LOCUS       NM_010357                970 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus glutathione S-transferase, alpha 4 (Gsta4), mRNA.
ACCESSION   NM_010357
VERSION     NM_010357.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 970)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 970)
  AUTHORS   Habeos,G.I., Filippopoulou,F., Habeos,E.E., Kalaitzopoulou,E.,
            Skipitari,M., Papadea,P., Lagoumintzis,G., Niarchos,A.,
            Georgiou,C.D. and Chartoumpekis,D.V.
  TITLE     Maternal Calorie Restriction Induces a Transcriptional
            Cytoprotective Response in Embryonic Liver Partially Dependent on
            Nrf2
  JOURNAL   Antioxidants (Basel) 11 (11), 2274 (2022)
   PUBMED   36421460
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 970)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 970)
  AUTHORS   Park,H.J., Kim,M.J., Han,C., White,K., Ding,D., Boyd,K., Salvi,R.
            and Someya,S.
  TITLE     Effects of Gsta4 deficiency on age-related cochlear pathology and
            hearing loss in mice
  JOURNAL   Exp Gerontol 133, 110872 (2020)
   PUBMED   32044382
  REMARK    GeneRIF: Effects of Gsta4 deficiency on age-related cochlear
            pathology and hearing loss in mice.
REFERENCE   5  (bases 1 to 970)
  AUTHORS   Park,H.J., Kim,M.J., Rothenberger,C., Kumar,A., Sampson,E.M.,
            Ding,D., Han,C., White,K., Boyd,K., Manohar,S., Kim,Y.H.,
            Ticsa,M.S., Gomez,A.S., Caicedo,I., Bose,U., Linser,P.J.,
            Miyakawa,T., Tanokura,M., Foster,T.C., Salvi,R. and Someya,S.
  TITLE     GSTA4 mediates reduction of cisplatin ototoxicity in female mice
  JOURNAL   Nat Commun 10 (1), 4150 (2019)
   PUBMED   31515474
  REMARK    GeneRIF: GSTA4-dependent detoxification may play a role in
            estrogen-mediated neuroprotection.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 970)
  AUTHORS   Faria,T.N., LaRosa,G.J., Wilen,E., Liao,J. and Gudas,L.J.
  TITLE     Characterization of genes which exhibit reduced expression during
            the retinoic acid-induced differentiation of F9 teratocarcinoma
            cells: involvement of cyclin D3 in RA-mediated growth arrest
  JOURNAL   Mol Cell Endocrinol 143 (1-2), 155-166 (1998)
   PUBMED   9806360
REFERENCE   7  (bases 1 to 970)
  AUTHORS   Krengel,U., Schroter,K.H., Hoier,H., Arkema,A., Kalk,K.H.,
            Zimniak,P. and Dijkstra,B.W.
  TITLE     Crystal structure of a murine alpha-class glutathione S-transferase
            involved in cellular defense against oxidative stress
  JOURNAL   FEBS Lett 422 (3), 285-290 (1998)
   PUBMED   9498801
REFERENCE   8  (bases 1 to 970)
  AUTHORS   Zimniak,P., Singhal,S.S., Srivastava,S.K., Awasthi,S., Sharma,R.,
            Hayden,J.B. and Awasthi,Y.C.
  TITLE     Estimation of genomic complexity, heterologous expression, and
            enzymatic characterization of mouse glutathione S-transferase
            mGSTA4-4 (GST 5.7)
  JOURNAL   J Biol Chem 269 (2), 992-1000 (1994)
   PUBMED   7904605
REFERENCE   9  (bases 1 to 970)
  AUTHORS   Zimniak,P., Eckles,M.A., Saxena,M. and Awasthi,Y.C.
  TITLE     A subgroup of class alpha glutathione S-transferases. Cloning of
            cDNA for mouse lung glutathione S-transferase GST 5.7
  JOURNAL   FEBS Lett 313 (2), 173-176 (1992)
   PUBMED   1426286
REFERENCE   10 (bases 1 to 970)
  AUTHORS   Medh,R.D., Saxena,M., Singhal,S.S., Ahmad,H. and Awasthi,Y.C.
