LOCUS       NM_008184               1138 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus glutathione S-transferase, mu 6 (Gstm6), transcript
            variant 4, mRNA.
ACCESSION   NM_008184
VERSION     NM_008184.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1138)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1138)
  AUTHORS   Lee,F.Y., Faivre,E.J., Suzawa,M., Lontok,E., Ebert,D., Cai,F.,
            Belsham,D.D. and Ingraham,H.A.
  TITLE     Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic
            hedgehog signaling and disruption of endocrine development
  JOURNAL   Dev Cell 21 (2), 315-327 (2011)
   PUBMED   21820362
REFERENCE   3  (bases 1 to 1138)
  AUTHORS   Beverdam,A., Svingen,T., Bagheri-Fam,S., Bernard,P., McClive,P.,
            Robson,M., Khojasteh,M.B., Salehi,M., Sinclair,A.H., Harley,V.R.
            and Koopman,P.
  TITLE     Sox9-dependent expression of Gstm6 in Sertoli cells during testis
            development in mice
  JOURNAL   Reproduction 137 (3), 481-486 (2009)
   PUBMED   19098141
REFERENCE   4  (bases 1 to 1138)
  AUTHORS   De Bruin,W.C., Te Morsche,R.H., Wagenmans,M.J., Alferink,J.C.,
            Townsend,A.J., Wieringa,B. and Peters,W.H.
  TITLE     Identification of a novel murine glutathione S-transferase class mu
            gene
  JOURNAL   Biochem J 330 (Pt 2) (Pt 2), 623-626 (1998)
   PUBMED   9480867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079042.31.
            
            On Apr 6, 2020 this sequence version replaced NM_008184.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031818.1, SRR5189685.179519.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AC079042.31        73418-73554
            138-213             AC079042.31        73832-73907
            214-278             AC079042.31        74386-74450
            279-360             AC079042.31        74738-74819
            361-461             AC079042.31        74919-75019
            462-557             AC079042.31        75868-75963
            558-668             AC079042.31        76049-76159
            669-1138            AC079042.31        77836-78305
FEATURES             Location/Qualifiers
     source          1..1138
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.83 cM"
     gene            1..1138
                     /gene="Gstm6"
                     /note="glutathione S-transferase, mu 6"
                     /db_xref="GeneID:14867"
                     /db_xref="MGI:MGI:1309467"
     exon            1..137
                     /gene="Gstm6"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..758
                     /gene="Gstm6"
                     /EC_number="2.5.1.18"
                     /note="isoform 4 is encoded by transcript variant 4; GST
                     class-mu 6; glutathione-S-transferase class M5;
                     glutathione S-transferase Mu 6"
                     /codon_start=1
                     /product="glutathione S-transferase Mu 6 isoform 4"
                     /protein_id="NP_032210.3"
                     /db_xref="CCDS:CCDS38596.1"
                     /db_xref="GeneID:14867"
                     /db_xref="MGI:MGI:1309467"
                     /translation="MPVTLGYWDIRGLGHAIRLLLEYTETGYEEKRYAMGDAPDYDRS
                     QWLNDKFKLDLDFPNLPYLIDGSHKVTQSNAILRYLGRKHNLCGETEEERIRVDILEK
                     QVMDTRIQMGMLCYSADFEKRKPEFLKGLPDQLKLYSEFLGKQPWFAGDKITFADFLV
                     YDVLDQHRMFEPTCLDAFPNLKDFMARFEGLRKISAYMKTSRFLPSPVYLKQATWGNE
                     "
     exon            138..213
                     /gene="Gstm6"
                     /inference="alignment:Splign:2.1.0"
     exon            214..278
                     /gene="Gstm6"
                     /inference="alignment:Splign:2.1.0"
     exon            279..360
                     /gene="Gstm6"
                     /inference="alignment:Splign:2.1.0"
     exon            361..461
                     /gene="Gstm6"
                     /inference="alignment:Splign:2.1.0"
     exon            462..557
                     /gene="Gstm6"
                     /inference="alignment:Splign:2.1.0"
     exon            558..668
                     /gene="Gstm6"
                     /inference="alignment:Splign:2.1.0"
     exon            669..1138
                     /gene="Gstm6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1118..1123
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gstm6"
                     /note="hexamer: AGTAAA"
     polyA_site      1138
                     /gene="Gstm6"
                     /note="major polyA site"
ORIGIN      
        1 agagcagctc cggacctgtt ctcagactca tcagctgagc attacagagt ctttcccgac
       61 cagtgactga ctgcacagtc ttcgaggctg gaatagcaat catgcccgtg actctgggtt
      121 attgggatat ccgtggactg ggtcacgcca tccgcctgct cctggaatac acagaaacag
      181 gctatgaaga gaagagatac gccatggggg acgctcctga ctatgacaga agccagtggc
      241 tgaatgacaa gttcaagctg gacctggact ttcccaatct gccctactta attgatgggt
      301 cacacaaggt cacccagagc aatgccatcc tgcgctacct tggccggaag cacaacctgt
      361 gtggagagac agaggaggag aggatccgtg tggacatttt ggagaaacag gtcatggaca
      421 ctcgaattca gatgggcatg ctttgctaca gcgctgactt tgagaaacgg aagccagagt
      481 tcttgaaggg cctcccagat cagctgaaac tctactcgga gttcctgggg aagcagccat
      541 ggtttgcagg ggacaagatc acctttgcag acttcctcgt ctatgatgtc cttgatcagc
      601 atcgaatgtt tgaacccacg tgcctggacg ccttcccaaa cctgaaggac ttcatggccc
      661 gctttgaggg cctgaggaag atctctgcct atatgaagac cagccgcttc cttccaagtc
      721 ctgtgtactt aaaacaggcc acgtggggca atgagtaaga ccatgcatgg agtgccggtg
      781 ttggtgggga agatctatca gtgtgcctgt caccgtgaac actgaccggg ccacagctag
      841 cttccagtaa cttctcttca tcaatcttcc catttttttc cctctgtctt ttcattaact
      901 ttccctctac aagaactcct tgtctcccct ttcactcaag cctccaatgt cagctccctg
      961 tcctcagcaa agtcctttgc ttcccttgtt tctttctgcc atgtttctaa ccagacaatc
     1021 tttcactgca ctttgagcag cttagcccaa agatccatac tccccagtat gcaggctcca
     1081 tctccagagt gggaaggccc agtcttgtgt gagctctagt aaagtgttat ccatacta
//
