LOCUS       NM_028812               3078 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus general transcription factor II E, polypeptide 1
            (alpha subunit) (Gtf2e1), transcript variant 1, mRNA.
ACCESSION   NM_028812
VERSION     NM_028812.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3078)
  AUTHORS   Alpern,D., Langer,D., Ballester,B., Le Gras,S., Romier,C.,
            Mengus,G. and Davidson,I.
  TITLE     TAF4, a subunit of transcription factor II D, directs promoter
            occupancy of nuclear receptor HNF4A during post-natal hepatocyte
            differentiation
  JOURNAL   Elife 3, e03613 (2014)
   PUBMED   25209997
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3078)
  AUTHORS   Kamileri,I., Karakasilioti,I., Sideri,A., Kosteas,T., Tatarakis,A.,
            Talianidis,I. and Garinis,G.A.
  TITLE     Defective transcription initiation causes postnatal growth failure
            in a mouse model of nucleotide excision repair (NER) progeria
  JOURNAL   Proc Natl Acad Sci U S A 109 (8), 2995-3000 (2012)
   PUBMED   22323595
REFERENCE   3  (bases 1 to 3078)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   4  (bases 1 to 3078)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154762.2.
            
            On Sep 26, 2017 this sequence version replaced NM_028812.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056966.1, AK011543.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AC154762.2         55052-55188         c
            138-610             AC154762.2         51120-51592         c
            611-812             AC154762.2         38150-38351         c
            813-1054            AC154762.2         31118-31359         c
            1055-3078           AC154762.2         25195-27218         c
FEATURES             Location/Qualifiers
     source          1..3078
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 26.38 cM"
     gene            1..3078
                     /gene="Gtf2e1"
                     /gene_synonym="2610024P03Rik; 56kDa; FE; TFIIE-A"
                     /note="general transcription factor II E, polypeptide 1
                     (alpha subunit)"
                     /db_xref="GeneID:74197"
                     /db_xref="MGI:MGI:1921447"
     exon            1..137
                     /gene="Gtf2e1"
                     /gene_synonym="2610024P03Rik; 56kDa; FE; TFIIE-A"
                     /inference="alignment:Splign:2.1.0"
     exon            138..610
                     /gene="Gtf2e1"
                     /gene_synonym="2610024P03Rik; 56kDa; FE; TFIIE-A"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..1485
                     /gene="Gtf2e1"
                     /gene_synonym="2610024P03Rik; 56kDa; FE; TFIIE-A"
                     /note="general transcription factor IIE, polypeptide 1
                     (alpha subunit, 56kDa); general transcription factor II E,
                     polypeptide 1 (alpha subunit, 56kDa); TFIIE-alpha; general
                     transcription factor IIE 56 kDa subunit; transcription
                     initiation factor IIE subunit alpha"
                     /codon_start=1
                     /product="general transcription factor IIE subunit 1"
                     /protein_id="NP_083088.1"
                     /db_xref="CCDS:CCDS28160.1"
                     /db_xref="GeneID:74197"
                     /db_xref="MGI:MGI:1921447"
                     /translation="MADPDVLTEVPAALKRLAKYVIRGFYGIEHVLALDILIRNPCVK
                     EEDMLELLKFDRKQLRSVLNNLKGDKFIKCRMRVETAADGKTTRHNYYFINYRTLVNV
                     VKYKLDHMRRRIETDERNSTNRASFKCPVCCSTFTDLEANQLFDPMTGTFRCTFCHTE
                     VEEDESAMPKKDARTLLARFNEQIEPIYALLRETEDVNLAYEILEPEPTEIPALKQSK
                     DRAATAAGAAGLAGGHHREAWTNKGPSYEDLYTQNVVINMDDQDDVHRPSLEGKAAKE
                     RPIWLRESTVQGAYSSEEMKEGGIDVDTFQEREEARAGPDDNEEVMRALLIHEKKTSS
                     VTAGSVGAAAPVTAANGSDSESETSESDDDSPPRPAAAAPPHHHRDEDEEDEEFEEVA
                     DDPIVMVAGCPFSYSEVSQRPELVAQMTPEEKEAYIAMGQRMFEDLFE"
     exon            611..812
                     /gene="Gtf2e1"
                     /gene_synonym="2610024P03Rik; 56kDa; FE; TFIIE-A"
                     /inference="alignment:Splign:2.1.0"
     exon            813..1054
                     /gene="Gtf2e1"
                     /gene_synonym="2610024P03Rik; 56kDa; FE; TFIIE-A"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..3078
