LOCUS       NM_145546               1267 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus general transcription factor IIB (Gtf2b), mRNA.
ACCESSION   NM_145546
VERSION     NM_145546.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1267)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1267)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 1267)
  AUTHORS   Canovas,J., Berndt,F.A., Sepulveda,H., Aguilar,R., Veloso,F.A.,
            Montecino,M., Oliva,C., Maass,J.C., Sierralta,J. and Kukuljan,M.
  TITLE     The Specification of Cortical Subcerebral Projection Neurons
            Depends on the Direct Repression of TBR1 by CTIP1/BCL11a
  JOURNAL   J Neurosci 35 (19), 7552-7564 (2015)
   PUBMED   25972180
REFERENCE   4  (bases 1 to 1267)
  AUTHORS   Sayed,D., Yang,Z., He,M., Pfleger,J.M. and Abdellatif,M.
  TITLE     Acute targeting of general transcription factor IIB restricts
            cardiac hypertrophy via selective inhibition of gene transcription
  JOURNAL   Circ Heart Fail 8 (1), 138-148 (2015)
   PUBMED   25398966
  REMARK    GeneRIF: by acutely targeting TFIIB, we were able to inhibit
            selectively the former set of genes and ameliorate pressure
            overload hypertrophy.
REFERENCE   5  (bases 1 to 1267)
  AUTHORS   Alpern,D., Langer,D., Ballester,B., Le Gras,S., Romier,C.,
            Mengus,G. and Davidson,I.
  TITLE     TAF4, a subunit of transcription factor II D, directs promoter
            occupancy of nuclear receptor HNF4A during post-natal hepatocyte
            differentiation
  JOURNAL   Elife 3, e03613 (2014)
   PUBMED   25209997
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1267)
  AUTHORS   Pitulescu,M.E., Teichmann,M., Luo,L. and Kessel,M.
  TITLE     TIPT2 and geminin interact with basal transcription factors to
            synergize in transcriptional regulation
  JOURNAL   BMC Biochem 10, 16 (2009)
   PUBMED   19515240
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1267)
  AUTHORS   Shiraishi,S., Tamamura,N., Jogo,M., Tanaka,Y. and Tamura,T.A.
  TITLE     Rapid proteasomal degradation of transcription factor IIB in
            accordance with F9 cell differentiation
  JOURNAL   Gene 436 (1-2), 115-120 (2009)
   PUBMED   19393171
  REMARK    GeneRIF: Study suggest that components of the transcription
            machinery decreased in accordance with cell differentiation and
            that TFIIB is specifically and rapidly degraded by the
            ubiquitin-proteasome pathway.
REFERENCE   8  (bases 1 to 1267)
  AUTHORS   Tatarakis,A., Margaritis,T., Martinez-Jimenez,C.P., Kouskouti,A.,
            Mohan,W.S. 2nd, Haroniti,A., Kafetzopoulos,D., Tora,L. and
            Talianidis,I.
  TITLE     Dominant and redundant functions of TFIID involved in the
            regulation of hepatic genes
  JOURNAL   Mol Cell 31 (4), 531-543 (2008)
   PUBMED   18722179
REFERENCE   9  (bases 1 to 1267)
  AUTHORS   Hsu,L.C., Liu,S., Abedinpour,F., Beech,R.D., Lahti,J.M., Kidd,V.J.,
            Greenspan,J.A. and Yeung,C.Y.
  TITLE     The murine G+C-rich promoter binding protein mGPBP is required for
            promoter-specific transcription
  JOURNAL   Mol Cell Biol 23 (23), 8773-8785 (2003)
   PUBMED   14612417
REFERENCE   10 (bases 1 to 1267)
  AUTHORS   Kwok,R.P., Lundblad,J.R., Chrivia,J.C., Richards,J.P.,
            Bachinger,H.P., Brennan,R.G., Roberts,S.G., Green,M.R. and
            Goodman,R.H.
