LOCUS       NM_026619               1305 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus glutathione S-transferase omega 2 (Gsto2), transcript
            variant 1, mRNA.
ACCESSION   NM_026619
VERSION     NM_026619.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1305)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1305)
  AUTHORS   Lin,L., Li,X.N., Xie,Z.Y., Hu,Y.Z., Long,Q.S., Wen,Y.Q., Wei,X.B.,
            Zhang,L.Y. and Li,X.S.
  TITLE     Pivotal Role of GSTO2 in Ferroptotic Neuronal Injury After
            Intracerebral Hemorrhage
  JOURNAL   J Mol Neurosci 74 (1), 24 (2024)
   PUBMED   38386166
  REMARK    GeneRIF: Pivotal Role of GSTO2 in Ferroptotic Neuronal Injury After
            Intracerebral Hemorrhage.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1305)
  AUTHORS   Hamilton,L.E., Suzuki,J., Aguila,L., Meinsohn,M.C., Smith,O.E.,
            Protopapas,N., Xu,W., Sutovsky,P. and Oko,R.
  TITLE     Sperm-borne glutathione-S-transferase omega 2 accelerates the
            nuclear decondensation of spermatozoa during fertilization in
            micedagger
  JOURNAL   Biol Reprod 101 (2), 368-376 (2019)
   PUBMED   31087045
  REMARK    GeneRIF: Sperm-borne glutathione-S-transferase omega 2 accelerates
            the nuclear decondensation of spermatozoa during fertilization in
            micedagger.
REFERENCE   4  (bases 1 to 1305)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1305)
  AUTHORS   Hamilton,L.E., Acteau,G., Xu,W., Sutovsky,P. and Oko,R.
  TITLE     The developmental origin and compartmentalization of
            glutathione-s-transferase omega 2 isoforms in the perinuclear theca
            of eutherian spermatozoa
  JOURNAL   Biol Reprod 97 (4), 612-621 (2017)
   PUBMED   29036365
  REMARK    GeneRIF: GSTO2 is transported and deposited in the postacrosomal
            sheath (PAS) region by the manchette, and that the late assembly of
            GSTO2 and its localization in the PAS suggests a role in regulating
            the oxidative and reductive state of covalently linked
            spermatid/sperm proteins, especially during the disassembly of the
            sperm accessory structures after fertilization
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK075753.1, AK018953.1 and AK077086.1.
            
            On Mar 17, 2009 this sequence version replaced NM_026619.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK018953.1, AK075753.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AK075753.1         2-10
            10-306              AK018953.1         1-297
            307-1305            AK077086.1         261-1259
FEATURES             Location/Qualifiers
     source          1..1305
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 40.41 cM"
     gene            1..1305
                     /gene="Gsto2"
                     /gene_synonym="1700020F09Rik; 4930425C18Rik; GSTO 2-2"
                     /note="glutathione S-transferase omega 2"
                     /db_xref="GeneID:68214"
                     /db_xref="MGI:MGI:1915464"
     exon            1..136
                     /gene="Gsto2"
                     /gene_synonym="1700020F09Rik; 4930425C18Rik; GSTO 2-2"
                     /inference="alignment:Splign:2.1.0"
     exon            137..211
                     /gene="Gsto2"
                     /gene_synonym="1700020F09Rik; 4930425C18Rik; GSTO 2-2"
                     /inference="alignment:Splign:2.1.0"
     exon            212..326
                     /gene="Gsto2"
                     /gene_synonym="1700020F09Rik; 4930425C18Rik; GSTO 2-2"
                     /inference="alignment:Splign:2.1.0"
     exon            327..476
                     /gene="Gsto2"
