LOCUS       NM_010360                842 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Mus musculus glutathione S-transferase, mu 5 (Gstm5), mRNA.
ACCESSION   NM_010360
VERSION     NM_010360.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 842)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 842)
  AUTHORS   Chung,C., Kim,T., Kim,M., Kim,M., Song,H., Kim,T.S., Seo,E.,
            Lee,S.H., Kim,H., Kim,S.K., Yoo,G., Lee,D.H., Hwang,D.S.,
            Kinashi,T., Kim,J.M. and Lim,D.S.
  TITLE     Hippo-Foxa2 signaling pathway plays a role in peripheral lung
            maturation and surfactant homeostasis
  JOURNAL   Proc Natl Acad Sci U S A 110 (19), 7732-7737 (2013)
   PUBMED   23620511
REFERENCE   3  (bases 1 to 842)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   4  (bases 1 to 842)
  AUTHORS   Pearson,W.R.
  TITLE     Phylogenies of glutathione transferase families
  JOURNAL   Methods Enzymol 401, 186-204 (2005)
   PUBMED   16399387
  REMARK    Review article
REFERENCE   5  (bases 1 to 842)
  AUTHORS   Thomson,R.E., Bigley,A.L., Foster,J.R., Jowsey,I.R., Elcombe,C.R.,
            Orton,T.C. and Hayes,J.D.
  TITLE     Tissue-specific expression and subcellular distribution of murine
            glutathione S-transferase class kappa
  JOURNAL   J Histochem Cytochem 52 (5), 653-662 (2004)
   PUBMED   15100242
REFERENCE   6  (bases 1 to 842)
  AUTHORS   Rowe,J.D., Patskovsky,Y.V., Patskovska,L.N., Novikova,E. and
            Listowsky,I.
  TITLE     Rationale for reclassification of a distinctive subdivision of
            mammalian class Mu glutathione S-transferases that are primarily
            expressed in testis
  JOURNAL   J Biol Chem 273 (16), 9593-9601 (1998)
   PUBMED   9545290
REFERENCE   7  (bases 1 to 842)
  AUTHORS   De Bruin,W.C., Te Morsche,R.H., Wagenmans,M.J., Alferink,J.C.,
            Townsend,A.J., Wieringa,B. and Peters,W.H.
  TITLE     Identification of a novel murine glutathione S-transferase class mu
            gene
  JOURNAL   Biochem J 330 (Pt 2) (Pt 2), 623-626 (1998)
   PUBMED   9480867
REFERENCE   8  (bases 1 to 842)
  AUTHORS   Fulcher,K.D., Welch,J.E., Klapper,D.G., O'Brien,D.A. and Eddy,E.M.
  TITLE     Identification of a unique mu-class glutathione S-transferase in
            mouse spermatogenic cells
  JOURNAL   Mol Reprod Dev 42 (4), 415-424 (1995)
   PUBMED   8607970
REFERENCE   9  (bases 1 to 842)
  AUTHORS   Reinhart,J. and Pearson,W.R.
  TITLE     The structure of two murine class-mu glutathione transferase genes
            coordinately induced by butylated hydroxyanisole
  JOURNAL   Arch Biochem Biophys 303 (2), 383-393 (1993)
   PUBMED   8512323
REFERENCE   10 (bases 1 to 842)
  AUTHORS   Pearson,W.R., Windle,J.J., Morrow,J.F., Benson,A.M. and Talalay,P.
  TITLE     Increased synthesis of glutathione S-transferases in response to
            anticarcinogenic antioxidants. Cloning and measurement of messenger
            RNA
  JOURNAL   J Biol Chem 258 (3), 2052-2062 (1983)
   PUBMED   6822548
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079042.31.
