LOCUS       NM_001419459            1848 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus general transcription factor IIF, polypeptide 1
            (Gtf2f1), transcript variant 2, mRNA.
ACCESSION   NM_001419459
VERSION     NM_001419459.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1848)
  AUTHORS   Kamileri,I., Karakasilioti,I., Sideri,A., Kosteas,T., Tatarakis,A.,
            Talianidis,I. and Garinis,G.A.
  TITLE     Defective transcription initiation causes postnatal growth failure
            in a mouse model of nucleotide excision repair (NER) progeria
  JOURNAL   Proc Natl Acad Sci U S A 109 (8), 2995-3000 (2012)
   PUBMED   22323595
REFERENCE   2  (bases 1 to 1848)
  AUTHORS   Wagner,S.D., Kugel,J.F. and Goodrich,J.A.
  TITLE     TFIIF facilitates dissociation of RNA polymerase II from noncoding
            RNAs that lack a repression domain
  JOURNAL   Mol Cell Biol 30 (1), 91-97 (2010)
   PUBMED   19841064
REFERENCE   3  (bases 1 to 1848)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (bases 1 to 1848)
  AUTHORS   Combes,A.N., Lesieur,E., Harley,V.R., Sinclair,A.H., Little,M.H.,
            Wilhelm,D. and Koopman,P.
  TITLE     Three-dimensional visualization of testis cord morphogenesis, a
            novel tubulogenic mechanism in development
  JOURNAL   Dev Dyn 238 (5), 1033-1041 (2009)
   PUBMED   19334288
REFERENCE   5  (bases 1 to 1848)
  AUTHORS   Newberry,E.P., Latifi,T., Battaile,J.T. and Towler,D.A.
  TITLE     Structure-function analysis of Msx2-mediated transcriptional
            suppression
  JOURNAL   Biochemistry 36 (34), 10451-10462 (1997)
   PUBMED   9265625
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT571247.13 and AC073683.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422589.11086.1,
                                           SRR17253012.10176393.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-290               CT571247.13        29475-29764         c
            291-355             CT571247.13        29342-29406         c
            356-428             CT571247.13        28054-28126         c
            429-503             CT571247.13        26198-26272         c
            504-622             AC073683.3         1-119
            623-793             AC073683.3         676-846
            794-978             AC073683.3         2288-2472
            979-1132            AC073683.3         3013-3166
            1133-1194           AC073683.3         3260-3321
            1195-1314           AC073683.3         3404-3523
            1315-1388           AC073683.3         3637-3710
            1389-1527           AC073683.3         3779-3917
            1528-1618           AC073683.3         4021-4111
            1619-1848           AC073683.3         4201-4430
FEATURES             Location/Qualifiers
     source          1..1848
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.62 cM"
     gene            1..1848
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /note="general transcription factor IIF, polypeptide 1"
                     /db_xref="GeneID:98053"
                     /db_xref="MGI:MGI:1923848"
     exon            1..290
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..1823
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /note="isoform 2 is encoded by transcript variant 2;
                     general transcription factor IIF subunit 1; general
                     transcription factor IIF polypeptide 1 (74kD subunit);
                     TFIIF-alpha; transcription initiation factor IIF subunit
                     alpha"
                     /codon_start=1
                     /product="general transcription factor IIF subunit 1
                     isoform 2"
                     /protein_id="NP_001406388.1"
                     /db_xref="GeneID:98053"
                     /db_xref="MGI:MGI:1923848"
                     /translation="MAALTPALLQGSSSQNVTEYVVRVPKNTAKRYNIMAFNAADKVN
                     FATWNQARLERDLSNKKIYQEEEMPESGAGSEFNRKLREEARRKKYGIVLKEFRPEDQ
