LOCUS       NP_080860                292 aa            linear   ROD 09-FEB-2025
DEFINITION  general transcription factor IIE subunit 2 [Mus musculus].
ACCESSION   NP_080860
VERSION     NP_080860.3
DBSOURCE    REFSEQ: accession NM_026584.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 292)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 292)
  AUTHORS   Alpern,D., Langer,D., Ballester,B., Le Gras,S., Romier,C.,
            Mengus,G. and Davidson,I.
  TITLE     TAF4, a subunit of transcription factor II D, directs promoter
            occupancy of nuclear receptor HNF4A during post-natal hepatocyte
            differentiation
  JOURNAL   Elife 3, e03613 (2014)
   PUBMED   25209997
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 292)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (residues 1 to 292)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (residues 1 to 292)
  AUTHORS   De Cegli,R., Iacobacci,S., Flore,G., Gambardella,G., Mao,L.,
            Cutillo,L., Lauria,M., Klose,J., Illingworth,E., Banfi,S. and di
            Bernardo,D.
  TITLE     Reverse engineering a mouse embryonic stem cell-specific
            transcriptional network reveals a new modulator of neuronal
            differentiation
  JOURNAL   Nucleic Acids Res 41 (2), 711-726 (2013)
   PUBMED   23180766
REFERENCE   6  (residues 1 to 292)
  AUTHORS   Yoshikawa,T., Piao,Y., Zhong,J., Matoba,R., Carter,M.G., Wang,Y.,
            Goldberg,I. and Ko,M.S.
  TITLE     High-throughput screen for genes predominantly expressed in the ICM
            of mouse blastocysts by whole mount in situ hybridization
  JOURNAL   Gene Expr Patterns 6 (2), 213-224 (2006)
   PUBMED   16325481
REFERENCE   7  (residues 1 to 292)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (residues 1 to 292)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   9  (residues 1 to 292)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   10 (residues 1 to 292)
  AUTHORS   De Graeve,F., Bahr,A., Chatton,B. and Kedinger,C.
  TITLE     A murine ATFa-associated factor with transcriptional repressing
            activity
  JOURNAL   Oncogene 19 (14), 1807-1819 (2000)
   PUBMED   10777215
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY256665.1, AK146803.1, DV042794.1 and AW538417.1.
            
            On Nov 19, 2009 this sequence version replaced NP_080860.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1-3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088342.1, AK146803.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..292
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 20.79 cM"
     Protein         1..292
                     /product="general transcription factor IIE subunit 2"
                     /note="general transcription factor II E, polypeptide 2
                     (beta subunit, 34kD); general transcription factor IIE,
                     polypeptide 2 (beta subunit, 34kD); TFIIE-beta;
                     transcription initiation factor IIE subunit beta"
                     /calculated_mol_wt=32916
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P29084; propagated from
                     UniProtKB/Swiss-Prot (Q9D902.2)"
     Region          17..64
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D902.2)"
     Site            62
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P29084; propagated from
                     UniProtKB/Swiss-Prot (Q9D902.2)"
     Region          69..147
                     /region_name="TFIIE_beta_winged_helix"
                     /note="TFIIE_beta_winged_helix domain, located at the
                     central core region of TFIIE beta, with double-stranded
                     DNA binding activity; cd07977"
                     /db_xref="CDD:153423"
     Site            75
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q9D902.2)"
     Region          147..205
                     /region_name="TFA2_Winged_2"
                     /note="TFA2 Winged helix domain 2; pfam18121"
                     /db_xref="CDD:465658"
     Region          245..277
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D902.2)"
     CDS             1..292
                     /gene="Gtf2e2"
                     /gene_synonym="34kDa; C330006J08Rik"
                     /coded_by="NM_026584.3:68..946"
                     /db_xref="CCDS:CCDS22236.1"
                     /db_xref="GeneID:68153"
                     /db_xref="MGI:MGI:1915403"
ORIGIN      
        1 mdpsllrdre lfkkralstp vvekravpse spssssskkk kakvehggss gskqnsdhnn
       61 gsfnlkalsg ssgykfgvla kivnymktrh qrgdthpltl eeildetqhl diglkqkqwl
      121 mtealvnnpk ievvdgkyaf kpkynlkdkk allrlldnhd qrglggille dieeglpnsq
      181 kavkalgdqi lfvsrpdkkk ilffndkscq fsvdeefqkl wrsvtvdsmd eekieeylkr
      241 qgissmqesg pkkvasiqrr kkpasqkkrr fkthnehlag vlkdysditp gk
//
