LOCUS       NM_010358               1310 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus glutathione S-transferase, mu 1 (Gstm1), transcript
            variant 2, mRNA.
ACCESSION   NM_010358
VERSION     NM_010358.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1310)
  AUTHORS   Wang,B., Zhang,Z., Zhao,J., Ma,Y., Wang,Y., Yin,N. and Song,T.
  TITLE     Spatiotemporal Evolution of Developing Palate in Mice
  JOURNAL   J Dent Res 103 (5), 546-554 (2024)
   PUBMED   38619065
REFERENCE   2  (bases 1 to 1310)
  AUTHORS   Li,P., Liu,Z., Wang,J., Bi,X., Xiao,Y., Qiao,R., Zhou,X., Guo,S.,
            Wan,P., Chang,M., Hong,G., Liu,Z., Ming,X., Gao,J. and Fu,X.
  TITLE     Gstm1/Gstt1 is essential for reducing cisplatin ototoxicity in
            CBA/CaJ mice
  JOURNAL   FASEB J 36 (6), e22373 (2022)
   PUBMED   35621716
  REMARK    GeneRIF: Gstm1/Gstt1 is essential for reducing cisplatin
            ototoxicity in CBA/CaJ mice.
REFERENCE   3  (bases 1 to 1310)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1310)
  AUTHORS   Kano,S.I., Choi,E.Y., Dohi,E., Agarwal,S., Chang,D.J., Wilson,A.M.,
            Lo,B.D., Rose,I.V.L., Gonzalez,S., Imai,T. and Sawa,A.
  TITLE     Glutathione S-transferases promote proinflammatory
            astrocyte-microglia communication during brain inflammation
  JOURNAL   Sci Signal 12 (569) (2019)
   PUBMED   30783009
  REMARK    GeneRIF: Glutathione S-transferase mu 1 (GSTM1) and glutathione
            S-transferase theta 2 (GSTT2) were required in astrocytes for the
            enhancement of microglia activation during brain inflammation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1310)
  AUTHORS   Walsh,J., Jenkins,R.E., Wong,M., Olayanju,A., Powell,H., Copple,I.,
            O'Neill,P.M., Goldring,C.E., Kitteringham,N.R. and Park,B.K.
  TITLE     Identification and quantification of the basal and inducible
            Nrf2-dependent proteomes in mouse liver: biochemical,
            pharmacological and toxicological implications
  JOURNAL   J Proteomics 108 (100), 171-187 (2014)
   PUBMED   24859727
  REMARK    GeneRIF: Six proteins were regulated at both basal and inducible
            levels exhibiting the largest dynamic range of Nrf2 regulation:
            cytochrome CYP2A5, GSTM3, GSTM1, ENTPD5,UDPGDH, and EPHX1.
REFERENCE   6  (bases 1 to 1310)
  AUTHORS   Awasthi,S., Singhal,S.S., Srivastava,S.K. and Awasthi,Y.C.
  TITLE     Purification and characterization of glutathione S-transferase of
            murine ovary and testis
  JOURNAL   Arch Biochem Biophys 301 (1), 143-150 (1993)
   PUBMED   8442656
REFERENCE   7  (bases 1 to 1310)
  AUTHORS   Townsend,A.J., Goldsmith,M.E., Pickett,C.B. and Cowan,K.H.
  TITLE     Isolation, characterization, and expression in Escherichia coli of
            two murine Mu class glutathione S-transferase cDNAs homologous to
            the rat subunits 3 (Yb1) and 4 (Yb2)
  JOURNAL   J Biol Chem 264 (36), 21582-21590 (1989)
   PUBMED   2689439
REFERENCE   8  (bases 1 to 1310)
  AUTHORS   Pearson,W.R., Reinhart,J., Sisk,S.C., Anderson,K.S. and Adler,P.N.
  TITLE     Tissue-specific induction of murine glutathione transferase mRNAs
            by butylated hydroxyanisole
  JOURNAL   J Biol Chem 263 (26), 13324-13332 (1988)
   PUBMED   3417659
REFERENCE   9  (bases 1 to 1310)
  AUTHORS   Mannervik,B., Alin,P., Guthenberg,C., Jensson,H., Tahir,M.K.,
            Warholm,M. and Jornvall,H.
  TITLE     Identification of three classes of cytosolic glutathione
            transferase common to several mammalian species: correlation
            between structural data and enzymatic properties
  JOURNAL   Proc Natl Acad Sci U S A 82 (21), 7202-7206 (1985)
   PUBMED   3864155
REFERENCE   10 (bases 1 to 1310)
  AUTHORS   Pearson,W.R., Windle,J.J., Morrow,J.F., Benson,A.M. and Talalay,P.
  TITLE     Increased synthesis of glutathione S-transferases in response to
            anticarcinogenic antioxidants. Cloning and measurement of messenger
            RNA
  JOURNAL   J Biol Chem 258 (3), 2052-2062 (1983)
   PUBMED   6822548
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671877.15, BC046758.1 and AI841190.1.
