LOCUS       NM_008185               1049 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus glutathione S-transferase, theta 1 (Gstt1), transcript
            variant 1, mRNA.
ACCESSION   NM_008185
VERSION     NM_008185.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1049)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1049)
  AUTHORS   Aure,M.H., Symonds,J.M., Villapudua,C.U., Dodge,J.T., Werner,S.,
            Knosp,W.M. and Hoffman,M.P.
  TITLE     FGFR2 is essential for salivary gland duct homeostasis and
            MAPK-dependent seromucous acinar cell differentiation
  JOURNAL   Nat Commun 14 (1), 6485 (2023)
   PUBMED   37838739
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1049)
  AUTHORS   Li,P., Liu,Z., Wang,J., Bi,X., Xiao,Y., Qiao,R., Zhou,X., Guo,S.,
            Wan,P., Chang,M., Hong,G., Liu,Z., Ming,X., Gao,J. and Fu,X.
  TITLE     Gstm1/Gstt1 is essential for reducing cisplatin ototoxicity in
            CBA/CaJ mice
  JOURNAL   FASEB J 36 (6), e22373 (2022)
   PUBMED   35621716
  REMARK    GeneRIF: Gstm1/Gstt1 is essential for reducing cisplatin
            ototoxicity in CBA/CaJ mice.
REFERENCE   4  (bases 1 to 1049)
  AUTHORS   Patel,V.N., Pineda,D.L., Berenstein,E., Hauser,B.R., Choi,S.,
            Prochazkova,M., Zheng,C., Goldsmith,C.M., van Kuppevelt,T.H.,
            Kulkarni,A., Song,Y., Linhardt,R.J., Chibly,A.M. and Hoffman,M.P.
  TITLE     Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to
            reduce epithelial morphogenesis and adult salivary gland function
  JOURNAL   Matrix Biol 103-104, 37-57 (2021)
   PUBMED   34653670
REFERENCE   5  (bases 1 to 1049)
  AUTHORS   Hauser,B.R., Aure,M.H., Kelly,M.C., Hoffman,M.P. and Chibly,A.M.
  CONSRTM   Genomics and Computational Biology Core
  TITLE     Generation of a Single-Cell RNAseq Atlas of Murine Salivary Gland
            Development
  JOURNAL   iScience 23 (12), 101838 (2020)
   PUBMED   33305192
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1049)
  AUTHORS   Sherratt,P.J., Williams,S., Foster,J., Kernohan,N., Green,T. and
            Hayes,J.D.
  TITLE     Direct comparison of the nature of mouse and human GST T1-1 and the
            implications on dichloromethane carcinogenicity
  JOURNAL   Toxicol Appl Pharmacol 179 (2), 89-97 (2002)
   PUBMED   11884241
  REMARK    GeneRIF: The carcinogenic effects of DCM in the mouse are caused by
            the interaction with DNA of a glutathione (GSH) conjugate that is
            produced by the class theta glutathione S-transferase T1-1 (GST
            T1-1).
REFERENCE   7  (bases 1 to 1049)
  AUTHORS   Landi,S.
  TITLE     Mammalian class theta GST and differential susceptibility to
            carcinogens: a review
  JOURNAL   Mutat Res 463 (3), 247-283 (2000)
   PUBMED   11018744
  REMARK    Review article
REFERENCE   8  (bases 1 to 1049)
  AUTHORS   Whittington,A., Vichai,V., Webb,G., Baker,R., Pearson,W. and
            Board,P.
  TITLE     Gene structure, expression and chromosomal localization of murine
            theta class glutathione transferase mGSTT1-1
  JOURNAL   Biochem J 337 (Pt 1) (Pt 1), 141-151 (1999)
   PUBMED   9854036
REFERENCE   9  (bases 1 to 1049)
  AUTHORS   Mainwaring,G.W., Williams,S.M., Foster,J.R., Tugwood,J. and
            Green,T.
  TITLE     The distribution of theta-class glutathione S-transferases in the
            liver and lung of mouse, rat and human
  JOURNAL   Biochem J 318 (Pt 1) (Pt 1), 297-303 (1996)
   PUBMED   8761485
REFERENCE   10 (bases 1 to 1049)
  AUTHORS   Mainwaring,G.W., Nash,J., Davidson,M. and Green,T.
  TITLE     Isolation of a mouse theta glutathione S-transferase active with
            methylene chloride
  JOURNAL   Biochem J 314 (Pt 2) (Pt 2), 445-448 (1996)
   PUBMED   8670055
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK002338.1, BY015234.1, W54467.1 and AI255817.1.
