LOCUS       NM_010363               1683 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus glutathione transferase zeta 1 (maleylacetoacetate
            isomerase) (Gstz1), transcript variant 1, mRNA.
ACCESSION   NM_010363
VERSION     NM_010363.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1683)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1683)
  AUTHORS   Luo,H., Wang,Q., Yang,F., Liu,R., Gao,Q., Cheng,B., Lin,X.,
            Huang,L., Chen,C., Xiang,J., Wang,K., Qin,B. and Tang,N.
  TITLE     Signaling metabolite succinylacetone activates HIF-1alpha and
            promotes angiogenesis in GSTZ1-deficient hepatocellular carcinoma
  JOURNAL   JCI Insight 8 (23), e164968 (2023)
   PUBMED   37906252
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1683)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1683)
  AUTHORS   Wang,Q., Bin,C., Xue,Q., Gao,Q., Huang,A., Wang,K. and Tang,N.
  TITLE     GSTZ1 sensitizes hepatocellular carcinoma cells to
            sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis
  JOURNAL   Cell Death Dis 12 (5), 426 (2021)
   PUBMED   33931597
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1683)
  AUTHORS   Li,J., Wang,Q., Yang,Y., Lei,C., Yang,F., Liang,L., Chen,C.,
            Xia,J., Wang,K. and Tang,N.
  TITLE     GSTZ1 deficiency promotes hepatocellular carcinoma proliferation
            via activation of the KEAP1/NRF2 pathway
  JOURNAL   J Exp Clin Cancer Res 38 (1), 438 (2019)
   PUBMED   31666108
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1683)
  AUTHORS   Lim,C.E., Matthaei,K.I., Blackburn,A.C., Davis,R.P.,
            Dahlstrom,J.E., Koina,M.E., Anders,M.W. and Board,P.G.
  TITLE     Mice deficient in glutathione transferase zeta/maleylacetoacetate
            isomerase exhibit a range of pathological changes and elevated
            expression of alpha, mu, and pi class glutathione transferases
  JOURNAL   Am J Pathol 165 (2), 679-693 (2004)
   PUBMED   15277241
REFERENCE   7  (bases 1 to 1683)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 1683)
  AUTHORS   Ammini,C.V., Fernandez-Canon,J., Shroads,A.L., Cornett,R.,
            Cheung,J., James,M.O., Henderson,G.N., Grompe,M. and Stacpoole,P.W.
  TITLE     Pharmacologic or genetic ablation of maleylacetoacetate isomerase
            increases levels of toxic tyrosine catabolites in rodents
  JOURNAL   Biochem Pharmacol 66 (10), 2029-2038 (2003)
   PUBMED   14599561
REFERENCE   9  (bases 1 to 1683)
  AUTHORS   Fernandez-Canon,J.M., Baetscher,M.W., Finegold,M., Burlingame,T.,
            Gibson,K.M. and Grompe,M.
  TITLE     Maleylacetoacetate isomerase (MAAI/GSTZ)-deficient mice reveal a
            glutathione-dependent nonenzymatic bypass in tyrosine catabolism
  JOURNAL   Mol Cell Biol 22 (13), 4943-4951 (2002)
   PUBMED   12052898
  REMARK    GeneRIF: Maleylacetoacetate isomerase (MAAI/GSTZ)-deficient mice
            reveal a glutathione-dependent nonenzymatic bypass in tyrosine
            catabolism
REFERENCE   10 (bases 1 to 1683)
  AUTHORS   Fernandez-Canon,J.M., Hejna,J., Reifsteck,C., Olson,S. and
            Grompe,M.
  TITLE     Gene structure, chromosomal location, and expression pattern of
            maleylacetoacetate isomerase
  JOURNAL   Genomics 58 (3), 263-269 (1999)
   PUBMED   10373324
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY072664.1, AK075927.1 and AA244513.1.
