LOCUS       NM_026764               1684 bp    mRNA    linear   ROD 05-FEB-2024
DEFINITION  Mus musculus glutathione S-transferase, mu 4 (Gstm4), transcript
            variant 1, mRNA.
ACCESSION   NM_026764
VERSION     NM_026764.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1684)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   2  (bases 1 to 1684)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 1684)
  AUTHORS   Yuan,R., Flurkey,K., Van Aelst-Bouma,R., Zhang,W., King,B.,
            Austad,S., Miller,R.A. and Harrison,D.E.
  TITLE     Altered growth characteristics of skin fibroblasts from
            wild-derived mice, and genetic loci regulating fibroblast clone
            size
  JOURNAL   Aging Cell 5 (3), 203-212 (2006)
   PUBMED   16842493
REFERENCE   4  (bases 1 to 1684)
  AUTHORS   Norrgard,M.A., Ivarsson,Y., Tars,K. and Mannervik,B.
  TITLE     Alternative mutations of a positively selected residue elicit gain
            or loss of functionalities in enzyme evolution
  JOURNAL   Proc Natl Acad Sci U S A 103 (13), 4876-4881 (2006)
   PUBMED   16549767
REFERENCE   5  (bases 1 to 1684)
  AUTHORS   Guo,J., Zimniak,L., Zimniak,P., Orchard,J.L. and Singh,S.V.
  TITLE     Cloning and expression of a novel Mu class murine glutathione
            transferase isoenzyme
  JOURNAL   Biochem J 366 (Pt 3), 817-824 (2002)
   PUBMED   12069689
REFERENCE   6  (bases 1 to 1684)
  AUTHORS   Chanas,S.A., Jiang,Q., McMahon,M., McWalter,G.K., McLellan,L.I.,
            Elcombe,C.R., Henderson,C.J., Wolf,C.R., Moffat,G.J., Itoh,K.,
            Yamamoto,M. and Hayes,J.D.
  TITLE     Loss of the Nrf2 transcription factor causes a marked reduction in
            constitutive and inducible expression of the glutathione
            S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in
            the livers of male and female mice
  JOURNAL   Biochem J 365 (Pt 2), 405-416 (2002)
   PUBMED   11991805
REFERENCE   7  (bases 1 to 1684)
  AUTHORS   Reinhart,J. and Pearson,W.R.
  TITLE     The structure of two murine class-mu glutathione transferase genes
            coordinately induced by butylated hydroxyanisole
  JOURNAL   Arch Biochem Biophys 303 (2), 383-393 (1993)
   PUBMED   8512323
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY289676.1, CK335113.1, AK003418.1, BX524259.1 and AI842977.1.
            
            [WARNING] On Mar 12, 2024 this sequence was replaced by
            NM_026764.4.
            
            On May 24, 2009 this sequence version replaced NM_026764.2.
            
