LOCUS       NM_010361               1370 bp    mRNA    linear   ROD 05-FEB-2024
DEFINITION  Mus musculus glutathione S-transferase, theta 2 (Gstt2), mRNA.
ACCESSION   NM_010361
VERSION     NM_010361.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1370)
  AUTHORS   Kano,S.I., Choi,E.Y., Dohi,E., Agarwal,S., Chang,D.J., Wilson,A.M.,
            Lo,B.D., Rose,I.V.L., Gonzalez,S., Imai,T. and Sawa,A.
  TITLE     Glutathione S-transferases promote proinflammatory
            astrocyte-microglia communication during brain inflammation
  JOURNAL   Sci Signal 12 (569) (2019)
   PUBMED   30783009
  REMARK    GeneRIF: Glutathione S-transferase mu 1 (GSTM1) and glutathione
            S-transferase theta 2 (GSTT2) were required in astrocytes for the
            enhancement of microglia activation during brain inflammation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1370)
  AUTHORS   Kamileri,I., Karakasilioti,I., Sideri,A., Kosteas,T., Tatarakis,A.,
            Talianidis,I. and Garinis,G.A.
  TITLE     Defective transcription initiation causes postnatal growth failure
            in a mouse model of nucleotide excision repair (NER) progeria
  JOURNAL   Proc Natl Acad Sci U S A 109 (8), 2995-3000 (2012)
   PUBMED   22323595
REFERENCE   3  (bases 1 to 1370)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   4  (bases 1 to 1370)
  AUTHORS   Endoh-Yamagami,S., Karkar,K.M., May,S.R., Cobos,I., Thwin,M.T.,
            Long,J.E., Ashique,A.M., Zarbalis,K., Rubenstein,J.L. and
            Peterson,A.S.
  TITLE     A mutation in the pericentrin gene causes abnormal interneuron
            migration to the olfactory bulb in mice
  JOURNAL   Dev Biol 340 (1), 41-53 (2010)
   PUBMED   20096683
REFERENCE   5  (bases 1 to 1370)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   6  (bases 1 to 1370)
  AUTHORS   Board,P.G., Coggan,M., Chelvanayagam,G., Easteal,S., Jermiin,L.S.,
            Schulte,G.K., Danley,D.E., Hoth,L.R., Griffor,M.C., Kamath,A.V.,
            Rosner,M.H., Chrunyk,B.A., Perregaux,D.E., Gabel,C.A.,
            Geoghegan,K.F. and Pandit,J.
  TITLE     Identification, characterization, and crystal structure of the
            Omega class glutathione transferases
  JOURNAL   J Biol Chem 275 (32), 24798-24806 (2000)
   PUBMED   10783391
REFERENCE   7  (bases 1 to 1370)
  AUTHORS   Whittington,A., Vichai,V., Webb,G., Baker,R., Pearson,W. and
            Board,P.
  TITLE     Gene structure, expression and chromosomal localization of murine
            theta class glutathione transferase mGSTT1-1
  JOURNAL   Biochem J 337 (Pt 1) (Pt 1), 141-151 (1999)
   PUBMED   9854036
REFERENCE   8  (bases 1 to 1370)
  AUTHORS   Zobeley,E., Sufalko,D.K., Adkins,S. and Burmeister,M.
  TITLE     Fine genetic and comparative mapping of the deafness mutation Ames
            waltzer on mouse chromosome 10
  JOURNAL   Genomics 50 (2), 260-266 (1998)
   PUBMED   9653653
REFERENCE   9  (bases 1 to 1370)
  AUTHORS   Mainwaring,G.W., Williams,S.M., Foster,J.R., Tugwood,J. and
            Green,T.
  TITLE     The distribution of theta-class glutathione S-transferases in the
            liver and lung of mouse, rat and human
  JOURNAL   Biochem J 318 (Pt 1) (Pt 1), 297-303 (1996)
   PUBMED   8761485
REFERENCE   10 (bases 1 to 1370)
  AUTHORS   Whittington,A.T., Webb,G.C., Baker,R.T. and Board,P.G.
  TITLE     Characterization of a cDNA and gene encoding the mouse theta class
            glutathione transferase mGSTT2 and its localization to chromosome
            10B5-C1
  JOURNAL   Genomics 33 (1), 105-111 (1996)
   PUBMED   8617493
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU938629.1 and AK158939.1.
            
            [WARNING] On Mar 14, 2024 this sequence was replaced by
            NM_010361.3.
