LOCUS       NM_008178               1783 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus GS homeobox 1 (Gsx1), mRNA.
ACCESSION   NM_008178
VERSION     NM_008178.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1783)
  AUTHORS   Talley,M.J., Nardini,D., Ehrman,L.A., Lu,Q.R. and Waclaw,R.R.
  TITLE     Distinct requirements for Tcf3 and Tcf12 during oligodendrocyte
            development in the mouse telencephalon
  JOURNAL   Neural Dev 18 (1), 5 (2023)
   PUBMED   37684687
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1783)
  AUTHORS   Manuel,M., Tan,K.B., Kozic,Z., Molinek,M., Marcos,T.S.,
            Razak,M.F.A., Dobolyi,D., Dobie,R., Henderson,B.E.P.,
            Henderson,N.C., Chan,W.K., Daw,M.I., Mason,J.O. and Price,D.J.
  TITLE     Pax6 limits the competence of developing cerebral cortical cells to
            respond to inductive intercellular signals
  JOURNAL   PLoS Biol 20 (9), e3001563 (2022)
   PUBMED   36067211
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1783)
  AUTHORS   Su-Feher,L., Rubin,A.N., Silberberg,S.N., Catta-Preta,R., Lim,K.J.,
            Ypsilanti,A.R., Zdilar,I., McGinnis,C.S., McKinsey,G.L.,
            Rubino,T.E. Jr., Hawrylycz,M.J., Thompson,C., Gartner,Z.J.,
            Puelles,L., Zeng,H., Rubenstein,J.L.R. and Nord,A.S.
  TITLE     Single cell enhancer activity distinguishes GABAergic and
            cholinergic lineages in embryonic mouse basal ganglia
  JOURNAL   Proc Natl Acad Sci U S A 119 (15), e2108760119 (2022)
   PUBMED   35377797
REFERENCE   4  (bases 1 to 1783)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1783)
  AUTHORS   Zhang,K., Yu,F., Zhu,J., Han,S., Chen,J., Wu,X., Chen,Y., Shen,T.,
            Liao,J., Guo,W., Yang,X., Wang,R., Qian,Y., Yang,J., Cheng,L.,
            Zhao,Y., Hui,C.C., Li,J., Peng,G., He,S., Jing,N. and Tang,K.
  TITLE     Imbalance of Excitatory/Inhibitory Neuron Differentiation in
            Neurodevelopmental Disorders with an NR2F1 Point Mutation
  JOURNAL   Cell Rep 31 (3), 107521 (2020)
   PUBMED   32320667
REFERENCE   6  (bases 1 to 1783)
  AUTHORS   Mastick,G.S., Davis,N.M., Andrew,G.L. and Easter,S.S. Jr.
  TITLE     Pax-6 functions in boundary formation and axon guidance in the
            embryonic mouse forebrain
  JOURNAL   Development 124 (10), 1985-1997 (1997)
   PUBMED   9169845
REFERENCE   7  (bases 1 to 1783)
  AUTHORS   Li,H., Zeitler,P.S., Valerius,M.T., Small,K. and Potter,S.S.
  TITLE     Gsh-1, an orphan Hox gene, is required for normal pituitary
            development
  JOURNAL   EMBO J 15 (4), 714-724 (1996)
   PUBMED   8631293
REFERENCE   8  (bases 1 to 1783)
  AUTHORS   Sommers,C.L., Huang,K., Shores,E.W., Grinberg,A., Charlick,D.A.,
            Kozak,C.A. and Love,P.E.
  TITLE     Murine txk: a protein tyrosine kinase gene regulated by T cell
            activation
  JOURNAL   Oncogene 11 (2), 245-251 (1995)
   PUBMED   7542761
REFERENCE   9  (bases 1 to 1783)
  AUTHORS   Valerius,M.T., Li,H., Stock,J.L., Weinstein,M., Kaur,S., Singh,G.
            and Potter,S.S.
  TITLE     Gsh-1: a novel murine homeobox gene expressed in the central
            nervous system
  JOURNAL   Dev Dyn 203 (3), 337-351 (1995)
   PUBMED   8589431
REFERENCE   10 (bases 1 to 1783)
  AUTHORS   Singh,G., Kaur,S., Stock,J.L., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Potter,S.S.
  TITLE     Identification of 10 murine homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10706-10710 (1991)
   PUBMED   1683707
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115847.19.
