LOCUS       NM_001077353            1470 bp    mRNA    linear   ROD 17-DEC-2022
DEFINITION  Mus musculus glutathione S-transferase, alpha 3 (Gsta3), transcript
            variant 1, mRNA.
ACCESSION   NM_001077353
VERSION     NM_001077353.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1470)
  AUTHORS   Ilic Z, Mondal TK, Guest I, Crawford DR and Sell S.
  TITLE     Participation of liver stem cells in cholangiocarcinogenesis after
            aflatoxin B1 exposure of glutathione S-transferase A3 knockout mice
  JOURNAL   Tumour Biol 40 (5), 1010428318777344 (2018)
   PUBMED   29804515
  REMARK    GeneRIF: aflatoxin B1 induces cholangiocarcinomas in GSTA3-/- mice
REFERENCE   2  (bases 1 to 1470)
  AUTHORS   Crawford DR, Ilic Z, Guest I, Milne GL, Hayes JD and Sell S.
  TITLE     Characterization of liver injury, oval cell proliferation and
            cholangiocarcinogenesis in glutathione S-transferase A3 knockout
            mice
  JOURNAL   Carcinogenesis 38 (7), 717-727 (2017)
   PUBMED   28535182
  REMARK    GeneRIF: There were no significant compensatory changes in KO mice
            GST subunits, GST enzymatic activity, epoxide hydrolase, or CYP1A2
            and CYP3A11 levels. Finally, there was a modest increase in
            F2-isoprostane and isofuran in KO mice that confirmed putative
            GSTA3 hydroperoxidase activity in vivo for the first time.
REFERENCE   3  (bases 1 to 1470)
  AUTHORS   Kumar V, Bouameur JE, Bar J, Rice RH, Hornig-Do HT, Roop DR,
            Schwarz N, Brodesser S, Thiering S, Leube RE, Wiesner RJ, Vijayaraj
            P, Brazel CB, Heller S, Binder H, Loffler-Wirth H, Seibel P and
            Magin TM.
  TITLE     A keratin scaffold regulates epidermal barrier formation,
            mitochondrial lipid composition, and activity
  JOURNAL   J Cell Biol 211 (5), 1057-1075 (2015)
   PUBMED   26644517
  REMARK    Erratum:[J Cell Biol. 2016 Mar 28;212(7):877. PMID: 27002167]
REFERENCE   4  (bases 1 to 1470)
  AUTHORS   Kensler KH, Slocum SL, Chartoumpekis DV, Dolan PM, Johnson NM, Ilic
            Z, Crawford DR, Sell S, Groopman JD, Kensler TW and Egner PA.
  TITLE     Genetic or pharmacologic activation of Nrf2 signaling fails to
            protect against aflatoxin genotoxicity in hypersensitive GSTA3
            knockout mice
  JOURNAL   Toxicol Sci 139 (2), 293-300 (2014)
   PUBMED   24675090
REFERENCE   5  (bases 1 to 1470)
  AUTHORS   Ilic Z, Crawford D, Vakharia D, Egner PA and Sell S.
  TITLE     Glutathione-S-transferase A3 knockout mice are sensitive to acute
            cytotoxic and genotoxic effects of aflatoxin B1
  JOURNAL   Toxicol Appl Pharmacol 242 (3), 241-246 (2010)
   PUBMED   19850059
  REMARK    Erratum:[Toxicol Appl Pharmacol. 2010 Jun 1;245(2):280. PMID:
            20852735]
REFERENCE   6  (bases 1 to 1470)
  AUTHORS   Mitchell AE, Morin D, Lame MW and Jones AD.
  TITLE     Purification, mass spectrometric characterization, and covalent
            modification of murine glutathione S-transferases
  JOURNAL   Chem Res Toxicol 8 (8), 1054-1062 (1995)
   PUBMED   8605288
REFERENCE   7  (bases 1 to 1470)
  AUTHORS   Hayes JD, Judah DJ, Neal GE and Nguyen T.
  TITLE     Molecular cloning and heterologous expression of a cDNA encoding a
            mouse glutathione S-transferase Yc subunit possessing high
            catalytic activity for aflatoxin B1-8,9-epoxide
  JOURNAL   Biochem J 285 (Pt 1) (Pt 1), 173-180 (1992)
   PUBMED   1637297
REFERENCE   8  (bases 1 to 1470)
  AUTHORS   Buetler TM and Eaton DL.
  TITLE     Complementary DNA cloning, messenger RNA expression, and induction
            of alpha-class glutathione S-transferases in mouse tissues
  JOURNAL   Cancer Res 52 (2), 314-318 (1992)
   PUBMED   1728405
REFERENCE   9  (bases 1 to 1470)
  AUTHORS   McLellan LI, Kerr LA, Cronshaw AD and Hayes JD.
  TITLE     Regulation of mouse glutathione S-transferases by chemoprotectors.
            Molecular evidence for the existence of three distinct alpha-class
            glutathione S-transferase subunits, Ya1, Ya2, and Ya3, in mouse
            liver
  JOURNAL   Biochem J 276 (Pt 2) (Pt 2), 461-469 (1991)
   PUBMED   2049074
REFERENCE   10 (bases 1 to 1470)
  AUTHORS   Kasahara M, Matsumura E, Webb G, Board PG, Figueroa F and Klein J.
  TITLE     Mapping of class alpha glutathione S-transferase 2 (GST-2) genes to
            the vicinity of the d locus on mouse chromosome 9
  JOURNAL   Genomics 8 (1), 90-96 (1990)
   PUBMED   1981995
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163025.3, AI047326.1 and BC147272.1.
            
            [WARNING] On Apr 26, 2023 this sequence was replaced by
            NM_001077353.3.
