LOCUS       NM_010359               1189 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus glutathione S-transferase, mu 3 (Gstm3), mRNA.
ACCESSION   NM_010359
VERSION     NM_010359.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1189)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1189)
  AUTHORS   Walsh,J., Jenkins,R.E., Wong,M., Olayanju,A., Powell,H., Copple,I.,
            O'Neill,P.M., Goldring,C.E., Kitteringham,N.R. and Park,B.K.
  TITLE     Identification and quantification of the basal and inducible
            Nrf2-dependent proteomes in mouse liver: biochemical,
            pharmacological and toxicological implications
  JOURNAL   J Proteomics 108 (100), 171-187 (2014)
   PUBMED   24859727
  REMARK    GeneRIF: Six proteins were regulated at both basal and inducible
            levels exhibiting the largest dynamic range of Nrf2 regulation:
            cytochrome CYP2A5, GSTM3, GSTM1, ENTPD5,UDPGDH, and EPHX1.
REFERENCE   3  (bases 1 to 1189)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   4  (bases 1 to 1189)
  AUTHORS   Pearson,W.R.
  TITLE     Phylogenies of glutathione transferase families
  JOURNAL   Methods Enzymol 401, 186-204 (2005)
   PUBMED   16399387
  REMARK    Review article
REFERENCE   5  (bases 1 to 1189)
  AUTHORS   Rowe,J.D., Patskovsky,Y.V., Patskovska,L.N., Novikova,E. and
            Listowsky,I.
  TITLE     Rationale for reclassification of a distinctive subdivision of
            mammalian class Mu glutathione S-transferases that are primarily
            expressed in testis
  JOURNAL   J Biol Chem 273 (16), 9593-9601 (1998)
   PUBMED   9545290
REFERENCE   6  (bases 1 to 1189)
  AUTHORS   Fulcher,K.D., Welch,J.E., Klapper,D.G., O'Brien,D.A. and Eddy,E.M.
  TITLE     Identification of a unique mu-class glutathione S-transferase in
            mouse spermatogenic cells
  JOURNAL   Mol Reprod Dev 42 (4), 415-424 (1995)
   PUBMED   8607970
REFERENCE   7  (bases 1 to 1189)
  AUTHORS   Reinhart,J. and Pearson,W.R.
  TITLE     The structure of two murine class-mu glutathione transferase genes
            coordinately induced by butylated hydroxyanisole
  JOURNAL   Arch Biochem Biophys 303 (2), 383-393 (1993)
   PUBMED   8512323
REFERENCE   8  (bases 1 to 1189)
  AUTHORS   Pearson,W.R., Reinhart,J., Sisk,S.C., Anderson,K.S. and Adler,P.N.
  TITLE     Tissue-specific induction of murine glutathione transferase mRNAs
            by butylated hydroxyanisole
  JOURNAL   J Biol Chem 263 (26), 13324-13332 (1988)
   PUBMED   3417659
REFERENCE   9  (bases 1 to 1189)
  AUTHORS   Mannervik,B., Alin,P., Guthenberg,C., Jensson,H., Tahir,M.K.,
            Warholm,M. and Jornvall,H.
  TITLE     Identification of three classes of cytosolic glutathione
            transferase common to several mammalian species: correlation
            between structural data and enzymatic properties
  JOURNAL   Proc Natl Acad Sci U S A 82 (21), 7202-7206 (1985)
   PUBMED   3864155
REFERENCE   10 (bases 1 to 1189)
  AUTHORS   Pearson,W.R., Windle,J.J., Morrow,J.F., Benson,A.M. and Talalay,P.
  TITLE     Increased synthesis of glutathione S-transferases in response to
            anticarcinogenic antioxidants. Cloning and measurement of messenger
            RNA
  JOURNAL   J Biol Chem 258 (3), 2052-2062 (1983)
   PUBMED   6822548
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079042.31.