            
            On Nov 18, 2011 this sequence version replaced NM_010363.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031777.1, SRR1660813.89776.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                BY072664.1         2-48
            48-1665             AK075927.1         2-1619
            1666-1683           AA244513.1         340-357
FEATURES             Location/Qualifiers
     source          1..1683
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 41.34 cM"
     gene            1..1683
                     /gene="Gstz1"
                     /gene_synonym="GSTZ1-1; MAAI"
                     /note="glutathione transferase zeta 1 (maleylacetoacetate
                     isomerase)"
                     /db_xref="GeneID:14874"
                     /db_xref="MGI:MGI:1341859"
     exon            1..138
                     /gene="Gstz1"
                     /gene_synonym="GSTZ1-1; MAAI"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..774
                     /gene="Gstz1"
                     /gene_synonym="GSTZ1-1; MAAI"
                     /EC_number="2.5.1.18"
                     /EC_number="5.2.1.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glutathione S-transferase zeta 1; maleylacetoacetate
                     isomerase"
                     /codon_start=1
                     /product="maleylacetoacetate isomerase isoform 1"
                     /protein_id="NP_034493.1"
                     /db_xref="CCDS:CCDS26071.1"
                     /db_xref="GeneID:14874"
                     /db_xref="MGI:MGI:1341859"
                     /translation="MQAGKPILYSYFRSSCSWRVRIALALKGIDYEIVPINLIKDGGQ
                     QFTEEFQTLNPMKQVPALKIDGITIVQSLAIMEYLEETRPIPRLLPQDPQKRAIVRMI
                     SDLIASGIQPLQNLSVLKQVGQENQMQWAQKVITSGFNALEKILQSTAGKYCVGDEVS
                     MADVCLVPQVANAERFKVDLSPYPTISHINKELLALEVFQVSHPRRQPDTPAELRT"
     exon            139..190
                     /gene="Gstz1"
                     /gene_synonym="GSTZ1-1; MAAI"
                     /inference="alignment:Splign:2.1.0"
     exon            191..258
                     /gene="Gstz1"
                     /gene_synonym="GSTZ1-1; MAAI"
                     /inference="alignment:Splign:2.1.0"
     exon            259..339
                     /gene="Gstz1"
                     /gene_synonym="GSTZ1-1; MAAI"
                     /inference="alignment:Splign:2.1.0"
     exon            340..465
                     /gene="Gstz1"
                     /gene_synonym="GSTZ1-1; MAAI"
                     /inference="alignment:Splign:2.1.0"
     exon            466..544
                     /gene="Gstz1"
                     /gene_synonym="GSTZ1-1; MAAI"
                     /inference="alignment:Splign:2.1.0"
     exon            545..597
                     /gene="Gstz1"
                     /gene_synonym="GSTZ1-1; MAAI"
                     /inference="alignment:Splign:2.1.0"
     exon            598..647
                     /gene="Gstz1"
                     /gene_synonym="GSTZ1-1; MAAI"
                     /inference="alignment:Splign:2.1.0"
     exon            648..1667
                     /gene="Gstz1"
                     /gene_synonym="GSTZ1-1; MAAI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1647..1652
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gstz1"
                     /gene_synonym="GSTZ1-1; MAAI"
                     /note="hexamer: AATAAA"
     polyA_site      1667
                     /gene="Gstz1"
                     /gene_synonym="GSTZ1-1; MAAI"
                     /note="major polyA site"
ORIGIN      
        1 gggggcgggg ccagcccgaa ggagggaggc catctagtcc aaccttcgct ctctggaccc
       61 cgctaggcct cagtcatctt ctagtcccga gagctgactt tcttggccgg ccgaccgggc
      121 gagatgcaag ccgggaagcc tatcctctac tcctatttcc gaagctcctg ttcatggaga
      181 gttcgaattg ctctggcgtt aaaaggcatt gactatgaga tagtgcccat caacctcata
      241 aaggatggcg ggcaacagtt cactgaggaa tttcagaccc tgaaccccat gaagcaagtg
      301 ccagcgctga aaattgatgg aatcaccatt gtccagtcac tggccatcat ggagtacctg
      361 gaagagactc ggcctatccc acggctcctg cctcaggacc cacagaaaag agccatcgtg
      421 cgcatgattt ctgacctcat cgctagtggc atccagcccc ttcagaacct gtctgtcctg
      481 aagcaagtgg gacaggagaa ccagatgcaa tgggcccaaa aggttattac ttccggcttt
      541 aacgctctgg agaagattct gcagagcaca gcagggaagt actgcgtagg agatgaggta
      601 tccatggctg atgtgtgctt agtaccccaa gtggcaaatg ctgaaaggtt caaggtggat
      661 ctaagcccct accctaccat cagtcacatc aacaaggagc tgctagcctt agaggttttc
      721 caagtgtctc acccccgtcg acagccagat acccctgccg agctgaggac ttagctccca
      781 aaccatgccc attggtacag ggaagggagt aggcccagat gctgggtgtt ctactgctgt
      841 gaagagacac catgaccatg gcaactctga caaagaaaga cgttcaatta gcttacagtt
      901 tcagagattc agtccattat catgatggta gaaagcaagg cacatgtaag gcagtcatgg
      961 tgctggagag gtagcagaga attcacatct ggatccaaag gcagcaagaa gagtgacact
     1021 gggcctgctg tgagcaatct gaaacctcaa agcccacccc cagagacaca acgtcctcca
     1081 agaaggccac acctcctatt agtgcaactc cctatatgcc tttttattca aaccagaaca
     1141 ggcccagaaa tgaatgcatt atagcagagg atttgaactt gagctctttc ctcaggaagc
     1201 agcagattca tggagtccag gctatttctt ccaggtcccc gtattaaagt tttctctagc
     1261 aacatgaagc cagttcgata tatcttcctt ctgcttgcac tatagtcact acagtctgca
     1321 ttaattctct tatctgtcac gtgttaggag ggggtaggca gagacatgac cagctctcac
     1381 cggctaatgt taattgtcaa cttgaaataa agctagaatc accagggaga agggccttta
     1441 taaatgtctg ttgggggtta tattggtacc attgaggtgg gatggcaccc agcatggatg
     1501 gcaccattcc ctaggcagag gatcctgggg cccagaagag tagagaagga gtggagcaac
     1561 caccacacgt gcattatgat cagctgctca cgctgatgtc ttgacttccc tgccattatg
     1621 gactataccc tgaaaccatg ggctaaaata aaccttctct cctttaaaaa aaaaaaaaaa
     1681 aaa
//