            
            On Oct 27, 2022 this sequence version replaced NM_008178.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U21224.1, BC137769.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-617               AC115847.19        105556-106172
            618-1783            AC115847.19        106652-107817
FEATURES             Location/Qualifiers
     source          1..1783
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 86.79 cM"
     gene            1..1783
                     /gene="Gsx1"
                     /gene_synonym="Gsh-1; Gsh1"
                     /note="GS homeobox 1"
                     /db_xref="GeneID:14842"
                     /db_xref="MGI:MGI:95842"
     exon            1..617
                     /gene="Gsx1"
                     /gene_synonym="Gsh-1; Gsh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..994
                     /gene="Gsx1"
                     /gene_synonym="Gsh-1; Gsh1"
                     /note="homeobox protein GSH-1; genomic screened homeo box
                     1"
                     /codon_start=1
                     /product="GS homeobox 1"
                     /protein_id="NP_032204.1"
                     /db_xref="CCDS:CCDS19877.1"
                     /db_xref="GeneID:14842"
                     /db_xref="MGI:MGI:95842"
                     /translation="MPRSFLVDSLVLREASDKKAPEGSPPPLFPYAVPPPHALHGLSP
                     GACHARKAGLLCVCPLCVTASQLHGPPGPPALPLLKASFPPFGSQYCHAPLGRQHSVS
                     PGVAHGPAAAAAAAALYQTSYPLPDPRQFHCISVDSSSNQLPSSKRMRTAFTSTQLLE
                     LEREFASNMYLSRLRRIEIATYLNLSEKQVKIWFQNRRVKHKKEGKGSNHRGGAGAGA
                     GGGAPQGCKCSSLSSAKCSEDDDELPMSPSSSGKDDRDLTVTP"
     exon            618..1783
                     /gene="Gsx1"
                     /gene_synonym="Gsh-1; Gsh1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1764..1769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gsx1"
                     /gene_synonym="Gsh-1; Gsh1"
                     /note="hexamer: AATAAA"
     polyA_site      1783
                     /gene="Gsx1"
                     /gene_synonym="Gsh-1; Gsh1"
                     /note="major polyA site"
ORIGIN      
        1 accactagcg ctggccagca cctcgcccgc tccgggaggt gcccgcagca gcagccaagg
       61 tgattccagc ccgggcttga gccgcgcgtg gagcctccgg ggcccgggaa gctgcgggtg
      121 gccgcggcca ggggaagcta cgacaggatc tgcagttccc tcgggctcca ggggcgggct
      181 ggcggcaggt ggaccgcgcg ccggagccat gccgcgctcc ttcctggtgg attcccttgt
      241 gctgcgggaa gccagcgaca agaaggctcc ggagggcagc ccgccaccgc tcttccccta
      301 cgcggtcccg ccgccgcacg cgctccacgg cctctcgccg ggcgcctgcc acgcgcgcaa
      361 ggccggcttg ctgtgcgtgt gtcccctctg tgtcaccgct tcgcagctgc acgggccccc
      421 cgggccgccg gcactgccgc tactcaaggc gtccttccct cccttcggat cgcagtactg
      481 ccacgcaccc ctgggccgcc agcactccgt gtcccctgga gtcgcccacg gcccggctgc
      541 ggccgcagca gctgctgcac tctaccagac ctcctacccg ctgccggatc ccagacagtt
      601 tcactgcatc tctgtggaca gcagctcgaa ccagctgccc agcagcaaga ggatgcggac
      661 ggcgttcacc agcacacagc tcctggagct ggagcgagag ttcgcctcca acatgtacct
      721 ctcccgcctg cggcgcatcg agatcgcgac ctatctgaac ctgtccgaga agcaggtgaa
      781 gatctggttt cagaaccgcc gggtgaagca caagaaagaa ggcaaaggca gtaaccaccg
      841 cggcggagct ggggcggggg ccggcggggg cgcaccgcaa ggctgcaagt gctcttcgct
      901 ctcctcagcc aaatgctcag aggacgacga cgaattgccc atgtctccat cttcctccgg
      961 gaaggatgac agagatctca cagtcactcc gtaggtgcgc cttttagagg accattggtt
     1021 tccccacccc ccaccccgac ccttcccgca ctggtcccca ggcacccgct ggccaaccga
     1081 cggatttcgt tgggctttgc ggtggtgcgc agctttaggc agagctaaga ccttagcaga
     1141 cacttgaaga cagtgcccct gtcccttggg cttcagggtg tttaggagga ctccaagcga
     1201 tgaaggctga gtcctcctcc taggacacag cctcttctcc caggcacgca ggccggagca
     1261 cagcgccttg ctgaccgcca gcgcctcttc gcctgccaac tctgggctgg ttcaagcttc
     1321 ctcggttcca ctattctctc cttctcggtc aatctgggct tttcactccg cgagtggctg
     1381 tttgcttttc ttttaacatt tctttcttgc ccccaactcg tctcccccca ctgtggtcct
     1441 ttatgcaaca cgtctatgga cttaactttt ccttccctcc tcaggaagtc tctcccttct
     1501 gtccgtttgt cccttaaaca gggatcaggt cttgctgttc gaagaagtcc ccctagcaga
     1561 gagaactgtc tcacatggta ttgtattggg gaaaatgact ctgtttccaa tacgctctaa
     1621 acccccttca aatgaagccg ctgtaaccaa cctctcccca ttgtccaggc cccgactccc
     1681 tctggggact gactgactgt gtcattgtat cgtctctgta atgccagaag atatttattt
     1741 atttatttat gtacaaaatt ttaaataaac tttttttttc tta
//