  TITLE     Characterization of a novel glutathione S-transferase isoenzyme
            from mouse lung and liver having structural similarity to rat
            glutathione S-transferase 8-8
  JOURNAL   Biochem J 278 (Pt 3) (Pt 3), 793-799 (1991)
   PUBMED   1898365
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU953110.1, AK019271.1, AK010098.1, AK008400.1 and AI043064.1.
            
            [WARNING] On Jul 10, 2024 this sequence was replaced by
            NM_010357.4.
            
            On Nov 14, 2007 this sequence version replaced NM_010357.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012639.1, AK008189.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BU953110.1         4-29
            27-46               AK019271.1         2-21
            47-47               AK010098.1         1-1
            48-822              AK008400.1         32-806
            823-957             AK010098.1         777-911
            958-970             AI043064.1         1-13                c
FEATURES             Location/Qualifiers
     source          1..970
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 43.65 cM"
     gene            1..970
                     /gene="Gsta4"
                     /gene_synonym="GST5.7; mGsta4"
                     /note="glutathione S-transferase, alpha 4"
                     /db_xref="GeneID:14860"
                     /db_xref="MGI:MGI:1309515"
     exon            1..99
                     /gene="Gsta4"
                     /gene_synonym="GST5.7; mGsta4"
                     /inference="alignment:Splign:2.1.0"
     exon            100..206
                     /gene="Gsta4"
                     /gene_synonym="GST5.7; mGsta4"
                     /inference="alignment:Splign:2.1.0"
     exon            207..258
                     /gene="Gsta4"
                     /gene_synonym="GST5.7; mGsta4"
                     /inference="alignment:Splign:2.1.0"
     exon            259..391
                     /gene="Gsta4"
                     /gene_synonym="GST5.7; mGsta4"
                     /inference="alignment:Splign:2.1.0"
     exon            392..533
                     /gene="Gsta4"
                     /gene_synonym="GST5.7; mGsta4"
                     /inference="alignment:Splign:2.1.0"
     exon            534..665
                     /gene="Gsta4"
                     /gene_synonym="GST5.7; mGsta4"
                     /inference="alignment:Splign:2.1.0"
     exon            666..958
                     /gene="Gsta4"
                     /gene_synonym="GST5.7; mGsta4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      938..943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gsta4"
                     /gene_synonym="GST5.7; mGsta4"
                     /note="hexamer: ATTAAA"
     polyA_site      958
                     /gene="Gsta4"
                     /gene_synonym="GST5.7; mGsta4"
                     /note="major polyA site"
ORIGIN      
        1 ggtgggcgga gcttccaaaa cgacctgcag gacggtgaac tttcgctcgc agaaccgctt
       61 ctttccagtg cctggagaca acaatcccac aagaataagg aagctctgaa gcaggagtca
      121 tggcagccaa acctaagctc tactacttta atggcagggg acggatggag tcgatccgct
      181 ggctgctggc tgcggctgga gtggagtttg aggaagaatt tcttgagaca agggaacagt
      241 atgagaagat gcaaaaggat ggacacctgc ttttcggcca agtacccttg gttgaaatcg
      301 atgggatgat gctgacacag accagggcca tcctcagcta cctcgctgcc aagtacaact
      361 tgtatgggaa ggacctgaag gagagagtca ggattgacat gtatgcagat ggcacccagg
      421 acctgatgat gatgattgcc gtggctccat ttaaaacccc caaggaaaaa gaggagagct
      481 atgatttgat actgtcaaga gctaaaaccc gttacttccc agtgtttgaa aagattttaa
      541 aagaccacgg agaggctttt ctcgttggca accagctcag ttgggcagac atccagctcc
      601 tagaagccat tttgatggtg gaagaactca gtgcccctgt actgtccgac ttccctctgc
      661 tgcaggcatt taagacaaga atcagcaaca ttcctacaat taagaagttc ctgcaacccg
      721 gaagtcagag gaagcctcct ccagatggcc cctatgttga ggtggtcagg actgtcctga
      781 agttctagtg cagcgtgctt taaggtggca cccacaaggt tccaattgca gtgtcaccac
      841 aggccagctg cagagcattc cagaagcaag gtatatagat cccaggagtc aagctcttca
      901 aacaacaaaa ccactctgcc cacaatgaca aatgccaatt aaatacagtg gaaaactaaa
      961 aaaaaaaaaa
//
