LOCUS       NM_001282083            1186 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus general transcription factor II A, 2 (Gtf2a2),
            transcript variant 1, mRNA.
ACCESSION   NM_001282083
VERSION     NM_001282083.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1186)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   2  (bases 1 to 1186)
  AUTHORS   Takeda,S., Sasagawa,S., Oyama,T., Searleman,A.C., Westergard,T.D.,
            Cheng,E.H. and Hsieh,J.J.
  TITLE     Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by
            limiting Cdkn2a locus transcription
  JOURNAL   J Clin Invest 125 (3), 1203-1214 (2015)
   PUBMED   25664857
REFERENCE   3  (bases 1 to 1186)
  AUTHORS   Kamileri,I., Karakasilioti,I., Sideri,A., Kosteas,T., Tatarakis,A.,
            Talianidis,I. and Garinis,G.A.
  TITLE     Defective transcription initiation causes postnatal growth failure
            in a mouse model of nucleotide excision repair (NER) progeria
  JOURNAL   Proc Natl Acad Sci U S A 109 (8), 2995-3000 (2012)
   PUBMED   22323595
REFERENCE   4  (bases 1 to 1186)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   5  (bases 1 to 1186)
  AUTHORS   Anderson,D.M., Beres,B.J., Wilson-Rawls,J. and Rawls,A.
  TITLE     The homeobox gene Mohawk represses transcription by recruiting the
            sin3A/HDAC co-repressor complex
  JOURNAL   Dev Dyn 238 (3), 572-580 (2009)
   PUBMED   19235719
REFERENCE   6  (bases 1 to 1186)
  AUTHORS   Han,S.Y., Zhou,L., Upadhyaya,A., Lee,S.H., Parker,K.L. and
            DeJong,J.
  TITLE     TFIIAalpha/beta-like factor is encoded by a germ cell-specific gene
            whose expression is up-regulated with other general transcription
            factors during spermatogenesis in the mouse
  JOURNAL   Biol Reprod 64 (2), 507-517 (2001)
   PUBMED   11159353
REFERENCE   7  (bases 1 to 1186)
  AUTHORS   Roeder,R.G.
  TITLE     The role of general initiation factors in transcription by RNA
            polymerase II
  JOURNAL   Trends Biochem Sci 21 (9), 327-335 (1996)
   PUBMED   8870495
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB842876.1, AK050621.1, BG088284.2, CR514895.1 and AK165466.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Both variants 1 and
            2 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050621.1, SRR7345562.3998584.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BB842876.1         5-27
            24-782              AK050621.1         2-760
            783-903             BG088284.2         451-571
            904-1170            CR514895.1         6-272               c
            1171-1186           AK165466.1         879-894
FEATURES             Location/Qualifiers
     source          1..1186
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 39.18 cM"
     gene            1..1186
                     /gene="Gtf2a2"
                     /gene_synonym="TFIIA-gamma; Tfiia2; TfIIg"
                     /note="general transcription factor II A, 2"
                     /db_xref="GeneID:235459"
                     /db_xref="MGI:MGI:1933289"
     exon            1..405
                     /gene="Gtf2a2"
                     /gene_synonym="TFIIA-gamma; Tfiia2; TfIIg"
                     /inference="alignment:Splign:2.1.0"
     exon            406..524
                     /gene="Gtf2a2"
                     /gene_synonym="TFIIA-gamma; Tfiia2; TfIIg"
                     /inference="alignment:Splign:2.1.0"
     CDS             453..782
                     /gene="Gtf2a2"