            Transcript Variant: This variant (1) is the longer transcript and
            encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030444.1, SRR1660817.151415.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BY289676.1         1-15
            16-554              CK335113.1         1-539
            555-1236            AK003418.1         351-1032
            1237-1353           BX524259.1         385-501
            1354-1684           AI842977.1         1-331               c
FEATURES             Location/Qualifiers
     source          1..1684
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.83 cM"
     gene            1..1684
                     /gene="Gstm4"
                     /gene_synonym="1110004G14Rik; Gstb-4; Gstb4; GSTM4-4;
                     GSTM7-7"
                     /note="glutathione S-transferase, mu 4"
                     /db_xref="GeneID:14865"
                     /db_xref="MGI:MGI:95862"
     exon            1..220
                     /gene="Gstm4"
                     /gene_synonym="1110004G14Rik; Gstb-4; Gstb4; GSTM4-4;
                     GSTM7-7"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..841
                     /gene="Gstm4"
                     /gene_synonym="1110004G14Rik; Gstb-4; Gstb4; GSTM4-4;
                     GSTM7-7"
                     /EC_number="2.5.1.18"
                     /EC_number="4.4.1.20"
                     /note="isoform 1 is encoded by transcript variant 1; GST
                     class-mu 4; leukotriene C4 synthase GSTM4; glutathione
                     transferase GSTM7-7"
                     /codon_start=1
                     /product="glutathione S-transferase Mu 4 isoform 1"
                     /protein_id="NP_081040.1"
                     /db_xref="CCDS:CCDS17748.1"
                     /db_xref="GeneID:14865"
                     /db_xref="MGI:MGI:95862"
                     /translation="MPMTLGYWDIRGLAHAIRLLLEYTGSSYEEKRYTMGDAPDYDRS
                     QWLSEKFKLGLDFPNLPYLIDGSHKITQSNAILRYIARKHNLCGETEEEKIRVDILEN
                     QAMDVSNQLARVCYSPDFEKLKVEYLEQLPGMVKLFSQFLGQRTWFVGEKITFVDFLA
                     YDILDLHLIFEPTCLDAFPNLKDFVARFEVLKRISAYMKTSRFLRTPLYTKVATWGNK
                     "
     exon            221..296
                     /gene="Gstm4"
                     /gene_synonym="1110004G14Rik; Gstb-4; Gstb4; GSTM4-4;
                     GSTM7-7"
                     /inference="alignment:Splign:2.1.0"
     exon            297..361
                     /gene="Gstm4"
                     /gene_synonym="1110004G14Rik; Gstb-4; Gstb4; GSTM4-4;
                     GSTM7-7"
                     /inference="alignment:Splign:2.1.0"
     exon            362..443
                     /gene="Gstm4"
                     /gene_synonym="1110004G14Rik; Gstb-4; Gstb4; GSTM4-4;
                     GSTM7-7"
                     /inference="alignment:Splign:2.1.0"
     exon            444..544
                     /gene="Gstm4"
                     /gene_synonym="1110004G14Rik; Gstb-4; Gstb4; GSTM4-4;
                     GSTM7-7"
                     /inference="alignment:Splign:2.1.0"
     exon            545..640
                     /gene="Gstm4"
                     /gene_synonym="1110004G14Rik; Gstb-4; Gstb4; GSTM4-4;
                     GSTM7-7"
                     /inference="alignment:Splign:2.1.0"
     exon            641..751
                     /gene="Gstm4"
                     /gene_synonym="1110004G14Rik; Gstb-4; Gstb4; GSTM4-4;
                     GSTM7-7"
                     /inference="alignment:Splign:2.1.0"
     exon            752..1669
                     /gene="Gstm4"
                     /gene_synonym="1110004G14Rik; Gstb-4; Gstb4; GSTM4-4;
                     GSTM7-7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatttggctt ctgtaggtga ctgtcagggg aaaagctgta gagcagggtg tgtgttgcgg
       61 ggcagagtct ggaggggcag gatcacgccg ggcaccagcc ccgcccaggg acccgagggc
      121 actaggataa agtcaaagtt gctcacaccg gaggccggtg gactcagtct caggcaccag
      181 catcatgcct atgacactgg gttactggga catccgtggg ctagctcacg ctattcggct
      241 gctcctagaa tacacaggct caagctatga agagaagaga tacaccatgg gagacgctcc
      301 tgactatgac cgaagccagt ggctgagtga gaagttcaaa ttgggcctgg actttcccaa
      361 tttgccttac ttgattgatg ggtcacacaa gatcacgcag agcaatgcca tcctgcgcta
      421 cattgcccgc aagcacaacc tgtgtgggga gacagaggaa gagaagattc gcgtggacat
      481 tttggagaac caggctatgg atgtctccaa tcagctggct cgagtctgtt acagcccaga
      541 ctttgagaaa ctgaaggtgg aatacttgga gcagctccct ggaatggtga agctcttctc
      601 acagttcctg ggccagcgga catggtttgt tggtgaaaag attacttttg tagatttcct
      661 ggcttacgat atcctggacc tgcaccttat attcgaaccc acgtgcctgg acgccttccc
      721 aaacctgaag gactttgtgg cccgctttga ggtactgaag aggatctctg cttacatgaa
      781 gaccagccgc ttcctccgaa cacccctata tacaaaggtg gccacttggg gcaataagta
      841 gagccttgac tgggcaggaa gtgggaaccg ggggttctgg gaacagttga acttcctgta
      901 gccctagtgc tgctttctgt ccatcccctt cctgacccca gagtgtcaaa ggtcctcttt
      961 tctttcatcc agtccctgcc ctttcaaacc ctctaaagcc taggctccta gttttccttt
     1021 agcaaaatgc ccttctagca tgactgtgtc ccgcgcccac ttgatggtct tgcctgccag
     1081 cagctgtgct gttgtgaaga gttgggactc tccatcagca ctcagcctgg ggctccccat
     1141 gcttgtctgg agaccagaga cggctggtgt gtgaatttgg tctctgcaca gctcttttgg
     1201 gtccctcctg taaagcctga accacactgg ctctggctgc cgcactacca gcttttacta
     1261 ctatctccag tggctgccta gtgacccggg cagaggctga gttcacaggg attttagttg
     1321 gataggcagg ggtttggccc ttcctagccc cacctgtttg tttctcagga ggcagctgca
     1381 gaaggctctg tggagctcaa agggagctta gatctccttt atgctagcag cactgagatt
     1441 tgtcatgcag gtctcagtgg tgaggatcca ggctgatagg agtccccagc agaaagccag
     1501 gatcctctct gcccactgtg ctatggctgc cttatatcta tatgtctcca ggatcctgtc
     1561 tctgatgtct tcagagtatc ccgtcttggt caccagggat gggggccatc ttggttaatc
     1621 cctcctcttt gtgagccccc gtgaaataaa tttcttcatg ctttcgtaaa aaaaaaaaaa
     1681 aaaa
//