                     /gene="Gtf2e1"
                     /gene_synonym="2610024P03Rik; 56kDa; FE; TFIIE-A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3044..3049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtf2e1"
                     /gene_synonym="2610024P03Rik; 56kDa; FE; TFIIE-A"
                     /note="hexamer: AATAAA"
     polyA_site      3068
                     /gene="Gtf2e1"
                     /gene_synonym="2610024P03Rik; 56kDa; FE; TFIIE-A"
ORIGIN      
        1 cggattagcg ggcggtttcc aaaccggtcg caggaattag gcgttcgtcc ttgtctcgca
       61 agtggcgtgg gctggctgaa gccggtagtt gaggtgctga gggcggctgt agtgggagtg
      121 ttcgagcatc cacttggttg aaggtgaagc ttcctgttga agatggcaga cccagatgtt
      181 ctcactgaag ttccggcggc attgaagcgg ctagccaagt atgtcatccg gggcttttat
      241 ggcattgagc acgtgttggc cttggacatc ttgatccgga acccctgtgt aaaagaagag
      301 gacatgctgg agctgctcaa gtttgatcgg aagcaacttc gatccgtttt gaataattta
      361 aagggagaca agttcatcaa atgcagaatg agggtagaga ctgctgcaga tgggaagacc
      421 acccgccata actactactt catcaattac cgcactcttg ttaatgtagt gaaatataag
      481 ctggaccaca tgagaagaag gattgaaaca gatgagagaa attccaccaa tcgggcttcc
      541 ttcaaatgtc ctgtctgctg cagcactttc actgacctag aagccaatca actgtttgat
      601 cccatgacag gaactttccg ctgcaccttt tgccatacag aggtagaaga agatgaatca
      661 gcaatgccca aaaaagatgc tcgcacgctt ttggcaagat ttaatgaaca aattgagccc
      721 atttatgcat tgcttcggga gacagaggat gtaaacttgg cctatgaaat acttgaacca
      781 gaacccacag aaatcccagc actgaagcaa agcaaggacc gagcagcaac tgctgctgga
      841 gctgctggcc tggcaggtgg gcaccaccga gaggcgtgga ccaacaaagg cccctcgtat
      901 gaggacttgt atactcagaa tgttgtcatt aacatggatg atcaagatga tgtgcatcgc
      961 ccctcgctgg aagggaaagc tgccaaagag agacccattt ggttgagaga gagcactgtc
     1021 caaggggcat acagttctga agagatgaag gaaggtggca tcgatgtgga cacatttcag
     1081 gagcgcgagg aagcccgtgc ggggcctgat gacaatgagg aggtcatgcg agctctactc
     1141 attcatgaga agaagacttc ctcggtgaca gctggctctg tgggagcagc cgctccggtg
     1201 acagctgcta atggcagtga ctctgagagt gagaccagcg agtcagatga tgactctcca
     1261 cctcggccag cagctgcggc tcctcctcat catcatcgcg atgaagatga ggaagacgag
     1321 gagtttgagg aagtagcaga tgaccccatt gttatggtgg ctggctgtcc attttcctac
     1381 agtgaagtta gccagcggcc ggagctggtg gcccagatga ccccagaaga gaaggaagca
     1441 tacatagcca tgggccagcg tatgtttgag gatctctttg agtgagcttt ccctgctctc
     1501 cctgctgctg cccattgcag agaaactccc atcaggtgct taagggcctt cccgcccgtg
     1561 taagaaagca cctggtaatc tagcacagaa gcatagtagg agagcaaatt tgattttttt
     1621 ttttaatgta agaaacttcc cagaaaggta ggtaggttat aagtattcag ttccctctta
     1681 ctattaaagt attaatattt ttctctattt ctttatctaa ttttttcctt tcctttttaa
     1741 gacatagttt tctcactctg agtaaaatgt tcctgtctac gttcagaacc ccactaggga
     1801 taagtgttcc ctagtattgc agctgcactg tggtcaggcg tctgagacaa ttgcttataa
     1861 tcctgccaac caaagcagct taccaagaag caggtcactg cttaggggaa tggagtaccc
     1921 aagcacttca tcttcctcaa aactgagtgt gggccagtct gtaaatggag tgagagagta
     1981 caggagaggg gggcctgaac cttaggttcc tgtgtaagct agaaccctcg tctgtagagc
     2041 ccataaggcc ggtagattgt ttccttctca tagacctttt gggttgtact ttagataaac
     2101 aaagcaggtt aggtctaccc gcatggagaa attcaaggag cacatgcatg aagggaagga
     2161 gtctgcatcc aggttgacga atggagagta ctgggaactg tgccttagag ctgcctcagt
     2221 gtgatttgga aatctcagat ggaaagctga gactggcccc acttccccca cttgttctac
     2281 agacctgtgc cagcgctctg aattgaggag cctttccagt actgagcagt gtagaagtgc
     2341 tgattccccc actttcctca ctcttccaga ggtcatcaaa acctttattt gtctctcctt
     2401 tgagcctcat cagatatcgt acttcagtgc ctctactgtg ttgttgagca ttgtaacctc
     2461 aaggaacata gtcattagca tggtgttatt cctgaaggca gaacttaaaa aataaaggac
     2521 tttcatataa ggtctacagc aatgaaactt ttatagtatt ttcccttgca ttgtgacttt
     2581 tagttgtcat tttgtagtat atgtgtgaag ctaagaacgt tttagagaat ctgagccttg
     2641 tataaagtga tgacatggtt acctggttgt tggatgactg aatattgaca gtcgacttac
     2701 tacagggtaa agctggttag tttctggctc tgacttcttg gagcatacct accatgagca
     2761 ctctttccat gtaaagatgt tagaggctcc tcatcggtca ttgtcttaag agcacaggtg
     2821 caatttgatg cgacttaaac ttttggcaat gaattgcctt aaaaaacctt tttatgtatt
     2881 tatcttaaat acatgaactg ttcaacttta aaattttgtt ttttaaacct tcatggttgt
     2941 agaaagatgt taatttgtaa aacgttaatt tttaaactat atgttctttg tttcgtttta
     3001 tatgagattg tgtaagttac atttcagtag tggaaaatgt actaataaag gcgctcatta
     3061 aagctgcatt tgaaatag
//
