LOCUS       NM_026584               1550 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus general transcription factor II E, polypeptide 2 (beta
            subunit) (Gtf2e2), transcript variant 2, mRNA.
ACCESSION   NM_026584
VERSION     NM_026584.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1550)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1550)
  AUTHORS   Alpern,D., Langer,D., Ballester,B., Le Gras,S., Romier,C.,
            Mengus,G. and Davidson,I.
  TITLE     TAF4, a subunit of transcription factor II D, directs promoter
            occupancy of nuclear receptor HNF4A during post-natal hepatocyte
            differentiation
  JOURNAL   Elife 3, e03613 (2014)
   PUBMED   25209997
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1550)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 1550)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 1550)
  AUTHORS   De Cegli,R., Iacobacci,S., Flore,G., Gambardella,G., Mao,L.,
            Cutillo,L., Lauria,M., Klose,J., Illingworth,E., Banfi,S. and di
            Bernardo,D.
  TITLE     Reverse engineering a mouse embryonic stem cell-specific
            transcriptional network reveals a new modulator of neuronal
            differentiation
  JOURNAL   Nucleic Acids Res 41 (2), 711-726 (2013)
   PUBMED   23180766
REFERENCE   6  (bases 1 to 1550)
  AUTHORS   Yoshikawa,T., Piao,Y., Zhong,J., Matoba,R., Carter,M.G., Wang,Y.,
            Goldberg,I. and Ko,M.S.
  TITLE     High-throughput screen for genes predominantly expressed in the ICM
            of mouse blastocysts by whole mount in situ hybridization
  JOURNAL   Gene Expr Patterns 6 (2), 213-224 (2006)
   PUBMED   16325481
REFERENCE   7  (bases 1 to 1550)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 1550)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   9  (bases 1 to 1550)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   10 (bases 1 to 1550)
  AUTHORS   De Graeve,F., Bahr,A., Chatton,B. and Kedinger,C.
  TITLE     A murine ATFa-associated factor with transcriptional repressing
            activity
  JOURNAL   Oncogene 19 (14), 1807-1819 (2000)
   PUBMED   10777215
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY256665.1, AK146803.1, DV042794.1 and AW538417.1.
            
            On Nov 19, 2009 this sequence version replaced NM_026584.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1-3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088342.1, AK146803.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BY256665.1         2-20
            20-789              AK146803.1         7-776
            790-1355            DV042794.1         112-677
            1356-1550           AW538417.1         1-195               c
FEATURES             Location/Qualifiers
     source          1..1550
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 20.79 cM"
     gene            1..1550
                     /gene="Gtf2e2"
                     /gene_synonym="34kDa; C330006J08Rik"
                     /note="general transcription factor II E, polypeptide 2
                     (beta subunit)"
                     /db_xref="GeneID:68153"
                     /db_xref="MGI:MGI:1915403"
     exon            1..63
                     /gene="Gtf2e2"
                     /gene_synonym="34kDa; C330006J08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            64..236
                     /gene="Gtf2e2"
                     /gene_synonym="34kDa; C330006J08Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..946
                     /gene="Gtf2e2"
                     /gene_synonym="34kDa; C330006J08Rik"
                     /note="general transcription factor II E, polypeptide 2
                     (beta subunit, 34kD); general transcription factor IIE,
                     polypeptide 2 (beta subunit, 34kD); TFIIE-beta;
                     transcription initiation factor IIE subunit beta"
                     /codon_start=1
                     /product="general transcription factor IIE subunit 2"
                     /protein_id="NP_080860.3"
                     /db_xref="CCDS:CCDS22236.1"
                     /db_xref="GeneID:68153"
                     /db_xref="MGI:MGI:1915403"
                     /translation="MDPSLLRDRELFKKRALSTPVVEKRAVPSESPSSSSSKKKKAKV
