LOCUS       NM_010362               1192 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus glutathione S-transferase omega 1 (Gsto1), mRNA.
ACCESSION   NM_010362
VERSION     NM_010362.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1192)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1192)
  AUTHORS   Iram,S., Mashaal,A., Go,S. and Kim,J.
  TITLE     Inhibition of glutathione S-transferase omega 1-catalyzed protein
            deglutathionylation suppresses adipocyte differentiation
  JOURNAL   BMB Rep 56 (8), 457-462 (2023)
   PUBMED   37156632
  REMARK    GeneRIF: Inhibition of glutathione S-transferase omega 1-catalyzed
            protein deglutathionylation suppresses adipocyte differentiation.
REFERENCE   3  (bases 1 to 1192)
  AUTHORS   Piaggi,S., Marchi,E., Carnicelli,V., Zucchi,R., Griese,M.,
            Hector,A., Sorio,C., Pompella,A. and Corti,A.
  TITLE     Airways glutathione S-transferase omega-1 and its A140D
            polymorphism are associated with severity of inflammation and
            respiratory dysfunction in cystic fibrosis
  JOURNAL   J Cyst Fibros 20 (6), 1053-1061 (2021)
   PUBMED   33583732
  REMARK    GeneRIF: Airways glutathione S-transferase omega-1 and its A140D
            polymorphism are associated with severity of inflammation and
            respiratory dysfunction in cystic fibrosis.
REFERENCE   4  (bases 1 to 1192)
  AUTHORS   Li,S., Wang,L., Xu,Z., Huang,Y., Xue,R., Yue,T., Xu,L., Gong,F.,
            Bai,S., Wu,Q., Liu,J., Lin,B., Zhang,H., Xue,Y., Xu,P., Hou,J.,
            Yang,X., Jin,T., Zhou,R., Lou,J., Xu,T. and Bai,L.
  TITLE     ASC deglutathionylation is a checkpoint for NLRP3 inflammasome
            activation
  JOURNAL   J Exp Med 218 (9) (2021)
   PUBMED   34342641
  REMARK    GeneRIF: ASC deglutathionylation is a checkpoint for NLRP3
            inflammasome activation.
REFERENCE   5  (bases 1 to 1192)
  AUTHORS   Tummala,P., Rooke,M., Dahlstrom,J.E., Takahashi,S., Casarotto,M.G.,
            Fernando,N., Hughes,M.M., O'Neill,L.A.J. and Board,P.G.
  TITLE     Glutathione transferase Omega 1 confers protection against
            azoxymethane-induced colorectal tumour formation
  JOURNAL   Carcinogenesis 42 (6), 853-863 (2021)
   PUBMED   33564842
  REMARK    GeneRIF: Glutathione transferase Omega 1 confers protection against
            azoxymethane-induced colorectal tumour formation.
REFERENCE   6  (bases 1 to 1192)
  AUTHORS   Tanaka,K., Tamura,H., Tanaka,H., Katoh,M., Futamata,Y., Seki,N.,
            Nishimune,Y. and Hara,T.
  TITLE     Spermatogonia-dependent expression of testicular genes in mice
  JOURNAL   Dev Biol 246 (2), 466-479 (2002)
   PUBMED   12051830
REFERENCE   7  (bases 1 to 1192)
  AUTHORS   Rouimi,P., Anglade,P., Benzekri,A., Costet,P., Debrauwer,L.,
            Pineau,T. and Tulliez,J.
  TITLE     Purification and characterization of a glutathione S-transferase
            Omega in pig: evidence for two distinct organ-specific transcripts
  JOURNAL   Biochem J 358 (Pt 1), 257-262 (2001)
   PUBMED   11485575
REFERENCE   8  (bases 1 to 1192)
  AUTHORS   Board,P.G., Coggan,M., Chelvanayagam,G., Easteal,S., Jermiin,L.S.,
            Schulte,G.K., Danley,D.E., Hoth,L.R., Griffor,M.C., Kamath,A.V.,
            Rosner,M.H., Chrunyk,B.A., Perregaux,D.E., Gabel,C.A.,
            Geoghegan,K.F. and Pandit,J.
  TITLE     Identification, characterization, and crystal structure of the
            Omega class glutathione transferases
  JOURNAL   J Biol Chem 275 (32), 24798-24806 (2000)
   PUBMED   10783391
REFERENCE   9  (bases 1 to 1192)
  AUTHORS   Retief,J.D., Lynch,K.R. and Pearson,W.R.
  TITLE     Panning for genes--A visual strategy for identifying novel gene
            orthologs and paralogs
  JOURNAL   Genome Res 9 (4), 373-382 (1999)
   PUBMED   10207159
REFERENCE   10 (bases 1 to 1192)
  AUTHORS   Kodym,R., Calkins,P. and Story,M.
  TITLE     The cloning and characterization of a new stress response protein.
            A mammalian member of a family of theta class glutathione
            s-transferase-like proteins
  JOURNAL   J Biol Chem 274 (8), 5131-5137 (1999)
   PUBMED   9988762
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC126679.2, BE860946.1,
            AK146834.1 and AI846704.1.
            
            On Dec 4, 2015 this sequence version replaced NM_010362.2.
