LOCUS       NM_008183               1045 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus glutathione S-transferase, mu 2 (Gstm2), mRNA.
ACCESSION   NM_008183
VERSION     NM_008183.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1045)
  AUTHORS   Fafian-Labora,J.A., Rodriguez-Navarro,J.A. and O'Loghlen,A.
  TITLE     Small Extracellular Vesicles Have GST Activity and Ameliorate
            Senescence-Related Tissue Damage
  JOURNAL   Cell Metab 32 (1), 71-86 (2020)
   PUBMED   32574561
  REMARK    GeneRIF: Small Extracellular Vesicles Have GST Activity and
            Ameliorate Senescence-Related Tissue Damage.
REFERENCE   2  (bases 1 to 1045)
  AUTHORS   Liu,D., Hewawasam,R., Karunasekara,Y., Casarotto,M.G.,
            Dulhunty,A.F. and Board,P.G.
  TITLE     The inhibitory glutathione transferase M2-2 binding site is located
            in divergent region 3 of the cardiac ryanodine receptor
  JOURNAL   Biochem Pharmacol 83 (11), 1523-1529 (2012)
   PUBMED   22406107
REFERENCE   3  (bases 1 to 1045)
  AUTHORS   Ni,H., Yu,X.J., Liu,H.J., Lei,W., Rengaraj,D., Li,X.J. and
            Yang,Z.M.
  TITLE     Progesterone regulation of glutathione S-transferase Mu2 expression
            in mouse uterine luminal epithelium during preimplantation period
  JOURNAL   Fertil Steril 91 (5 Suppl), 2123-2130 (2009)
   PUBMED   18692819
  REMARK    GeneRIF: Gstm2 is highly expressed in the uterine luminal
            epithelium during preimplantation period and up-regulated by
            progesterone.
REFERENCE   4  (bases 1 to 1045)
  AUTHORS   Beverdam,A., Svingen,T., Bagheri-Fam,S., Bernard,P., McClive,P.,
            Robson,M., Khojasteh,M.B., Salehi,M., Sinclair,A.H., Harley,V.R.
            and Koopman,P.
  TITLE     Sox9-dependent expression of Gstm6 in Sertoli cells during testis
            development in mice
  JOURNAL   Reproduction 137 (3), 481-486 (2009)
   PUBMED   19098141
REFERENCE   5  (bases 1 to 1045)
  AUTHORS   Dolado,I., Swat,A., Ajenjo,N., De Vita,G., Cuadrado,A. and
            Nebreda,A.R.
  TITLE     p38alpha MAP kinase as a sensor of reactive oxygen species in
            tumorigenesis
  JOURNAL   Cancer Cell 11 (2), 191-205 (2007)
   PUBMED   17292829
REFERENCE   6  (bases 1 to 1045)
  AUTHORS   Muskhelishvili,L., Turturro,A., Hart,R.W. and James,S.J.
  TITLE     Pi-class glutathione-S-transferase-positive hepatocytes in aging
            B6C3F1 mice undergo apoptosis induced by dietary restriction
  JOURNAL   Am J Pathol 149 (5), 1585-1591 (1996)
   PUBMED   8909248
REFERENCE   7  (bases 1 to 1045)
  AUTHORS   Beiswanger,C.M., Diegmann,M.H., Novak,R.F., Philbert,M.A.,
            Graessle,T.L., Reuhl,K.R. and Lowndes,H.E.
  TITLE     Developmental changes in the cellular distribution of glutathione
            and glutathione S-transferases in the murine nervous system
  JOURNAL   Neurotoxicology 16 (3), 425-440 (1995)
   PUBMED   8584275
REFERENCE   8  (bases 1 to 1045)
  AUTHORS   Zhong,S., Spurr,N.K., Hayes,J.D. and Wolf,C.R.
  TITLE     Deduced amino acid sequence, gene structure and chromosomal
            location of a novel human class Mu glutathione S-transferase, GSTM4
  JOURNAL   Biochem J 291 (Pt 1) (Pt 1), 41-50 (1993)
   PUBMED   8471052
REFERENCE   9  (bases 1 to 1045)
  AUTHORS   Awasthi,S., Singhal,S.S., Srivastava,S.K. and Awasthi,Y.C.
  TITLE     Purification and characterization of glutathione S-transferase of
            murine ovary and testis
  JOURNAL   Arch Biochem Biophys 301 (1), 143-150 (1993)
   PUBMED   8442656
REFERENCE   10 (bases 1 to 1045)
  AUTHORS   Townsend,A.J., Goldsmith,M.E., Pickett,C.B. and Cowan,K.H.
  TITLE     Isolation, characterization, and expression in Escherichia coli of
            two murine Mu class glutathione S-transferase cDNAs homologous to
            the rat subunits 3 (Yb1) and 4 (Yb2)
  JOURNAL   J Biol Chem 264 (36), 21582-21590 (1989)
   PUBMED   2689439
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV042593.1, AU042962.1 and AI838612.1.
