LOCUS       NM_026231               3505 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus glutathione S-transferase, C-terminal domain
            containing (Gstcd), transcript variant 2, mRNA.
ACCESSION   NM_026231
VERSION     NM_026231.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3505)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3505)
  AUTHORS   Liu,B., Henry,A.P., Azimi,S., Miller,S., Lee,F.K., Lee,J.C.,
            Probert,K., Kotlikoff,M.I., Sayers,I. and Hall,I.P.
  TITLE     Exposure to lipopolysaccharide (LPS) reduces contractile response
            of small airways from GSTCD-/- mice
  JOURNAL   PLoS One 14 (9), e0221899 (2019)
   PUBMED   31513609
  REMARK    GeneRIF: Data potentially highlight an unrecognised function of
            GSTCD in mediating inflammatory signals that affect airway caliber,
            and may in part underlie the genetic associations seen at the GSTCD
            locus with lung function and COPD phenotypes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3505)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 3505)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 3505)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY740821.1, BC047136.1 and AC124593.4.
            
            On Sep 29, 2017 this sequence version replaced NM_026231.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033409.1, BC047136.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                BY740821.1         1-85
            86-2705             BC047136.1         1-2620
            2706-3505           AC124593.4         45699-46498         c
FEATURES             Location/Qualifiers
     source          1..3505
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 61.54 cM"
     gene            1..3505
                     /gene="Gstcd"
                     /gene_synonym="4933434L15Rik"
                     /note="glutathione S-transferase, C-terminal domain
                     containing"
                     /db_xref="GeneID:67553"
                     /db_xref="MGI:MGI:1914803"
     exon            1..246
                     /gene="Gstcd"
                     /gene_synonym="4933434L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            247..696
                     /gene="Gstcd"
                     /gene_synonym="4933434L15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..2172
                     /gene="Gstcd"
                     /gene_synonym="4933434L15Rik"
                     /codon_start=1
                     /product="glutathione S-transferase C-terminal
                     domain-containing protein"
                     /protein_id="NP_080507.2"
                     /db_xref="CCDS:CCDS17847.1"
                     /db_xref="GeneID:67553"
                     /db_xref="MGI:MGI:1914803"
                     /translation="MKGIKKSPTEESLYLEYSHQTEGCIFPLHTSVTLFLLSYCECKV
                     FNVCLVLTEESTDTSDTSFLKEALPQDLEIQVISKQALPPIVQNCCLPAVVDQPDVFC
                     RAGLAVVLRHIIQKSYEAEPSRKEILELLGFKKTCLKACAEVSQWTRLCELTIPLAVE
                     NFLQESSEHPPTIPEEILELERKLSEPVRVHNDDKLRRQKLKQQKAAGSEPPSGKGKA
                     KSKASAQKTPKDLAAPSKSLELKVAFSKLTVQEDAAASNREPSHIRKAKAADLPPLEH
                     VFAEGLYFTLADIVLLPCIHHFLVIICKKFSEKLEQFPLLTSWYQRIQEVPKVKTAAS
                     KCGIYFLYLPELLNSARKQPVNSDEVAAVDEQSDPLFIGGPRPTMTKLMEKGIEAMFS