                     PWLLRVNGKSGRKFKGIKKGGVTENTAYYIFTQCADGAFEAFPVQNWYNFTPLARHRT
                     LTAEEAEEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRSRKKPSELRIHDLED
                     DLEMSSDASDASGEEGSRTSKAKKKAPVTKAGRKKKKKKGSDDEAFEDSDDGDFEGQE
                     VDYMSDGSSSSPDETEGKPKVPQQEDGPKGVDEQSESSEESEEEKPPEEDKEEEEEKK
                     APTPQEKKRRKDSSDDSDSSEESDIDSETSSALFMAKKKTPPKRERKPSGGSSKGTSR
                     PGTPSAEAASTSSTLRAAASKLEQGKRTSETPAAKRLRMDTGPQSLSGKSTPSSGDVQ
                     VTEDAVRRYLTRKPMTTKDLLKKFQTKKTGLSSEQTVNVLAQILKRLNPERKMIGDKM
                     HFSLKE"
     exon            291..355
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            356..428
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            429..622
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            623..793
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            794..978
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1132
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1194
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1314
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1388
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1527
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1618
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1848
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1828..1833
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /note="hexamer: AATAAA"
     polyA_site      1848
                     /gene="Gtf2f1"
                     /gene_synonym="2810405L04Rik; RAP74"
                     /note="major polyA site"
ORIGIN      
        1 ggctttctct ccgaagctgg tgatctagag tagttacagc ggctgcgctc ttctcggtgt
       61 ggcagctcaa cttccgggtc aggctctaac gcatgcgcag agagttaggt ctctttttct
      121 cgtcttccag cattctccga gacttaagga tttggaaatc caaagcacag catcacacta
      181 acgtgacaac caggaaaggt gccttccctt tcctggagcc gagggacaca acgaagttca
      241 tcccgtcagg ccgaccggga gcagcttgag caacggccat ggcggctcta acccctgctc
      301 tcttgcaggg ctccagcagc cagaatgtca ccgagtacgt cgtccgagtc cccaagaaca
      361 cagccaaaag atacaacata atggctttta atgcagccga taaagtcaac tttgctacct
      421 ggaaccaggc acggctggag cgagatctga gcaacaagaa gatttaccag gaagaagaga
      481 tgccagagtc cggtgcaggc agtgaattca accgcaagct tagggaggag gcgcgccgga
      541 agaagtatgg cattgtccta aaggagtttc ggcctgagga ccagccttgg ctactccgtg
      601 tcaatggcaa atcaggacgg aagttcaaag gcattaagaa aggcggggta acagagaaca
      661 cagcctacta catcttcaca cagtgtgctg atggtgcctt tgaggctttc cctgtacaga
      721 actggtacaa tttcacacca ctggcccgac accgcacact cactgctgag gaagccgagg
      781 aggaatggga gaggaggaac aaggtcctaa accacttcag catcatgcag cagcggcggc
      841 tcaaggacca ggaccaggat gaagatgagg aggagaagga gaagcgcagt cgcaagaagc
      901 ctagtgagct gcgcattcat gacctggagg atgacctgga aatgtcctcc gatgccagcg
      961 atgccagtgg tgaagagggc agcagaacct ccaaggctaa gaaaaaggcc cctgtgacca
     1021 aggcaggcag gaagaagaaa aagaagaagg gctcagatga tgaggctttt gaggacagcg
     1081 atgatgggga cttcgagggc caggaggtag actacatgtc tgatggctcc agcagctctc
     1141 cagatgagac agaaggcaag cccaaagtgc cccagcagga ggatggccca aagggggtgg
     1201 atgagcagag cgagagcagt gaggagagtg aggaggagaa gccccccgag gaggacaagg
     1261 aggaggaaga agagaagaag gcccctaccc cacaagagaa gaagcgcagg aaagacagca
     1321 gtgatgactc agacagctca gaagagagcg acattgacag tgagacctcc tctgcactct
     1381 tcatggcgaa gaagaagaca cccccaaaga gggagcggaa gccatcgggg gggagttcaa
     1441 agggcaccag tcggccaggg actcccagtg cagaagcagc aagcacctct tctaccctgc
     1501 gggctgcagc cagcaagctg gagcagggga agcggacgag tgagactcca gcagccaagc
     1561 gtcttcggat ggacacgggt ccccagagcc tgtctgggaa gtccacaccc agcagcggtg
     1621 atgtccaggt gacagaggac gctgtgcgcc gctacctgac ccgcaagccc atgaccacaa
     1681 aggacctgct gaagaagttc cagaccaaga agacagggct gagcagcgag cagacagtaa
     1741 atgtgctggc gcagatcctc aagcgcctca accctgagcg caagatgatt ggtgataaga
     1801 tgcacttctc cctcaaagag tgatgccaat aaagagagca ggcccaga
//