            
            On Jan 27, 2018 this sequence version replaced NM_008183.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037068.2, AK002845.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-755               DV042593.1         66-820
            756-1030            AU042962.1         5-279               c
            1031-1045           AI838612.1         1-15                c
FEATURES             Location/Qualifiers
     source          1..1045
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.83 cM"
     gene            1..1045
                     /gene="Gstm2"
                     /gene_synonym="Gstb-2; Gstb2"
                     /note="glutathione S-transferase, mu 2"
                     /db_xref="GeneID:14863"
                     /db_xref="MGI:MGI:95861"
     exon            1..63
                     /gene="Gstm2"
                     /gene_synonym="Gstb-2; Gstb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..684
                     /gene="Gstm2"
                     /gene_synonym="Gstb-2; Gstb2"
                     /EC_number="2.5.1.18"
                     /note="GST 5-5; GST class-mu 2; glutathione S-transferase
                     pmGT2"
                     /codon_start=1
                     /product="glutathione S-transferase Mu 2"
                     /protein_id="NP_032209.1"
                     /db_xref="CCDS:CCDS17746.1"
                     /db_xref="GeneID:14863"
                     /db_xref="MGI:MGI:95861"
                     /translation="MPMTLGYWDIRGLAHAIRLLLEYTDTSYEDKKYTMGDAPDYDRS
                     QWLSEKFKLGLDFPNLPYLIDGSHKITQSNAILRYLARKHNLCGETEEERIRVDILEN
                     QAMDTRIQLAMVCYSPDFEKKKPEYLEGLPEKMKLYSEFLGKQPWFAGNKVTYVDFLV
                     YDVLDQHRIFEPKCLDAFPNLKDFMGRFEGLKKISDYMKSSRFLSKPIFAKMAFWNPK
                     "
     exon            64..139
                     /gene="Gstm2"
                     /gene_synonym="Gstb-2; Gstb2"
                     /inference="alignment:Splign:2.1.0"
     exon            140..204
                     /gene="Gstm2"
                     /gene_synonym="Gstb-2; Gstb2"
                     /inference="alignment:Splign:2.1.0"
     exon            205..286
                     /gene="Gstm2"
                     /gene_synonym="Gstb-2; Gstb2"
                     /inference="alignment:Splign:2.1.0"
     exon            287..387
                     /gene="Gstm2"
                     /gene_synonym="Gstb-2; Gstb2"
                     /inference="alignment:Splign:2.1.0"
     exon            388..483
                     /gene="Gstm2"
                     /gene_synonym="Gstb-2; Gstb2"
                     /inference="alignment:Splign:2.1.0"
     exon            484..594
                     /gene="Gstm2"
                     /gene_synonym="Gstb-2; Gstb2"
                     /inference="alignment:Splign:2.1.0"
     exon            595..1031
                     /gene="Gstm2"
                     /gene_synonym="Gstb-2; Gstb2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1014..1019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gstm2"
                     /gene_synonym="Gstb-2; Gstb2"
                     /note="hexamer: AATAAA"
     polyA_site      1031
                     /gene="Gstm2"
                     /gene_synonym="Gstb-2; Gstb2"
                     /note="major polyA site"
ORIGIN      
        1 ggttggtctg ctctggacac cagcactatg cctatgacac taggttactg ggacatccgt
       61 gggctggctc acgccatccg cctgctcctg gaatacacag acacaagcta tgaggacaag
      121 aaatacacca tgggggacgc tcctgactat gaccgaagcc agtggctgag tgagaagttc
      181 aagctgggcc tggactttcc caatctgccc tacttgattg atggatcaca caagatcacc
      241 cagagcaatg ccatcctgcg ctaccttgcc cgaaagcaca acctgtgtgg agagacagag
      301 gaggagagga ttcgtgtgga cattttggag aaccaggcta tggacacccg catacagttg
      361 gccatggttt gctacagccc tgactttgag aaaaagaagc cagagtactt agagggtctc
      421 cctgagaaga tgaagctcta ctctgagttt ctgggcaagc agccatggtt tgcagggaac
      481 aaggtcacct atgtggattt tcttgtttat gatgtccttg atcaacaccg aatatttgag
      541 cccaagtgcc tggatgcctt cccaaacctg aaggacttca tgggtcgctt tgagggcctg
      601 aagaagatat ctgactacat gaagagcagc cgcttcctct ccaagccaat ctttgcaaag
      661 atggcctttt ggaacccaaa gtaggattac aaagcccaga cctgggggaa tactcatgag
      721 tgctctgctg gccctagctc ttaccacgtg cagctttctt ctcctttcca ttccctattc
      781 ctccatttcc tcttcccagc ccttccctca gccaagcctc tgggtccttg ggctctccat
      841 ttcttcatta gtctcctcct atcccttgtc tctgccctgc atccagccct tccctcagtg
      901 atggttggag gaatgtacta gacccgagaa tccccggcct ggcctgagag attagatctg
      961 tctgtgtgct gccttggtcc tcagagtaag cagctaagcc ccatttggtt ctcaataaag
     1021 tgtgaatcac aaaaaaaaaa aaaaa
//