            
            On Oct 3, 2022 this sequence version replaced NM_010359.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC044927.1, CA462450.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AC079042.31        47984-48047
            65-140              AC079042.31        48314-48389
            141-205             AC079042.31        48952-49016
            206-287             AC079042.31        49305-49386
            288-388             AC079042.31        49477-49577
            389-484             AC079042.31        50778-50873
            485-595             AC079042.31        50955-51065
            596-1189            AC079042.31        52856-53449
FEATURES             Location/Qualifiers
     source          1..1189
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.83 cM"
     gene            1..1189
                     /gene="Gstm3"
                     /gene_synonym="Fsc2; mGSTM5"
                     /note="glutathione S-transferase, mu 3"
                     /db_xref="GeneID:14864"
                     /db_xref="MGI:MGI:106026"
     exon            1..64
                     /gene="Gstm3"
                     /gene_synonym="Fsc2; mGSTM5"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..685
                     /gene="Gstm3"
                     /gene_synonym="Fsc2; mGSTM5"
                     /EC_number="2.5.1.18"
                     /note="GST class-mu 3; glutathione S-transferase GT9.3"
                     /codon_start=1
                     /product="glutathione S-transferase Mu 3"
                     /protein_id="NP_034489.1"
                     /db_xref="CCDS:CCDS17744.1"
                     /db_xref="GeneID:14864"
                     /db_xref="MGI:MGI:106026"
                     /translation="MPMTLGYWNTRGLTHSIRLLLEYTDSSYEEKRYVMGDAPNFDRS
                     QWLSEKFNLGLDFPNLPYLIDGSHKVTQSNAILRYLGRKHNLCGETEEERIRVDTLEN
                     QVMDTRIQLMIVCCSPDFEKQKPEFLKAIPEKMKLYSEFLGKRPWFAGDKVTYVDFLA
                     YDILDQYRMFEPKCLDAFPNLRDFLARFEGLKKISAYMKSSRFLPRPVFTKIAQWGTD
                     "
     exon            65..140
                     /gene="Gstm3"
                     /gene_synonym="Fsc2; mGSTM5"
                     /inference="alignment:Splign:2.1.0"
     exon            141..205
                     /gene="Gstm3"
                     /gene_synonym="Fsc2; mGSTM5"
                     /inference="alignment:Splign:2.1.0"
     exon            206..287
                     /gene="Gstm3"
                     /gene_synonym="Fsc2; mGSTM5"
                     /inference="alignment:Splign:2.1.0"
     exon            288..388
                     /gene="Gstm3"
                     /gene_synonym="Fsc2; mGSTM5"
                     /inference="alignment:Splign:2.1.0"
     exon            389..484
                     /gene="Gstm3"
                     /gene_synonym="Fsc2; mGSTM5"
                     /inference="alignment:Splign:2.1.0"
     exon            485..595
                     /gene="Gstm3"
                     /gene_synonym="Fsc2; mGSTM5"
                     /inference="alignment:Splign:2.1.0"
     exon            596..1189
                     /gene="Gstm3"
                     /gene_synonym="Fsc2; mGSTM5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1172..1177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gstm3"
                     /gene_synonym="Fsc2; mGSTM5"
                     /note="hexamer: AATAAA"
     polyA_site      1189
                     /gene="Gstm3"
                     /gene_synonym="Fsc2; mGSTM5"
                     /note="major polyA site"
ORIGIN      
        1 agtctgagaa gaccacagca tcagcgccat gcctatgaca ctgggctatt ggaacacccg
       61 cggactgact cactccatcc gcttgctcct ggaatacaca gattcaagct atgaggagaa
      121 gagatatgtc atgggggatg cccccaactt tgaccgaagc cagtggctga gtgagaaatt
      181 caatcttggc ctggattttc ccaatctgcc ctacttaatt gatgggtcac acaaggtcac
      241 ccagagcaat gccatcctgc gctaccttgg ccggaagcac aacctgtgtg gagagacaga
      301 ggaggagagg atccgtgtgg atactttgga gaaccaagtt atggacaccc gcatacagct
      361 catgatagtc tgctgcagtc ccgattttga gaagcagaag ccagagttct tgaaggccat
      421 ccctgagaaa atgaagctct actctgagtt cctgggcaag aggccatggt ttgcagggga
      481 caaggtcacc tatgtggatt tccttgctta tgacattctt gaccagtatc gtatgtttga
      541 gcccaagtgc ctggacgcct tcccaaacct gagggacttc ctggcccgct tcgagggcct
      601 caagaagatc tctgcctaca tgaagagtag ccgcttcctc ccaagacctg tgtttactaa
      661 gatagcccag tggggcactg attaggcccc tgccatgctg tcactcagag tgggggacct
      721 gtccatactg cggatcctgc aggctctggg tggggacagc accctggcct tctgcactgt
      781 ggctcccggt tctctctcct tcccgctccc ttctgcagct tggtcagccc catctcctca
      841 tcctcacccc agtcaagccc atgcagcctt tattctcccc attttttttt cacatggccc
      901 cttcttcatt ggtgcccaga cccaacctca cagccctttt ctgcaatctg aggtctgtcc
      961 tgaactcagg ctccctagag ttaccccaat ggtcaacact atcttagtgc cagccctccc
     1021 tagagatacc ctgatggtca atactatctt agtgacggcc ctccctagag ttaccctgaa
     1081 ggtcaatact cgagtgccag cctgttcctg tttaaggagc tgccccaggc ctgtctcatg
     1141 tacaataaag cctgaaacac acttgaaaca caataaacac tgaacactt
//