            
            On Oct 3, 2022 this sequence version replaced NM_010360.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DV041758.1, BC008206.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                AC079042.31        121154-121228       c
            76-151              AC079042.31        120779-120854       c
            152-216             AC079042.31        120462-120526       c
            217-298             AC079042.31        119783-119864       c
            299-399             AC079042.31        119590-119690       c
            400-495             AC079042.31        119090-119185       c
            496-606             AC079042.31        118876-118986       c
            607-842             AC079042.31        118466-118701       c
FEATURES             Location/Qualifiers
     source          1..842
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.83 cM"
     gene            1..842
                     /gene="Gstm5"
                     /gene_synonym="Fsc2"
                     /note="glutathione S-transferase, mu 5"
                     /db_xref="GeneID:14866"
                     /db_xref="MGI:MGI:1309466"
     exon            1..75
                     /gene="Gstm5"
                     /gene_synonym="Fsc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..705
                     /gene="Gstm5"
                     /gene_synonym="Fsc2"
                     /EC_number="2.5.1.18"
                     /note="GST class-mu 5; fibrous sheath component 2"
                     /codon_start=1
                     /product="glutathione S-transferase Mu 5"
                     /protein_id="NP_034490.1"
                     /db_xref="CCDS:CCDS17741.1"
                     /db_xref="GeneID:14866"
                     /db_xref="MGI:MGI:1309466"
                     /translation="MSSKSMVLGYWDIRGLAHAIRMLLEFTDTSYEEKRYICGEAPDY
                     DRSQWLDVKFKLDLDFPNLPYLMDGKNKITQSNAILRYIARKHNMCGDTEEEKIRVDI
                     MENQIMDFRMQLVRLCYNSNHENLKPQYLEQLPAQLKQFSLFLGKFTWFAGEKLTFVD
                     FLTYDVLDQNRIFEPKCLDEFPNLKAFMCRFEALEKIAAFLQSDRFFKMPINNKMAKW
                     GNKCLC"
     exon            76..151
                     /gene="Gstm5"
                     /gene_synonym="Fsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            152..216
                     /gene="Gstm5"
                     /gene_synonym="Fsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            217..298
                     /gene="Gstm5"
                     /gene_synonym="Fsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            299..399
                     /gene="Gstm5"
                     /gene_synonym="Fsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            400..495
                     /gene="Gstm5"
                     /gene_synonym="Fsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            496..606
                     /gene="Gstm5"
                     /gene_synonym="Fsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            607..842
                     /gene="Gstm5"
                     /gene_synonym="Fsc2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      822..827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gstm5"
                     /gene_synonym="Fsc2"
                     /note="hexamer: AATAAA"
     polyA_site      842
                     /gene="Gstm5"
                     /gene_synonym="Fsc2"
                     /note="major polyA site"
ORIGIN      
        1 gtatccccga aggggctaag atcgcccaaa atgtcatcca agtctatggt tctgggttac
       61 tgggatatcc gcgggctggc tcatgctatc cgcatgcttc tggagtttac tgataccagc
      121 tatgaggaga aacggtacat ctgtggggaa gctcctgact atgatagaag ccaatggctg
      181 gacgtgaaat tcaagctaga tctggacttt cctaacctgc cctacctcat ggacgggaag
      241 aacaagatca cccagagtaa cgccatcctg agatacatcg cacgcaagca caacatgtgt
      301 ggtgacactg aagaagaaaa gatacgagta gacatcatgg agaaccagat catggacttc
      361 cgcatgcagc tggttcgcct ctgctacaat tctaaccacg aaaacctgaa gcctcagtac
      421 ttggaacagc tacctgcaca gctgaaacaa ttctcattgt tcctggggaa attcacatgg
      481 tttgcaggag aaaagctgac ctttgtggat tttctcacct atgatgtctt ggatcagaac
      541 cgtatatttg agcccaagtg tctggatgag ttcccaaacc tgaaggcttt catgtgccgt
      601 tttgaggctt tggagaagat tgctgcattc ctgcagtctg accgcttctt caagatgcca
      661 atcaataaca agatggccaa gtggggtaac aagtgcttat gctgagccag agctcgctgc
      721 tgctgagcca tcttgccctg aggggcccac actcttagct cactgtcagt cttgttccat
      781 cctgtcctga gggcccccac tctgtctcct ctgctctttc taataaacag cagttgcatt
      841 aa
//