            
            Summary: This gene encodes a member of the omega class of
            glutathione S-transferase (GST) proteins. GSTs are involved in the
            metabolism of xenobiotics and carcinogens. There is evidence that
            the encoded protein is involved in the biotransformation of
            arsenic. [provided by RefSeq, Dec 2015].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085165.1, U80819.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC126679.2         146300-146315       c
            17-59               BE860946.1         4-46
            60-1175             AK146834.1         6-1121
            1176-1192           AI846704.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1192
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 40.41 cM"
     gene            1..1192
                     /gene="Gsto1"
                     /gene_synonym="Gsto-1; Gstx; p28; Spg-r"
                     /note="glutathione S-transferase omega 1"
                     /db_xref="GeneID:14873"
                     /db_xref="MGI:MGI:1342273"
     exon            1..150
                     /gene="Gsto1"
                     /gene_synonym="Gsto-1; Gstx; p28; Spg-r"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..839
                     /gene="Gsto1"
                     /gene_synonym="Gsto-1; Gstx; p28; Spg-r"
                     /EC_number="2.5.1.18"
                     /EC_number="1.8.5.1"
                     /EC_number="1.20.4.2"
                     /note="glutathione-S-transferase like; Glutathione
                     transferase omega 1 (GSTO 1-1) (p28); MMA(V) reductase;
                     monomethylarsonic acid reductase; S-(Phenacyl)glutathione
                     reductase; glutathione S-transferase omega 1-1;
                     glutathione-dependent dehydroascorbate reductase"
                     /codon_start=1
                     /product="glutathione S-transferase omega-1"
                     /protein_id="NP_034492.1"
                     /db_xref="CCDS:CCDS29893.1"
                     /db_xref="GeneID:14873"
                     /db_xref="MGI:MGI:1342273"
                     /translation="MSGESSRSLGKGSAPPGPVPEGQIRVYSMRFCPFAQRTLMVLKA
                     KGIRHEVININLKNKPEWFFEKNPLGLVPVLENSQGHLVTESVITCEYLDEAYPEKKL
                     FPDDPYKKARQKMTLESFSKVPPLIASFVRSKRKEDSPNLREALENEFKKLEEGMDNY
                     KSFLGGDSPSMVDYLTWPWFQRLEALELKECLAHTPKLKLWMAAMQQDPVASSHKIDA
                     KTYREYLNLYLQDSPEACDYGL"
     exon            151..259
                     /gene="Gsto1"
                     /gene_synonym="Gsto-1; Gstx; p28; Spg-r"
                     /inference="alignment:Splign:2.1.0"
     exon            260..482
                     /gene="Gsto1"
                     /gene_synonym="Gsto-1; Gstx; p28; Spg-r"
                     /inference="alignment:Splign:2.1.0"
     exon            483..581
                     /gene="Gsto1"
                     /gene_synonym="Gsto-1; Gstx; p28; Spg-r"
                     /inference="alignment:Splign:2.1.0"
     exon            582..685
                     /gene="Gsto1"
                     /gene_synonym="Gsto-1; Gstx; p28; Spg-r"
                     /inference="alignment:Splign:2.1.0"
     exon            686..1179
                     /gene="Gsto1"
                     /gene_synonym="Gsto-1; Gstx; p28; Spg-r"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1145..1150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gsto1"
                     /gene_synonym="Gsto-1; Gstx; p28; Spg-r"
                     /note="hexamer: ATTAAA"
     polyA_site      1179
                     /gene="Gsto1"
                     /gene_synonym="Gsto-1; Gstx; p28; Spg-r"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcggtct gggcggggct gagttctagg acagtgtaca agacctcgtg cttccagagt
       61 cgcccgcaaa cgggagcgga acccgcgtgg ctctcggcct gcacggcggc tcagcgatgt
      121 cgggagaatc ctccaggagc ctggggaagg gaagcgcgcc ccccggcccg gtcccggagg
      181 gccagatccg cgtctacagc atgaggttct gccccttcgc tcagaggacg ctgatggtcc
      241 tgaaggccaa gggaatccgg cacgaagtca tcaatatcaa cctgaagaat aagcccgagt
      301 ggttctttga gaagaatccc cttgggctgg tgccggttct ggagaacagc cagggtcact
      361 tggtcaccga atctgtcatc acttgtgagt acctggatga ggcctaccca gagaagaagt
      421 tatttccaga tgacccgtac aagaaggcac gtcagaagat gacccttgag tcattctcta
      481 aggtgccgcc tttgattgca agctttgtta ggtcgaagag aaaggaagac tctccgaacc
      541 taagggaagc gttggagaac gaattcaaaa agctagagga gggcatggat aattacaaga
      601 gcttccttgg tggggattct ccttctatgg ttgattatct tacttggcct tggtttcagc
      661 gactggaagc attggagctc aaggagtgtc tagcccacac ccccaagctc aagctctgga
      721 tggcggccat gcagcaagac cctgtggcat cctctcacaa aattgatgcc aagacctacc
      781 gcgagtactt aaatctctac ctacaggaca gccccgaggc ctgtgattat gggctctgaa
      841 gggcaagagc cctcagcaaa tgctgtttcc cctcactgat tgaatatcat gcttattttg
      901 tccagtattc tcactggctc ctttctcata atttgacctt ctggcctaag cggtgccccc
      961 cagggcccca ctcctgtatt tctatttcag aacaatctga tctaatggtc ctaacagtct
     1021 tcactgccat ccccaaggcc atcacctctg gtttgataca gacatctaga tttggatatc
     1081 aagaaaaatg tcaagttttt gattactcat gtctgaaaac tgtgatttcc ccatactttc
     1141 catcattaaa tctcttattc ctcttgtgag catcgaaaaa aaaaaaaaaa aa
//