                     PHPCPAWTLDWSSLPAAVSPKEGKMSTDRALRKQQQLNNLVYLVLNQAKPGDRIVDFC
                     SGGGHVGIVLAHMLPSCQVTLIENKELSLIRAKKRSDELGLSNIWFIQANMEYFTGMF
                     NIGVALHACGVATDMVIEHCIQTRASFITCPCCYGFIQNTSKFNFPKSEKFKKTLSYK
                     EHMLLCRFADQTAVQLPPERRLIGKQCMGLVDLDRAAAAGEHGYSVQVISMEPESCSP
                     KNNMIVGVPL"
     exon            697..1164
                     /gene="Gstcd"
                     /gene_synonym="4933434L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1416
                     /gene="Gstcd"
                     /gene_synonym="4933434L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1510
                     /gene="Gstcd"
                     /gene_synonym="4933434L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1626
                     /gene="Gstcd"
                     /gene_synonym="4933434L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1671
                     /gene="Gstcd"
                     /gene_synonym="4933434L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1800
                     /gene="Gstcd"
                     /gene_synonym="4933434L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1934
                     /gene="Gstcd"
                     /gene_synonym="4933434L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..1965
                     /gene="Gstcd"
                     /gene_synonym="4933434L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2035
                     /gene="Gstcd"
                     /gene_synonym="4933434L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..3505
                     /gene="Gstcd"
                     /gene_synonym="4933434L15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3419..3424
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gstcd"
                     /gene_synonym="4933434L15Rik"
                     /note="hexamer: AATATA"
     polyA_site      3441
                     /gene="Gstcd"
                     /gene_synonym="4933434L15Rik"
                     /note="major polyA site"
     regulatory      3480..3485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gstcd"
                     /gene_synonym="4933434L15Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      3503
                     /gene="Gstcd"
                     /gene_synonym="4933434L15Rik"
ORIGIN      
        1 tccttccggt ccgccggatt atgaatggcg ttgggcgggg gacgcgcaga cacgttgtct
       61 cttccttctt tttgccccct ttcccctgct cagggcctcg ctgggaggcg agtgctcctc
      121 ctcaggccgc ggcttccaga agtagcctcg gagtcccggc tcgagctggg cgggaaggcg
      181 cggtggcccg cgtcgtcgcc cgcatgctcc cgcgccctcc ctgcctggcc gcgcccctgc
      241 gaccaggtga cccaatgaca acagaagatg aaaggcatta agaaaagtcc tacggaggaa
      301 tctctgtacc tggagtactc tcaccaaaca gaaggctgca tctttcctct ccacacgtct
      361 gtaactttgt ttttactatc atactgtgaa tgcaaggtct ttaacgtttg cttagtcctc
      421 actgaagaaa gtacagatac ttcagacact tcgttcctaa aagaggcact gccccaggac
      481 ctggaaatac aggttatttc aaagcaggcg ctccctccga ttgtccagaa ttgctgtttg
      541 cctgcagtgg tagatcaacc tgacgttttc tgtagggcag gccttgctgt tgtcctgaga
      601 cacataatcc aaaaatccta tgaagctgag ccctcaagaa aggaaatttt ggaacttctg
      661 ggttttaaaa agacttgttt gaaagcttgt gctgaagtta gtcagtggac caggctatgt
      721 gaactcacca tccctttggc tgttgagaat tttctccaag agtcctctga gcatccccca
      781 actatccctg aagaaatcct agagctcgag aggaagctca gtgagcctgt cagagtacac