                     /gene_synonym="1700020F09Rik; 4930425C18Rik; GSTO 2-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             443..1189
                     /gene="Gsto2"
                     /gene_synonym="1700020F09Rik; 4930425C18Rik; GSTO 2-2"
                     /EC_number="2.5.1.18"
                     /EC_number="1.8.5.1"
                     /EC_number="1.20.4.2"
                     /note="GSTO-2; MMA(V) reductase; monomethylarsonic acid
                     reductase; glutathione S-transferase omega 2-2;
                     glutathione-dependent dehydroascorbate reductase"
                     /codon_start=1
                     /product="glutathione S-transferase omega-2"
                     /protein_id="NP_080895.2"
                     /db_xref="CCDS:CCDS29894.1"
                     /db_xref="GeneID:68214"
                     /db_xref="MGI:MGI:1915464"
                     /translation="MSGDLSRCLGKGSCPPGPVPEGVIRIYSMRFCPYSHRARLVLKA
                     KGIRHEVININLKSKPDWYYTKHPFGQIPVLENSQCQLVYESVIACEYLDDVYPGRKL
                     FPYDPYERARQKMLLELFCKVPPLSKECLIALRCGRDCTDLKVALRQELCNMEEILEY
                     QNTTFFGGDCISMIDYLVWPWFERLDVYGLADCVNHTPMLRLWIASMKQDPAVCALHT
                     DKSVFLGFLNLYFQNNPCAFDFGLCNPIIR"
     exon            477..585
                     /gene="Gsto2"
                     /gene_synonym="1700020F09Rik; 4930425C18Rik; GSTO 2-2"
                     /inference="alignment:Splign:2.1.0"
     exon            586..808
                     /gene="Gsto2"
                     /gene_synonym="1700020F09Rik; 4930425C18Rik; GSTO 2-2"
                     /inference="alignment:Splign:2.1.0"
     exon            809..910
                     /gene="Gsto2"
                     /gene_synonym="1700020F09Rik; 4930425C18Rik; GSTO 2-2"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1017
                     /gene="Gsto2"
                     /gene_synonym="1700020F09Rik; 4930425C18Rik; GSTO 2-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1305
                     /gene="Gsto2"
                     /gene_synonym="1700020F09Rik; 4930425C18Rik; GSTO 2-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgtcggccg ccgggcgtcc caactccggg ttggagccat agccgcccga aggttgctct
       61 gagatgcttt ttctgccacc gccactgggg ggttcggcct cacctgcgct gtgtcggaag
      121 ggaaaaggat tttgagaacc tgggtgtggt ctcctcggcg gttatctgct gtatttatgt
      181 gaaaggtgaa tgaaagacaa gaaataaaaa gtcttaccat ccagcctgtc cgtctctatc
      241 agagttagtt ccaggggagt agttgcctgt gagacctgca tctgctgcag tggaaagtga
      301 gctgcctgct ccctcagcac agcaagagtg ctgtcgactg ttgagaaatt cagtttgggt
      361 ctggagggag cgcagtaagc agcagaggcc cacaaggcgg cgactgtgag ctttccggta
      421 ccgcatagat aactggagat tgatgtccgg ggatttgtca agatgcttgg gaaaaggaag
      481 ctgtccccca gggccggtcc ctgagggtgt gatccgaatc tacagcatga ggttctgccc
      541 ctactcgcac agggcacgcc tggttctcaa ggccaaaggc atcaggcatg aagtgatcaa
      601 tattaacctg aaaagcaagc ctgactggta ctatacaaag catccttttg gccaaattcc
      661 tgtcttggag aacagccagt gtcagctggt ctatgaatct gtcattgctt gtgagtacct
      721 ggatgacgtc tacccgggaa gaaagctgtt tccgtatgac ccgtatgaac gagctcgcca
      781 gaagatgtta ttggagctat tctgtaaggt cccgccttta agcaaggaat gtctgatagc
      841 gctgagatgc ggaagagact gtacggatct gaaggtcgcc ctgcgtcagg agttgtgcaa
      901 catggaagag attcttgaat atcagaacac taccttcttc ggcggagact gtatatccat
      961 gattgattac ctcgtctggc cctggtttga gcgcctggac gtatatggac tggctgactg
     1021 cgtgaatcac accccgatgc tgcggctctg gatagcctcc atgaagcagg accctgcagt
     1081 gtgtgctctg cacactgata agagcgtctt cctgggcttc ttgaatctct atttccaaaa
     1141 caacccttgt gcctttgatt ttgggctgtg taacccaatc atacgataat ccaggcattg
     1201 cccgggactc tcggtcattc tgatgtctgc atcacgggtc atcttggggt tccgtgtatt
     1261 tgttcttttt ttttgaggtc cctaataaat atggatgtgt aaaat
//