                     /gene_synonym="TFIIA-gamma; Tfiia2; TfIIg"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription initiation factor IIA subunit 2; general
                     transcription factor IIA, 2 (12kD subunit); transcription
                     initiation factor IIA gamma chain"
                     /codon_start=1
                     /product="transcription initiation factor IIA subunit 2
                     isoform 1"
                     /protein_id="NP_001269012.1"
                     /db_xref="CCDS:CCDS52851.1"
                     /db_xref="GeneID:235459"
                     /db_xref="MGI:MGI:1933289"
                     /translation="MAYQLYRNTTLGNSLQESLDELIQSQQITPQLALQVLLQFDKAI
                     NSALAQRVRNRVNFRGSLNTYRFCDNVWTFVLNDVEFREVTELIKVDKVKIVACDGKN
                     TGSNTTE"
     exon            525..629
                     /gene="Gtf2a2"
                     /gene_synonym="TFIIA-gamma; Tfiia2; TfIIg"
                     /inference="alignment:Splign:2.1.0"
     exon            630..756
                     /gene="Gtf2a2"
                     /gene_synonym="TFIIA-gamma; Tfiia2; TfIIg"
                     /inference="alignment:Splign:2.1.0"
     exon            757..1186
                     /gene="Gtf2a2"
                     /gene_synonym="TFIIA-gamma; Tfiia2; TfIIg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1038..1043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtf2a2"
                     /gene_synonym="TFIIA-gamma; Tfiia2; TfIIg"
                     /note="hexamer: AATAAA"
     polyA_site      1058
                     /gene="Gtf2a2"
                     /gene_synonym="TFIIA-gamma; Tfiia2; TfIIg"
                     /note="major polyA site"
     regulatory      1148..1153
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gtf2a2"
                     /gene_synonym="TFIIA-gamma; Tfiia2; TfIIg"
                     /note="hexamer: AATAAA"
     polyA_site      1178
                     /gene="Gtf2a2"
                     /gene_synonym="TFIIA-gamma; Tfiia2; TfIIg"
ORIGIN      
        1 gtgagcactt ccgggtcact ggcacagggc tgcggtttcc gcggccgagg aggtggtcgc
       61 agcgggctcc ctacctggct ctgctaccgc cgtggcggaa gcgccttccc tcaggtaggc
      121 ggcggcgggg ccgggagcgg ggaggccgcg gcgaggcggg cggtaccgag cgctgtgccc
      181 gccggaaggc gaccccagac agacgcagcc gcgcgggagc agccgccttc ccgctctcct
      241 caggccgcgc ttaggcgacc ggcgtcccgc tcggatgccg ggcacacacg gcgcctgcgc
      301 tccagctctg cagtgaggag gggattccga agttctgcag ttgccgccac ctttaaagat
      361 tggagatggc cgagccagct cgtttcagca gacgtcgaag tcgctgacat caatgcaagc
      421 ctgaagaaaa agtaattgct tccttttaag ccatggccta tcagttatac agaaatacaa
      481 ctttggggaa cagtcttcaa gagagccttg atgagctcat acagtctcaa cagatcaccc
      541 cccagcttgc gcttcaagtt ctacttcagt ttgataaagc tataaattca gcattggctc
      601 agagagtcag gaacagagtc aatttcaggg gctctctaaa tacatacaga ttctgcgata
      661 atgtttggac ttttgtattg aatgatgttg aattcagaga ggtgacagaa cttattaaag
      721 tggataaagt gaaaattgta gcctgtgatg gtaaaaatac tggctcgaat actacggaat
      781 gagtagagaa atgcagcttt ttttatgcca ccttctgtta ttttcatcgc tttttgaaga
      841 gaaacatgga agagactttt ttttatttat tctcacggtg cagaaatgac aacactgtgc
      901 tatatctact acccagggtc ccgcagagag aagcatgcga ctctgttctc gtaatgacct
      961 ttagtacaca gcataaagaa atgtaacttt tttttaatga caaatcaaaa gtggttgcct
     1021 tcataagatt attcttcaat aaactcgttt taaaacttgt tgtgagtaat acttgatgca
     1081 gctggttagc agggaattgt caaaaatacc agagaaattg aagaggggct tgaaaaaggt
     1141 gtccttcaat aaaattttgt ttaccttgtc gattgtaatt ttatct
//