            
            On Nov 14, 2007 this sequence version replaced NM_008185.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002338.1, BY702875.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AK002338.1         1-14
            15-20               BY015234.1         2-7
            21-127              AK002338.1         21-127
            128-571             W54467.1           79-522
            572-1035            AK002338.1         572-1035
            1036-1049           AI255817.1         1-14                c
FEATURES             Location/Qualifiers
     source          1..1049
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 38.58 cM"
     gene            1..1049
                     /gene="Gstt1"
                     /gene_synonym="Gstt1-1"
                     /note="glutathione S-transferase, theta 1"
                     /db_xref="GeneID:14871"
                     /db_xref="MGI:MGI:107379"
     exon            1..200
                     /gene="Gstt1"
                     /gene_synonym="Gstt1-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..811
                     /gene="Gstt1"
                     /gene_synonym="Gstt1-1"
                     /EC_number="2.5.1.18"
                     /note="isoform 1 is encoded by transcript variant 1; GST
                     class-theta-1"
                     /codon_start=1
                     /product="glutathione S-transferase theta-1 isoform 1"
                     /protein_id="NP_032211.3"
                     /db_xref="CCDS:CCDS23932.1"
                     /db_xref="GeneID:14871"
                     /db_xref="MGI:MGI:107379"
                     /translation="MVLELYLDLLSQPCRAIYIFAKKNNIPFQMHTVELRKGEHLSDA
                     FARVNPMKRVPAMMDGGFTLCESVAILLYLAHKYKVPDHWYPQDLQARARVDEYLAWQ
                     HTGLRRSCLRALWHKVMFPVFLGEQIPPETLAATLAELDVNLQVLEDKFLQDKDFLVG
                     PHISLADLVAITELMHPVGGGCPVFEGHPRLAAWYQRVEAAVGKDLFREAHEVILKVK
                     DCPPADLIIKQKLMPRVLAMIQ"
     exon            201..288
                     /gene="Gstt1"
                     /gene_synonym="Gstt1-1"
                     /inference="alignment:Splign:2.1.0"
     exon            289..439
                     /gene="Gstt1"
                     /gene_synonym="Gstt1-1"
                     /inference="alignment:Splign:2.1.0"
     exon            440..616
                     /gene="Gstt1"
                     /gene_synonym="Gstt1-1"
                     /inference="alignment:Splign:2.1.0"
     exon            617..1037
                     /gene="Gstt1"
                     /gene_synonym="Gstt1-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1009..1014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gstt1"
                     /gene_synonym="Gstt1-1"
                     /note="hexamer: AATAAA"
     polyA_site      1037
                     /gene="Gstt1"
                     /gene_synonym="Gstt1-1"
                     /note="major polyA site"
ORIGIN      
        1 acacttggct tgatagggat ccctactagc cagcctggac tttttgatag tctggccagt
       61 tacagaagtg gttcccgccg cctatgccat ggttctggag ctgtacctgg atctgctgtc
      121 gcagccctgt cgcgccattt atatcttcgc caagaagaac aatatcccgt tccagatgca
      181 cacggtggag ctgcgcaagg gtgagcacct cagcgatgcg tttgcccggg tgaaccccat
      241 gaagagggta ccagccatga tggatggtgg cttcaccctg tgtgagagtg tggctatctt
      301 gctctacctg gcacacaagt ataaggttcc tgaccactgg tacccccaag acctgcaggc
      361 tcgtgctcgt gtagacgagt acctggcatg gcagcatacg ggccttcgga gaagctgcct
      421 cagggccctg tggcataagg tgatgttccc tgttttcctt ggtgagcaaa tacctcctga
      481 aacactggca gccacgttgg cagaactgga tgttaaccta caggtgcttg aagacaagtt
      541 cctccaggac aaagacttcc ttgttgggcc ccacatctcc ctggccgact tggtggccat
      601 cacagagctg atgcatcctg taggtggtgg ctgcccagtc tttgaagggc atcccaggct
      661 ggctgcatgg taccagcgag tggaggcagc tgtggggaag gacctcttcc gggaagccca
      721 tgaagtcatc ctgaaggtga aggactgtcc ccctgctgac ctcatcataa agcagaagct
      781 gatgcccaga gtgctggcaa tgatccagtg acgtcagacg cttcatccct gcaccagctg
      841 cggcagttca caactcacag ttcacaattc acaacttgca ttacactggg gatgcacctc
      901 actcctcaca ccatgatggc tctcaggctc agctccatct tcaccctttt tctgtgatag
      961 ccacacatga cctcaactat aatcactact ttccccttga gtctgggtaa taaactgggg
     1021 cttgatttgg gctttaaaaa aaaaaaaaa
//