            
            On Dec 25, 2013 this sequence version replaced NM_001077353.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a). Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AI047326.1, SRR5189679.59923.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC163025.3         142483-142504
            23-132              AI047326.1         1-110
            133-1030            BC147272.1         1-898
            1031-1470           AC163025.3         167034-167473
FEATURES             Location/Qualifiers
     source          1..1470
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 6.5 cM"
     gene            1..1470
                     /gene="Gsta3"
                     /gene_synonym="Gst2-3"
                     /note="glutathione S-transferase, alpha 3"
                     /db_xref="GeneID:14859"
                     /db_xref="MGI:MGI:95856"
     exon            1..75
                     /gene="Gsta3"
                     /gene_synonym="Gst2-3"
                     /inference="alignment:Splign:2.1.0"
     exon            76..170
                     /gene="Gsta3"
                     /gene_synonym="Gst2-3"
                     /inference="alignment:Splign:2.1.0"
     exon            171..278
                     /gene="Gsta3"
                     /gene_synonym="Gst2-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..857
                     /gene="Gsta3"
                     /gene_synonym="Gst2-3"
                     /EC_number="2.5.1.18"
                     /note="isoform a is encoded by transcript variant 1;
                     glutathione S-transferase A3; GST class-alpha member 3;
                     glutathione S-transferase Yc; glutathione S-transferase
                     Ya3"
                     /codon_start=1
                     /product="glutathione S-transferase A3 isoform a"
                     /protein_id="NP_001070821.1"
                     /db_xref="CCDS:CCDS14847.1"
                     /db_xref="GeneID:14859"
                     /db_xref="MGI:MGI:95856"
                     /translation="MAGKPVLHYFDGRGRMEPIRWLLAAAGVEFEEKFLKTRDDLARL
                     RSDGSLMFQQVPMVEIDGMKLVQTKAILNYIASKYNLYGKDMKERAIIDMYTEGVADL
                     EIMILYYPHMPPEEKEASLAKIKEQTRNRYFPAFEKVLKSHGQDYLVGNRLSRADIAL
                     VELLYHVEELDPGVVDNFPLLKALRSRVSNLPTVKKFLQPGSQRKPFDDAKCVESAKK
                     IFS"
     exon            279..330
                     /gene="Gsta3"
                     /gene_synonym="Gst2-3"
                     /inference="alignment:Splign:2.1.0"
     exon            331..463
                     /gene="Gsta3"
                     /gene_synonym="Gst2-3"
                     /inference="alignment:Splign:2.1.0"
     exon            464..605
                     /gene="Gsta3"
                     /gene_synonym="Gst2-3"
                     /inference="alignment:Splign:2.1.0"
     exon            606..737
                     /gene="Gsta3"
                     /gene_synonym="Gst2-3"
                     /inference="alignment:Splign:2.1.0"
     exon            738..1470
                     /gene="Gsta3"
                     /gene_synonym="Gst2-3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtagcttac aaaacagcag aaactcttgc atatggtaaa agctagcttt ttagagggaa
       61 cagcttttta acaaggtgaa ctgaagattt gagggataga gtcccagaga gatttagact
      121 ccaagcggca gtgcagggac caggagagcc tacttgaggt acagcacaat aaaacccaag
      181 caactgctgc catggcgggg aagccagtcc ttcattactt tgatggcagg ggaagaatgg
      241 agcctatccg gtggctcttg gctgcagctg gtgtggagtt tgaagaaaaa tttctgaaaa
      301 ctcgggatga cctggcaagg ttacgaagtg atgggagtct gatgttccag caagtgccca
      361 tggtagagat cgacgggatg aaactggtgc agaccaaagc cattctcaac tacattgcct
      421 ccaaatacaa cctctatggg aaggacatga aggagagagc catcattgac atgtacacag
      481 aaggagtggc ggatctggag ataatgattc tctattaccc ccacatgccc cctgaggaga
      541 aagaggcaag ccttgccaag atcaaggaac aaaccaggaa ccgttacttc cctgcctttg
      601 aaaaggtgtt gaagagccat ggacaagatt atctcgttgg caacaggctg agcagggctg
      661 atattgccct ggttgaactc ctctaccatg tggaagagct ggacccgggc gttgtggaca
      721 acttccctct cctgaaagcg ctgagaagca gagtcagcaa cctccccaca gtgaagaagt
      781 ttcttcaacc tggcagccag aggaagcctt ttgatgacgc aaaatgtgtt gagtcagcaa
      841 agaagatttt cagttaattc aggcaactat aagtacatag cccccacaaa gccaaccttc
      901 taaaattttg catcacattg aagtgttttg actaagtgtt gaccctactt agaaagctaa
      961 caagttttct aaggcgtctg tgtcaattca ggtagacatg actgacgagg aacggccgga
     1021 tgctctctag ttgtagttaa aattgaaatc atgatcactt cctcggatat tttcttactg
     1081 ttcaataaaa caaaacaagc ttcttagact ctggagtatt cgaacattgt cattcaatag
     1141 ctgtcatatc cttgtcaaac ggagaaatct tcctgtcaaa ttctggttga tgcaaaaata
     1201 atctttcctt atggagagtg cccttcctga ccaaatacac acagatgtgt gcacactcaa
     1261 actgtgagga actcttttcc tttaacttag taatggtttt cttattcagt tatacaaaca
     1321 atacatttat gttcaatata gagcaattga tttccctggg gctgcatgaa tgatggatac
     1381 agcagggaca atcaaattac ccagccacag aatcttgaat ttctgtaata aaagtattaa
     1441 aaacttaggt attcctaata cagaactgga
//