                     EHGGSSGSKQNSDHNNGSFNLKALSGSSGYKFGVLAKIVNYMKTRHQRGDTHPLTLEE
                     ILDETQHLDIGLKQKQWLMTEALVNNPKIEVVDGKYAFKPKYNLKDKKALLRLLDNHD
                     QRGLGGILLEDIEEGLPNSQKAVKALGDQILFVSRPDKKKILFFNDKSCQFSVDEEFQ
                     KLWRSVTVDSMDEEKIEEYLKRQGISSMQESGPKKVASIQRRKKPASQKKRRFKTHNE
                     HLAGVLKDYSDITPGK"
     exon            237..328
                     /gene="Gtf2e2"
                     /gene_synonym="34kDa; C330006J08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            329..436
                     /gene="Gtf2e2"
                     /gene_synonym="34kDa; C330006J08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            437..619
                     /gene="Gtf2e2"
                     /gene_synonym="34kDa; C330006J08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            620..713
                     /gene="Gtf2e2"
                     /gene_synonym="34kDa; C330006J08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            714..829
                     /gene="Gtf2e2"
                     /gene_synonym="34kDa; C330006J08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            830..1550
                     /gene="Gtf2e2"
                     /gene_synonym="34kDa; C330006J08Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1323..1328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtf2e2"
                     /gene_synonym="34kDa; C330006J08Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1342
                     /gene="Gtf2e2"
                     /gene_synonym="34kDa; C330006J08Rik"
                     /note="major polyA site"
     regulatory      1524..1529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtf2e2"
                     /gene_synonym="34kDa; C330006J08Rik"
                     /note="hexamer: AATAAA"
     regulatory      1539..1544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtf2e2"
                     /gene_synonym="34kDa; C330006J08Rik"
                     /note="hexamer: AATATA"
     polyA_site      1540
                     /gene="Gtf2e2"
                     /gene_synonym="34kDa; C330006J08Rik"
     polyA_site      1546
                     /gene="Gtf2e2"
                     /gene_synonym="34kDa; C330006J08Rik"
                     /note="major polyA site"
ORIGIN      
        1 gagtgcgtgc gtgcgtgcgg ccgaggcgga ggctgggagg cggcgcgggc tgcgggcgct
       61 gagcattatg gatccaagcc tattgagaga tcgagagctg ttcaaaaaac gagctctttc
      121 cactcctgtg gtagaaaaac gtgctgtgcc ttctgagtca ccctcctcct cctcatccaa
      181 gaagaagaag gcaaaagtcg aacatggagg atcctcaggc tctaaacaaa attcagatca
      241 taacaatgga tcatttaact tgaaagctct gtctggaagc tctggatata agttcggtgt
      301 tcttgctaag attgtgaatt atatgaaaac acgacatcag cggggagata cacatcctct
      361 aacgttggaa gagattctgg atgagacaca gcacttagac atcggactca agcagaaaca
      421 gtggctgatg acggaggctt tagtcaacaa tcctaaaatt gaagtagtgg atgggaaata
      481 tgccttcaaa cctaagtaca acttgaaaga taagaaggcc ctgcttaggc ttttagacaa
      541 tcatgaccag cggggactag gaggaattct cttagaagac atagaagagg gactgcctaa
      601 ttcccagaaa gctgtcaagg ctttagggga ccagatacta tttgtaagtc gtcctgataa
      661 gaagaaaata ctattcttca atgataaaag ctgtcagttt tctgtggatg aagaattcca
      721 gaaactgtgg aggagtgtca ctgtggattc aatggatgag gagaaaattg aagagtatct
      781 gaagcgacag ggtatttctt ccatgcagga atctggacca aagaaagtgg cctctattca
      841 gagaaggaaa aagcctgctt cacagaaaaa gcgacggttt aagactcaca atgaacactt
      901 ggctggagtg ctgaaggatt actcggacat taccccgggc aaatagggaa cacttttatt
      961 cctaaacaca gttacagaca cgcagtcgag atctttcttg atgcttggga tctcaagact
     1021 gtctgccttc ctgcctgctc ctcaggcctg agagaggagc tgctcagttt acagaacagg
     1081 agcgggttac cagactcatt cttttcatcc agcaggctag tgggaaggaa tgggtgttcc
     1141 tgtttaactt tctgggtttg tttgttttat tttattagaa agacacttat atgacactca
     1201 ggtgtctgct atttatcttg atttctaaat ggttctggat tccatgtttt ctctattcgt
     1261 ttagaagaag ttggaggatg gtgctgaatg cagttttgtt tattccaaga aaaaatattt
     1321 ataataaaat catttgtagg aagatgttta agaagttagg aaattcagtt tgtctcttac
     1381 ttcttgaaaa tggcagggag cagctgcagc ccctgacttg tctgggggga tgtttaggat
     1441 atgacagagg ttagagtcag tactgttggc gtaaggattt catctttgga acacagggta
     1501 tgcctctggt taataagcta agcaataaaa ttacacgaaa tataaatgtt
//