            
            On Jun 16, 2009 this sequence version replaced NM_010358.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04632.1, BC046758.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AL671877.15        105218-105364       c
            148-1284            BC046758.1         1-1137
            1285-1310           AI841190.1         1-26                c
FEATURES             Location/Qualifiers
     source          1..1310
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.83 cM"
     gene            1..1310
                     /gene="Gstm1"
                     /gene_synonym="Gstb-1; Gstb1"
                     /note="glutathione S-transferase, mu 1"
                     /db_xref="GeneID:14862"
                     /db_xref="MGI:MGI:95860"
     exon            1..234
                     /gene="Gstm1"
                     /gene_synonym="Gstb-1; Gstb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..855
                     /gene="Gstm1"
                     /gene_synonym="Gstb-1; Gstb1"
                     /EC_number="2.5.1.18"
                     /note="isoform 2 is encoded by transcript variant 2;
                     pmGT10; GST 1-1; GST class-mu 1; glutathione S-transferase
                     GT8.7"
                     /codon_start=1
                     /product="glutathione S-transferase Mu 1 isoform 2"
                     /protein_id="NP_034488.1"
                     /db_xref="CCDS:CCDS17747.1"
                     /db_xref="GeneID:14862"
                     /db_xref="MGI:MGI:95860"
                     /translation="MPMILGYWNVRGLTHPIRMLLEYTDSSYDEKRYTMGDAPDFDRS
                     QWLNEKFKLGLDFPNLPYLIDGSHKITQSNAILRYLARKHHLDGETEEERIRADIVEN
                     QVMDTRMQLIMLCYNPDFEKQKPEFLKTIPEKMKLYSEFLGKRPWFAGDKVTYVDFLA
                     YDILDQYRMFEPKCLDAFPNLRDFLARFEGLKKISAYMKSSRYIATPIFSKMAHWSNK
                     "
     exon            235..310
                     /gene="Gstm1"
                     /gene_synonym="Gstb-1; Gstb1"
                     /inference="alignment:Splign:2.1.0"
     exon            311..375
                     /gene="Gstm1"
                     /gene_synonym="Gstb-1; Gstb1"
                     /inference="alignment:Splign:2.1.0"
     exon            376..457
                     /gene="Gstm1"
                     /gene_synonym="Gstb-1; Gstb1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..558
                     /gene="Gstm1"
                     /gene_synonym="Gstb-1; Gstb1"
                     /inference="alignment:Splign:2.1.0"
     exon            559..654
                     /gene="Gstm1"
                     /gene_synonym="Gstb-1; Gstb1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..765
                     /gene="Gstm1"
                     /gene_synonym="Gstb-1; Gstb1"
                     /inference="alignment:Splign:2.1.0"
     exon            766..1294
                     /gene="Gstm1"
                     /gene_synonym="Gstb-1; Gstb1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1267..1272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gstm1"
                     /gene_synonym="Gstb-1; Gstb1"
                     /note="hexamer: AATAAA"
     polyA_site      1284
                     /gene="Gstm1"
                     /gene_synonym="Gstb-1; Gstb1"
                     /note="major polyA site"
ORIGIN      
        1 ctgccttccg ctttagggtc tgctgctctg gttacagacc taggaagggg agtgcctaat
       61 tgggattggt gcagggttgg gagggacccg ctgttttgtc ctgcccacgt ttctctagta
      121 gtctgtataa agtcacaact ccaaacacac aggtcagtcc tgctgaagcc agtttgagaa
      181 gaccacagca ccagcaccat gcctatgata ctgggatact ggaacgtccg cggactgaca
      241 cacccgatcc gcatgctcct ggaatacaca gactcaagct atgatgagaa gagatacacc
      301 atgggtgacg ctcccgactt tgacagaagc cagtggctga atgagaagtt caagctgggc
      361 ctggactttc ccaatctgcc ttacttgatc gatggatcac acaagatcac ccagagcaat
      421 gccatcctgc gctaccttgc ccgaaagcac cacctggatg gagagacaga ggaggagagg
      481 atccgtgcag acattgtgga gaaccaggtc atggacaccc gcatgcagct catcatgctc
      541 tgttacaacc ctgactttga gaagcagaag ccagagttct tgaagaccat ccctgagaaa
      601 atgaagctct actctgagtt cctgggcaag aggccatggt ttgcagggga caaggtcacc
      661 tatgtggatt tccttgctta tgacattctt gaccagtacc gtatgtttga gcccaagtgc
      721 ctggacgcct tcccaaacct gagggacttc ctggcccgct tcgagggcct caagaagatc
      781 tctgcctaca tgaagagtag ccgctacatc gcaacaccta tattttcaaa gatggcccac
      841 tggagtaaca agtaggccct tgctacacgg gcactcacta ggaggacctg tccacactgg
      901 ggatcctgca ggccctgggt ggggacagca ccctggcctt ctgcactgtg gctcctggtt
      961 ctctctcctt cccgctccct tctgcagctt ggtcagcccc atctcctcac cctcttccca
     1021 gtcaagtcca cacagccttc attctcccca gtttctttca catggcccct tcttcattgg
     1081 ctccctgacc caacctcaca gcccgtttct gcgaactgag gtctgtcctg aactcacgct
     1141 tcctagaatt accccgatgg tcaacactat cttagtgcta gccctcccta gagttacccc
     1201 gaaggtcaat acttgagtgc cagcctgttc ctggtggagt agcctcccca ggtctgtctc
     1261 gtctacaata aagtctgaaa cacacttgcc atgaaaaaaa aaaaaaaaaa
//
