.3         4201-4430
FEATURES             Location/Qualifiers
     source          1..1827
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.62 cM"
     gene            1..1827
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /note="general transcription factor IIF, polypeptide 1"
                     /db_xref="GeneID:98053"
                     /db_xref="MGI:MGI:1923848"
     exon            1..290
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..1802
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /note="isoform 4 is encoded by transcript variant 4;
                     general transcription factor IIF subunit 1; general
                     transcription factor IIF polypeptide 1 (74kD subunit);
                     TFIIF-alpha; transcription initiation factor IIF subunit
                     alpha"
                     /codon_start=1
                     /product="general transcription factor IIF subunit 1
                     isoform 4"
                     /protein_id="NP_001406392.1"
                     /db_xref="GeneID:98053"
                     /db_xref="MGI:MGI:1923848"
                     /translation="MAALGSSSQNVTEYVVRVPKNTAKRYNIMAFNAADKVNFATWNQ
                     ARLERDLSNKKIYQEEEMPESGAGSEFNRKLREEARRKKYGIVLKEFRPEDQPWLLRV
                     NGKSGRKFKGIKKGGVTENTAYYIFTQCADGAFEAFPVQNWYNFTPLARHRTLTAEEA
                     EEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRSRKKPSELRIHDLEDDLEMSS
                     DASDASGEEGSRTSKAKKKAPVTKAGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSD
                     GSSSSPDETEGKPKVPQQEDGPKGVDEQSESSEESEEEKPPEEDKEEEEEKKAPTPQE
                     KKRRKDSSDDSDSSEESDIDSETSSALFMAKKTPPKRERKPSGGSSKGTSRPGTPSAE
                     AASTSSTLRAAASKLEQGKRTSETPAAKRLRMDTGPQSLSGKSTPSSGDVQVTEDAVR
                     RYLTRKPMTTKDLLKKFQTKKTGLSSEQTVNVLAQILKRLNPERKMIGDKMHFSLKE"
     exon            291..337
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            338..410
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            411..604
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            605..775
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            776..960
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1114
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1176
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1296
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1370
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1506
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1597
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1827
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1807..1812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /note="hexamer: AATAAA"
     polyA_site      1827
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /note="major polyA site"
ORIGIN      
        1 ggctttctct ccgaagctgg tgatctagag tagttacagc ggctgcgctc ttctcggtgt
       61 ggcagctcaa cttccgggtc aggctctaac gcatgcgcag agagttaggt ctctttttct
      121 cgtcttccag cattctccga gacttaagga tttggaaatc caaagcacag catcacacta
      181 acgtgacaac caggaaaggt gccttccctt tcctggagcc gagggacaca acgaagttca
      241 tcccgtcagg ccgaccggga gcagcttgag caacggccat ggcggctcta ggctccagca
      301 gccagaatgt caccgagtac gtcgtccgag tccccaagaa cacagccaaa agatacaaca
      361 taatggcttt taatgcagcc gataaagtca actttgctac ctggaaccag gcacggctgg
      421 agcgagatct gagcaacaag aagatttacc aggaagaaga gatgccagag tccggtgcag
      481 gcagtgaatt caaccgcaag cttagggagg aggcgcgccg gaagaagtat ggcattgtcc
      541 taaaggagtt tcggcctgag gaccagcctt ggctactccg tgtcaatggc aaatcaggac
      601 ggaagttcaa aggcattaag aaaggcgggg taacagagaa cacagcctac tacatcttca
      661 cacagtgtgc tgatggtgcc tttgaggctt tccctgtaca gaactggtac aatttcacac
      721 cactggcccg acaccgcaca ctcactgctg aggaagccga ggaggaatgg gagaggagga
      781 acaaggtcct aaaccacttc agcatcatgc agcagcggcg gctcaaggac caggaccagg
      841 atgaagatga ggaggagaag gagaagcgca gtcgcaagaa gcctagtgag ctgcgcattc
      901 atgacctgga ggatgacctg gaaatgtcct ccgatgccag cgatgccagt ggtgaagagg
      961 gcagcagaac ctccaaggct aagaaaaagg cccctgtgac caaggcaggc aggaagaaga
     1021 aaaagaagaa gggctcagat gatgaggctt ttgaggacag cgatgatggg gacttcgagg
     1081 gccaggaggt agactacatg tctgatggct ccagcagctc tccagatgag acagaaggca
     1141 agcccaaagt gccccagcag gaggatggcc caaagggggt ggatgagcag agcgagagca
     1201 gtgaggagag tgaggaggag aagccccccg aggaggacaa ggaggaggaa gaagagaaga
     1261 aggcccctac cccacaagag aagaagcgca ggaaagacag cagtgatgac tcagacagct
     1321 cagaagagag cgacattgac agtgagacct cctctgcact cttcatggcg aagaagacac
     1381 ccccaaagag ggagcggaag ccatcggggg ggagttcaaa gggcaccagt cggccaggga
     1441 ctcccagtgc agaagcagca agcacctctt ctaccctgcg ggctgcagcc agcaagctgg
     1501 agcaggggaa gcggacgagt gagactccag cagccaagcg tcttcggatg gacacgggtc
     1561 cccagagcct gtctgggaag tccacaccca gcagcggtga tgtccaggtg acagaggacg
     1621 ctgtgcgccg ctacctgacc cgcaagccca tgaccacaaa ggacctgctg aagaagttcc
     1681 agaccaagaa gacagggctg agcagcgagc agacagtaaa tgtgctggcg cagatcctca
     1741 agcgcctcaa ccctgagcgc aagatgattg gtgataagat gcacttctcc ctcaaagagt
     1801 gatgccaata aagagagcag gcccaga
//