            
            On Oct 10, 2007 this sequence version replaced NM_010361.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158939.1, BC012707.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BU938629.1         157-166
            11-1370             AK158939.1         2-1361
FEATURES             Location/Qualifiers
     source          1..1370
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 38.58 cM"
     gene            1..1370
                     /gene="Gstt2"
                     /gene_synonym="mGSTT2; Yrs"
                     /note="glutathione S-transferase, theta 2"
                     /db_xref="GeneID:14872"
                     /db_xref="MGI:MGI:106188"
     exon            1..707
                     /gene="Gstt2"
                     /gene_synonym="mGSTT2; Yrs"
                     /inference="alignment:Splign:2.1.0"
     CDS             596..1330
                     /gene="Gstt2"
                     /gene_synonym="mGSTT2; Yrs"
                     /EC_number="2.5.1.18"
                     /note="GST class-theta-2"
                     /codon_start=1
                     /product="glutathione S-transferase theta-2"
                     /protein_id="NP_034491.2"
                     /db_xref="CCDS:CCDS48601.1"
                     /db_xref="GeneID:14872"
                     /db_xref="MGI:MGI:106188"
                     /translation="MGLELYLDLLSQPSRAVYIFAKKNGIPFQTRTVDILKGQHMSEQ
                     FSQVNCLNKVPVLKDGSFVLTESTAILIYLSSKYQVADHWYPADLQARAQVHEYLGWH
                     ADNIRGTFGVLLWTKVLGPLIGVQVPQEKVERNRDRMVLVLQQLEDKFLRDRAFLVGQ
                     QVTLADLMSLEELMQPVALGYNLFEGRPQLTAWRERVEAFLGAELCQEAHSTILSILG
                     QAAKKMLPVPPPEVHASMQLRIARIP"
     exon            708..795
                     /gene="Gstt2"
                     /gene_synonym="mGSTT2; Yrs"
                     /inference="alignment:Splign:2.1.0"
     exon            796..946
                     /gene="Gstt2"
                     /gene_synonym="mGSTT2; Yrs"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1120
                     /gene="Gstt2"
                     /gene_synonym="mGSTT2; Yrs"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1370
                     /gene="Gstt2"
                     /gene_synonym="mGSTT2; Yrs"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctaccgt ggagagtgtt ggaggcgggc gagagaggtg gtcctgtgac tccttcaagc
       61 tttgctgccc agcctcacag atctggggag gtccagtgtt cttagacgac ctgttttgca
      121 cggggcagct ggaccaacca cagttcttcc ttaaggcaaa gtttctagca gcctgcaaca
      181 agcttcaccc gttaaagaag gatcagcgat cagcctctaa gatcccctcc tgcagtaact
      241 gagagctagg agctgagcgg tctagttccc cgcaaacgac tacgtccaca gaactctgag
      301 ttgggtccac gaaagcccag ctaggccatt tccgcgtccg ggtgagacta aggtcctggg
      361 ctggattcct ggctccacgg tccgctggag caaatcgcat aagtcagtct gagtgcgcgc
      421 gcacctcagc cctgcttttg gtataaagtc ctccaaagcg tctccctccc caagatcagc
      481 aggtgtcagc tatccagagg aggaaatcgt ttggcttggc caactgaggc tgtgctggac
      541 cccagcttgc tgttatcgaa cgcagtcggc acaccatctt gtgtcgctac cggcaatggg
      601 cttggagctc tacctggacc tgctgtcaca acccagccgc gctgtctaca tcttcgccaa
      661 gaagaatggc atccccttcc agacgcgtac cgtggatata ctcaaagggc agcacatgag
      721 cgagcaattc tcccaggtga actgcttaaa caaagttcct gtactcaaag acggaagctt
      781 cgtgttgacc gaaagcacag ccatcttgat ttacctgagt tccaagtacc aggtggcaga
      841 ccactggtac ccggccgacc tacaggcccg tgcccaagtc cacgaatacc tgggctggca
      901 tgccgacaac atccgtggta ctttcggagt gctcctatgg accaaggtgt tggggccact
      961 cattggggtc caggttcccc aggagaaggt ggaacggaac agagatagaa tggtcctggt
     1021 tctgcaacag ctggaggaca agttcctcag ggacagggcc ttccttgttg gccagcaggt
     1081 gacgctagcg gatctcatgt ctctggagga gttgatgcag cccgtggctc ttggctataa
     1141 cctgtttgag ggacggcctc agctgacagc atggcgagag agggtggagg cgttcttggg
     1201 tgctgagctg tgtcaggagg ctcatagcac catcctgagc atcctgggac aggcagccaa
     1261 gaaaatgtta ccagtacccc ctccggaggt ccatgccagc atgcagcttc gaattgctag
     1321 gattccttga gtggtctgac cagcaataaa gactcatttt gtgttttttc
//