  TITLE     Nuclear protein CBP is a coactivator for the transcription factor
            CREB
  JOURNAL   Nature 370 (6486), 223-226 (1994)
   PUBMED   7913207
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC016637.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016637.1, AK131856.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1267
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="CZECHII"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 66.69 cM"
     gene            1..1267
                     /gene="Gtf2b"
                     /note="general transcription factor IIB"
                     /db_xref="GeneID:229906"
                     /db_xref="MGI:MGI:2385191"
     exon            1..42
                     /gene="Gtf2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..976
                     /gene="Gtf2b"
                     /EC_number="2.3.1.48"
                     /note="general transcription factor TFIIB; RNA polymerase
                     II alpha initiation factor"
                     /codon_start=1
                     /product="transcription initiation factor IIB"
                     /protein_id="NP_663521.1"
                     /db_xref="CCDS:CCDS17882.1"
                     /db_xref="GeneID:229906"
                     /db_xref="MGI:MGI:2385191"
                     /translation="MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECGLVVGDR
                     VIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQ
                     NRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIA
                     SACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRF
                     CSNLCLPKQVQMAATHIARKAVELDLVPGRSPISVAAAAIYMASQASAEKRTQKEIGD
                     IAGVADVTIRQSYRLIYPRAPDLFPSDFKFDTPVDKLPQL"
     exon            43..149
                     /gene="Gtf2b"
                     /inference="alignment:Splign:2.1.0"
     exon            150..283
                     /gene="Gtf2b"
                     /inference="alignment:Splign:2.1.0"
     exon            284..430
                     /gene="Gtf2b"
                     /inference="alignment:Splign:2.1.0"
     exon            431..560
                     /gene="Gtf2b"
                     /inference="alignment:Splign:2.1.0"
     exon            561..842
                     /gene="Gtf2b"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1253
                     /gene="Gtf2b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1234..1239
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtf2b"
                     /note="hexamer: AATAAA"
     polyA_site      1253
                     /gene="Gtf2b"
                     /note="major polyA site"
ORIGIN      
        1 cggagctgtt ggcggagccg cgaagatggc gtcgaccagc cgtttggatg ctctcccaag
       61 agtcacatgt ccgaatcatc cagatgcaat tttagttgaa gactacagag ctggcgatat
      121 gatctgtccc gaatgtggcc tagttgtagg ggaccgagtt attgatgtgg gatctgaatg
      181 gagaactttc agcaatgaca aagcaacaaa agacccatct agagttggag actctcagaa
      241 tcctcttctg agtgatggag atttgtccac catgattggc aagggtacag gagctgcaag
      301 ttttgatgag tttggcaatt ctaagtatca gaaccggaga acaatgagta gctctgatcg
      361 agcaatgatg aacgcattca aggaaatcac gaccatggcg gacagaatca acctccctcg
      421 caatatagtt gatcgaacaa ataatttatt caagcaagtg tatgagcaga agagcctgaa
      481 gggcagagct aatgacgcga tagcctctgc ttgtctgtac atcgcctgta gacaagaagg
      541 cgttcccagg acatttaaag aaatatgtgc tgtgtctcga atctctaaga aagaaattgg
      601 ccgctgtttt aaactgattt tgaaagctct ggaaaccagc gtggatctga tcacaactgg
      661 ggacttcatg tccaggttct gctccaacct ttgcctcccc aagcaagtgc agatggcagc
      721 tacacacata gcccgcaagg cagtggagct ggacttggtt cctggcagga gcccgatctc
      781 tgtggcggca gcagctattt acatggcttc ccaggcttca gctgagaagc gaacacagaa
      841 agaaatcggg gatattgctg gtgttgctga tgttacaatc cgacagtcct acagactgat
      901 ctaccctcgg gctccggatc tcttcccttc agacttcaag tttgacaccc cagtggacaa
      961 attaccccag ctataagctg aggcaactaa gtgtcacact cttaatgtac atggaatatg
     1021 gaactttgta catagccaca cagtgctggt tgagccttta atgaggaaaa aggagatggt
     1081 acccattcca gagctaaata ttattgctta gtcttctgta tgtatatact agtgcaacat
     1141 atttaatgac ttaaatttct tactgaatct gctttctttt ttagtgatct aggaaacagt
     1201 attttggaag gtattaaaat aatgtaattc tcaaataaaa atttaaaacc aaaaaaaaaa
     1261 aaaaaaa
//