      841 aatgatgaca aactccgaag acagaagctg aagcaacaga aggctgctgg cagtgagcct
      901 ccctccggga aggggaaagc aaagagcaag gcaagtgcac agaagacacc caaagacttg
      961 gctgctccct ccaagagtct ggaactgaag gtggcgttct caaagctcac agtgcaagaa
     1021 gatgcagctg ctagcaacag ggagccttct cacatcagga aagcaaaagc cgccgacctc
     1081 ccgcctctgg agcacgtgtt tgcagaagga ctgtacttca ctttggcaga catcgtgctt
     1141 ttgccctgta ttcaccactt tttggtaatt atctgcaaga aattttcaga gaagctggaa
     1201 cagtttccac tactaacctc ttggtatcag aggattcagg aagtgccaaa agtcaaaaca
     1261 gcagcttcca agtgtgggat ctactttctg tatttaccag aattgctgaa ctctgcaagg
     1321 aaacagcctg tgaattctga tgaagtagca gctgtagatg agcaaagtga ccctttattt
     1381 ataggaggac caagaccgac tatgaccaag ttgatggaaa aaggcattga agccatgttt
     1441 tctccgcacc cttgtcctgc ttggaccctt gactggagca gtcttcctgc tgccgtcagc
     1501 ccgaaggaag gtaaaatgtc cactgaccga gctctgagga aacagcagca gttaaacaac
     1561 cttgtctacc tggtgctgaa tcaagccaaa cctggggaca gaattgtgga tttctgcagt
     1621 ggcgggggcc atgttggaat tgtccttgcc cacatgctgc cctcgtgcca ggttacgtta
     1681 atagagaaca aggaattatc attaatccgt gctaagaaga gaagtgacga acttggttta
     1741 agcaatattt ggttcattca agcaaatatg gagtatttca caggaatgtt taacattggg
     1801 gtggccttgc acgcttgtgg agtggcaaca gacatggtga tcgagcactg catccaaaca
     1861 cgggcttcct tcatcacatg cccctgctgt tacgggttca ttcagaacac atccaagttt
     1921 aacttcccaa aaagtgaaaa attcaagaaa actttatcat acaaggaaca catgctcctc
     1981 tgcagatttg ccgatcagac agctgtccag ctcccacccg agaggagact catagggaag
     2041 cagtgcatgg gcctggtgga tctggaccga gcagcagcag caggagaaca cggctactct
     2101 gttcaagtga tctctatgga gccagagagc tgctctccca agaacaacat gattgtgggt
     2161 gtccccttgt agacgggcac tcaaacgtga tgctctgcca ttggcttcgt gaggagagcc
     2221 cggggccgtc cagggagcct ttgctgtgct cctggaagca gcactgagct gagcatgctg
     2281 ggccggctgg gaaagctgca ggaagacctt ggaagaggga tgctccgctg tgtgcgcaga
     2341 aggatgacag gcttccaaga ggggattccc cgaagcctta gccgccagag tcgttctcag
     2401 tggccaagat tccctccaca gatccatttc ctcccacttc cctgatgatg tcagtggaat
     2461 attcaacctg ggctatgacc tcacagcctt gactttataa tctttagata ttcatacttg
     2521 gtgaccagag ctaaactcaa ggtagttgag gttttatagt tttaacaatg taccttttct
     2581 atagattttt ttaaagtcta gaatggtaaa tttagtgttt tttttttaaa tctgacattg
     2641 gttgatctgc atatcatgta ctatcctcct tttaaatata aatatatgtc ccataaatta
     2701 acaaataagt ttactgctgg ttcaaagatt tcacctaaaa atttataagt caattgcact
     2761 aaattacata ttctaaaagt ggaatttaga tgtaaatttt aactaaacag taaatgtatg
     2821 cgttgtttag ttccgagata taactaacaa atgctagggt ctattgttct ccaaaccctg
     2881 gccttgcttt ctctgaaaat gcaagaatga attacatgag gtacattgtt ttgccctcca
     2941 agggagatct tctagatcta aaagagaaga cttgggtggg gggggggggg gtccattcta
     3001 taatcatgcc atcatgtgta gccttctgtt tgggtgtgaa gtgtgcagac tctgaaaagc
     3061 tcatttggac agtgctggct gcctatgttt tctttccagc agccagcttt ttaaattacg
     3121 tgtacagaca actatcggct gtgtgatgct aactataagc ctacagtatt agcattaaga
     3181 ttaattattt tatcttgatg ttttcatatc taaagcaaaa tcttaaggat tttatttatc
     3241 tgccactatg ctttaaaatg catgaataat ttaaaaggca atatggaggg ggaaactttg
     3301 ttaatttatg agatgattta agatgagaga tggtcctgat acctatgtat tttatccact
     3361 ggtactgtta actataccct gctttgcttc ttttttaaat tgagatatgc tttgatacaa
     3421 tataatacat agatttttgt attcctattt tatttaattg aaaaaaaacc ttttcatata
     3481 gtaaactgtc gtcatggctc tccgc
//
